AU2010271345B2 - Etomidate analogues that do not inhibit adrenocortical steroid synthesis - Google Patents

Etomidate analogues that do not inhibit adrenocortical steroid synthesis Download PDF

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Publication number
AU2010271345B2
AU2010271345B2 AU2010271345A AU2010271345A AU2010271345B2 AU 2010271345 B2 AU2010271345 B2 AU 2010271345B2 AU 2010271345 A AU2010271345 A AU 2010271345A AU 2010271345 A AU2010271345 A AU 2010271345A AU 2010271345 B2 AU2010271345 B2 AU 2010271345B2
Authority
AU
Australia
Prior art keywords
compound
etomidate
cio
carboetomidate
lic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010271345A
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English (en)
Other versions
AU2010271345A1 (en
Inventor
Joseph F. Cotten
Gregory D. Cuny
Stuart A. Forman
Syed S. Husain
Keith W. Miller
Douglas E. Raines
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
The Brigham and Women's Hospital Inc
General Hospital Corp
Original Assignee
The Brigham and Women's Hospital Inc
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Brigham and Women's Hospital Inc, General Hospital Corp filed Critical The Brigham and Women's Hospital Inc
Publication of AU2010271345A1 publication Critical patent/AU2010271345A1/en
Application granted granted Critical
Publication of AU2010271345B2 publication Critical patent/AU2010271345B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
AU2010271345A 2009-07-10 2010-07-08 Etomidate analogues that do not inhibit adrenocortical steroid synthesis Ceased AU2010271345B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22475109P 2009-07-10 2009-07-10
US61/224,751 2009-07-10
PCT/US2010/041379 WO2011005969A2 (en) 2009-07-10 2010-07-08 Etomidate analogues that do not inhibit adrenocortical steroid synthesis

Publications (2)

Publication Number Publication Date
AU2010271345A1 AU2010271345A1 (en) 2012-02-02
AU2010271345B2 true AU2010271345B2 (en) 2014-12-04

Family

ID=43429834

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010271345A Ceased AU2010271345B2 (en) 2009-07-10 2010-07-08 Etomidate analogues that do not inhibit adrenocortical steroid synthesis

Country Status (9)

Country Link
US (2) US8765973B2 (enExample)
EP (1) EP2451779B1 (enExample)
JP (1) JP5925121B2 (enExample)
CN (1) CN102548964B (enExample)
AU (1) AU2010271345B2 (enExample)
BR (1) BR112012000606A2 (enExample)
CA (1) CA2767112C (enExample)
RU (1) RU2559888C2 (enExample)
WO (1) WO2011005969A2 (enExample)

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CN104168899B (zh) * 2012-01-13 2017-04-05 通用医疗公司 麻醉剂化合物及其相关的使用方法
PE20150974A1 (es) * 2012-11-14 2015-07-04 Teijin Pharma Ltd Derivados de piridina
EP3206683A4 (en) 2014-10-16 2018-06-13 The Board of Trustees of the Leland Stanford Junior University Novel methods, compounds, and compositions for anesthesia
KR20180090785A (ko) 2015-10-07 2018-08-13 아펠리스 파마슈티컬스 인코포레이티드 투여 요법
EP3360863B1 (en) * 2015-10-10 2022-04-20 Jiangsu Nhwaluokang Pharmaceutical Research and Development Co., Ltd. Etomidate derivative and intermediate, preparation method and use thereof
CN107445898A (zh) * 2016-05-30 2017-12-08 四川海思科制药有限公司 N‑取代咪唑羧酸酯类化合物及其制备方法和在医药上的用途
CN107522662A (zh) * 2016-06-16 2017-12-29 四川海思科制药有限公司 N‑取代咪唑羧酸酯类化合物及其制备方法和在医药上的用途
CN107641105A (zh) * 2016-07-22 2018-01-30 四川海思科制药有限公司 N‑取代咪唑羧酸酯类化合物及其制备方法和在医药上的用途
CN107652239B (zh) * 2017-02-24 2020-08-04 四川大学华西医院 N-取代咪唑羧酸酯类化合物、制备方法及用途
BR112019020955A2 (pt) 2017-04-07 2020-05-05 Apellis Pharmaceuticals, Inc. regimes de dosagem e composições e métodos relacionados
JP2021507884A (ja) 2017-12-15 2021-02-25 アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 投与レジメンならびに関連組成物および方法
CN109776512A (zh) * 2018-01-30 2019-05-21 成都安诺晨创医药科技有限公司 一种n-取代咪唑甲酸酯类衍生物及其用途
CN110003188B (zh) * 2019-03-27 2022-08-26 成都麻沸散医药科技有限公司 取代吡咯甲酸酯类衍生物及其用途
CN110669017B (zh) * 2019-10-11 2023-08-04 成都麻沸散医药科技有限公司 多取代三唑甲酸酯类衍生物及其用途
CN112174890B (zh) * 2020-10-09 2022-05-27 成都麻沸散医药科技有限公司 酮取代杂环化合物及其麻醉作用

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US5242939A (en) * 1990-09-28 1993-09-07 Warner-Lambert Company Anilide derivatives with angiotensin ii antagonist properties

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US4038286A (en) 1975-03-10 1977-07-26 Janssen Pharmaceutica N.V. Racemates and optical isomers of 1-(1-phenylethyl)-1h-imidazole-5-carboylic acid derivatives
GR64915B (en) 1978-09-14 1980-06-09 Janssen Pharmaceutica Nv Improved etomidate-containing compositions
US4878940A (en) 1987-04-02 1989-11-07 Janssen Pharmaceutica N.V. Herbicidal 1,5-substituted 1H-imidazoles
CA2008616C (en) * 1989-01-31 2000-07-18 Roger A. Parker Aryl- or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds useful in treating interleukin-1 mediated conditions
US5019583A (en) 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
JP3374922B2 (ja) 1991-05-09 2003-02-10 日産化学工業株式会社 複素環式第３級アミンの製造方法
JPH06345728A (ja) 1993-06-11 1994-12-20 Nissan Chem Ind Ltd Ｎ−置換アゾール誘導体の製造方法
US5466700A (en) 1993-08-30 1995-11-14 Glaxo Wellcome Inc. Anesthetic use of N-phenyl-N-(4-piperidinyl)amides
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US5242939A (en) * 1990-09-28 1993-09-07 Warner-Lambert Company Anilide derivatives with angiotensin ii antagonist properties

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Also Published As

Publication number Publication date
WO2011005969A3 (en) 2011-05-12
CA2767112A1 (en) 2011-01-13
US20130079381A1 (en) 2013-03-28
BR112012000606A2 (pt) 2016-11-22
CA2767112C (en) 2018-06-19
CN102548964A (zh) 2012-07-04
CN102548964B (zh) 2014-09-24
EP2451779A2 (en) 2012-05-16
RU2012104761A (ru) 2013-08-20
EP2451779A4 (en) 2013-04-24
US8765973B2 (en) 2014-07-01
AU2010271345A1 (en) 2012-02-02
JP5925121B2 (ja) 2016-05-25
US20150011603A1 (en) 2015-01-08
HK1172026A1 (en) 2013-04-12
US9187421B2 (en) 2015-11-17
WO2011005969A2 (en) 2011-01-13
RU2559888C2 (ru) 2015-08-20
JP2012532883A (ja) 2012-12-20
EP2451779B1 (en) 2014-09-03

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired