AU2010232995C1 - Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administration - Google Patents

Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administration Download PDF

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Publication number
AU2010232995C1
AU2010232995C1 AU2010232995A AU2010232995A AU2010232995C1 AU 2010232995 C1 AU2010232995 C1 AU 2010232995C1 AU 2010232995 A AU2010232995 A AU 2010232995A AU 2010232995 A AU2010232995 A AU 2010232995A AU 2010232995 C1 AU2010232995 C1 AU 2010232995C1
Authority
AU
Australia
Prior art keywords
pharmaceutical composition
nasal
tetracaine
composition according
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010232995A
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English (en)
Other versions
AU2010232995B2 (en
AU2010232995A1 (en
Inventor
Mark David Kollar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ST RENATUS LLC
Original Assignee
ST RENATUS LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ST RENATUS LLC filed Critical ST RENATUS LLC
Publication of AU2010232995A1 publication Critical patent/AU2010232995A1/en
Application granted granted Critical
Publication of AU2010232995B2 publication Critical patent/AU2010232995B2/en
Priority to AU2015242984A priority Critical patent/AU2015242984B2/en
Publication of AU2010232995C1 publication Critical patent/AU2010232995C1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M19/00—Local anaesthesia; Hypothermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2010232995A 2009-04-03 2010-04-02 Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administration Ceased AU2010232995C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2015242984A AU2015242984B2 (en) 2009-04-03 2015-10-13 Dental Anesthetic Comprising Tetracaine and a Vasoconstrictor For Intranasal Administration

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16668009P 2009-04-03 2009-04-03
US61/166,680 2009-04-03
PCT/US2010/001002 WO2010114622A1 (en) 2009-04-03 2010-04-02 Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administration

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2015242984A Division AU2015242984B2 (en) 2009-04-03 2015-10-13 Dental Anesthetic Comprising Tetracaine and a Vasoconstrictor For Intranasal Administration

Publications (3)

Publication Number Publication Date
AU2010232995A1 AU2010232995A1 (en) 2011-10-20
AU2010232995B2 AU2010232995B2 (en) 2015-07-16
AU2010232995C1 true AU2010232995C1 (en) 2016-01-28

Family

ID=42164462

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2010232995A Ceased AU2010232995C1 (en) 2009-04-03 2010-04-02 Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administration
AU2015242984A Expired - Fee Related AU2015242984B2 (en) 2009-04-03 2015-10-13 Dental Anesthetic Comprising Tetracaine and a Vasoconstrictor For Intranasal Administration

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2015242984A Expired - Fee Related AU2015242984B2 (en) 2009-04-03 2015-10-13 Dental Anesthetic Comprising Tetracaine and a Vasoconstrictor For Intranasal Administration

Country Status (18)

Country Link
US (7) US8580282B2 (enExample)
EP (1) EP2413899B1 (enExample)
JP (3) JP5788864B2 (enExample)
KR (2) KR20170026639A (enExample)
CN (2) CN103932973B (enExample)
AU (2) AU2010232995C1 (enExample)
BR (1) BRPI1010303A2 (enExample)
CA (1) CA2757032C (enExample)
DK (1) DK2413899T3 (enExample)
EA (1) EA024184B1 (enExample)
ES (1) ES2861064T3 (enExample)
IL (1) IL215489A0 (enExample)
MX (1) MX2011010445A (enExample)
NZ (2) NZ612063A (enExample)
PL (1) PL2413899T3 (enExample)
PT (1) PT2413899T (enExample)
WO (1) WO2010114622A1 (enExample)
ZA (2) ZA201107011B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2413899B1 (en) 2009-04-03 2021-01-27 St. Renatus, LLC Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administration
WO2014052859A1 (en) * 2012-09-28 2014-04-03 St. Renatus, Llc Pharmaceutical composition comprising benzyl alcohol for the treatment of migraines
EP3086785A4 (en) * 2014-01-01 2017-08-30 Real Time Imaging Technologies, LLC Improved local anesthetic solution for dental and/or contrast media use
CA2952622A1 (en) * 2014-06-16 2015-12-23 Loewi LLC Methods of anesthetizing nerve tissue in the trigeminal nerve pathway and medical uses thereof
CA2971156A1 (en) * 2014-12-23 2016-06-30 St. Renatus, Llc Tetracaine-based anesthetic
EP3244800A1 (en) 2015-01-12 2017-11-22 Real Time Imaging Technologies, LLC Low-dose x-ray imaging system
US10039830B2 (en) * 2016-03-04 2018-08-07 Cetylite Industries, Inc. Topical anesthetic composition
US20170360718A1 (en) * 2016-06-01 2017-12-21 St. Renatus, Llc Intranasal dental anesthetic
AU2019403903A1 (en) 2018-12-19 2021-06-24 Acasti Pharma U.S., Inc. Therapeutic composition of intranasal lidocaine
CN111494310A (zh) * 2020-04-29 2020-08-07 周晓玲 一种局部麻醉药物的制备及使用方法
EP4355313A1 (en) * 2021-06-14 2024-04-24 Pharmavax AS Combinations of local anesthetics for improved pain relief
EP4648760A1 (en) * 2023-01-13 2025-11-19 Smilanich, Michael D. Composition for local anesthesia and uses thereof
GB2628149A (en) * 2023-03-16 2024-09-18 Lee Nathaniel Wurie Nasal spray for performing sphenopalatine ganglion block

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3832460A (en) * 1971-03-19 1974-08-27 C Kosti Anesthetic-vasoconstrictor-antihistamine composition for the treatment of hypertrophied oral tissue
US5585398A (en) * 1994-07-15 1996-12-17 Ernst; Amy A. Topical anesthetic comprising lidocaine, adrenaline, and tetracaine, and its method of use
US6413499B1 (en) * 2000-01-06 2002-07-02 Bryan M. Clay Methods and kits for maxillary dental anesthesia by means of a nasal deliverable anesthetic
US20040131665A1 (en) * 1999-10-22 2004-07-08 Wepfer Scott T. Topical anesthetic formulation
JP2004196786A (ja) * 2002-12-03 2004-07-15 Taisho Pharmaceut Co Ltd 難溶性抗ウイルス成分含有水溶性外用剤組成物

Family Cites Families (11)

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US5209724A (en) 1988-04-11 1993-05-11 Dhaliwal Avtar S Composite anesthetic article and method of use
BR9306816A (pt) 1992-07-28 1998-12-08 Procter & Gamble Composição farmaceutica para uso tópico contendo um polímero catiônico reticulado e um eter alcoxilado
US5854269A (en) 1993-11-19 1998-12-29 Schering-Plough Healthcare Products, Inc. Nasal spray compositions
US6075059A (en) 1999-02-24 2000-06-13 The Ohio State University Compositions for dental anesthesia
US20040045546A1 (en) 2002-09-05 2004-03-11 Peirce Management, Llc Pharmaceutical delivery system for oral inhalation through nebulization consisting of inert substrate impregnated with substance (S) to be solubilized or suspended prior to use
ES2223277B1 (es) * 2003-06-19 2006-03-01 Fernando Bouffard Fita Composicion anestesica para administracion topica.
WO2005065696A1 (en) 2004-01-01 2005-07-21 Panacea Biotec Ltd. Pharmaceutical compositions comprising an extract of euphorbia prostrata
US20060052305A1 (en) * 2004-05-10 2006-03-09 Nastech Pharmaceutical Company Inc. Method of treating osteoporosis using intranasal parathyroid hormone
US20070154402A1 (en) 2005-10-24 2007-07-05 Collegium Pharmaceutical, Inc. Topical Pharmaceutical Foam Composition
US9252862B2 (en) 2008-09-17 2016-02-02 Qualcomm Incorporated MIMO preamble for initial access with an unknown number of transmit antennas
EP2413899B1 (en) * 2009-04-03 2021-01-27 St. Renatus, LLC Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administration

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3832460A (en) * 1971-03-19 1974-08-27 C Kosti Anesthetic-vasoconstrictor-antihistamine composition for the treatment of hypertrophied oral tissue
US5585398A (en) * 1994-07-15 1996-12-17 Ernst; Amy A. Topical anesthetic comprising lidocaine, adrenaline, and tetracaine, and its method of use
US20040131665A1 (en) * 1999-10-22 2004-07-08 Wepfer Scott T. Topical anesthetic formulation
US6413499B1 (en) * 2000-01-06 2002-07-02 Bryan M. Clay Methods and kits for maxillary dental anesthesia by means of a nasal deliverable anesthetic
JP2004196786A (ja) * 2002-12-03 2004-07-15 Taisho Pharmaceut Co Ltd 難溶性抗ウイルス成分含有水溶性外用剤組成物

Also Published As

Publication number Publication date
KR20120042729A (ko) 2012-05-03
IL215489A0 (en) 2011-12-29
JP5788864B2 (ja) 2015-10-07
KR20170026639A (ko) 2017-03-08
US8580282B2 (en) 2013-11-12
NZ595376A (en) 2013-09-27
BRPI1010303A2 (pt) 2016-03-15
JP2015034167A (ja) 2015-02-19
PL2413899T3 (pl) 2021-09-20
ZA201309321B (en) 2016-07-27
AU2015242984B2 (en) 2017-09-14
JP2017031226A (ja) 2017-02-09
CA2757032A1 (en) 2010-10-07
EA024184B1 (ru) 2016-08-31
US10456377B2 (en) 2019-10-29
JP2012522783A (ja) 2012-09-27
CN102421416A (zh) 2012-04-18
CN102421416B (zh) 2014-05-28
US20160184269A1 (en) 2016-06-30
US9855247B2 (en) 2018-01-02
ZA201107011B (en) 2014-03-26
EP2413899A1 (en) 2012-02-08
US9308191B2 (en) 2016-04-12
US20200268715A1 (en) 2020-08-27
DK2413899T3 (da) 2021-04-19
US20170319547A1 (en) 2017-11-09
US20140234421A1 (en) 2014-08-21
US10420750B2 (en) 2019-09-24
EA201171215A1 (ru) 2012-07-30
MX2011010445A (es) 2012-01-19
KR101747979B1 (ko) 2017-06-15
CA2757032C (en) 2022-06-07
US20120039960A1 (en) 2012-02-16
WO2010114622A1 (en) 2010-10-07
AU2015242984A1 (en) 2015-11-05
ES2861064T3 (es) 2021-10-05
EP2413899B1 (en) 2021-01-27
US20170326112A1 (en) 2017-11-16
AU2010232995B2 (en) 2015-07-16
US20170326111A1 (en) 2017-11-16
PT2413899T (pt) 2021-03-30
NZ612063A (en) 2015-02-27
CN103932973B (zh) 2017-08-11
CN103932973A (zh) 2014-07-23
AU2010232995A1 (en) 2011-10-20

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Legal Events

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DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 13 OCT 2015 .

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 13 OCT 2015

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired