AU2010255502B2 - Tamper resistant dosage form comprising a matrix and melt - extruded particulates comprising a drug - Google Patents
Tamper resistant dosage form comprising a matrix and melt - extruded particulates comprising a drug Download PDFInfo
- Publication number
- AU2010255502B2 AU2010255502B2 AU2010255502A AU2010255502A AU2010255502B2 AU 2010255502 B2 AU2010255502 B2 AU 2010255502B2 AU 2010255502 A AU2010255502 A AU 2010255502A AU 2010255502 A AU2010255502 A AU 2010255502A AU 2010255502 B2 AU2010255502 B2 AU 2010255502B2
- Authority
- AU
- Australia
- Prior art keywords
- dosage form
- melt
- particulates
- drug
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 239000002552 dosage form Substances 0.000 title claims abstract description 253
- 239000003814 drug Substances 0.000 title claims abstract description 117
- 229940079593 drug Drugs 0.000 title claims abstract description 108
- 239000011159 matrix material Substances 0.000 title claims abstract description 68
- 239000000203 mixture Substances 0.000 claims description 70
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- 229960002085 oxycodone Drugs 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 46
- 239000003795 chemical substances by application Substances 0.000 claims description 43
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- 150000003839 salts Chemical class 0.000 claims description 29
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims description 28
- 229960001410 hydromorphone Drugs 0.000 claims description 28
- 239000003402 opiate agonist Substances 0.000 claims description 21
- 238000002156 mixing Methods 0.000 claims description 20
- 239000000155 melt Substances 0.000 claims description 19
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- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 2
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- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
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Classifications
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Landscapes
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- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| GB0909680.1 | 2009-06-05 | ||
| GBGB0909680.1A GB0909680D0 (en) | 2009-06-05 | 2009-06-05 | Dosage form |
| PCT/GB2010/050948 WO2010140007A2 (en) | 2009-06-05 | 2010-06-07 | Dosage form |
Publications (2)
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| AU2010255502A1 AU2010255502A1 (en) | 2012-01-12 |
| AU2010255502B2 true AU2010255502B2 (en) | 2016-09-22 |
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| AU2010255502A Ceased AU2010255502B2 (en) | 2009-06-05 | 2010-06-07 | Tamper resistant dosage form comprising a matrix and melt - extruded particulates comprising a drug |
Country Status (18)
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| EP (1) | EP2437729B1 (https=) |
| JP (1) | JP5635082B2 (https=) |
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| CN (2) | CN102481260A (https=) |
| AU (1) | AU2010255502B2 (https=) |
| BR (1) | BRPI1012004A2 (https=) |
| CA (1) | CA2764517C (https=) |
| EA (1) | EA022801B1 (https=) |
| ES (1) | ES2713957T3 (https=) |
| GB (1) | GB0909680D0 (https=) |
| IL (1) | IL216748A0 (https=) |
| MX (1) | MX2011012929A (https=) |
| MY (1) | MY173629A (https=) |
| NZ (1) | NZ596879A (https=) |
| SG (2) | SG176304A1 (https=) |
| WO (1) | WO2010140007A2 (https=) |
| ZA (1) | ZA201109221B (https=) |
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| DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
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| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
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-
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- 2010-06-07 NZ NZ596879A patent/NZ596879A/xx not_active IP Right Cessation
- 2010-06-07 WO PCT/GB2010/050948 patent/WO2010140007A2/en not_active Ceased
- 2010-06-07 SG SG2011089273A patent/SG176304A1/en unknown
- 2010-06-07 JP JP2012513685A patent/JP5635082B2/ja not_active Expired - Fee Related
- 2010-06-07 EA EA201171389A patent/EA022801B1/ru not_active IP Right Cessation
- 2010-06-07 KR KR1020127000058A patent/KR101816130B1/ko not_active Expired - Fee Related
- 2010-06-07 EP EP10725263.7A patent/EP2437729B1/en active Active
- 2010-06-07 MY MYPI2011005869A patent/MY173629A/en unknown
- 2010-06-07 MX MX2011012929A patent/MX2011012929A/es active IP Right Grant
- 2010-06-07 CN CN2010800344131A patent/CN102481260A/zh active Pending
- 2010-06-07 CA CA2764517A patent/CA2764517C/en not_active Expired - Fee Related
- 2010-06-07 SG SG10201402810XA patent/SG10201402810XA/en unknown
- 2010-06-07 CN CN201610970584.4A patent/CN106667919A/zh active Pending
- 2010-06-07 US US13/376,113 patent/US9814679B2/en active Active
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- 2010-06-07 AU AU2010255502A patent/AU2010255502B2/en not_active Ceased
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2011
- 2011-12-04 IL IL216748A patent/IL216748A0/en unknown
- 2011-12-14 ZA ZA2011/09221A patent/ZA201109221B/en unknown
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Also Published As
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|---|---|
| WO2010140007A2 (en) | 2010-12-09 |
| ES2713957T3 (es) | 2019-05-24 |
| NZ596879A (en) | 2013-06-28 |
| WO2010140007A9 (en) | 2012-01-19 |
| MX2011012929A (es) | 2012-04-20 |
| WO2010140007A3 (en) | 2011-11-17 |
| EP2437729B1 (en) | 2019-01-23 |
| KR101816130B1 (ko) | 2018-01-08 |
| CA2764517A1 (en) | 2010-12-09 |
| SG176304A1 (en) | 2012-01-30 |
| KR20120026595A (ko) | 2012-03-19 |
| EA022801B1 (ru) | 2016-03-31 |
| EA201171389A1 (ru) | 2012-05-30 |
| ZA201109221B (en) | 2012-08-29 |
| SG10201402810XA (en) | 2014-08-28 |
| CN106667919A (zh) | 2017-05-17 |
| JP2012528845A (ja) | 2012-11-15 |
| JP5635082B2 (ja) | 2014-12-03 |
| CA2764517C (en) | 2017-07-04 |
| US20120135075A1 (en) | 2012-05-31 |
| IL216748A0 (en) | 2012-02-29 |
| MY173629A (en) | 2020-02-12 |
| AU2010255502A1 (en) | 2012-01-12 |
| US9814679B2 (en) | 2017-11-14 |
| GB0909680D0 (en) | 2009-07-22 |
| BRPI1012004A2 (pt) | 2016-05-10 |
| CN102481260A (zh) | 2012-05-30 |
| EP2437729A2 (en) | 2012-04-11 |
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