AU2012348529B2 - Isolated stereoisomeric forms of (S) 2-N (3-O-(propan 2-ol) -1-propyl-4-hydroxybenzene) -3-phenylpropylamide - Google Patents

Isolated stereoisomeric forms of (S) 2-N (3-O-(propan 2-ol) -1-propyl-4-hydroxybenzene) -3-phenylpropylamide Download PDF

Info

Publication number
AU2012348529B2
AU2012348529B2 AU2012348529A AU2012348529A AU2012348529B2 AU 2012348529 B2 AU2012348529 B2 AU 2012348529B2 AU 2012348529 A AU2012348529 A AU 2012348529A AU 2012348529 A AU2012348529 A AU 2012348529A AU 2012348529 B2 AU2012348529 B2 AU 2012348529B2
Authority
AU
Australia
Prior art keywords
pain
compound
treatment
pharmaceutical composition
propan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2012348529A
Other languages
English (en)
Other versions
AU2012348529A1 (en
Inventor
Eliahu Kaplan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novaremed Ltd
Original Assignee
Novaremed Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novaremed Ltd filed Critical Novaremed Ltd
Publication of AU2012348529A1 publication Critical patent/AU2012348529A1/en
Application granted granted Critical
Publication of AU2012348529B2 publication Critical patent/AU2012348529B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/22Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2012348529A 2011-12-08 2012-12-06 Isolated stereoisomeric forms of (S) 2-N (3-O-(propan 2-ol) -1-propyl-4-hydroxybenzene) -3-phenylpropylamide Active AU2012348529B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161568219P 2011-12-08 2011-12-08
US61/568,219 2011-12-08
PCT/IL2012/050512 WO2013084238A1 (en) 2011-12-08 2012-12-06 Isolated stereoisomeric forms of (s) 2-n (3-o-(propan 2-ol) -1-propyl-4-hydroxybenzene) -3-phenylpropylamide

Publications (2)

Publication Number Publication Date
AU2012348529A1 AU2012348529A1 (en) 2014-06-12
AU2012348529B2 true AU2012348529B2 (en) 2017-03-30

Family

ID=48573665

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012348529A Active AU2012348529B2 (en) 2011-12-08 2012-12-06 Isolated stereoisomeric forms of (S) 2-N (3-O-(propan 2-ol) -1-propyl-4-hydroxybenzene) -3-phenylpropylamide

Country Status (11)

Country Link
US (1) US9381173B2 (enExample)
EP (1) EP2788317B1 (enExample)
JP (2) JP6411893B2 (enExample)
CN (1) CN103998420B (enExample)
AU (1) AU2012348529B2 (enExample)
CA (1) CA2856665C (enExample)
DK (1) DK2788317T3 (enExample)
ES (1) ES2763946T3 (enExample)
HU (1) HUE048570T2 (enExample)
IN (1) IN2014MN00919A (enExample)
WO (1) WO2013084238A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015173813A1 (en) * 2014-05-14 2015-11-19 Novaremed Ltd. Pharmaceutical composition comprising stereoisomers of n-(1-(4-hydroxyphenyl)-3-(2-hydroxypropoxy)propan-2-yl)-3-phenylpropanamide for the prevention and treatment of type ii diabetes
KR102062268B1 (ko) 2018-05-18 2020-01-03 한국교통대학교 산학협력단 발광 특성 또는 전하 전달 특성이 우수한 아지드계 가교제
JP7611148B2 (ja) * 2019-01-23 2025-01-09 ノヴァレメド リミテッド 疼痛、炎症および/または自己免疫の処置または予防における使用のための化合物
EP3939578A1 (en) 2020-07-13 2022-01-19 Novaremed Ltd. Compounds for treatment or prevention of an infection resulting from a coronavirus and/or a coronavirus-induced disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110086910A1 (en) * 2009-09-09 2011-04-14 Novaremed Limited Method of treating or preventing pain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004031129A2 (en) 2002-10-03 2004-04-15 New Era Biotech, Ltd. Compounds for use in the treatment of autoimmune diseases, immuno-allergical diseases and organ or tissue transplantation rejection
US7674829B2 (en) 2004-03-26 2010-03-09 Novaremed Limited Compounds for the treatment of AIDS and other viral diseases
US20090197781A1 (en) 2008-01-31 2009-08-06 Hari Babu Sunkara Wellbore Fluids Comprising Poly(trimethylene ether) glycol Polymers
GB0804213D0 (en) * 2008-03-06 2008-04-16 New Era Biotech Ltd A method of printing or preventing pain
HUE047515T2 (hu) 2009-09-09 2020-04-28 Novaremed Ltd N-Szubsztituált benzolpropánamidok fájdalom és gyulladás kezelésében történõ alkalmazásra
GB0916073D0 (en) 2009-09-14 2009-10-28 Cintec Int Ltd Improvements in and relating to building anchor systems

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110086910A1 (en) * 2009-09-09 2011-04-14 Novaremed Limited Method of treating or preventing pain

Also Published As

Publication number Publication date
HK1201059A1 (en) 2015-08-21
WO2013084238A1 (en) 2013-06-13
US20140275270A1 (en) 2014-09-18
EP2788317A4 (en) 2015-07-08
JP6411893B2 (ja) 2018-10-31
EP2788317B1 (en) 2019-10-02
CA2856665A1 (en) 2013-06-13
IN2014MN00919A (enExample) 2015-04-17
HUE048570T2 (hu) 2020-08-28
US9381173B2 (en) 2016-07-05
CA2856665C (en) 2019-11-12
JP2015500831A (ja) 2015-01-08
AU2012348529A1 (en) 2014-06-12
DK2788317T3 (da) 2020-01-20
CN103998420B (zh) 2018-04-17
EP2788317A1 (en) 2014-10-15
JP2018021023A (ja) 2018-02-08
CN103998420A (zh) 2014-08-20
ES2763946T3 (es) 2020-06-01

Similar Documents

Publication Publication Date Title
EP0934061B1 (en) Isobutylgaba and its derivatives for the treatment of pain
Leggio et al. Effectiveness and safety of baclofen in the treatment of alcohol dependent patients
Walker Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 1994: NSAID: An Update on Their Analgesic Effects
US9381173B2 (en) Isolated stereoisomeric forms of (S)2-N(3-O-(propan 2-Ol)-1-propyl-4-hydroxybenzene)-3-phenylpropylamide
US10265304B2 (en) Nootropic compositions for improving memory performance
Zorowitz et al. Usage of pain medications during stroke rehabilitation: the Post-Stroke Rehabilitation Outcomes Project (PSROP)
EP1219624B1 (en) Remedies for neuropathic pain and model animals of neuropathic pain
Huang et al. Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via inhibiting NF-κB signaling
US6774131B1 (en) Remedies for endothelin-induced diseases
Norkus et al. Pharmacokinetics of intravenous and oral amitriptyline and its active metabolite nortriptyline in Greyhound dogs
Kotagale et al. Agmatine prevents development of tolerance to anti-nociceptive effect of ethanol in mice
Negus et al. Effects of chronic methadone treatment on cocaine-and food-maintained responding under second-order, progressive-ratio and concurrent-choice schedules in rhesus monkeys
AU2005223655B2 (en) Methods for treating alcoholism
RU2322977C1 (ru) Синтетическое анальгетическое средство и способ лечения на основе этого средства
HK1201059B (en) Isolated stereoisomeric forms of (s) 2-n (3-o-(propan 2-ol) -1-propyl-4-hydroxybenzene) -3-phenylpropylamide
JP6461961B2 (ja) ジエチル(2−シアノエチル)ホスホネートの医薬組成物および使用
CN1196932A (zh) (+)-o-去甲基反胺苯环醇作为止痛药的口服应用
EP2545915A1 (en) 2-amino-2-oxoethyl trans-3-[5-(6-methoxy-naphtalen-1-yl)-1,3-dioxan-2-yl]propyl-carbamate for use in the treatment of persistent cancer pain
BRPI0613281A2 (pt) combinação terapêutica contendo um bloqueador de receptor nmda e uma substáncia analgésica e narcótica
EP2545914A1 (en) 2-amino-2-oxoethyl trans-3-[5-(6-methoxy-naphtalen-1-yl)-1,3-dioxan-2-yl]propyl-carbamate for use in the treatment of persistent cancer pain

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)