AU2010296044B2 - Method and composition for treating Alzheimer-type dementia - Google Patents

Method and composition for treating Alzheimer-type dementia Download PDF

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Publication number
AU2010296044B2
AU2010296044B2 AU2010296044A AU2010296044A AU2010296044B2 AU 2010296044 B2 AU2010296044 B2 AU 2010296044B2 AU 2010296044 A AU2010296044 A AU 2010296044A AU 2010296044 A AU2010296044 A AU 2010296044A AU 2010296044 B2 AU2010296044 B2 AU 2010296044B2
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Australia
Prior art keywords
acceptable salts
pharmaceutically acceptable
amount
achei
dose
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AU2010296044A
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AU2010296044A1 (en
Inventor
Thomas N. Chase
Kathleen E. Clarence-Smith
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Chase Pharmaceuticals Corp
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Chase Pharmaceuticals Corp
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Priority to AU2015213396A priority Critical patent/AU2015213396B2/en
Priority to AU2018201519A priority patent/AU2018201519A1/en
Priority to AU2020203741A priority patent/AU2020203741A1/en
Priority to AU2022246374A priority patent/AU2022246374A1/en
Ceased legal-status Critical Current
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
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  • Organic Chemistry (AREA)
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  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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AU2010296044A 2009-09-18 2010-09-13 Method and composition for treating Alzheimer-type dementia Ceased AU2010296044B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2015213396A AU2015213396B2 (en) 2009-09-18 2015-08-14 Method and composition for treating Alzheimer-type dementia
AU2018201519A AU2018201519A1 (en) 2009-09-18 2018-03-02 Method and composition for treating Alzheimer-type dementia
AU2020203741A AU2020203741A1 (en) 2009-09-18 2020-06-05 Method and composition for treating Alzheimer-type dementia
AU2022246374A AU2022246374A1 (en) 2009-09-18 2022-10-04 Method and composition for treating Alzheimer-type dementia

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27238209P 2009-09-18 2009-09-18
US61/272,382 2009-09-18
PCT/US2010/002475 WO2011034568A1 (en) 2009-09-18 2010-09-13 Method and composition for treating alzheimer-type dementia

Related Child Applications (1)

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AU2015213396A Division AU2015213396B2 (en) 2009-09-18 2015-08-14 Method and composition for treating Alzheimer-type dementia

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AU2010296044A1 AU2010296044A1 (en) 2012-03-22
AU2010296044B2 true AU2010296044B2 (en) 2015-05-14

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AU2010296044A Ceased AU2010296044B2 (en) 2009-09-18 2010-09-13 Method and composition for treating Alzheimer-type dementia

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US (6) US8877768B2 (h)
EP (1) EP2478099B1 (h)
JP (2) JP6050115B2 (h)
AU (1) AU2010296044B2 (h)
CA (1) CA2773592C (h)
ES (1) ES2746480T3 (h)
IN (1) IN2012DN02122A (h)
MX (2) MX345236B (h)
WO (1) WO2011034568A1 (h)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8969402B2 (en) 2006-11-15 2015-03-03 Steven A. Rich Combined acetylcholinesterase inhibitor and quaternary ammonium antimuscarinic therapy to alter progression of cognitive diseases
WO2011034568A1 (en) * 2009-09-18 2011-03-24 Chase Pharmaceuticals Corporation Method and composition for treating alzheimer-type dementia
US20110201597A1 (en) 2008-03-27 2011-08-18 Chase Thomas N Method and composition for treating alzheimer-type dementia
EP3178477A1 (en) 2008-03-27 2017-06-14 Chase Pharmaceuticals Corporation Combination of a nspacha (peripheral anticholinergic agent) like solifenacin and an achei (acetyl choline esterase inhibitor) like donepezil for treating dementia
US9561218B2 (en) 2012-09-05 2017-02-07 Chase Pharmaceuticals Corporation Anticholinergic neuroprotective composition and methods
SG11201509932XA (en) * 2013-07-02 2016-01-28 Eustralis Pharmaceuticals Ltd Trading As Pressura Neuro Method for preventing and/or treating chronic traumatic encephalopathy-i
CA2845443A1 (en) * 2014-03-04 2015-09-04 Pharmascience Inc. Orally disintegrating tablet of nabilone and method of manufacturing
US20170010030A1 (en) * 2014-03-07 2017-01-12 Mitsubishi Electric Corporation Air-conditioning apparatus
EP3242659A4 (en) 2015-01-09 2018-09-12 Chase Pharmaceuticals Corporation Oxybutynin transdermal therapeutic system combination
US10307409B2 (en) * 2015-03-06 2019-06-04 Chase Pharmaceuticals Corporation Muscarinic combinations and their use for combating hypocholinergic disorders of the central nervous system
CA2978201A1 (en) 2015-03-06 2016-09-15 Chase Pharmaceuticals Corporation Use of oxybutynin transdermal formulations to reduce side effects associated with muscarinic agonists
CA2989579A1 (en) 2015-06-15 2016-12-22 Qaam Pharmaceuticals, Llc Glycopyrronium fatty acid salts and methods of making same
US20170143664A1 (en) * 2015-08-06 2017-05-25 Charles E. Ankner Cannabinoid formulation for the sedation and/or anaesthetizing of a human or animal
CA2996717A1 (en) 2015-09-11 2017-03-16 Chase Pharmaceuticals Corporation Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
WO2018039159A1 (en) * 2016-08-22 2018-03-01 Chase Pharmaceuticals Corporation Muscarinic m2-antagonist combination
EP3589369A4 (en) * 2017-01-09 2020-03-18 DAS-MG, Inc. USE AND COMPOSITION FOR TREATING SEVERE MYASTHENIA AND OTHER MYASTHENIC SYNDROMES
US20200000756A1 (en) * 2017-01-24 2020-01-02 Gt Biopharma, Inc. Neostigmine combination and compositions
JP7557939B2 (ja) * 2017-03-27 2024-09-30 チェイス セラピューティクス コーポレイション シヌクレイノパチーを処置するための組成物および方法
EA201992532A1 (ru) 2017-04-24 2020-04-03 Чейс Терапьютикс Корпорейшн Композиции и способ для лечения депрессии
WO2018236807A1 (en) * 2017-06-19 2018-12-27 Clarence Smith Kathleen E Use and composition for protection against organophosphorus poisoning
EA202090180A1 (ru) 2017-06-30 2020-05-26 Чейс Терапьютикс Корпорейшн Композиции nk1-антагониста и способы лечения депрессии
WO2019023175A1 (en) 2017-07-25 2019-01-31 Gt Biopharma, Inc. PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE AND NEOSTIGMINE AND AN ANTAGONIST NK-1 FOR THE TREATMENT OF SEVERE MYASTHENIA
CA3089750A1 (en) * 2018-01-29 2019-08-01 Solantech Inc. Methods of treating and/or preventing bedsores using nabilone
US11931366B2 (en) * 2018-04-19 2024-03-19 Washington University Compositions and methods of use thereof for treatment of proteinopathies
US11065265B2 (en) 2018-05-18 2021-07-20 Spes Pharmaceuticals Inc. Compositions of fosaprepitant and methods of preparation
EP3937749A1 (en) 2019-03-11 2022-01-19 Integrated Endoscopy, Inc. Cordless disposable endoscope
US10639314B1 (en) 2019-04-30 2020-05-05 LA PharmaTech Inc. Method of treating Alzheimer's disease
US10898493B2 (en) 2019-04-12 2021-01-26 LA PharmaTech Inc. Pharmaceutical compositions and methods for psychiatric symptoms of patients with Alzheimer's disease
US11389458B2 (en) 2019-04-12 2022-07-19 LA PharmaTech Inc. Pharmaceutical compositions and methods for treating parkinson's and huntington's disease
US11744833B2 (en) 2019-04-12 2023-09-05 LA PharmaTech Inc. Pharmaceutical compositions and methods for treatment of insomnia
US11938139B2 (en) 2019-04-12 2024-03-26 LA PharmaTech Inc. Pharmaceutical compositions and methods for anxiety, depression and other psychiatric disorders
US11318144B2 (en) 2019-04-12 2022-05-03 LA PharmaTech Inc. Compositions and methods for treating Alzheimer's disease and Parkinson's disease
US11690849B2 (en) 2019-04-12 2023-07-04 LA PharmaTech Inc. Method of treating dementia
US10966989B2 (en) 2019-04-12 2021-04-06 LA PharmaTech Inc. Pharmaceutical compositions and methods for treating mental, behavioral, cognitive disorders
US10639315B1 (en) 2019-05-21 2020-05-05 LA PharmaTech Inc. Pharmaceutical compositions and methods for treating Alzheimer's disease
JP2023553274A (ja) * 2020-11-18 2023-12-21 エフビー－エイチアールエス リミテッド ライアビリティ カンパニー ドフェチリド及びメキシレチンを含有する組成物並びにその使用
US12109202B2 (en) 2021-01-29 2024-10-08 Qaam Pharmaceuticals, Llc Fixed dose combination of cholinesterase inhibitor and a quaternary ammonium antimuscarinic agent to treat neurodegenerative cognitive disorders
EP4297868A4 (en) 2021-02-23 2025-01-08 Hoth Therapeutics, Inc. USE OF APREPITANT TO TREAT ALZHEIMER'S
US11351179B1 (en) 2021-08-05 2022-06-07 LA PharmaTech Inc. Pharmaceutical compositions and methods for treatment of psychiatric disorders

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1204580A (en) 1968-10-05 1970-09-09 Aspro Nicholas Ltd Pharmaceutical dosage forms
US4663318A (en) 1986-01-15 1987-05-05 Bonnie Davis Method of treating Alzheimer's disease
GB9423588D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
US5576317A (en) * 1994-12-09 1996-11-19 Pfizer Inc. NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis
EP0976404A3 (en) 1998-07-30 2001-06-27 Pfizer Products Inc. A pharmaceutical composition for the prevention and treatment of diseases of cognitive dysfunction in a mammal
ID27504A (id) * 1998-10-01 2001-04-12 Novartis Ag Formulasi oral baru
US7427280B2 (en) 2002-09-06 2008-09-23 Medtronic, Inc. Method, system and device for treating disorders of the pelvic floor by delivering drugs to various nerves or tissues
CN1520818A (zh) 2003-02-09 2004-08-18 山东绿叶天然药物研究开发有限公司 治疗老年性痴呆的胆碱酯酶抑制剂药物组合物
GB0322140D0 (en) 2003-09-22 2003-10-22 Pfizer Ltd Combinations
EP1709003B1 (en) 2004-01-16 2009-09-23 Wyeth Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole
US7390816B2 (en) 2005-06-21 2008-06-24 Bridge Pharma, Inc. Methods for treating urinary incontinence in patients suffering from memory disorders
US20070224259A1 (en) 2005-09-21 2007-09-27 Gupta Anil K Anti-inflammatory pharmaceutical composition
JP2009534385A (ja) 2006-04-21 2009-09-24 ワイス キラル的に純粋なアミノアルコール中間体、それらの誘導体の製造、及びそれらの使用
US20070259933A1 (en) 2006-05-04 2007-11-08 Xenoport, Inc. Compositions, dosage forms and methods of treating emesis
US20080119452A1 (en) 2006-09-12 2008-05-22 Dolle Roland E Methods for enhancing cognitive function
US8097633B2 (en) 2006-11-15 2012-01-17 Rich Steven A Uses for quaternary ammonium anticholinergic muscarinic receptor antagonists in patients being treated for cognitive impairment or acute delirium
EP3178477A1 (en) 2008-03-27 2017-06-14 Chase Pharmaceuticals Corporation Combination of a nspacha (peripheral anticholinergic agent) like solifenacin and an achei (acetyl choline esterase inhibitor) like donepezil for treating dementia
US20110201597A1 (en) 2008-03-27 2011-08-18 Chase Thomas N Method and composition for treating alzheimer-type dementia
WO2011034568A1 (en) * 2009-09-18 2011-03-24 Chase Pharmaceuticals Corporation Method and composition for treating alzheimer-type dementia

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Cutler NR, et al., Clinical Pharmacology and Therapeutics, 1998; 63(2): 188 *
Diez-Ariza M, et al., Psychopharmacology (Berl). 2003, Aug; 169(1): 35-41. *
Forette F, et al., Eur J Neurol. 1999 Jul;6(4):423-9. *
Jhee SS, et al., Clin Neuropharmacol. 2002 Mar-Apr; 25(2):122-3. *

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