AU2012281242B2 - Sequence based genotyping based on oligonucleotide ligation assays - Google Patents
Sequence based genotyping based on oligonucleotide ligation assays Download PDFInfo
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- AU2012281242B2 AU2012281242B2 AU2012281242A AU2012281242A AU2012281242B2 AU 2012281242 B2 AU2012281242 B2 AU 2012281242B2 AU 2012281242 A AU2012281242 A AU 2012281242A AU 2012281242 A AU2012281242 A AU 2012281242A AU 2012281242 B2 AU2012281242 B2 AU 2012281242B2
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- AU
- Australia
- Prior art keywords
- probes
- sequence
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- probe
- ligated
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
- C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Chemical Kinetics & Catalysis (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161505787P | 2011-07-08 | 2011-07-08 | |
| US61/505,787 | 2011-07-08 | ||
| PCT/NL2012/050493 WO2013009175A1 (en) | 2011-07-08 | 2012-07-09 | Sequence based genotyping based on oligonucleotide ligation assays |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2012281242A1 AU2012281242A1 (en) | 2014-02-27 |
| AU2012281242B2 true AU2012281242B2 (en) | 2016-12-22 |
Family
ID=46579302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012281242A Active AU2012281242B2 (en) | 2011-07-08 | 2012-07-09 | Sequence based genotyping based on oligonucleotide ligation assays |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US9777322B2 (enExample) |
| EP (2) | EP2980226A1 (enExample) |
| JP (1) | JP6028025B2 (enExample) |
| AU (1) | AU2012281242B2 (enExample) |
| CA (1) | CA2840929C (enExample) |
| DK (1) | DK2729580T3 (enExample) |
| ES (1) | ES2556580T3 (enExample) |
| WO (1) | WO2013009175A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11203786B2 (en) | 2010-08-06 | 2021-12-21 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| US10533223B2 (en) | 2010-08-06 | 2020-01-14 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| US20130040375A1 (en) | 2011-08-08 | 2013-02-14 | Tandem Diagnotics, Inc. | Assay systems for genetic analysis |
| US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
| US20130261003A1 (en) | 2010-08-06 | 2013-10-03 | Ariosa Diagnostics, In. | Ligation-based detection of genetic variants |
| US8700338B2 (en) | 2011-01-25 | 2014-04-15 | Ariosa Diagnosis, Inc. | Risk calculation for evaluation of fetal aneuploidy |
| US9777322B2 (en) * | 2011-07-08 | 2017-10-03 | Keygene N.V. | Sequence based genotyping based on oligonucleotide ligation assays |
| WO2013142389A1 (en) | 2012-03-20 | 2013-09-26 | University Of Washington Through Its Center For Commercialization | Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing |
| WO2013192292A1 (en) * | 2012-06-21 | 2013-12-27 | Justin Lamb | Massively-parallel multiplex locus-specific nucleic acid sequence analysis |
| JP6234463B2 (ja) * | 2012-09-10 | 2017-11-22 | ジーンスカイ ダイアグノスティクス（スーツォウ） インコーポレーテッドＧｅｎｅｓｋｙ Ｄｉａｇｎｏｓｔｉｃｓ （Ｓｕｚｈｏｕ） Ｉｎｃ． | 核酸の多重分析の方法 |
| US9270344B2 (en) * | 2013-02-01 | 2016-02-23 | Creating Revolutions, LLC | Combination process interaction |
| CN105074007A (zh) * | 2013-03-12 | 2015-11-18 | 考希尔股份有限公司 | 用于产前遗传分析的系统和方法 |
| JP6088710B2 (ja) | 2013-08-19 | 2017-03-01 | シンギュラー・バイオ・インコーポレイテッド | 単分子検出アッセイおよびその使用 |
| JP6442534B2 (ja) * | 2014-06-02 | 2018-12-19 | ベース４ イノベーション リミテッド | ヌクレオチド多型の検出方法 |
| JP6793112B2 (ja) * | 2014-08-01 | 2020-12-02 | アリオサ ダイアグノスティックス インコーポレイテッドＡｒｉｏｓａ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． | 胎児コピー数変異の統計的尤度を提供するアッセイ方法および胎児染色体異数性の尤度決定のためのアッセイ方法 |
| CN104372093B (zh) * | 2014-11-10 | 2016-09-21 | 博奥生物集团有限公司 | 一种基于高通量测序的snp检测方法 |
| WO2016134191A1 (en) * | 2015-02-18 | 2016-08-25 | Singular Bio, Inc. | Assays for single molecule detection and use thereof |
| GB2536446B (en) * | 2015-03-17 | 2020-06-03 | Salisbury Nhs Found Trust | PCR method |
| US10844428B2 (en) * | 2015-04-28 | 2020-11-24 | Illumina, Inc. | Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS) |
| CN106435744B (zh) | 2015-08-13 | 2022-02-01 | 生捷科技控股公司 | 使用y-接头和消失限制位点的文库构建 |
| ES2911421T3 (es) | 2015-12-08 | 2022-05-19 | Twinstrand Biosciences Inc | Adaptadores, métodos y composiciones mejorados para secuenciación dúplex |
| WO2018127408A1 (en) * | 2017-01-05 | 2018-07-12 | Tervisetehnoloogiate Arenduskeskus As | Quantifying dna sequences |
| US10844429B2 (en) | 2017-01-18 | 2020-11-24 | Illumina, Inc. | Methods and systems for generation and error-correction of unique molecular index sets with heterogeneous molecular lengths |
| US11447818B2 (en) | 2017-09-15 | 2022-09-20 | Illumina, Inc. | Universal short adapters with variable length non-random unique molecular identifiers |
| US11739367B2 (en) | 2017-11-08 | 2023-08-29 | Twinstrand Biosciences, Inc. | Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters |
| US11639928B2 (en) | 2018-02-22 | 2023-05-02 | 10X Genomics, Inc. | Methods and systems for characterizing analytes from individual cells or cell populations |
| EP3768853A4 (en) * | 2018-03-23 | 2021-04-28 | Board Of Regents The University Of Texas System | EFFICIENT SEQUENCING OF DSDNA WITH EXTREMELY LOW ERROR RATE |
| JP7491576B2 (ja) | 2018-06-12 | 2024-05-28 | キージーン ナムローゼ フェンノートシャップ | 核酸増幅法 |
| AU2019300172A1 (en) | 2018-07-12 | 2021-01-28 | Twinstrand Biosciences, Inc. | Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications |
| JP7602464B2 (ja) * | 2019-01-04 | 2024-12-18 | ウィリアム マーシュ ライス ユニバーシティ | 多重コピー数変異検出および対立遺伝子比定量化のための定量的アンプリコン配列決定 |
| CA3127572A1 (en) | 2019-02-21 | 2020-08-27 | Keygene N.V. | Genotyping of polyploids |
| CA3153533A1 (en) * | 2019-09-09 | 2021-03-18 | Sherlock Biosciences, Inc. | System |
| WO2021048291A1 (en) * | 2019-09-12 | 2021-03-18 | Glaxosmithkline Intellectual Property Development Limited | Method for screening libraries |
| WO2022182682A1 (en) | 2021-02-23 | 2022-09-01 | 10X Genomics, Inc. | Probe-based analysis of nucleic acids and proteins |
| US20230348962A1 (en) * | 2021-11-04 | 2023-11-02 | Florida State University Research Foundation, Inc. | Using Hairpin Formation To Identify DNA and RNA Sequences Having A Target Nucleic Acid Sequence |
| CN118006735B (zh) * | 2023-05-30 | 2025-07-04 | 深圳赛陆医疗科技有限公司 | 一种snp芯片及其制备方法和应用 |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4883750A (en) | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US5242794A (en) | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| GB8612087D0 (en) | 1986-05-19 | 1986-06-25 | Ici Plc | Hybridisation probes |
| CA1323293C (en) | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
| DE68926504T2 (de) | 1988-07-20 | 1996-09-12 | David Segev | Verfahren zur amplifizierung und zum nachweis von nukleinsäuresequenzen |
| US5185243A (en) | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
| EP0439182B1 (en) | 1990-01-26 | 1996-04-24 | Abbott Laboratories | Improved method of amplifying target nucleic acids applicable to both polymerase and ligase chain reactions |
| RU2182176C2 (ru) | 1991-09-24 | 2002-05-10 | Кейгене Н.В. | Способ селективной амплификации, олигонуклеотид и набор для селективной амплификации |
| US5470705A (en) | 1992-04-03 | 1995-11-28 | Applied Biosystems, Inc. | Probe composition containing a binding domain and polymer chain and methods of use |
| AU684279B2 (en) | 1993-04-12 | 1997-12-11 | Northwestern University | Method of forming oligonucleotides |
| US5692223A (en) | 1993-10-22 | 1997-11-25 | Minolta Co., Ltd. | Remotely-controlled flash photographing system |
| SE9400522D0 (sv) | 1994-02-16 | 1994-02-16 | Ulf Landegren | Method and reagent for detecting specific nucleotide sequences |
| US20070269799A9 (en) | 1994-06-22 | 2007-11-22 | Zhang David Y | Nucleic acid amplification methods |
| US5876924A (en) | 1994-06-22 | 1999-03-02 | Mount Sinai School Of Medicine | Nucleic acid amplification method hybridization signal amplification method (HSAM) |
| US5942391A (en) | 1994-06-22 | 1999-08-24 | Mount Sinai School Of Medicine | Nucleic acid amplification method: ramification-extension amplification method (RAM) |
| WO1996015271A1 (en) | 1994-11-16 | 1996-05-23 | Abbott Laboratories | Multiplex ligations-dependent amplification |
| SE506908C2 (sv) | 1995-09-08 | 1998-03-02 | Ulf Landegren Inst F Medicinsk | Medicinsk användning av padlockprober |
| EP0912761A4 (en) | 1996-05-29 | 2004-06-09 | Cornell Res Foundation Inc | DETERMINATION OF DIFFERENCES IN THE NUCLEIC ACID SEQUENCE BY MEANS OF A COMBINATION OF LIGASE DETERMINATION AND POLYMERASE CHAIN REACTION |
| US6312892B1 (en) | 1996-07-19 | 2001-11-06 | Cornell Research Foundation, Inc. | High fidelity detection of nucleic acid differences by ligase detection reaction |
| ATE236997T1 (de) | 1998-07-21 | 2003-04-15 | Keygene Nv | Verbesserte primer zur aflp amplifizierung |
| ATE309390T1 (de) | 1998-07-30 | 2005-11-15 | Solexa Ltd | Matrizen von biomolekülen und ihre verwendung in sequenzierung |
| GB0002310D0 (en) | 2000-02-01 | 2000-03-22 | Solexa Ltd | Polynucleotide sequencing |
| EP1131153A1 (en) | 1998-11-06 | 2001-09-12 | Solexa Ltd. | A method for reproducing molecular arrays |
| WO2000058507A1 (en) | 1999-03-30 | 2000-10-05 | Solexa Ltd. | Polynucleotide sequencing |
| US20020086289A1 (en) | 1999-06-15 | 2002-07-04 | Don Straus | Genomic profiling: a rapid method for testing a complex biological sample for the presence of many types of organisms |
| US6156178A (en) | 1999-07-13 | 2000-12-05 | Molecular Dynamics, Inc. | Increased throughput analysis of small compounds using multiple temporally spaced injections |
| WO2001023610A2 (en) | 1999-09-29 | 2001-04-05 | Solexa Ltd. | Polynucleotide sequencing |
| GB0002389D0 (en) | 2000-02-02 | 2000-03-22 | Solexa Ltd | Molecular arrays |
| US6221603B1 (en) | 2000-02-04 | 2001-04-24 | Molecular Dynamics, Inc. | Rolling circle amplification assay for nucleic acid analysis |
| EP1130113A1 (en) | 2000-02-15 | 2001-09-05 | Johannes Petrus Schouten | Multiplex ligation dependent amplification assay |
| AU2001265121A1 (en) | 2000-05-30 | 2001-12-11 | Applera Corporation | Methods for detecting target nucleic acids using coupled ligation and amplification |
| AU2002231934A1 (en) | 2001-01-30 | 2002-08-12 | Solexa Ltd. | Arrayed polynucleotides and their use in genome analysis |
| CA2453207A1 (en) | 2001-07-06 | 2003-01-16 | 454 Corporation | Method for isolation of independent, parallel chemical micro-reactions using a porous filter |
| GB0119719D0 (en) | 2001-08-13 | 2001-10-03 | Solexa Ltd | DNA sequence analysis |
| US6902921B2 (en) | 2001-10-30 | 2005-06-07 | 454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| US20030119004A1 (en) | 2001-12-05 | 2003-06-26 | Wenz H. Michael | Methods for quantitating nucleic acids using coupled ligation and amplification |
| EP1319718A1 (en) | 2001-12-14 | 2003-06-18 | Keygene N.V. | High throughput analysis and detection of multiple target sequences |
| DE10162904B4 (de) | 2001-12-20 | 2006-05-11 | Jeyes Deutschland Gmbh | Vorrichtung zur Abgabe eines flüssigen Wirkstoffs in ein Spülwasser |
| US20060088826A1 (en) * | 2001-12-28 | 2006-04-27 | Van Eijk Michael Josephus Ther | Discrimination and detection of target nucleotide sequences using mass spectrometry |
| EP3438116B1 (en) | 2002-08-23 | 2021-02-17 | Illumina Cambridge Limited | Labelled nucleotides |
| JP2006509040A (ja) | 2002-08-23 | 2006-03-16 | ソレックサ リミテッド | 修飾されたヌクレオチド |
| EP1567669B1 (en) | 2002-12-02 | 2010-03-24 | Illumina Cambridge Limited | Determination of methylation of nucleic acid sequences |
| EP1594980B2 (en) | 2003-01-29 | 2017-08-16 | 454 Life Sciences Corporation | Bead emulsion nucleic acid amplification |
| GB0304371D0 (en) | 2003-02-26 | 2003-04-02 | Solexa Ltd | DNA Sequence analysis |
| US20050239089A1 (en) * | 2003-06-06 | 2005-10-27 | Johnson Martin D | Mobility cassettes |
| EP1633888B1 (en) | 2003-06-17 | 2009-03-25 | Keygene N.V. | Means and method for the detection of target nucleotide sequences using ligation assays with improved oligonucleotide probe pairs |
| GB0320059D0 (en) | 2003-08-27 | 2003-10-01 | Solexa Ltd | A method of sequencing |
| WO2005026389A2 (en) | 2003-08-29 | 2005-03-24 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Ligation-based method of analysis of single nucleotide polymorphisms on genomic dna |
| DK1664345T3 (da) | 2003-09-02 | 2015-06-22 | Keygene Nv | OLA-baserede fremgangsmåder til detektion af target-nukleinsyresekvenser |
| EP1602733A1 (en) | 2004-06-02 | 2005-12-07 | Keygene N.V. | Detection of target nucleotide sequences using an asymmetric oligonucleotide ligation assay |
| GB0326073D0 (en) | 2003-11-07 | 2003-12-10 | Solexa Ltd | Improvements in or relating to polynucleotide arrays |
| EP1701785A1 (en) | 2004-01-07 | 2006-09-20 | Solexa Ltd. | Modified molecular arrays |
| GB0400584D0 (en) | 2004-01-12 | 2004-02-11 | Solexa Ltd | Nucleic acid chacterisation |
| GB0400974D0 (en) | 2004-01-16 | 2004-02-18 | Solexa Ltd | Multiple inexact matching |
| GB0402895D0 (en) | 2004-02-10 | 2004-03-17 | Solexa Ltd | Arrayed polynucleotides |
| US20060211000A1 (en) * | 2005-03-21 | 2006-09-21 | Sorge Joseph A | Methods, compositions, and kits for detection of microRNA |
| EP1910537A1 (en) | 2005-06-06 | 2008-04-16 | 454 Life Sciences Corporation | Paired end sequencing |
| EP2363504A1 (en) * | 2005-12-22 | 2011-09-07 | Keygene N.V. | Method for high-throughtput AFLP-based polymorphism detection |
| WO2007101075A2 (en) * | 2006-02-22 | 2007-09-07 | Applera Corporation | Double-ligation method for haplotype and large-scale polymorphism detection |
| JP5237126B2 (ja) | 2006-03-01 | 2013-07-17 | キージーン ナムローゼ フェンノートシャップ | ライゲーションアッセイを用いてハイスループットシークエンスに基づき遺伝子関連配列を検出する方法 |
| EP2677309B9 (en) | 2006-12-14 | 2014-11-19 | Life Technologies Corporation | Methods for sequencing a nucleic acid using large scale FET arrays, configured to measure a limited pH range |
| US8349167B2 (en) | 2006-12-14 | 2013-01-08 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
| US8852864B2 (en) | 2008-01-17 | 2014-10-07 | Sequenom Inc. | Methods and compositions for the analysis of nucleic acids |
| EP2307577B1 (en) | 2008-06-25 | 2015-06-03 | Life Technologies Corporation | Methods for measuring analytes using large scale fet arrays |
| CN102203597A (zh) | 2008-06-26 | 2011-09-28 | 生命技术公司 | 使用fet阵列检测分子相互作用的方法和装置 |
| US20100035252A1 (en) | 2008-08-08 | 2010-02-11 | Ion Torrent Systems Incorporated | Methods for sequencing individual nucleic acids under tension |
| US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
| US20100301398A1 (en) | 2009-05-29 | 2010-12-02 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
| US8546128B2 (en) | 2008-10-22 | 2013-10-01 | Life Technologies Corporation | Fluidics system for sequential delivery of reagents |
| EP2342552B1 (en) | 2008-10-22 | 2022-09-14 | Life Technologies Corporation | Floating gate chemical field effect transistor array with bilayer gate dielectric |
| WO2010126614A2 (en) | 2009-04-30 | 2010-11-04 | Good Start Genetics, Inc. | Methods and compositions for evaluating genetic markers |
| EP2435461B1 (en) | 2009-05-29 | 2017-08-09 | Life Technologies Corporation | Scaffolded nucleic acid polymer particles and methods of making and using |
| US8574835B2 (en) | 2009-05-29 | 2013-11-05 | Life Technologies Corporation | Scaffolded nucleic acid polymer particles and methods of making and using |
| US8673627B2 (en) | 2009-05-29 | 2014-03-18 | Life Technologies Corporation | Apparatus and methods for performing electrochemical reactions |
| US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
| US20120077191A1 (en) | 2010-08-11 | 2012-03-29 | Celula, Inc. | Genotyping dna |
| AU2012255121B2 (en) | 2011-05-17 | 2017-03-09 | Dxterity Diagnostics Incorporated | Methods and compositions for detecting target nucleic acids |
| US9777322B2 (en) * | 2011-07-08 | 2017-10-03 | Keygene N.V. | Sequence based genotyping based on oligonucleotide ligation assays |
-
2012
- 2012-07-09 US US14/131,181 patent/US9777322B2/en active Active
- 2012-07-09 EP EP15185310.8A patent/EP2980226A1/en not_active Withdrawn
- 2012-07-09 AU AU2012281242A patent/AU2012281242B2/en active Active
- 2012-07-09 DK DK12738652.2T patent/DK2729580T3/en active
- 2012-07-09 JP JP2014518468A patent/JP6028025B2/ja active Active
- 2012-07-09 ES ES12738652.2T patent/ES2556580T3/es active Active
- 2012-07-09 EP EP12738652.2A patent/EP2729580B1/en active Active
- 2012-07-09 CA CA2840929A patent/CA2840929C/en active Active
- 2012-07-09 WO PCT/NL2012/050493 patent/WO2013009175A1/en not_active Ceased
-
2017
- 2017-08-22 US US15/683,063 patent/US10422001B2/en active Active
-
2019
- 2019-08-13 US US16/539,119 patent/US10988807B2/en active Active
-
2021
- 2021-03-22 US US17/208,728 patent/US11873529B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013009175A1 (en) | 2013-01-17 |
| US10988807B2 (en) | 2021-04-27 |
| US9777322B2 (en) | 2017-10-03 |
| US20200071757A1 (en) | 2020-03-05 |
| US11873529B2 (en) | 2024-01-16 |
| JP2014520525A (ja) | 2014-08-25 |
| US20140221217A1 (en) | 2014-08-07 |
| EP2729580B1 (en) | 2015-09-16 |
| CA2840929C (en) | 2020-03-24 |
| US20210207213A1 (en) | 2021-07-08 |
| EP2980226A1 (en) | 2016-02-03 |
| US10422001B2 (en) | 2019-09-24 |
| JP6028025B2 (ja) | 2016-11-16 |
| ES2556580T3 (es) | 2016-01-19 |
| DK2729580T3 (en) | 2015-12-14 |
| US20180023135A1 (en) | 2018-01-25 |
| AU2012281242A1 (en) | 2014-02-27 |
| CA2840929A1 (en) | 2013-01-17 |
| EP2729580A1 (en) | 2014-05-14 |
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