AU2011249908A1 - Methods for diagnosing, staging, predicting risk for developing and identifying treatment responders for rheumatoid arthritis - Google Patents
Methods for diagnosing, staging, predicting risk for developing and identifying treatment responders for rheumatoid arthritis Download PDFInfo
- Publication number
- AU2011249908A1 AU2011249908A1 AU2011249908A AU2011249908A AU2011249908A1 AU 2011249908 A1 AU2011249908 A1 AU 2011249908A1 AU 2011249908 A AU2011249908 A AU 2011249908A AU 2011249908 A AU2011249908 A AU 2011249908A AU 2011249908 A1 AU2011249908 A1 AU 2011249908A1
- Authority
- AU
- Australia
- Prior art keywords
- concentration
- less
- totmmp
- healthy volunteer
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 194
- 206010039073 rheumatoid arthritis Diseases 0.000 title abstract description 241
- 208000027866 inflammatory disease Diseases 0.000 claims abstract description 310
- 102000013691 Interleukin-17 Human genes 0.000 claims description 956
- 108050003558 Interleukin-17 Proteins 0.000 claims description 956
- 108090001005 Interleukin-6 Proteins 0.000 claims description 326
- 241000282414 Homo sapiens Species 0.000 claims description 283
- 239000000523 sample Substances 0.000 claims description 209
- 102000000589 Interleukin-1 Human genes 0.000 claims description 110
- 108010002352 Interleukin-1 Proteins 0.000 claims description 110
- 238000002560 therapeutic procedure Methods 0.000 claims description 101
- 230000005750 disease progression Effects 0.000 claims description 21
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 13
- 208000011231 Crohn disease Diseases 0.000 claims description 13
- 201000004681 Psoriasis Diseases 0.000 claims description 13
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 13
- 201000010099 disease Diseases 0.000 claims description 13
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 11
- 239000013610 patient sample Substances 0.000 claims description 5
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 claims 63
- 102100039065 Interleukin-1 beta Human genes 0.000 claims 63
- 101100537532 Rattus norvegicus Tnni3 gene Proteins 0.000 claims 9
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 102000004889 Interleukin-6 Human genes 0.000 description 212
- 229940100601 interleukin-6 Drugs 0.000 description 212
- 102100036859 Troponin I, cardiac muscle Human genes 0.000 description 113
- 101710128251 Troponin I, cardiac muscle Proteins 0.000 description 113
- 239000000090 biomarker Substances 0.000 description 60
- LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 description 54
- 102000003777 Interleukin-1 beta Human genes 0.000 description 54
- 108090000193 Interleukin-1 beta Proteins 0.000 description 54
- 210000002966 serum Anatomy 0.000 description 16
- 210000002381 plasma Anatomy 0.000 description 8
- 108010006035 Metalloproteases Proteins 0.000 description 7
- 102000005741 Metalloproteases Human genes 0.000 description 7
- 102000004127 Cytokines Human genes 0.000 description 6
- 108090000695 Cytokines Proteins 0.000 description 6
- 238000003556 assay Methods 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- 239000000833 heterodimer Substances 0.000 description 6
- 238000003018 immunoassay Methods 0.000 description 6
- 108700012920 TNF Proteins 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 230000008859 change Effects 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 102100026802 72 kDa type IV collagenase Human genes 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 3
- 101000645296 Homo sapiens Metalloproteinase inhibitor 2 Proteins 0.000 description 3
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 description 3
- 102100026262 Metalloproteinase inhibitor 2 Human genes 0.000 description 3
- 208000001132 Osteoporosis Diseases 0.000 description 3
- 102100040247 Tumor necrosis factor Human genes 0.000 description 3
- 239000012491 analyte Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 210000000845 cartilage Anatomy 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 210000004872 soft tissue Anatomy 0.000 description 3
- 230000001755 vocal effect Effects 0.000 description 3
- 101710151806 72 kDa type IV collagenase Proteins 0.000 description 2
- 208000008822 Ankylosis Diseases 0.000 description 2
- 241001303910 Erenna Species 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 101000990902 Homo sapiens Matrix metalloproteinase-9 Proteins 0.000 description 2
- 206010023198 Joint ankylosis Diseases 0.000 description 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 2
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 description 2
- 206010028289 Muscle atrophy Diseases 0.000 description 2
- 208000032234 No therapeutic response Diseases 0.000 description 2
- 101100032842 Oryza sativa subsp. japonica RA16 gene Proteins 0.000 description 2
- 101100467533 Oryza sativa subsp. japonica RAG1 gene Proteins 0.000 description 2
- 101100193637 Oryza sativa subsp. japonica RAG2 gene Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 208000004760 Tenosynovitis Diseases 0.000 description 2
- 206010051083 Therapy responder Diseases 0.000 description 2
- 108010031372 Tissue Inhibitor of Metalloproteinase-2 Proteins 0.000 description 2
- 102000005354 Tissue Inhibitor of Metalloproteinase-2 Human genes 0.000 description 2
- 229920004890 Triton X-100 Polymers 0.000 description 2
- 239000013504 Triton X-100 Substances 0.000 description 2
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 description 2
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 description 2
- 239000012131 assay buffer Substances 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 239000012149 elution buffer Substances 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 210000002443 helper t lymphocyte Anatomy 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 230000020763 muscle atrophy Effects 0.000 description 2
- 201000000585 muscular atrophy Diseases 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 230000000770 proinflammatory effect Effects 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000003656 tris buffered saline Substances 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 208000006358 Hand Deformities Diseases 0.000 description 1
- 101000627872 Homo sapiens 72 kDa type IV collagenase Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 102000004388 Interleukin-4 Human genes 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 206010023204 Joint dislocation Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 102000001776 Matrix metalloproteinase-9 Human genes 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 210000003567 ascitic fluid Anatomy 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 229940028885 interleukin-4 Drugs 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000004880 lymph fluid Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000005291 magnetic effect Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000003571 opsonizing effect Effects 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 229950001060 parsalmide Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 210000004910 pleural fluid Anatomy 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000005065 subchondral bone plate Anatomy 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 230000008409 synovial inflammation Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/34—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Corynebacterium (G)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/12—Pulmonary diseases
- G01N2800/122—Chronic or obstructive airway disorders, e.g. asthma COPD
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/20—Dermatological disorders
- G01N2800/205—Scaling palpular diseases, e.g. psoriasis, pytiriasis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33208110P | 2010-05-06 | 2010-05-06 | |
| US61/332,081 | 2010-05-06 | ||
| US201061428500P | 2010-12-30 | 2010-12-30 | |
| US61/428,500 | 2010-12-30 | ||
| US201161444702P | 2011-02-19 | 2011-02-19 | |
| US61/444,702 | 2011-02-19 | ||
| PCT/US2011/035584 WO2011140484A1 (en) | 2010-05-06 | 2011-05-06 | Methods for diagnosing, staging, predicting risk for developing and identifying treatment responders for rheumatoid arthritis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2011249908A1 true AU2011249908A1 (en) | 2012-11-22 |
Family
ID=44904110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2011249908A Abandoned AU2011249908A1 (en) | 2010-05-06 | 2011-05-06 | Methods for diagnosing, staging, predicting risk for developing and identifying treatment responders for rheumatoid arthritis |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20110301053A1 (enExample) |
| EP (1) | EP2566971B1 (enExample) |
| JP (1) | JP2013525820A (enExample) |
| AU (1) | AU2011249908A1 (enExample) |
| CA (1) | CA2798149A1 (enExample) |
| WO (1) | WO2011140484A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130261016A1 (en) * | 2012-03-28 | 2013-10-03 | Meso Scale Technologies, Llc | Diagnostic methods for inflammatory disorders |
| AU2014407088B2 (en) | 2014-09-26 | 2021-09-23 | Somalogic Operating Co., Inc. | Cardiovascular risk event prediction and uses thereof |
Family Cites Families (143)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4071298A (en) | 1974-06-27 | 1978-01-31 | Stanford Research Institute | Laser Raman/fluorescent device for analyzing airborne particles |
| DE2732272C2 (de) | 1977-07-16 | 1979-07-05 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts, 6900 Heidelberg | Verfahren und Vorrichtung zur Fluoreszenzanalyse von gefärbten Partikeln, insbesondere biologischen Zellen |
| US4251733A (en) | 1978-06-29 | 1981-02-17 | Hirleman Jr Edwin D | Technique for simultaneous particle size and velocity measurement |
| US4172227A (en) | 1978-07-21 | 1979-10-23 | Becton, Dickinson And Company | Flow microfluorometer |
| US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
| US4521733A (en) | 1983-05-23 | 1985-06-04 | General Electric Company | NMR Imaging of the transverse relaxation time using multiple spin echo sequences |
| US4768879A (en) | 1986-06-17 | 1988-09-06 | The Dow Chemical Company | Method for measuring the size of objects in a fluid medium |
| US4770183A (en) | 1986-07-03 | 1988-09-13 | Advanced Magnetics Incorporated | Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents |
| US4988191A (en) | 1987-03-09 | 1991-01-29 | University Of Illinois | Electro-optical method and system for determining the direction of motion in double-exposure velocimetry by shifting an optical image field |
| US5041733A (en) | 1987-03-20 | 1991-08-20 | Agency Of Industrial Science & Technology | Method and apparatus for identifying chromosomes or cells |
| DE3720844A1 (de) | 1987-06-24 | 1989-01-05 | Stefan Miltenyi | Trennsaeule fuer die magnetische separierung von zellen, zellaggregaten, und zellulaeren bestandteilen |
| US4793705A (en) | 1987-10-07 | 1988-12-27 | The United States Of America As Represented By The United States Department Of Energy | Single molecule tracking |
| US4927265A (en) | 1988-04-29 | 1990-05-22 | 501 Microphoretic Systems, Inc. | Detector for fluorescence and absorption spectroscopy |
| US5155581A (en) | 1988-05-06 | 1992-10-13 | Minolta Camera Kabushiki Kaisha | Electronic still video camera |
| US5002389A (en) | 1988-12-22 | 1991-03-26 | Honeywell Inc. | Pulsed fluorescence velocimeter |
| US5385707A (en) | 1988-12-28 | 1995-01-31 | Stefan Miltenyi | Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same |
| US4979824A (en) | 1989-05-26 | 1990-12-25 | Board Of Trustees Of The Leland Stanford Junior University | High sensitivity fluorescent single particle and single molecule detection apparatus and method |
| US5108179A (en) | 1989-08-09 | 1992-04-28 | Myers Stephen A | System and method for determining changes in fluorescence of stained nucleic acid in electrophoretically separated bands |
| US5274240A (en) | 1990-01-12 | 1993-12-28 | The Regents Of The University Of California | Capillary array confocal fluorescence scanner and method |
| US5770029A (en) | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
| CA2079005A1 (en) | 1990-04-11 | 1991-10-12 | Geoffrey Stephen Begg | Methods and apparatus allowing sequential chemical reactions |
| US5094594A (en) | 1990-04-23 | 1992-03-10 | Genomyx, Incorporated | Piezoelectric pumping device |
| US5230997A (en) | 1990-07-19 | 1993-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of detecting the presence of human herpesvirus-7 infection |
| US5269937A (en) | 1990-10-23 | 1993-12-14 | Cetus Corporation | HPLC light scattering detector for biopolymers |
| US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| US5846708A (en) | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
| US5290834A (en) | 1991-12-04 | 1994-03-01 | Rohm & Haas Company | Method for controlling elution rate of agent |
| US5209834A (en) | 1992-03-09 | 1993-05-11 | The United States Of America As Represented By The United States Department Of Energy | Ordered transport and identification of particles |
| DK0679251T3 (da) | 1993-01-18 | 1999-01-25 | Evotec Biosystems Aktiengesell | Fremgangsmåde og apparat til vurdering af biopolymerers fitness |
| GB9301122D0 (en) | 1993-01-21 | 1993-03-10 | Scient Generics Ltd | Method of analysis/separation |
| US5547849A (en) | 1993-02-17 | 1996-08-20 | Biometric Imaging, Inc. | Apparatus and method for volumetric capillary cytometry |
| JPH06265447A (ja) | 1993-03-16 | 1994-09-22 | Hitachi Ltd | 微量反応装置およびこれを使用する微量成分測定装置 |
| US5543838A (en) | 1993-08-31 | 1996-08-06 | Xerox Corporation | Signal multiplexing system for an image sensor array |
| JP3290786B2 (ja) | 1993-11-26 | 2002-06-10 | シスメックス株式会社 | 粒子分析装置 |
| DE4405005A1 (de) | 1994-02-17 | 1995-08-24 | Rossendorf Forschzent | Mikro-Fluiddiode |
| US5540494A (en) | 1994-06-03 | 1996-07-30 | Purvis, Jr.; Norman B. | Method and apparatus for determining absolute particle size, surface area and volume normalized fluorescence using forward angle light scatter intensity in flow cytometry |
| US6001229A (en) | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
| US5658413A (en) | 1994-10-19 | 1997-08-19 | Hewlett-Packard Company | Miniaturized planar columns in novel support media for liquid phase analysis |
| US5645702A (en) | 1995-06-07 | 1997-07-08 | Hewlett-Packard Company | Low voltage miniaturized column analytical apparatus and method |
| US5571410A (en) | 1994-10-19 | 1996-11-05 | Hewlett Packard Company | Fully integrated miniaturized planar liquid sample handling and analysis device |
| US5603351A (en) | 1995-06-07 | 1997-02-18 | David Sarnoff Research Center, Inc. | Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device |
| US5585069A (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
| FI98765C (fi) | 1995-01-16 | 1997-08-11 | Erkki Soini | Virtaussytometrinen menetelmä ja laite |
| DE19508366C2 (de) | 1995-03-10 | 1998-01-29 | Evotec Biosystems Gmbh | Verfahren zum direkten Nachweisen weniger Nucleinsäurestränge |
| US5793485A (en) | 1995-03-20 | 1998-08-11 | Sandia Corporation | Resonant-cavity apparatus for cytometry or particle analysis |
| US5682038A (en) | 1995-04-06 | 1997-10-28 | Becton Dickinson And Company | Fluorescent-particle analyzer with timing alignment for analog pulse subtraction of fluorescent pulses arising from different excitation locations |
| US6991907B1 (en) | 1995-04-18 | 2006-01-31 | Biosite, Inc. | Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays |
| DE19524572A1 (de) | 1995-07-06 | 1997-01-09 | Bayer Ag | Verfahren zur Herstellung eines synthetischen Kalibrators für den Einsatz in Immunoassays, bestehend aus den Analyten oder Teilsequenzen davon, die an inerten Trägermoleküle konjugiert sind |
| US5798222A (en) | 1995-07-17 | 1998-08-25 | Guava Technologies, Inc. | Apparatus for monitoring substances in organisms |
| US6132580A (en) | 1995-09-28 | 2000-10-17 | The Regents Of The University Of California | Miniature reaction chamber and devices incorporating same |
| US5716825A (en) | 1995-11-01 | 1998-02-10 | Hewlett Packard Company | Integrated nucleic acid analysis system for MALDI-TOF MS |
| DE19548028A1 (de) | 1995-12-21 | 1997-06-26 | Bayer Ag | Verfahren zur Herstellung eines synthetischen Kalibrators für den Einsatz in Sandwich-Immunoassays, bestehend aus einem Antikörper gegen einen der im Assay benutzten Antikörper und einer Sequenz des Analyten |
| US5746901A (en) | 1996-04-05 | 1998-05-05 | Regents Of The University Of California | Hybrid slab-microchannel gel electrophoresis system |
| US6399023B1 (en) | 1996-04-16 | 2002-06-04 | Caliper Technologies Corp. | Analytical system and method |
| US5795758A (en) | 1997-04-18 | 1998-08-18 | Smithkline Beecham Corporation | DNA encoding histidyl tRNA synthetase variant from Streptococcus pneumoniae |
| US5863801A (en) | 1996-06-14 | 1999-01-26 | Sarnoff Corporation | Automated nucleic acid isolation |
| DE19630956A1 (de) | 1996-07-31 | 1998-02-05 | Basf Ag | Verfahren und Vorrichtung zur Raman-Korrelationsspektroskopie |
| DE19634873A1 (de) | 1996-08-29 | 1998-03-12 | Boehringer Mannheim Gmbh | System zur Unterscheidung fluoreszierender Molekülgruppen durch zeitaufgelöste Fluoreszenzmessung |
| DE19647927A1 (de) | 1996-11-20 | 1998-05-28 | Bayer Ag | Verfahren zur Herstellung einer stabilen Troponin I Präparation und dessen Verwendung als Kalibrator in Immunoassays |
| DE19649048C1 (de) | 1996-11-27 | 1998-04-09 | Evotec Biosystems Gmbh | Verfahren zur Unterscheidung oder Erfassung von Partikeln in einer Probe durch Identifizierung von Signalabschnitten zeitaufgelöster, optischer Rohsignale aus der Probe auf Basis von Einzelphotonendetektion |
| US5795158A (en) | 1996-12-02 | 1998-08-18 | Warinner; Peter | Apparatus to review clinical microbiology |
| ATE273381T1 (de) | 1997-02-12 | 2004-08-15 | Eugene Y Chan | Verfahren zur analyse von polymeren |
| US5999250A (en) | 1997-03-17 | 1999-12-07 | Tsi Corporation | System for detecting fluorescing components in aerosols |
| US6235471B1 (en) | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
| US5985214A (en) | 1997-05-16 | 1999-11-16 | Aurora Biosciences Corporation | Systems and methods for rapidly identifying useful chemicals in liquid samples |
| US6710871B1 (en) | 1997-06-09 | 2004-03-23 | Guava Technologies, Inc. | Method and apparatus for detecting microparticles in fluid samples |
| GB2326229A (en) | 1997-06-13 | 1998-12-16 | Robert Jeffrey Geddes Carr | Detecting and analysing submicron particles |
| US5989402A (en) | 1997-08-29 | 1999-11-23 | Caliper Technologies Corp. | Controller/detector interfaces for microfluidic systems |
| US6130101A (en) | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
| US6143152A (en) | 1997-11-07 | 2000-11-07 | The Regents Of The University Of California | Microfabricated capillary array electrophoresis device and method |
| US6049380A (en) | 1997-11-12 | 2000-04-11 | Regents Of The University Of California | Single molecule identification using selected fluorescence characteristics |
| WO1999026067A1 (en) | 1997-11-18 | 1999-05-27 | Bio-Rad Laboratories, Inc. | Multiplex flow immunoassays with magnetic particles as solid phase |
| US6041515A (en) | 1998-01-12 | 2000-03-28 | Life Technologies, Inc. | Apparatus for drying solutions containing macromolecules |
| SE9800360D0 (sv) | 1998-02-06 | 1998-02-06 | Goeteborg University Science I | Method, apparatus and flow cell for high sensitivity detection of fluorescent molecules |
| DE19822452C2 (de) | 1998-04-22 | 2003-02-13 | Stefan Seeger | Verfahren zur Bestimmung der Dichte lumineszierender Moleküle an einer Oberfläche, Verwendung des Verfahrens zur Bestimmung von Adsorptions- und Bindungskinetiken und Gleichgewichts- und Bindungskonstanten von Molekülen an einer Oberfläche durch Lumineszenz-Messungen und Vorrichtung zur Durchführung des Verfahrens |
| DE69835342T2 (de) | 1998-04-27 | 2007-08-23 | Corning Inc. | Verfahren zur Ablage von biologischen Proben mit Hilfe eines nachgezogenen Kapillarspeichers |
| US6689323B2 (en) | 1998-10-30 | 2004-02-10 | Agilent Technologies | Method and apparatus for liquid transfer |
| US6361671B1 (en) | 1999-01-11 | 2002-03-26 | The Regents Of The University Of California | Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels |
| JP2000208208A (ja) | 1999-01-18 | 2000-07-28 | Sony Corp | コネクタ装置及びそれを用いた電子機器並びにプラグ |
| US6249341B1 (en) | 1999-01-25 | 2001-06-19 | Amnis Corporation | Imaging and analyzing parameters of small moving objects such as cells |
| US6473176B2 (en) | 1999-01-25 | 2002-10-29 | Amnis Corporation | Imaging and analyzing parameters of small moving objects such as cells |
| US6671044B2 (en) | 1999-01-25 | 2003-12-30 | Amnis Corporation | Imaging and analyzing parameters of small moving objects such as cells in broad flat flow |
| DE19909326A1 (de) | 1999-03-03 | 2000-09-21 | Lucas Ind Plc | Vorrichtung und Verfahren zum Steuern der Fahrgeschwindigkeit eines Kraftfahrzeuges |
| US6403947B1 (en) | 1999-03-18 | 2002-06-11 | Cambridge Research & Instrumentation Inc. | High-efficiency multiple probe imaging system |
| US6242266B1 (en) | 1999-04-30 | 2001-06-05 | Agilent Technologies Inc. | Preparation of biopolymer arrays |
| AU770678B2 (en) | 1999-05-17 | 2004-02-26 | Caliper Life Sciences, Inc. | Focusing of microparticles in microfluidic systems |
| US6309886B1 (en) | 1999-06-04 | 2001-10-30 | The Regents Of The University Of California | High throughput analysis of samples in flowing liquid |
| US6811668B1 (en) | 1999-06-22 | 2004-11-02 | Caliper Life Sciences, Inc. | Apparatus for the operation of a microfluidic device |
| US6338746B1 (en) | 1999-07-23 | 2002-01-15 | Rlc Technologies, L.L.C. | Polymer-sulfur-polymer coated fertilizers |
| US6532067B1 (en) | 1999-08-09 | 2003-03-11 | The United States Of America As Represented By The Secretary Of The Army | Aerosol fluorescence spectrum analyzer for rapid measurement of single airborne particles |
| US6495104B1 (en) | 1999-08-19 | 2002-12-17 | Caliper Technologies Corp. | Indicator components for microfluidic systems |
| WO2002037096A1 (en) | 1999-10-01 | 2002-05-10 | University Of California | Microfabricated liquid sample loading system |
| US6296452B1 (en) | 2000-04-28 | 2001-10-02 | Agilent Technologies, Inc. | Microfluidic pumping |
| AU2001263286A1 (en) | 2000-05-19 | 2001-12-03 | Iowa State University Research Foundation Inc. | High-throughput methods of distinguishing at least one molecule individually in a sample comprising multiple molecules and systems for use therein |
| US6608680B2 (en) | 2000-08-25 | 2003-08-19 | Amnis Corporation | TDI imaging system for kinetic studies |
| WO2002026891A1 (en) | 2000-09-29 | 2002-04-04 | Molecular Probes, Inc. | Modified carbocyanine dyes and their conjugates |
| US6537437B1 (en) | 2000-11-13 | 2003-03-25 | Sandia Corporation | Surface-micromachined microfluidic devices |
| US6783992B2 (en) | 2001-01-03 | 2004-08-31 | Agilent Technologies, Inc. | Methods and using chemico-mechanical microvalve devices for the selective separation of components from multi-component fluid samples |
| EP1221678A1 (fr) | 2001-01-09 | 2002-07-10 | Telectronic SA | Récepteur destiné à capter un signal électromagnétique et dispositif utilisant un tel récepteur |
| US6850317B2 (en) | 2001-01-23 | 2005-02-01 | Schlumberger Technology Corporation | Apparatus and methods for determining velocity of oil in a flow stream |
| US6386219B1 (en) | 2001-02-01 | 2002-05-14 | Agilent Technologies, Inc. | Fluid handling system and method of manufacture |
| US6949377B2 (en) | 2001-03-05 | 2005-09-27 | Ho Winston Z | Chemiluminescence-based microfluidic biochip |
| US6802342B2 (en) | 2001-04-06 | 2004-10-12 | Fluidigm Corporation | Microfabricated fluidic circuit elements and applications |
| DE60233301D1 (de) | 2001-05-04 | 2009-09-24 | Biosite Inc | Diagnostische marker für akute herzerkrankungen und verfahren des gebrauchs |
| WO2002094195A2 (en) * | 2001-05-23 | 2002-11-28 | Boehringer Ingelheim Pharmaceuticals Inc. | Methods and compounds for the diagnosis of inflammatory disease and identification of pharmacological agents |
| US20070160576A1 (en) * | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
| US6766817B2 (en) | 2001-07-25 | 2004-07-27 | Tubarc Technologies, Llc | Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action |
| US20040219509A1 (en) | 2001-08-20 | 2004-11-04 | Biosite, Inc. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| US6394305B1 (en) | 2001-08-31 | 2002-05-28 | Beverly Sydlosky | Food holder and lifter with adjustable handles |
| US6867005B2 (en) | 2001-10-24 | 2005-03-15 | Beckman Coulter, Inc. | Method and apparatus for increasing the dynamic range and accuracy of binding assays |
| US20030124592A1 (en) | 2001-10-24 | 2003-07-03 | Bioprofile, Llc | Methods for detecting genetic haplotypes by interaction with probes |
| US6599436B1 (en) | 2001-12-06 | 2003-07-29 | Sandia Corporation | Formation of interconnections to microfluidic devices |
| AU2003224953A1 (en) | 2002-04-11 | 2003-10-27 | Bristol-Myers Squibb Company | Mass spectrometer autosampler |
| MXPA03004105A (es) | 2002-05-14 | 2004-10-15 | Hoffmann La Roche | Elaboracion de una prognosis en casos de enfermedad cardiaca usando una combinacion de marcadores. |
| AU2003298672A1 (en) | 2002-11-19 | 2005-01-28 | Singulex, Inc. | Detection of target molecules through interaction with probes |
| WO2004059293A2 (en) | 2002-12-24 | 2004-07-15 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| JP2006520463A (ja) | 2003-01-23 | 2006-09-07 | ユー．エス． ジェノミクス， インコーポレイテッド | ポリマー集団を解析するための方法 |
| FI20030652A0 (fi) | 2003-04-30 | 2003-04-30 | Susann Eriksson | Parannettu immunomääritys |
| US7074194B2 (en) | 2003-05-19 | 2006-07-11 | Ischemia Technologies, Inc. | Apparatus and method for risk stratification of patients with chest pain of suspected cardiac origin |
| EP1641822B1 (en) * | 2003-07-08 | 2013-05-15 | Genentech, Inc. | Il-17 a/f heterologous polypeptides and therapeutic uses thereof |
| US7547518B2 (en) | 2003-08-19 | 2009-06-16 | Becton, Dickinson And Company | Method of screening endothelial cells for angiogenic capability |
| DE602004030586D1 (de) * | 2003-09-15 | 2011-01-27 | Oklahoma Med Res Found | Verfahren zur verwendung von cytokintests zur diagnose, behandlung und beurteilung von ankyloider spondylitis |
| EP2186913B1 (en) | 2003-11-26 | 2016-02-10 | Celera Corporation | Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof |
| EP1725587A2 (en) | 2004-03-19 | 2006-11-29 | U.S. Genomics, Inc. | Compositions and methods for detection of single molecules |
| US7351538B2 (en) | 2004-08-23 | 2008-04-01 | U.S. Genomics | Systems and methods for detecting and analyzing polymers |
| US9040305B2 (en) | 2004-09-28 | 2015-05-26 | Singulex, Inc. | Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry |
| US7572640B2 (en) | 2004-09-28 | 2009-08-11 | Singulex, Inc. | Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties |
| EP1805500A4 (en) | 2004-09-28 | 2008-05-07 | Singulex Inc | SYSTEM AND METHOD FOR THE SPECTROSCOPIC ANALYSIS OF INDIVIDUAL PARTICLES |
| US8685711B2 (en) | 2004-09-28 | 2014-04-01 | Singulex, Inc. | Methods and compositions for highly sensitive detection of molecules |
| WO2006098772A2 (en) | 2004-10-13 | 2006-09-21 | U.S. Genomics, Inc. | Systems and methods for measurement optimization |
| TW200641353A (en) * | 2005-02-14 | 2006-12-01 | Wyeth Corp | Interleukin-17F antibodies and other IL-17F signaling antagonists and uses therefor |
| US20070249533A1 (en) * | 2005-09-28 | 2007-10-25 | Levin Steven D | Il-17a and il-17f antagonists and methods of using the same |
| KR101281298B1 (ko) | 2005-09-28 | 2013-07-08 | 백톤 디킨슨 앤드 컴퍼니 | 전신성 염증 상태를 예측 또는 진단하기 위한 리소포스파티딜콜린의 검출 |
| US20070259377A1 (en) | 2005-10-11 | 2007-11-08 | Mickey Urdea | Diabetes-associated markers and methods of use thereof |
| DE602007006429D1 (de) | 2006-02-10 | 2010-06-24 | Zymogenetics Inc | Lösliches il-17rcx4 und verfahren zu dessen anwendung bei entzündungen |
| US7838250B1 (en) | 2006-04-04 | 2010-11-23 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
| EP2016394A4 (en) | 2006-04-04 | 2013-04-24 | Singulex Inc | METHOD AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES |
| EP1887361A1 (en) | 2006-08-07 | 2008-02-13 | Bio-Rad Pasteur | Method for the prediction of vascular events |
| CL2008000883A1 (es) * | 2007-03-28 | 2008-10-03 | Wyeth6 3 | Metodo de deteccion de compuestos capaces de antagonizar la senalizacion de il-17f/il-17a; compuesto identificado por dicho metodo; uso de una cantidad de un antagonista de senalizacion de il-17f/il-17a, composicion farmaceutica que comprende dicho a |
| CN101946180B (zh) | 2007-12-19 | 2013-11-13 | 神谷来克斯公司 | 单分子检测用扫描分析器和使用方法 |
| CN102016552A (zh) * | 2008-03-05 | 2011-04-13 | 神谷来克斯公司 | 用于分子的高灵敏性检测的方法和组合物 |
| KR20170023209A (ko) * | 2008-05-05 | 2017-03-02 | 노비뮨 에스 에이 | 항-ｉｌ-１７ａ／ｉｌ-１７ｆ 교차-반응성 항체 및 그의 사용 방법 |
| JP2010071833A (ja) * | 2008-09-19 | 2010-04-02 | Kyoto Univ | 関節リウマチ疾患の検査方法および検査用キット |
-
2011
- 2011-05-06 WO PCT/US2011/035584 patent/WO2011140484A1/en not_active Ceased
- 2011-05-06 AU AU2011249908A patent/AU2011249908A1/en not_active Abandoned
- 2011-05-06 US US13/102,683 patent/US20110301053A1/en not_active Abandoned
- 2011-05-06 CA CA 2798149 patent/CA2798149A1/en not_active Abandoned
- 2011-05-06 EP EP11778442.1A patent/EP2566971B1/en not_active Not-in-force
- 2011-05-06 JP JP2013509303A patent/JP2013525820A/ja active Pending
-
2014
- 2014-09-04 US US14/476,820 patent/US10288623B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2566971A1 (en) | 2013-03-13 |
| WO2011140484A1 (en) | 2011-11-10 |
| CA2798149A1 (en) | 2011-11-10 |
| US20150119275A1 (en) | 2015-04-30 |
| JP2013525820A (ja) | 2013-06-20 |
| EP2566971B1 (en) | 2019-03-27 |
| US10288623B2 (en) | 2019-05-14 |
| EP2566971A4 (en) | 2013-12-25 |
| US20110301053A1 (en) | 2011-12-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102782501B (zh) | 在无症状患者中基于il-6检测的全身炎性应答综合征和败血症的早期诊断和预测 | |
| US11041864B2 (en) | Method for prediction of prognosis of sepsis | |
| EP2467724B1 (en) | Survival prognostic assay | |
| zur Wiesch et al. | Pediatric rheumatology Myeloid related proteins MRP8/MRP14 may predict disease flares in juvenile idiopathic arthritis | |
| JP5931200B2 (ja) | Ｌ−ｆａｂｐに基づく、急性事象後または外科的介入後の腎障害の診断 | |
| WO2011053832A1 (en) | Use of urinary ngal to diagnose sepsis in very low birth weight infants | |
| Sporek et al. | Urine NGAL is useful in the clinical evaluation of renal function in the early course of acute pancreatitis | |
| Kim et al. | Urinary YKL-40 as a Candidate Biomarker for Febrile Urinary Tract Infection in Young Children. | |
| US10288623B2 (en) | Methods for diagnosing, staging, predicting risk for developing and identifying treatment responders for rheumatoid arthritis | |
| US20220011311A1 (en) | Detection of bladder cancer | |
| WO2003069349A2 (en) | Method for diagnosis of inflammatory diseases using mrp8/mrp14 | |
| US20240402176A1 (en) | Detection of bladder cancer in males | |
| JP7614477B2 (ja) | 間質性肺炎のタンパク質診断バイオマーカー | |
| US20130252265A1 (en) | Method for testing for cerebral infarction via cartilage acidic protein 1 | |
| US20180003710A1 (en) | Method of assessing rheumatoid arthritis by measuring anti-ccp and anti-pik3cd | |
| JP2010071833A (ja) | 関節リウマチ疾患の検査方法および検査用キット | |
| Mohammadjafari et al. | Urinary neutrophil-gelatinase associated lipocalin is a more prognostic biomarker to distinguish antenatal hydronephrosis in neonates | |
| JPWO2005031360A1 (ja) | 関節リウマチの検出又は鑑別方法及び病期又は機能障害度の判別方法 | |
| JP7640168B2 (ja) | 夜尿症の患者の治療応答を予測する方法 | |
| Gilliam et al. | Pediatric rheumatology. Measurement of biomarkers in juvenile idiopathic arthritis patients and their significant association with disease severity: a comparative study | |
| El-aziz et al. | Impact of serum level of Dickkopf-1 in patients with Lupus nephritis | |
| Singh et al. | Comparison of Procalcitonin, C-reactive Protein, and Interleukin-6 in the Postoperative Course After Lung Decortication Surgery: A Prospective Observational Study | |
| McClerking | 35. CALCITONIN AND PROCALCITONIN | |
| Yordanova et al. | Application of Fecal Calprotectin in Inflammatory Bowel Disease | |
| HK1200216B (en) | L-fabp based diagnosis of kidney injury after an acute event or after a surgical intervention |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |