AU2012338914A1 - Device for filtration, drying and storage - Google Patents
Device for filtration, drying and storage Download PDFInfo
- Publication number
- AU2012338914A1 AU2012338914A1 AU2012338914A AU2012338914A AU2012338914A1 AU 2012338914 A1 AU2012338914 A1 AU 2012338914A1 AU 2012338914 A AU2012338914 A AU 2012338914A AU 2012338914 A AU2012338914 A AU 2012338914A AU 2012338914 A1 AU2012338914 A1 AU 2012338914A1
- Authority
- AU
- Australia
- Prior art keywords
- filter
- unit
- filtration
- drying
- suspension
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000001035 drying Methods 0.000 title claims abstract description 48
- 238000001914 filtration Methods 0.000 title claims abstract description 35
- 238000003860 storage Methods 0.000 title description 18
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 49
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 49
- 238000000034 method Methods 0.000 claims abstract description 39
- 239000000725 suspension Substances 0.000 claims abstract description 31
- 239000013078 crystal Substances 0.000 claims abstract description 26
- 239000007787 solid Substances 0.000 claims abstract description 23
- 238000011143 downstream manufacturing Methods 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims description 28
- 238000002425 crystallisation Methods 0.000 claims description 25
- 230000008025 crystallization Effects 0.000 claims description 25
- 238000009826 distribution Methods 0.000 claims description 11
- 239000002245 particle Substances 0.000 claims description 11
- 239000004033 plastic Substances 0.000 claims description 8
- 229920003023 plastic Polymers 0.000 claims description 8
- 230000000717 retained effect Effects 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- 238000012937 correction Methods 0.000 claims description 4
- 239000012452 mother liquor Substances 0.000 claims description 4
- 230000008859 change Effects 0.000 claims description 3
- 238000004090 dissolution Methods 0.000 claims description 2
- 238000013019 agitation Methods 0.000 claims 1
- 230000008569 process Effects 0.000 abstract description 11
- 230000001225 therapeutic effect Effects 0.000 abstract description 8
- 239000000126 substance Substances 0.000 abstract description 6
- 239000013543 active substance Substances 0.000 abstract description 3
- 230000000593 degrading effect Effects 0.000 abstract 1
- 238000009434 installation Methods 0.000 abstract 1
- 239000007789 gas Substances 0.000 description 26
- 239000000047 product Substances 0.000 description 23
- 239000012065 filter cake Substances 0.000 description 19
- 239000000243 solution Substances 0.000 description 9
- 239000004480 active ingredient Substances 0.000 description 7
- 238000004140 cleaning Methods 0.000 description 7
- -1 for example Substances 0.000 description 7
- 238000000746 purification Methods 0.000 description 7
- 238000000926 separation method Methods 0.000 description 7
- 230000008901 benefit Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 6
- 102000004196 processed proteins & peptides Human genes 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000011109 contamination Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000000543 intermediate Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 102000004877 Insulin Human genes 0.000 description 3
- 108090001061 Insulin Proteins 0.000 description 3
- 229930040373 Paraformaldehyde Natural products 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 3
- 239000000428 dust Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000004108 freeze drying Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 229940125396 insulin Drugs 0.000 description 3
- 229920006324 polyoxymethylene Polymers 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 238000010200 validation analysis Methods 0.000 description 3
- 238000010626 work up procedure Methods 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- 208000034809 Product contamination Diseases 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000012864 cross contamination Methods 0.000 description 2
- 230000006240 deamidation Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000006911 nucleation Effects 0.000 description 2
- 238000010899 nucleation Methods 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 238000013341 scale-up Methods 0.000 description 2
- 238000005063 solubilization Methods 0.000 description 2
- 230000007928 solubilization Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000009827 uniform distribution Methods 0.000 description 2
- 238000013022 venting Methods 0.000 description 2
- 101100082305 Drosophila melanogaster Panx gene Proteins 0.000 description 1
- 238000001159 Fisher's combined probability test Methods 0.000 description 1
- 239000004425 Makrolon Substances 0.000 description 1
- 229920000265 Polyparaphenylene Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 238000010352 biotechnological method Methods 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000022811 deglycosylation Effects 0.000 description 1
- 238000013400 design of experiment Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000001516 effect on protein Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000010100 freeform fabrication Methods 0.000 description 1
- 238000011194 good manufacturing practice Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000006317 isomerization reaction Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000003534 oscillatory effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 230000012846 protein folding Effects 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B17/00—Machines or apparatus for drying materials in loose, plastic, or fluidised form, e.g. granules, staple fibres, with progressive movement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Water Supply & Treatment (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Drying Of Solid Materials (AREA)
- Filtration Of Liquid (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11189343.4 | 2011-11-16 | ||
| EP11189343 | 2011-11-16 | ||
| PCT/EP2012/072581 WO2013072348A1 (de) | 2011-11-16 | 2012-11-14 | Vorrichtung zur filtration, trocknung und lagerung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2012338914A1 true AU2012338914A1 (en) | 2014-05-29 |
Family
ID=47191739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012338914A Abandoned AU2012338914A1 (en) | 2011-11-16 | 2012-11-14 | Device for filtration, drying and storage |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20140317951A1 (enExample) |
| EP (1) | EP2780355A1 (enExample) |
| JP (1) | JP6192649B2 (enExample) |
| KR (1) | KR20150000862A (enExample) |
| CN (1) | CN103930434A (enExample) |
| AU (1) | AU2012338914A1 (enExample) |
| BR (1) | BR112014011780A2 (enExample) |
| CA (1) | CA2855726A1 (enExample) |
| IL (1) | IL232490A0 (enExample) |
| IN (1) | IN2014DN03291A (enExample) |
| MX (1) | MX2014005591A (enExample) |
| RU (1) | RU2014124001A (enExample) |
| SG (1) | SG11201401646SA (enExample) |
| WO (1) | WO2013072348A1 (enExample) |
| ZA (1) | ZA201403471B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10773863B2 (en) | 2011-06-22 | 2020-09-15 | Sartorius Stedim North America Inc. | Vessel closures and methods for using and manufacturing same |
| JP2018150289A (ja) * | 2017-03-15 | 2018-09-27 | 株式会社日立製作所 | タンパク質精製方法及びタンパク質精製装置 |
| DE102017204786B4 (de) | 2017-03-22 | 2021-08-19 | Ult Ag | Vorrichtung zur Absaugung und Separation von Stoffen und Partikeln aus Abgasen |
| CN106925024A (zh) * | 2017-04-29 | 2017-07-07 | 贵州大学 | 一种自清洁页岩气返排污水过滤装置 |
| EP3688024A4 (en) * | 2017-09-26 | 2021-07-14 | Biocon Biologics India Limited | BUILT-IN AUTOMATED FILTRATION FOR SEPARATION, WASHING AND DRYING OF PEPTIDE CRYSTALS |
| US12252391B2 (en) | 2017-11-14 | 2025-03-18 | Sartorius Stedim North America Inc. | System for simultaneous distribution of fluid to multiple vessels and method of using the same |
| US11691866B2 (en) | 2017-11-14 | 2023-07-04 | Sartorius Stedim North America Inc. | System for simultaneous distribution of fluid to multiple vessels and method of using the same |
| US11577953B2 (en) | 2017-11-14 | 2023-02-14 | Sartorius Stedim North America, Inc. | System for simultaneous distribution of fluid to multiple vessels and method of using the same |
| EP3710361A4 (en) | 2017-11-14 | 2021-08-11 | Sartorius Stedim North America Inc. | LIQUID TRANSFER ARRANGEMENT WITH A TRANSITION WITH MULTIPLE FLUID PATHS |
| US11319201B2 (en) | 2019-07-23 | 2022-05-03 | Sartorius Stedim North America Inc. | System for simultaneous filling of multiple containers |
| CN108939661A (zh) * | 2018-09-30 | 2018-12-07 | 陕西燎原净化设备有限公司 | 一种自动在线清洗免拆过滤装置 |
| DE102018128261A1 (de) * | 2018-11-12 | 2020-05-14 | Sartorius Stedim Biotech Gmbh | Konfigurierbare Vorrichtungsanordnung für die Durchführung wenigstens einer Grundoperation in einem biopharmazeutischen Prozess |
| US11243883B2 (en) | 2019-05-24 | 2022-02-08 | Texas Instruments Incorporated | Cache coherence shared state suppression |
| DE102021102107A1 (de) * | 2021-01-29 | 2022-08-04 | Airbus Operations Gmbh | System zum Bereitstellen einer druckbeaufschlagten Flüssigkeit |
| US12239127B2 (en) | 2021-07-28 | 2025-03-04 | Sartorius Stedim North America Inc. | Thermal capacitors, systems, and methods for rapid freezing or heating of biological materials |
| CN115057094B (zh) * | 2022-07-07 | 2023-09-05 | 河津市炬华铝业有限公司 | 一种高比表面小孔径铝硅基催化材料干燥工艺 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4673647A (en) * | 1985-05-06 | 1987-06-16 | Miles Laboratories, Inc. | Process to solubilize enzymes and an enzyme liquid product produced thereby |
| JPH05329339A (ja) * | 1991-01-29 | 1993-12-14 | Fuji Photo Film Co Ltd | 濾過システム |
| DE19903125B4 (de) * | 1999-01-27 | 2006-01-05 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga |
| US6986847B2 (en) * | 2002-05-10 | 2006-01-17 | New Jersey Institute Of Technology | Method and apparatus for isolation and purification of biomolecules |
| US8919571B2 (en) * | 2007-10-04 | 2014-12-30 | Emd Millipore Corporation | Filtration device |
| US11143636B2 (en) | 2009-05-29 | 2021-10-12 | Cytiva Sweden Ab | Fluid distributor unit |
-
2012
- 2012-11-14 WO PCT/EP2012/072581 patent/WO2013072348A1/de not_active Ceased
- 2012-11-14 JP JP2014541635A patent/JP6192649B2/ja not_active Expired - Fee Related
- 2012-11-14 RU RU2014124001/05A patent/RU2014124001A/ru not_active Application Discontinuation
- 2012-11-14 BR BR112014011780A patent/BR112014011780A2/pt not_active IP Right Cessation
- 2012-11-14 AU AU2012338914A patent/AU2012338914A1/en not_active Abandoned
- 2012-11-14 MX MX2014005591A patent/MX2014005591A/es unknown
- 2012-11-14 KR KR1020147012758A patent/KR20150000862A/ko not_active Withdrawn
- 2012-11-14 IN IN3291DEN2014 patent/IN2014DN03291A/en unknown
- 2012-11-14 US US14/359,065 patent/US20140317951A1/en not_active Abandoned
- 2012-11-14 CN CN201280056262.9A patent/CN103930434A/zh active Pending
- 2012-11-14 SG SG11201401646SA patent/SG11201401646SA/en unknown
- 2012-11-14 EP EP12787704.1A patent/EP2780355A1/de not_active Withdrawn
- 2012-11-14 CA CA2855726A patent/CA2855726A1/en not_active Abandoned
-
2014
- 2014-05-07 IL IL232490A patent/IL232490A0/en unknown
- 2014-05-14 ZA ZA2014/03471A patent/ZA201403471B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IN2014DN03291A (enExample) | 2015-06-26 |
| CA2855726A1 (en) | 2013-05-23 |
| SG11201401646SA (en) | 2014-10-30 |
| IL232490A0 (en) | 2014-06-30 |
| WO2013072348A1 (de) | 2013-05-23 |
| CN103930434A (zh) | 2014-07-16 |
| US20140317951A1 (en) | 2014-10-30 |
| KR20150000862A (ko) | 2015-01-05 |
| JP6192649B2 (ja) | 2017-09-06 |
| BR112014011780A2 (pt) | 2017-05-09 |
| JP2015500202A (ja) | 2015-01-05 |
| MX2014005591A (es) | 2014-07-30 |
| RU2014124001A (ru) | 2015-12-27 |
| ZA201403471B (en) | 2015-07-29 |
| EP2780355A1 (de) | 2014-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |