AU2010221159B2 - Treatment of leukemias and chronic myeloproliferative diseases with antibodies to EphA3 - Google Patents
Treatment of leukemias and chronic myeloproliferative diseases with antibodies to EphA3 Download PDFInfo
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- AU2010221159B2 AU2010221159B2 AU2010221159A AU2010221159A AU2010221159B2 AU 2010221159 B2 AU2010221159 B2 AU 2010221159B2 AU 2010221159 A AU2010221159 A AU 2010221159A AU 2010221159 A AU2010221159 A AU 2010221159A AU 2010221159 B2 AU2010221159 B2 AU 2010221159B2
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- epha3
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- cells
- myeloproliferative disorder
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
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- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Cell Biology (AREA)
- Biotechnology (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (5)
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| US15828509P | 2009-03-06 | 2009-03-06 | |
| US61/158,285 | 2009-03-06 | ||
| US16813009P | 2009-04-09 | 2009-04-09 | |
| US61/168,130 | 2009-04-09 | ||
| PCT/US2010/026413 WO2010102244A1 (en) | 2009-03-06 | 2010-03-05 | Treatment of leukemias and chronic myeloproliferative diseases with antibodies to epha3 |
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| AU2010221159A1 AU2010221159A1 (en) | 2011-09-22 |
| AU2010221159B2 true AU2010221159B2 (en) | 2015-11-26 |
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| US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| JP5781762B2 (ja) * | 2007-08-10 | 2015-09-24 | プロテリックス、インク | ユニバーサルｉｉｉ型フィブロネクチン結合ドメインのライブラリ |
| US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
| JP2013508292A (ja) | 2009-10-14 | 2013-03-07 | カロバイオス ファーマシューティカルズ インコーポレイティッド | ＥｐｈＡ３に対する抗体 |
| WO2011078301A1 (ja) | 2009-12-25 | 2011-06-30 | ファーマロジカルズ・リサーチ プライベート リミテッド | Nog樹立癌細胞株が移植された非ヒト動物モデルを用いた抗癌剤ターゲット探索及びスクリーニング法 |
| SG189302A1 (en) | 2010-10-06 | 2013-05-31 | Pharmalogicals Res Pte Ltd | Cancer stem cell population and method for production thereof |
| GB201021623D0 (en) * | 2010-12-21 | 2011-02-02 | Isis Innovation | Detection of acute myeloid leukaemia |
| CA2844674A1 (en) * | 2011-08-12 | 2013-02-21 | Kalobios Pharmaceuticals, Inc. | Methods of treating hematological proliferative disorders by targeting epha3 expressed on aberrant vasculature in bone marrow |
| JP6077997B2 (ja) | 2011-09-07 | 2017-02-08 | 中外製薬株式会社 | 癌幹細胞の分離 |
| WO2013062083A1 (ja) * | 2011-10-28 | 2013-05-02 | ファーマロジカルズ・リサーチ プライベート リミテッド | 癌幹細胞特異的分子 |
| ES2729057T3 (es) | 2013-12-17 | 2019-10-30 | Aimm Therapeutics Bv | Medios y métodos para contrarrestar trastornos mieloproliferativos o linfoproliferativos |
| WO2021068040A1 (en) * | 2019-10-09 | 2021-04-15 | The Council Of The Queensland Institute Of Medical Research | Targeting epha3 and uses thereof |
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-
2010
- 2010-03-05 WO PCT/US2010/026413 patent/WO2010102244A1/en not_active Ceased
- 2010-03-05 JP JP2011553146A patent/JP5876728B2/ja not_active Expired - Fee Related
- 2010-03-05 AU AU2010221159A patent/AU2010221159B2/en not_active Ceased
- 2010-03-05 NZ NZ594950A patent/NZ594950A/xx not_active IP Right Cessation
- 2010-03-05 EP EP10708675A patent/EP2403879A1/en not_active Withdrawn
- 2010-03-05 US US12/718,768 patent/US8834870B2/en active Active
- 2010-03-05 CA CA2753995A patent/CA2753995A1/en not_active Abandoned
- 2010-03-05 CN CN2010800176719A patent/CN102405237A/zh active Pending
- 2010-03-05 EA EA201101241A patent/EA201101241A1/ru unknown
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2014
- 2014-08-29 US US14/473,821 patent/US20140370010A1/en not_active Abandoned
-
2015
- 2015-06-18 JP JP2015122537A patent/JP2015231994A/ja active Pending
-
2016
- 2016-09-14 US US15/265,625 patent/US20170226227A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| US8834870B2 (en) | 2014-09-16 |
| EA201101241A1 (ru) | 2012-04-30 |
| JP5876728B2 (ja) | 2016-03-02 |
| CN102405237A (zh) | 2012-04-04 |
| NZ594950A (en) | 2013-06-28 |
| WO2010102244A1 (en) | 2010-09-10 |
| AU2010221159A1 (en) | 2011-09-22 |
| EP2403879A1 (en) | 2012-01-11 |
| JP2012519707A (ja) | 2012-08-30 |
| US20170226227A1 (en) | 2017-08-10 |
| US20140370010A1 (en) | 2014-12-18 |
| CA2753995A1 (en) | 2010-09-10 |
| US20100226930A1 (en) | 2010-09-09 |
| JP2015231994A (ja) | 2015-12-24 |
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Owner name: HUMANIGEN, INC. Free format text: FORMER NAME(S): KALOBIOS PHARMACEUTICALS, INC. |
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| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |