AU2012265970A1 - Pyrazolo[3,4-d]pyrimidine compounds and their use as PDE2 inhibitors and/or CYP3A4 inhibitors - Google Patents
Pyrazolo[3,4-d]pyrimidine compounds and their use as PDE2 inhibitors and/or CYP3A4 inhibitors Download PDFInfo
- Publication number
- AU2012265970A1 AU2012265970A1 AU2012265970A AU2012265970A AU2012265970A1 AU 2012265970 A1 AU2012265970 A1 AU 2012265970A1 AU 2012265970 A AU2012265970 A AU 2012265970A AU 2012265970 A AU2012265970 A AU 2012265970A AU 2012265970 A1 AU2012265970 A1 AU 2012265970A1
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- methyl
- compound
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161494070P | 2011-06-07 | 2011-06-07 | |
| US61/494,070 | 2011-06-07 | ||
| PCT/IB2012/052627 WO2012168817A1 (en) | 2011-06-07 | 2012-05-24 | Pyrazolo[3,4-d]pyrimidine compounds and their use as pde2 inhibitors and/or cyp3a4 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2012265970A1 true AU2012265970A1 (en) | 2013-11-28 |
Family
ID=46298646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012265970A Abandoned AU2012265970A1 (en) | 2011-06-07 | 2012-05-24 | Pyrazolo[3,4-d]pyrimidine compounds and their use as PDE2 inhibitors and/or CYP3A4 inhibitors |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8829010B2 (enExample) |
| EP (1) | EP2718295A1 (enExample) |
| JP (1) | JP2014516074A (enExample) |
| KR (1) | KR101626681B1 (enExample) |
| CN (1) | CN103596956A (enExample) |
| AU (1) | AU2012265970A1 (enExample) |
| CA (1) | CA2836851C (enExample) |
| IL (1) | IL229606A0 (enExample) |
| MX (1) | MX2013014470A (enExample) |
| SG (1) | SG195085A1 (enExample) |
| WO (1) | WO2012168817A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201100441A (en) | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
| JP6000273B2 (ja) | 2010-11-29 | 2016-09-28 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 大環状キナーゼ阻害剤 |
| WO2014126954A1 (en) * | 2013-02-13 | 2014-08-21 | OSI Pharmaceuticals, LLC | Regioselective synthesis of substituted pyrimidines |
| CN104098574A (zh) * | 2013-04-12 | 2014-10-15 | 苏州科捷生物医药有限公司 | 氮杂环丁烷取代嘧啶类化合物及其用途 |
| US9961897B2 (en) * | 2013-08-20 | 2018-05-08 | E I Du Pont De Nemours And Company | Fungicidal pyrazoles |
| WO2015096651A1 (en) | 2013-12-23 | 2015-07-02 | Merck Sharp & Dohme Corp. | Pyrimidone carboxamide compounds as pde2 inhibitors |
| EP3091983B1 (en) | 2014-01-08 | 2019-10-02 | Intra-Cellular Therapies, Inc. | Pharmaceutical compositions comprising a pde-1 inhibitor and a pde-2 inhibitor |
| EP3134413B1 (en) | 2014-04-23 | 2019-09-11 | Dart NeuroScience (Cayman) Ltd. | Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as pde2 inhibitors |
| JP2017114764A (ja) * | 2014-04-25 | 2017-06-29 | 武田薬品工業株式会社 | 片頭痛治療剤 |
| WO2016073424A1 (en) | 2014-11-05 | 2016-05-12 | Dart Neuroscience, Llc | Substituted 5-methyl-[1, 2, 4] triazolo [1,5-a) pyrimidin-2-amine compounds as pde2 inhibitors |
| AU2015357498B2 (en) | 2014-12-06 | 2019-09-12 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US10300064B2 (en) * | 2014-12-06 | 2019-05-28 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EP3237401B1 (en) | 2014-12-22 | 2019-03-06 | Pfizer Inc | Antagonists of prostaglandin ep3 receptor |
| WO2016145614A1 (en) | 2015-03-17 | 2016-09-22 | Merck Sharp & Dohme Corp. | Triazolyl pyrimidinone compounds as pde2 inhibitors |
| WO2016154081A1 (en) | 2015-03-26 | 2016-09-29 | Merck Sharp & Dohme Corp. | Pyrazolyl pyrimidinone compounds as pde2 inhibitors |
| US10195201B2 (en) | 2015-05-05 | 2019-02-05 | Merck Sharp & Dohme Corp. | Heteroaryl-pyrimidinone compounds as PDE2 inhibitors |
| WO2016183741A1 (en) | 2015-05-15 | 2016-11-24 | Merck Sharp & Dohme Corp. | Pyrimidinone amide compounds as pde2 inhibitors |
| WO2016191935A1 (en) | 2015-05-29 | 2016-12-08 | Merck Sharp & Dohme Corp. | 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
| WO2016192083A1 (en) | 2015-06-04 | 2016-12-08 | Merck Sharp & Dohme Corp. | Dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
| US10647727B2 (en) | 2015-06-25 | 2020-05-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors |
| WO2017000277A1 (en) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Substituted triazolo bicycliccompounds as pde2 inhibitors |
| WO2017000276A1 (en) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Bicyclic heterocyclic compounds as pde2 inhibitors |
| ES2962865T3 (es) | 2016-11-18 | 2024-03-21 | Integrative Res Laboratories Sweden Ab | Nuevos derivados de azetidina útiles como moduladores de la neurotransmisión catecolaminérgica cortical |
| PT3713572T (pt) | 2017-11-23 | 2025-08-28 | Oslo Univ Hospital Hf | Tratamento da taquicardia |
| EP4056571A4 (en) * | 2019-11-09 | 2024-01-24 | Shanghai Simr Biotechnology Co., Ltd. | Tricyclic dihydroimidazopyrimidone derivative, preparation method therefor, pharmaceutical composition and use thereof |
| CN113244395B (zh) * | 2020-02-10 | 2024-07-23 | 广州市妇女儿童医疗中心 | 纤维化疾病机制及其治疗药物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005117909A2 (en) * | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
| MX2007008137A (es) | 2005-01-05 | 2007-07-19 | Altana Pharma Ag | Triazoloftalazinas como inhibidores de pde2. |
| EA012211B1 (ru) | 2005-01-07 | 2009-08-28 | Пфайзер Продактс Инк. | Гетероароматические соединения хинолинов и их применение в качестве ингибиторов pde10 |
| CN102020645B (zh) * | 2010-09-30 | 2012-12-12 | 中山大学 | 吡唑并嘧啶酮衍生物及其可药用盐、其制备方法和应用 |
-
2012
- 2012-05-24 EP EP12727686.3A patent/EP2718295A1/en not_active Withdrawn
- 2012-05-24 CA CA2836851A patent/CA2836851C/en not_active Expired - Fee Related
- 2012-05-24 SG SG2013086178A patent/SG195085A1/en unknown
- 2012-05-24 JP JP2014514172A patent/JP2014516074A/ja not_active Ceased
- 2012-05-24 US US14/116,064 patent/US8829010B2/en not_active Expired - Fee Related
- 2012-05-24 KR KR1020147000046A patent/KR101626681B1/ko not_active Expired - Fee Related
- 2012-05-24 CN CN201280027766.8A patent/CN103596956A/zh active Pending
- 2012-05-24 AU AU2012265970A patent/AU2012265970A1/en not_active Abandoned
- 2012-05-24 MX MX2013014470A patent/MX2013014470A/es unknown
- 2012-05-24 WO PCT/IB2012/052627 patent/WO2012168817A1/en not_active Ceased
-
2013
- 2013-11-25 IL IL229606A patent/IL229606A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140019466A (ko) | 2014-02-14 |
| US8829010B2 (en) | 2014-09-09 |
| US20140080806A1 (en) | 2014-03-20 |
| KR101626681B1 (ko) | 2016-06-01 |
| EP2718295A1 (en) | 2014-04-16 |
| CA2836851C (en) | 2016-06-21 |
| SG195085A1 (en) | 2013-12-30 |
| WO2012168817A1 (en) | 2012-12-13 |
| IL229606A0 (en) | 2014-01-30 |
| MX2013014470A (es) | 2014-03-21 |
| JP2014516074A (ja) | 2014-07-07 |
| CN103596956A (zh) | 2014-02-19 |
| CA2836851A1 (en) | 2012-12-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2836851C (en) | Pyrazolo[3,4-d]pyrimidine compounds and their use as pde2 inhibitors and/or cyp3a4 inhibitors | |
| US9200000B2 (en) | Imidazo[5,1-f][1,2,4]triazines for the treatment of neurological disorders | |
| US11390584B2 (en) | 1-cyano-pyrrolidine compounds as USP30 inhibitors | |
| ES2346674T3 (es) | Compuestos heteroaromaticos de quinolina y su uso como inhibidores de pde10. | |
| CA2661334C (en) | Pyrimidone compounds as gsk-3 inhibitors | |
| AU2012221828A1 (en) | Imidazo[5,1-f][1,2,4]triazines for treatment of neurological disorders | |
| EP2464641B1 (en) | Pyrimidine compounds as tuberculosis inhibitors | |
| JP2009522346A (ja) | Ｐｄｅ１０阻害剤としての二環式ヘテロアリール化合物 | |
| KR20150027267A (ko) | LRRK2 억제제로서의 4-(치환된-아미노)-7H-피롤로[2,3-d]피리미딘 | |
| TW201136937A (en) | Imidazopyrimidine derivatives | |
| CN116057045A (zh) | 成纤维细胞生长因子受体激酶抑制剂 | |
| US11814384B2 (en) | Inhibtors of Raf kinases | |
| HK1193814A (en) | Pyrazolo[3,4-d]pyrimidine compounds and their use as pde2 inhibitors and/or cyp3a4 inhibitors | |
| HK40085563A (en) | Inhibitors of fibroblast growth factor receptor kinases | |
| NZ613373B2 (en) | IMIDAZO[5,1-f][1,2,4]TRIAZINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | |
| OA18860A (en) | Pyrazolo[1,5-A)pyrazin-4-yl derivatives as Jak-inhibitors | |
| HK1188990A (en) | IMIDAZO[5, 1-ƒ][1,2-4]TRIAZINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | |
| HK1113926A (en) | Heteroaromatic quinoline compounds and their use as pde10 inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |