AU2011208374B2 - Sustained-release nucleic acid matrix compositions - Google Patents

Sustained-release nucleic acid matrix compositions Download PDF

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Publication number
AU2011208374B2
AU2011208374B2 AU2011208374A AU2011208374A AU2011208374B2 AU 2011208374 B2 AU2011208374 B2 AU 2011208374B2 AU 2011208374 A AU2011208374 A AU 2011208374A AU 2011208374 A AU2011208374 A AU 2011208374A AU 2011208374 B2 AU2011208374 B2 AU 2011208374B2
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another embodiment
coated substrate
peg
nucleic acid
fatty acid
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AU2011208374A1 (en
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Noam Emanuel
Yosef Rosenfeld
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Polypid Ltd
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Polypid Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
AU2011208374A 2010-01-19 2011-01-18 Sustained-release nucleic acid matrix compositions Active AU2011208374B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29604010P 2010-01-19 2010-01-19
US61/296,040 2010-01-19
PCT/IL2011/000054 WO2011089595A2 (en) 2010-01-19 2011-01-18 Sustained-release nucleic acid matrix compositions

Publications (2)

Publication Number Publication Date
AU2011208374A1 AU2011208374A1 (en) 2012-06-21
AU2011208374B2 true AU2011208374B2 (en) 2016-09-08

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AU2011208374A Active AU2011208374B2 (en) 2010-01-19 2011-01-18 Sustained-release nucleic acid matrix compositions

Country Status (7)

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US (2) US8795726B2 (cg-RX-API-DMAC7.html)
EP (1) EP2525778B1 (cg-RX-API-DMAC7.html)
JP (1) JP5860409B2 (cg-RX-API-DMAC7.html)
CN (1) CN102892406B (cg-RX-API-DMAC7.html)
AU (1) AU2011208374B2 (cg-RX-API-DMAC7.html)
CA (1) CA2783001C (cg-RX-API-DMAC7.html)
WO (1) WO2011089595A2 (cg-RX-API-DMAC7.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104274866B (zh) 2008-07-14 2016-08-24 波利皮得有限公司 持续释放药物载体组合物
JP5738856B2 (ja) 2009-07-14 2015-06-24 ポリピッド リミテッド 徐放性薬物担体組成物
CN103500847B (zh) * 2013-10-02 2016-08-17 中国地质大学（武汉） 锂硫电池添加剂、含有该添加剂的正极材料及其制备方法
US20160317560A1 (en) * 2013-11-07 2016-11-03 The University Of North Carolina At Chapel Hill Particles containing phospholipids or bioactive fatty acids and uses thereof
WO2015114633A1 (en) 2014-01-30 2015-08-06 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. Actin binding peptides and compositions comprising same for inhibiting angiogenes is and treating medical conditions associated with same
JP2016023148A (ja) * 2014-07-17 2016-02-08 富士フイルム株式会社 脂質粒子の製造法および脂質粒子を有する核酸送達キャリア
ES2900816T3 (es) * 2014-10-02 2022-03-18 Polypid Ltd Composiciones y métodos para el tratamiento y la profilaxis de las infecciones del sitio quirúrgico
EP3687503A1 (en) * 2017-09-26 2020-08-05 Nanomi B.V. Method for preparing micro-particles by double emulsion technique
CN107823725B (zh) * 2017-10-11 2020-10-09 上海君联医疗设备有限公司 一种可延期回收的血栓滤器及其制作方法
JP6388700B2 (ja) * 2017-10-20 2018-09-12 富士フイルム株式会社 脂質粒子の製造法および脂質粒子を有する核酸送達キャリア
EP3700965A1 (en) 2017-10-27 2020-09-02 Massachusetts Institute of Technology Poly (beta-amino esters) and uses thereof
WO2020077007A1 (en) 2018-10-09 2020-04-16 The University Of British Columbia Compositions and systems comprising transfection-competent vesicles free of organic-solvents and detergents and methods related thereto
WO2020086965A1 (en) * 2018-10-26 2020-04-30 Massachusetts Institute Of Technology Polymer-lipids and compositions
WO2022192176A1 (en) 2021-03-09 2022-09-15 Massachusetts Institute Of Technology Branched poly(-amino esters) for the delivery of nucleic acids

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999056731A1 (en) * 1998-04-30 1999-11-11 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US6022554A (en) * 1997-12-15 2000-02-08 American Home Products Corporation Polymeric microporous film coated subcutaneous implant
US6793938B2 (en) * 1998-07-17 2004-09-21 Skye Pharma, Inc. Biodegradable compositions for the controlled release of encapsulated substances
US20050181928A1 (en) * 2004-02-12 2005-08-18 Hayward Peter J. Reaction-bonded porous magnesia body
WO2008105773A2 (en) * 2006-03-31 2008-09-04 Massachusetts Institute Of Technology System for targeted delivery of therapeutic agents
WO2009110939A2 (en) * 2007-12-10 2009-09-11 Massachusetts Institute Of Technology Drug delivery system for pharmaceuticals and radiation

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4522803A (en) 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4882167A (en) 1983-05-31 1989-11-21 Jang Choong Gook Dry direct compression compositions for controlled release dosage forms
US4578384A (en) 1984-02-15 1986-03-25 The United States Of America As Represented By The Secretary Of The Army Polylactic-polyglycolic acids combined with an acidic phospholipid-lysozyme complex for healing osseous tissue
JPS6163613A (ja) 1984-09-04 1986-04-01 Mitsui Toatsu Chem Inc 顆粒状に調整された徐放性製剤
US5043166A (en) 1987-01-09 1991-08-27 Hadasit Medical Research, Inc. Liposome/anthraquinone drug composition and method
IL91664A (en) 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
ES2085465T3 (es) 1989-11-13 1996-06-01 Abraham J Domb Lipoesferas para la administracion controlada de sustancias.
US6120805A (en) 1990-04-06 2000-09-19 Rhone-Poulenc Rorer Sa Microspheres, process for their preparation and their use
JPH046115A (ja) 1990-04-25 1992-01-10 Olympus Optical Co Ltd 光学素子成形用型
JPH0418035A (ja) 1990-05-10 1992-01-22 Nkk Corp 徐放性製剤および製造法
JPH0446115A (ja) 1990-06-13 1992-02-17 Eisai Co Ltd マイクロスフィアの製造法
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US6180134B1 (en) 1993-03-23 2001-01-30 Sequus Pharmaceuticals, Inc. Enhanced ciruclation effector composition and method
WO1995024929A2 (en) 1994-03-15 1995-09-21 Brown University Research Foundation Polymeric gene delivery system
US6156337A (en) 1994-07-08 2000-12-05 Opperbas Holding B.V. Method for high loading of vesicles with biopolymeric substances
US6333021B1 (en) 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
US6040295A (en) 1995-01-13 2000-03-21 Genemedicine, Inc. Formulated nucleic acid compositions and methods of administering the same for gene therapy
US5919480A (en) 1996-06-24 1999-07-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal influenza vaccine composition and method
US5837221A (en) 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
WO1998007412A1 (en) 1996-08-21 1998-02-26 Alkermes Controlled Therapeutics, Inc. Controlled release microparticles with a hydrophobic material
DE69737915T2 (de) 1996-09-11 2008-03-13 Bristol-Myers Squibb Medical Imaging, Inc. Verfahren zur diagnostischen Bilderzeugung der Nierenregion unter Verwendung eines Kontrastmittels und eines Vasodilators
US6048551A (en) 1997-03-27 2000-04-11 Hilfinger; John M. Microsphere encapsulation of gene transfer vectors
IL129951A0 (en) 1997-07-02 2000-02-29 Euro Celtique Sa Prolonged anesthesia in joints and body spaces
US6287587B2 (en) 1997-07-15 2001-09-11 Takeda Chemical Industries, Ltd. Process for producing sustained-release preparation by in-water drying
US6787132B1 (en) 1997-12-04 2004-09-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combined chemo-immunotherapy with liposomal drugs and cytokines
ES2233036T3 (es) 1998-04-27 2005-06-01 Opperbas Holding B.V. Composicion farmaceutica que comprende factor viii y liposomas neutros.
ATE237312T1 (de) * 1998-07-20 2003-05-15 Protiva Biotherapeutics Inc In liposomen verkapselte nukleinsäurekomplexe
ATE355827T1 (de) 1998-08-12 2007-03-15 Yissum Res Dev Co Mittels ammoniumsulfatgradient hergestellte liposomale therapeutische zusammensetzungen
US6153217A (en) * 1999-01-22 2000-11-28 Biodelivery Sciences, Inc. Nanocochleate formulations, process of preparation and method of delivery of pharmaceutical agents
US6083482A (en) 1999-05-11 2000-07-04 Icn Pharmaceuticals, Inc. Conformationally locked nucleosides and oligonucleotides
WO2000078358A2 (en) 1999-06-18 2000-12-28 The Collaborative Group, Ltd. Hyaluronic acid microspheres for sustained gene transfer
DE10001172A1 (de) 2000-01-13 2001-07-26 Max Planck Gesellschaft Templatieren von Feststoffpartikeln mit Polymermultischichten
US6967028B2 (en) 2000-07-31 2005-11-22 Mainelab Prolonged release microspheres for injectable administration
MXPA03002918A (es) 2000-10-02 2004-04-20 Arizeke Pharmaceuticals Inc Composiciones y metodos para el transporte de agentes biologicamente activos a traves de barreras celulares.
FI20010540A0 (fi) 2001-03-16 2001-03-16 Yli Urpo Antti Komposiitti pehmyt- ja kovakudosvammojen korjaamiseksi ja mainitun komposiitin käyttö
US20020137433A1 (en) * 2001-03-26 2002-09-26 Lee Lawrence K. Abrasive drill bit
MXPA04002891A (es) 2001-09-28 2005-06-20 Johnson & Johnson Composicion farmaceutica a base de pasta de azucar.
TWI226249B (en) 2001-12-19 2005-01-11 Ind Tech Res Inst Biodegradable composite matrix for enhancing angiogenesis
EP1509203B1 (en) 2002-05-15 2016-04-13 California Pacific Medical Center Delivery of nucleic acid-like compounds
AU2004211991B2 (en) 2003-02-12 2011-03-31 Syncera, Inc. Random and non-random alkylene oxide polymer alloy compositions
WO2004081196A2 (en) 2003-03-11 2004-09-23 Qlt Usa Inc. Formulations for cell- schedule dependent anticancer agents
GB0305941D0 (en) 2003-03-14 2003-04-23 Camurus Ab Composition
CA2521916C (en) 2003-04-10 2013-06-25 Teijin Limited Biodegradable film having a honeycomb structure for the prevention of postoperative tissue adhesion
US20040247624A1 (en) 2003-06-05 2004-12-09 Unger Evan Charles Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US20060188573A1 (en) 2003-06-10 2006-08-24 Anna Imberg Composite materials and particles
WO2005039489A2 (en) 2003-09-24 2005-05-06 Polymerix Corporation Compositions and methods for the inhibition of bone growth and resorption
US7915028B2 (en) 2003-11-21 2011-03-29 Teijin Limited Tissue regeneration substrate, complex thereof with cells, and method for its production
CA2553426A1 (en) 2004-01-15 2005-08-04 Alza Corporation Liposome composition for delivery of therapeutic agents
US8277831B2 (en) 2004-02-17 2012-10-02 Advanced Technologies And Regenerative Medicine, Llc. Drug-enhanced adhesion prevention
US7744644B2 (en) 2004-03-19 2010-06-29 Boston Scientific Scimed, Inc. Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release
NZ551990A (en) 2004-06-04 2011-01-28 Camurus Ab Liquid depot formulations
CN101027065A (zh) 2004-06-15 2007-08-29 陈献 磷脂组合物及其制备和使用方法
JP2008507585A (ja) 2004-07-26 2008-03-13 コセリックス インク 微粒子製剤を用いて吸入したイロプロストによる肺高血圧症の治療
WO2006116565A2 (en) * 2005-04-25 2006-11-02 Amgen Inc. Biodegradable peptide sustained release compositions containing porogens
GB2430929A (en) * 2005-10-04 2007-04-11 Acco Uk Ltd Apparatus for dividing a bundle of sheet material from a larger bundle
US20070141134A1 (en) 2005-12-16 2007-06-21 Kosak Matthew K Shielded micelles for polynucleotide delivery
US20090318355A1 (en) 2006-02-15 2009-12-24 Chen Thomas T Compositions and methods for promoting tissue repair and wound healing
US8703167B2 (en) 2006-06-05 2014-04-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug
US20080181928A1 (en) * 2006-12-22 2008-07-31 Miv Therapeutics, Inc. Coatings for implantable medical devices for liposome delivery
CN101621999B (zh) 2007-03-02 2012-09-26 帝化制药株式会社 经皮吸收医药组合物、医药组合物储存单元以及利用了该储存单元的经皮吸收制剂
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
WO2009006311A2 (en) 2007-06-29 2009-01-08 Wisconsin Alumni Research Foundation Structuring effect of cholesterol in peg-phospholipid micelles, drug delivery of amphotericin b, and combination antifungals
US20090110713A1 (en) 2007-10-31 2009-04-30 Florencia Lim Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices
WO2009061515A1 (en) 2007-11-09 2009-05-14 Northeastern University Self-assembling micelle-like nanoparticles for systemic gene delivery
US8128983B2 (en) 2008-04-11 2012-03-06 Abbott Cardiovascular Systems Inc. Coating comprising poly(ethylene glycol)-poly(lactide-glycolide-caprolactone) interpenetrating network
CA2721333C (en) 2008-04-15 2020-12-01 Protiva Biotherapeutics, Inc. Novel lipid formulations for nucleic acid delivery
WO2010001325A2 (en) * 2008-06-30 2010-01-07 Silenseed Ltd Methods, compositions and systems for local delivery of drugs
CN104274866B (zh) 2008-07-14 2016-08-24 波利皮得有限公司 持续释放药物载体组合物
US9012622B2 (en) 2008-12-31 2015-04-21 Patrick Y. Lu Compositions and methods using siRNA molecules and siRNA cocktails for the treatment of breast cancer
JP5675784B2 (ja) 2009-05-16 2015-02-25 クニュアン クイＫｕｎｙｕａｎ Ｃｕｉ 治療用分子を送達するためのカチオン性両親媒性物質と共脂質とを含む組成物
JP5738856B2 (ja) 2009-07-14 2015-06-24 ポリピッド リミテッド 徐放性薬物担体組成物

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022554A (en) * 1997-12-15 2000-02-08 American Home Products Corporation Polymeric microporous film coated subcutaneous implant
WO1999056731A1 (en) * 1998-04-30 1999-11-11 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US20070104656A1 (en) * 1998-04-30 2007-05-10 Acusphere, Inc. Matrices Formed of Polymer and Hydrophobic Compounds For Use in Drug Delivery
US6793938B2 (en) * 1998-07-17 2004-09-21 Skye Pharma, Inc. Biodegradable compositions for the controlled release of encapsulated substances
US20050181928A1 (en) * 2004-02-12 2005-08-18 Hayward Peter J. Reaction-bonded porous magnesia body
WO2008105773A2 (en) * 2006-03-31 2008-09-04 Massachusetts Institute Of Technology System for targeted delivery of therapeutic agents
WO2009110939A2 (en) * 2007-12-10 2009-09-11 Massachusetts Institute Of Technology Drug delivery system for pharmaceuticals and radiation

Also Published As

Publication number Publication date
CA2783001A1 (en) 2011-07-28
EP2525778A2 (en) 2012-11-28
US9616032B2 (en) 2017-04-11
CN102892406B (zh) 2015-04-08
WO2011089595A2 (en) 2011-07-28
EP2525778A4 (en) 2013-07-03
US20120294944A1 (en) 2012-11-22
JP2013517265A (ja) 2013-05-16
EP2525778B1 (en) 2018-08-01
JP5860409B2 (ja) 2016-02-16
US8795726B2 (en) 2014-08-05
CN102892406A (zh) 2013-01-23
CA2783001C (en) 2017-12-12
US20140335165A1 (en) 2014-11-13
WO2011089595A3 (en) 2011-10-20
AU2011208374A1 (en) 2012-06-21

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