AU2010258821B2 - Genotype specific methods for treating human subjects using 4- methylpyrazole - Google Patents

Genotype specific methods for treating human subjects using 4- methylpyrazole Download PDF

Info

Publication number
AU2010258821B2
AU2010258821B2 AU2010258821A AU2010258821A AU2010258821B2 AU 2010258821 B2 AU2010258821 B2 AU 2010258821B2 AU 2010258821 A AU2010258821 A AU 2010258821A AU 2010258821 A AU2010258821 A AU 2010258821A AU 2010258821 B2 AU2010258821 B2 AU 2010258821B2
Authority
AU
Australia
Prior art keywords
subject
adh2
ethanol
acetaldehyde
alcohol dehydrogenase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010258821A
Other languages
English (en)
Other versions
AU2010258821A1 (en
Inventor
Thomas E. Daley
Elizabeth C. Squiers
Kin-Hung Peony Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Horizon Orphan LLC
Original Assignee
Raptor Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Raptor Therapeutics Inc filed Critical Raptor Therapeutics Inc
Publication of AU2010258821A1 publication Critical patent/AU2010258821A1/en
Application granted granted Critical
Publication of AU2010258821B2 publication Critical patent/AU2010258821B2/en
Assigned to HORIZON ORPHAN LLC reassignment HORIZON ORPHAN LLC Request to Amend Deed and Register Assignors: RAPTOR THERAPEUTICS INC.
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2010258821A 2009-06-10 2010-06-09 Genotype specific methods for treating human subjects using 4- methylpyrazole Ceased AU2010258821B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18588409P 2009-06-10 2009-06-10
US61/185,884 2009-06-10
PCT/US2010/037879 WO2010144518A1 (en) 2009-06-10 2010-06-09 Genotype specific methods for treating human subjects using 4- methylpyrazole

Publications (2)

Publication Number Publication Date
AU2010258821A1 AU2010258821A1 (en) 2012-01-19
AU2010258821B2 true AU2010258821B2 (en) 2016-03-10

Family

ID=43309203

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010258821A Ceased AU2010258821B2 (en) 2009-06-10 2010-06-09 Genotype specific methods for treating human subjects using 4- methylpyrazole

Country Status (13)

Country Link
US (4) US20120252857A1 (https=)
EP (2) EP2440049B1 (https=)
JP (2) JP5836270B2 (https=)
KR (3) KR20120032523A (https=)
CN (2) CN106943398A (https=)
AU (1) AU2010258821B2 (https=)
DK (1) DK2440049T3 (https=)
ES (1) ES2656489T3 (https=)
NO (1) NO2440049T3 (https=)
PT (1) PT2440049T (https=)
SG (1) SG176734A1 (https=)
TW (1) TWI523653B (https=)
WO (1) WO2010144518A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8901484B2 (en) * 2012-04-27 2014-12-02 Sanofi-Aventis Deutschland Gmbh Quantification of impurities for release testing of peptide products
WO2017072828A1 (ja) * 2015-10-26 2017-05-04 株式会社日立製作所 デバッグを支援する方法及び計算機システム
WO2019209123A1 (en) * 2018-04-27 2019-10-31 Remedius Biotech Limited Diagnosis, risk reduction and treatment of conditions associated with elevated aldehyde levels
CN109381458B (zh) * 2018-12-16 2020-09-01 李志武 甲吡唑及其盐在制备抗癫痫药物中的用途
CN120475912A (zh) 2022-12-01 2025-08-12 匹克生物酶高科技有限公司 用于改善行为和运功功能的新型醛脱氢酶食品和药剂组合物
AU2023402120A1 (en) * 2022-12-01 2025-06-12 PICOENTECH Co., LTD. Food and pharmaceutical composition for detoxifying endogenous aldehydes
WO2024117701A1 (en) * 2022-12-01 2024-06-06 PICOENTECH Co., LTD. Food and drug composition containing novel aldehyde dehydrogenase for suppressing tremor or movement disorder

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080021083A1 (en) * 2004-03-03 2008-01-24 Daley Thomas E 4-Methylpyrazole Formulations for Inhibiting Ethanol Intolerance

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57106620A (en) 1980-12-22 1982-07-02 Takara Shuzo Co Ltd Ameliorant for alcoholic metabolism
GB0404481D0 (en) 2004-02-28 2004-03-31 Rhodia Cons Spec Ltd Soap control agent
WO2009058874A1 (en) * 2007-11-02 2009-05-07 Monte Woodow C Methods and materials for treating or preventing diseases/disorders mediated by alcohol dehydrogenase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080021083A1 (en) * 2004-03-03 2008-01-24 Daley Thomas E 4-Methylpyrazole Formulations for Inhibiting Ethanol Intolerance

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THOMASSON, H.R. et al. "Alcohol and Aldehyde Dehydrogenase Genotypes and Alcoholism in Chinese Men" Am. J. Hum. Genet. (1991) 48:677-681 *

Also Published As

Publication number Publication date
US20120322843A1 (en) 2012-12-20
CN102458121A (zh) 2012-05-16
AU2010258821A1 (en) 2012-01-19
KR20140138318A (ko) 2014-12-03
US20120252857A1 (en) 2012-10-04
US20180098964A1 (en) 2018-04-12
TWI523653B (zh) 2016-03-01
EP2440049A1 (en) 2012-04-18
EP3311811A1 (en) 2018-04-25
KR20120032523A (ko) 2012-04-05
US20170007578A1 (en) 2017-01-12
CN106943398A (zh) 2017-07-14
JP2015155422A (ja) 2015-08-27
PT2440049T (pt) 2018-03-05
EP2440049A4 (en) 2012-12-05
DK2440049T3 (en) 2018-02-19
WO2010144518A1 (en) 2010-12-16
JP2012529526A (ja) 2012-11-22
JP5836270B2 (ja) 2015-12-24
KR20160147709A (ko) 2016-12-23
TW201110966A (en) 2011-04-01
EP2440049B1 (en) 2017-12-13
SG176734A1 (en) 2012-01-30
NO2440049T3 (https=) 2018-05-12
ES2656489T3 (es) 2018-02-27

Similar Documents

Publication Publication Date Title
US20170007578A1 (en) Genotype Specific Methods for Treating Human Subjects Using 4-Methylpyrazole
US20230348981A1 (en) Methods and compositions for inhibiting and treating neurological conditions
EP4005570B1 (en) Pridopidine for use in treating rett syndrome
US20220162610A1 (en) Novel rna transcript
US20160243082A1 (en) 4-Methylpyrazole Formulations for Inhibiting Ethanol Intolerance
US20180179594A1 (en) Multiple system atrophy and the treatment thereof
EP3870699A2 (en) Treatments for charcot-marie-tooth disease
US20120029031A1 (en) Metadoxine for use as inhibitor of hepatic fibrosis
HK1168993B (en) Genotype specific methods for treating human subjects using 4-methylpyrazole
HK1168993A (en) Genotype specific methods for treating human subjects using 4-methylpyrazole
US20240409928A1 (en) Novel rna transcript
WO2013139700A1 (en) Memory genes
Peet Association of the 5-HTTLPR with Prolactin Response to Citalopram in a Community Population
HK40009961B (en) Use of pridopidine for treating rett syndrome

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
HB Alteration of name in register

Owner name: HORIZON ORPHAN LLC

Free format text: FORMER NAME(S): RAPTOR THERAPEUTICS INC.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired