AU2010221993C1 - Generation, expression and characterization of the humanized K33N monoclonal antibody - Google Patents

Generation, expression and characterization of the humanized K33N monoclonal antibody Download PDF

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Publication number
AU2010221993C1
AU2010221993C1 AU2010221993A AU2010221993A AU2010221993C1 AU 2010221993 C1 AU2010221993 C1 AU 2010221993C1 AU 2010221993 A AU2010221993 A AU 2010221993A AU 2010221993 A AU2010221993 A AU 2010221993A AU 2010221993 C1 AU2010221993 C1 AU 2010221993C1
Authority
AU
Australia
Prior art keywords
antibody
seq
human
amino acid
integrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010221993A
Other languages
English (en)
Other versions
AU2010221993A1 (en
AU2010221993B2 (en
Inventor
Tatsuhiro Harada
Shankar Kumar
J. Yun Tso
Naoya Tsurushita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaken Pharmaceutical Co Ltd
Kidswell Bio Corp
Original Assignee
Kaken Pharmaceutical Co Ltd
Gene Techno Science Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharmaceutical Co Ltd, Gene Techno Science Co Ltd filed Critical Kaken Pharmaceutical Co Ltd
Publication of AU2010221993A1 publication Critical patent/AU2010221993A1/en
Application granted granted Critical
Publication of AU2010221993B2 publication Critical patent/AU2010221993B2/en
Publication of AU2010221993C1 publication Critical patent/AU2010221993C1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Mycology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2010221993A 2009-03-10 2010-03-10 Generation, expression and characterization of the humanized K33N monoclonal antibody Ceased AU2010221993C1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15888509P 2009-03-10 2009-03-10
US61/158,885 2009-03-10
US25107209P 2009-10-13 2009-10-13
US61/251,072 2009-10-13
PCT/JP2010/054483 WO2010104208A1 (en) 2009-03-10 2010-03-10 Generation, expression and characterization of the humanized k33n monoclonal antibody

Publications (3)

Publication Number Publication Date
AU2010221993A1 AU2010221993A1 (en) 2011-09-01
AU2010221993B2 AU2010221993B2 (en) 2015-01-15
AU2010221993C1 true AU2010221993C1 (en) 2015-07-09

Family

ID=42728486

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010221993A Ceased AU2010221993C1 (en) 2009-03-10 2010-03-10 Generation, expression and characterization of the humanized K33N monoclonal antibody

Country Status (8)

Country Link
US (1) US8735552B2 (enExample)
EP (1) EP2406285B1 (enExample)
JP (1) JP5995442B2 (enExample)
KR (1) KR101667227B1 (enExample)
CN (1) CN102333791B (enExample)
AU (1) AU2010221993C1 (enExample)
CA (1) CA2754591C (enExample)
WO (1) WO2010104208A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130309223A1 (en) 2012-05-18 2013-11-21 Seattle Genetics, Inc. CD33 Antibodies And Use Of Same To Treat Cancer
WO2015004632A1 (en) * 2013-07-12 2015-01-15 Neotope Biosciences Limited Antibodies that recognize iapp
WO2017160954A1 (en) 2016-03-15 2017-09-21 Seattle Genetics, Inc. Combinations of pbd-based antibody drug conjugates with bcl-2 inhibitors
EP3463463A4 (en) 2016-06-03 2020-01-15 Seattle Genetics, Inc. Combination of cd33 antibody drug conjugates with chemotherapeutic agents
EP3469001A4 (en) 2016-06-09 2020-05-06 Seattle Genetics, Inc. COMBINATIONS OF PBD-BASED ANTIBODY CONJUGATES WITH FLT3 INHIBITORS

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WO2006075784A1 (ja) * 2005-01-13 2006-07-20 Gene Techno Science Co., Ltd. 抗α９インテグリン抗体とその用途
WO2008007804A1 (en) * 2006-07-12 2008-01-17 Gene Techno Science Co., Ltd. ANTIHUMAN α9 INTEGRIN ANTIBODY AND USE OF THE SAME
WO2009088105A1 (en) * 2008-01-11 2009-07-16 Gene Techno Science Co., Ltd. HUMANIZED ANTI-α9 INTEGRIN ANTIBODIES AND THE USES THEREOF
WO2009088064A1 (ja) * 2008-01-11 2009-07-16 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute 改良型ヒト化抗ヒトα９インテグリン抗体
WO2010095270A1 (ja) * 2009-02-23 2010-08-26 株式会社ジーンテクノサイエンス 抗ヒトα９インテグリン抗体とその用途

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US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5258498A (en) 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
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AU4308689A (en) 1988-09-02 1990-04-02 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
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GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
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US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
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ATE414768T1 (de) 1991-04-10 2008-12-15 Scripps Research Inst Bibliotheken heterodimerer rezeptoren mittels phagemiden
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AU2238292A (en) 1991-06-14 1993-01-12 Xoma Corporation Microbially-produced antibody fragments and their conjugates
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WO2006075784A1 (ja) * 2005-01-13 2006-07-20 Gene Techno Science Co., Ltd. 抗α９インテグリン抗体とその用途
WO2008007804A1 (en) * 2006-07-12 2008-01-17 Gene Techno Science Co., Ltd. ANTIHUMAN α9 INTEGRIN ANTIBODY AND USE OF THE SAME
WO2009088105A1 (en) * 2008-01-11 2009-07-16 Gene Techno Science Co., Ltd. HUMANIZED ANTI-α9 INTEGRIN ANTIBODIES AND THE USES THEREOF
WO2009088064A1 (ja) * 2008-01-11 2009-07-16 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute 改良型ヒト化抗ヒトα９インテグリン抗体
WO2010095270A1 (ja) * 2009-02-23 2010-08-26 株式会社ジーンテクノサイエンス 抗ヒトα９インテグリン抗体とその用途

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Also Published As

Publication number Publication date
AU2010221993A1 (en) 2011-09-01
CN102333791A (zh) 2012-01-25
EP2406285A4 (en) 2012-08-15
JP2012526518A (ja) 2012-11-01
CN102333791B (zh) 2014-06-25
KR101667227B1 (ko) 2016-10-18
CA2754591C (en) 2018-03-06
WO2010104208A1 (en) 2010-09-16
US20110300139A1 (en) 2011-12-08
EP2406285A1 (en) 2012-01-18
EP2406285B1 (en) 2016-03-09
CA2754591A1 (en) 2010-09-16
KR20110128905A (ko) 2011-11-30
US8735552B2 (en) 2014-05-27
JP5995442B2 (ja) 2016-09-21
AU2010221993B2 (en) 2015-01-15

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Legal Events

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DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 20 JAN 2015 .

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 20 JAN 2015

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired