AU2009324495B2 - Methods for treating multiple sclerosis using tetracyclic pyrazinoindoles - Google Patents

Methods for treating multiple sclerosis using tetracyclic pyrazinoindoles Download PDF

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Publication number
AU2009324495B2
AU2009324495B2 AU2009324495A AU2009324495A AU2009324495B2 AU 2009324495 B2 AU2009324495 B2 AU 2009324495B2 AU 2009324495 A AU2009324495 A AU 2009324495A AU 2009324495 A AU2009324495 A AU 2009324495A AU 2009324495 B2 AU2009324495 B2 AU 2009324495B2
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AU
Australia
Prior art keywords
alkyl
pharmaceutically acceptable
hydrogen
multiple sclerosis
arylalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2009324495A
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English (en)
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AU2009324495A1 (en
Inventor
Spyros Deftereos
Andreas Persidis
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Biovista Inc
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Biovista Inc
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Publication of AU2009324495A1 publication Critical patent/AU2009324495A1/en
Application granted granted Critical
Publication of AU2009324495B2 publication Critical patent/AU2009324495B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2009324495A 2008-12-11 2009-12-11 Methods for treating multiple sclerosis using tetracyclic pyrazinoindoles Ceased AU2009324495B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12157408P 2008-12-11 2008-12-11
US61/121,574 2008-12-11
US23323509P 2009-08-12 2009-08-12
US61/233,235 2009-08-12
PCT/US2009/067673 WO2010068867A1 (en) 2008-12-11 2009-12-11 Methods for treating multiple sclerosis using tetracyclic pyrazinoindoles

Publications (2)

Publication Number Publication Date
AU2009324495A1 AU2009324495A1 (en) 2011-07-28
AU2009324495B2 true AU2009324495B2 (en) 2015-12-24

Family

ID=42243090

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009324495A Ceased AU2009324495B2 (en) 2008-12-11 2009-12-11 Methods for treating multiple sclerosis using tetracyclic pyrazinoindoles

Country Status (9)

Country Link
US (1) US20110268699A1 (enExample)
EP (1) EP2375900B1 (enExample)
JP (1) JP2012512165A (enExample)
CN (1) CN102395275A (enExample)
AU (1) AU2009324495B2 (enExample)
BR (1) BRPI0922871A2 (enExample)
CA (1) CA2747235C (enExample)
IL (1) IL213476A0 (enExample)
WO (1) WO2010068867A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2340254B8 (en) 2008-09-15 2014-05-21 Biovista, Inc. Compositions and methods for treating epilepsy
JP5934102B2 (ja) 2009-10-30 2016-06-15 レトロトップ、 インコーポレイテッドＲｅｔｒｏｔｏｐｅ， Ｉｎｃ． Ｐｕｆａ誘導体による酸化ストレス障害の緩和
RU2436786C1 (ru) * 2010-07-23 2011-12-20 Александр Васильевич Иващенко Замещенные индолы, противовирусный активный компонент, способ получения и применения
CA2834342C (en) 2011-04-26 2021-08-31 Retrotope, Inc. Impaired energy processing disorders and mitochondrial deficiency
WO2012148926A2 (en) * 2011-04-26 2012-11-01 Retrotope, Inc. Neurodegenerative disorders and muscle diseases implicating pufas
KR102110175B1 (ko) 2011-04-26 2020-05-13 레트로토프 인코포레이티드 Ｐｕｆａ 산화와 관련된 장애
AU2012249921B2 (en) 2011-04-26 2017-06-08 Biojiva Llc Oxidative retinal diseases
WO2013130422A1 (en) * 2012-02-27 2013-09-06 Biovista, Inc. Compositions and methods for treating mitochondrial diseases
CA2900503A1 (en) * 2013-02-15 2014-08-21 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with laquinimod
KR101521807B1 (ko) * 2014-01-20 2015-05-20 한국전자통신연구원 데이터 전송 제어 장치 및 그 방법
MX373227B (es) * 2014-05-09 2020-04-21 Tecnimede Sociedade Tecnico Medicinal S Sales farmacéuticamente aceptables de enantiómeros de pirlindol para utilizarse en medicina.
EP3380452B1 (en) 2015-11-23 2021-03-24 Retrotope, Inc. Site-specific isotopic labeling of 1, 4-diene systems
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
SMT202500136T1 (it) 2016-08-31 2025-05-12 Mapi Pharma Ltd Sistemi a deposito comprendenti glatiramer acetato
US11167003B2 (en) 2017-03-26 2021-11-09 Mapi Pharma Ltd. Methods for suppressing or alleviating primary or secondary progressive multiple sclerosis (PPMS or SPMS) using sustained release glatiramer depot systems
EP3520803A1 (en) * 2018-01-31 2019-08-07 Zarodex Therapeutics Limited Novel uses
US11779910B2 (en) 2020-02-21 2023-10-10 Biojiva Llc Processes for isotopic modification of polyunsaturated fatty acids and derivatives thereof
US12109194B2 (en) 2021-02-05 2024-10-08 Biojiva Llc Synergistic combination therapy for treating ALS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959470A (en) * 1972-11-28 1976-05-25 Mikhail Davidovich Mashkovsky Psychotropic medicinal preparation
WO2006048242A2 (en) * 2004-11-02 2006-05-11 Switch Biotech Ag Use of pirlindole for the treatment of diseases which are characterized by proliferation of t-lymphocytes and/or hyperproliferation of keratinocytes in particular atopic dermatitis and psoriasis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300645A (en) * 1993-04-14 1994-04-05 Eli Lilly And Company Tetrahydro-pyrido-indole
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
WO2004098638A1 (ja) * 2003-05-06 2004-11-18 Ono Pharmaceutical Co., Ltd. エフェクター細胞機能阻害剤
RU2281085C2 (ru) * 2004-05-25 2006-08-10 Закрытое акционерное общество "Мастерлек" Антидепрессивные лекарственные средства для парентерального применения на основе сульфонатных солей пирлиндола
CA2617102A1 (en) * 2005-07-28 2007-02-08 Bristol-Myers Squibb Company Substituted tetrahydro-1h-pyrido[4,3,b]indoles as serotonin receptor agonists and antagonists
CA2688327A1 (en) * 2007-05-25 2008-12-04 Medivation Neurology, Inc. Methods and compositions for stimulating cells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959470A (en) * 1972-11-28 1976-05-25 Mikhail Davidovich Mashkovsky Psychotropic medicinal preparation
WO2006048242A2 (en) * 2004-11-02 2006-05-11 Switch Biotech Ag Use of pirlindole for the treatment of diseases which are characterized by proliferation of t-lymphocytes and/or hyperproliferation of keratinocytes in particular atopic dermatitis and psoriasis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BOLAND A et al., British Journal of Pharmacology, vol. 135, no. 3, February 2002, pages 713-720 *

Also Published As

Publication number Publication date
IL213476A0 (en) 2011-07-31
EP2375900A1 (en) 2011-10-19
WO2010068867A1 (en) 2010-06-17
AU2009324495A1 (en) 2011-07-28
CA2747235A1 (en) 2010-06-17
EP2375900B1 (en) 2016-03-02
EP2375900A4 (en) 2012-05-02
BRPI0922871A2 (pt) 2016-11-16
JP2012512165A (ja) 2012-05-31
CA2747235C (en) 2021-02-09
US20110268699A1 (en) 2011-11-03
CN102395275A (zh) 2012-03-28

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired