IL229606A0 - Pyrazolone [3, 4-d] pyrimidine compounds and their use as 2pde inhibitors and/or 4a3 cyp inhibitors - Google Patents
Pyrazolone [3, 4-d] pyrimidine compounds and their use as 2pde inhibitors and/or 4a3 cyp inhibitorsInfo
- Publication number
- IL229606A0 IL229606A0 IL229606A IL22960613A IL229606A0 IL 229606 A0 IL229606 A0 IL 229606A0 IL 229606 A IL229606 A IL 229606A IL 22960613 A IL22960613 A IL 22960613A IL 229606 A0 IL229606 A0 IL 229606A0
- Authority
- IL
- Israel
- Prior art keywords
- inhibitors
- pyrazolo
- pyrimidine compounds
- cyp3a4
- pde2
- Prior art date
Links
- QUKPALAWEPMWOS-UHFFFAOYSA-N 1h-pyrazolo[3,4-d]pyrimidine Chemical class C1=NC=C2C=NNC2=N1 QUKPALAWEPMWOS-UHFFFAOYSA-N 0.000 title 1
- 208000009011 Cytochrome P-450 CYP3A Inhibitors Diseases 0.000 title 1
- 229940121828 Phosphodiesterase 2 inhibitor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161494070P | 2011-06-07 | 2011-06-07 | |
| PCT/IB2012/052627 WO2012168817A1 (en) | 2011-06-07 | 2012-05-24 | Pyrazolo[3,4-d]pyrimidine compounds and their use as pde2 inhibitors and/or cyp3a4 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL229606A0 true IL229606A0 (en) | 2014-01-30 |
Family
ID=46298646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL229606A IL229606A0 (en) | 2011-06-07 | 2013-11-25 | Pyrazolone [3, 4-d] pyrimidine compounds and their use as 2pde inhibitors and/or 4a3 cyp inhibitors |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8829010B2 (enExample) |
| EP (1) | EP2718295A1 (enExample) |
| JP (1) | JP2014516074A (enExample) |
| KR (1) | KR101626681B1 (enExample) |
| CN (1) | CN103596956A (enExample) |
| AU (1) | AU2012265970A1 (enExample) |
| CA (1) | CA2836851C (enExample) |
| IL (1) | IL229606A0 (enExample) |
| MX (1) | MX2013014470A (enExample) |
| SG (1) | SG195085A1 (enExample) |
| WO (1) | WO2012168817A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201100441A (en) | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
| JP6000273B2 (ja) | 2010-11-29 | 2016-09-28 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 大環状キナーゼ阻害剤 |
| WO2014126954A1 (en) * | 2013-02-13 | 2014-08-21 | OSI Pharmaceuticals, LLC | Regioselective synthesis of substituted pyrimidines |
| CN104098574A (zh) * | 2013-04-12 | 2014-10-15 | 苏州科捷生物医药有限公司 | 氮杂环丁烷取代嘧啶类化合物及其用途 |
| WO2015026646A1 (en) * | 2013-08-20 | 2015-02-26 | E. I. Du Pont De Nemours And Company | Fungicidal pyrazoles |
| EP3087060B1 (en) | 2013-12-23 | 2020-05-13 | Merck Sharp & Dohme Corp. | Pyrimidone carboxamide compounds as pde2 inhibitors |
| US9849132B2 (en) | 2014-01-08 | 2017-12-26 | Intra-Cellular Therapies, Inc. | Products and pharmaceutical compositions |
| HUE057317T2 (hu) | 2014-04-23 | 2022-04-28 | Dart Neuroscience Llc | Helyettesített [1,2,4]triazolo[1,5-A]pirimidin-7-IL vegyületeket tartalmazó készítmények mint PDE2 inhibítorok |
| JP2017114764A (ja) * | 2014-04-25 | 2017-06-29 | 武田薬品工業株式会社 | 片頭痛治療剤 |
| TWI568737B (zh) | 2014-11-05 | 2017-02-01 | 達特神經科學（開曼）有限責任公司 | 作為ｐｄｅ２抑制劑之經取代的５－甲基－［１，２，４］三唑并［１，５－ａ］嘧啶－２－胺化合物 |
| US10105349B2 (en) | 2014-12-06 | 2018-10-23 | Intra-Cellular Therapies, Inc. | Organic compounds |
| MX371158B (es) * | 2014-12-06 | 2020-01-20 | Intra Cellular Therapies Inc | Compuestos inhibidores de pde2. |
| WO2016103097A1 (en) | 2014-12-22 | 2016-06-30 | Pfizer Inc. | Antagonists of prostaglandin ep3 receptor |
| WO2016145614A1 (en) | 2015-03-17 | 2016-09-22 | Merck Sharp & Dohme Corp. | Triazolyl pyrimidinone compounds as pde2 inhibitors |
| WO2016154081A1 (en) | 2015-03-26 | 2016-09-29 | Merck Sharp & Dohme Corp. | Pyrazolyl pyrimidinone compounds as pde2 inhibitors |
| US10195201B2 (en) | 2015-05-05 | 2019-02-05 | Merck Sharp & Dohme Corp. | Heteroaryl-pyrimidinone compounds as PDE2 inhibitors |
| WO2016183741A1 (en) | 2015-05-15 | 2016-11-24 | Merck Sharp & Dohme Corp. | Pyrimidinone amide compounds as pde2 inhibitors |
| WO2016191935A1 (en) | 2015-05-29 | 2016-12-08 | Merck Sharp & Dohme Corp. | 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
| WO2016192083A1 (en) | 2015-06-04 | 2016-12-08 | Merck Sharp & Dohme Corp. | Dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
| US10647727B2 (en) | 2015-06-25 | 2020-05-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors |
| WO2017000277A1 (en) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Substituted triazolo bicycliccompounds as pde2 inhibitors |
| WO2017000276A1 (en) * | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Bicyclic heterocyclic compounds as pde2 inhibitors |
| US10875829B1 (en) | 2016-11-18 | 2020-12-29 | Integrative Research Laboratories Sweden Ab | Azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission |
| US11419874B2 (en) | 2017-11-23 | 2022-08-23 | Oslo University Hospital Hf | Treatment of tachycardia |
| EP4056571A4 (en) * | 2019-11-09 | 2024-01-24 | Shanghai Simr Biotechnology Co., Ltd. | Tricyclic dihydroimidazopyrimidone derivative, preparation method therefor, pharmaceutical composition and use thereof |
| CN118903419A (zh) * | 2020-02-10 | 2024-11-08 | 广州市妇女儿童医疗中心 | Pde抑制剂或其盐在制备用于预防和/或治疗胃肠道疾病的药物中的用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5213229B2 (ja) * | 2004-04-23 | 2013-06-19 | エグゼリクシス， インコーポレイテッド | キナーゼ調節因子および使用方法 |
| WO2006072615A2 (en) * | 2005-01-05 | 2006-07-13 | Nycomed Gmbh | Triazolophthalazines as pde2-inhibitors |
| ATE472543T1 (de) | 2005-01-07 | 2010-07-15 | Pfizer Prod Inc | Heteroaromatische chinolinverbindungen und deren verwendung als pde10-inhibitoren |
| CN102020645B (zh) * | 2010-09-30 | 2012-12-12 | 中山大学 | 吡唑并嘧啶酮衍生物及其可药用盐、其制备方法和应用 |
-
2012
- 2012-05-24 EP EP12727686.3A patent/EP2718295A1/en not_active Withdrawn
- 2012-05-24 CA CA2836851A patent/CA2836851C/en not_active Expired - Fee Related
- 2012-05-24 CN CN201280027766.8A patent/CN103596956A/zh active Pending
- 2012-05-24 SG SG2013086178A patent/SG195085A1/en unknown
- 2012-05-24 MX MX2013014470A patent/MX2013014470A/es unknown
- 2012-05-24 AU AU2012265970A patent/AU2012265970A1/en not_active Abandoned
- 2012-05-24 WO PCT/IB2012/052627 patent/WO2012168817A1/en not_active Ceased
- 2012-05-24 US US14/116,064 patent/US8829010B2/en not_active Expired - Fee Related
- 2012-05-24 KR KR1020147000046A patent/KR101626681B1/ko not_active Expired - Fee Related
- 2012-05-24 JP JP2014514172A patent/JP2014516074A/ja not_active Ceased
-
2013
- 2013-11-25 IL IL229606A patent/IL229606A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2718295A1 (en) | 2014-04-16 |
| AU2012265970A1 (en) | 2013-11-28 |
| US20140080806A1 (en) | 2014-03-20 |
| MX2013014470A (es) | 2014-03-21 |
| KR101626681B1 (ko) | 2016-06-01 |
| CA2836851A1 (en) | 2012-12-13 |
| CN103596956A (zh) | 2014-02-19 |
| SG195085A1 (en) | 2013-12-30 |
| KR20140019466A (ko) | 2014-02-14 |
| WO2012168817A1 (en) | 2012-12-13 |
| US8829010B2 (en) | 2014-09-09 |
| CA2836851C (en) | 2016-06-21 |
| JP2014516074A (ja) | 2014-07-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL229606A0 (en) | Pyrazolone [3, 4-d] pyrimidine compounds and their use as 2pde inhibitors and/or 4a3 cyp inhibitors | |
| AP3417A (en) | Pyrazolo [1,5-a] pyrimidines as antiviral agents | |
| PT2794611T (pt) | Pirazolo[1,5-a]pirimidinas como agentes antivirais | |
| ZA201307839B (en) | Pyrazolo[4,3-d] pyrimidines useful as kinase inhibitors | |
| CO6801740A2 (es) | Inhibidores de quinasa relacionados con pirrolo[2,3-d]pirimidina tropomiosina | |
| EP2751112A4 (en) | SUBSTITUTED PYRAZOLO [3,4-D] PYRIMIDINE AND ITS USE | |
| IL254224A0 (en) | 7-substituted 5-alkyl-[4,2,1]triazolo[5,1-a]pyrimidine derivatives as pde2 inhibitors | |
| IL266305B (en) | History of [4,2,1]triazolo[5,1-a]pyrimidine as pde2 inhibitors | |
| PH12013500226A1 (en) | 6-cycloalkyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a inhibitors | |
| IL227526A0 (en) | Derivatives of 6-cyclobutyl-1,5-dihydro-pyrazolo [3,4-d] pyrimidine-4-one and their use as a9pde inhibitors | |
| HUE061909T2 (hu) | Pirazolo[1,5-a]pirimidinek alkalmazása ATR kináz inhibítorként, rákos megbetegedések kezelésére | |
| ZA201204871B (en) | Thiazolo[5,4-d]pyrimidines and their use as agrochemicals | |
| ZA201306545B (en) | 6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine derivatives useful as inhibitors of betasecretase (bace) | |
| EP2739627A4 (en) | 2,3-DIHYDROIMIDAZO [1,2-C] PYRIMIDIN-5 (1H) -ONE COMPOUNDS AND USE AS INHIBITORS OF LP-PLA2 | |
| ZA201403441B (en) | [1,2,3]triazolo[4,5-d]pyrimidine derivatives as agonists of the cannabinoid | |
| ZA201406323B (en) | Triazolo[4,5-d]pyrimidine derivatives | |
| PL2694513T3 (pl) | Pochodne pirazolopirymidynowe | |
| PT2920174T (pt) | Compostos de pirazolo[3,4-d]pirimidina substituídos, preparação e utilização dos mesmos como ligantes recetores sigma | |
| EP2523552A4 (en) | PYRAZOLO- [1,5-A] PYRIMIDINE AS MARK HEMMER | |
| ZA201402226B (en) | 4-amino-3-phenylamino-6-phenylpyrazolo[3,4-d] pyrimidine derivatives, their manufacture and their use as antiviral active substances |