AU2012307326A1 - EP1 receptor ligands - Google Patents

EP1 receptor ligands Download PDF

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Publication number
AU2012307326A1
AU2012307326A1 AU2012307326A AU2012307326A AU2012307326A1 AU 2012307326 A1 AU2012307326 A1 AU 2012307326A1 AU 2012307326 A AU2012307326 A AU 2012307326A AU 2012307326 A AU2012307326 A AU 2012307326A AU 2012307326 A1 AU2012307326 A1 AU 2012307326A1
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AU
Australia
Prior art keywords
chloro
carboxylic acid
benzyl
oxy
indole
Prior art date
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Abandoned
Application number
AU2012307326A
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English (en)
Inventor
Francesc Xavier CALDENTEY FRONTERA
Elena Carceller Gonzalez
Ramon Merce Vidal
Antonio David Rodriguez Garrido
Jordi SALAS SOLANA
Antoni Torrens Jover
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Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
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Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of AU2012307326A1 publication Critical patent/AU2012307326A1/en
Abandoned legal-status Critical Current

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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C—CHEMISTRY; METALLURGY
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C—CHEMISTRY; METALLURGY
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D241/40—Benzopyrazines
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  • Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Pregnancy & Childbirth (AREA)
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  • Psychiatry (AREA)
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  • Gynecology & Obstetrics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2012307326A 2011-09-16 2012-09-14 EP1 receptor ligands Abandoned AU2012307326A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11382296A EP2570125A1 (en) 2011-09-16 2011-09-16 Ep1 receptor ligands
EP11382296.9 2011-09-16
PCT/EP2012/068101 WO2013037960A1 (en) 2011-09-16 2012-09-14 Ep1 receptor ligands

Publications (1)

Publication Number Publication Date
AU2012307326A1 true AU2012307326A1 (en) 2014-03-27

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AU2012307326A Abandoned AU2012307326A1 (en) 2011-09-16 2012-09-14 EP1 receptor ligands

Country Status (19)

Country Link
US (1) US9518015B2 (OSRAM)
EP (2) EP2570125A1 (OSRAM)
JP (1) JP6041880B2 (OSRAM)
KR (1) KR20140061475A (OSRAM)
CN (1) CN104220422B (OSRAM)
AR (1) AR092288A1 (OSRAM)
AU (1) AU2012307326A1 (OSRAM)
BR (1) BR112014006305A2 (OSRAM)
CA (1) CA2848786A1 (OSRAM)
CO (1) CO6970588A2 (OSRAM)
ES (1) ES2629481T3 (OSRAM)
IL (1) IL231518A0 (OSRAM)
IN (1) IN2014MN00697A (OSRAM)
MA (1) MA35444B1 (OSRAM)
MX (1) MX346143B (OSRAM)
PH (1) PH12014500575A1 (OSRAM)
SG (1) SG11201400680RA (OSRAM)
TN (1) TN2014000112A1 (OSRAM)
WO (1) WO2013037960A1 (OSRAM)

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AU2015253225B2 (en) 2014-05-01 2017-04-06 Novartis Ag Compounds and compositions as Toll-Like Receptor 7 agonists
WO2015179038A2 (en) 2014-05-23 2015-11-26 E. I. Du Pont De Nemours And Company Sulfonyl hydrazide compounds and a regio-selective process to prepare 4-aroyl pyrazole derivatives
CN103992319B (zh) * 2014-05-27 2015-09-16 天津市斯芬克司药物研发有限公司 一种吡啶羧酸类化合物的制备方法
EP3172197A4 (en) * 2014-07-25 2018-03-14 Innov17 LLC Benzimidazole retinoic acid receptor-related orphan receptor modulators and uses thereof
EP3310353A4 (en) * 2015-06-16 2019-02-06 Translatum Medicus, Inc. COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF EYE DISEASES
MA44334A (fr) 2015-10-29 2018-09-05 Novartis Ag Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
EP3668840A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Novel sulfonamide carboxamide compounds
EP3990433A4 (en) 2019-06-25 2023-07-26 Translatum Medicus Inc. METHODS FOR THE MANUFACTURE OF 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES
KR20220028736A (ko) * 2020-08-31 2022-03-08 (주)녹십자웰빙 구절초 추출물을 포함하는 통증 완화용 또는 항산화용 건강기능식품
JP7588224B2 (ja) 2020-10-05 2024-11-21 エンライブン インコーポレイテッド Ｂｃｒ－ａｂｌチロシンキナーゼの阻害のための５－及び６－アザインドール化合物
CN114163438A (zh) * 2021-12-13 2022-03-11 无锡捷化医药科技有限公司 一种2-甲基-3-羰基吡唑并[4,3-c]吡啶-7-羧酸盐酸盐的制备方法
CN121127453A (zh) * 2023-04-19 2025-12-12 海湃泰克(北京)生物医药科技有限公司 化合物、组合物及其方法

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