AU2009316076B2 - IL-4-derived peptides for modulation of the chronic inflammatory response and treatment of autoimmune diseases - Google Patents

IL-4-derived peptides for modulation of the chronic inflammatory response and treatment of autoimmune diseases Download PDF

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Publication number
AU2009316076B2
AU2009316076B2 AU2009316076A AU2009316076A AU2009316076B2 AU 2009316076 B2 AU2009316076 B2 AU 2009316076B2 AU 2009316076 A AU2009316076 A AU 2009316076A AU 2009316076 A AU2009316076 A AU 2009316076A AU 2009316076 B2 AU2009316076 B2 AU 2009316076B2
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disease
peptide
seq
amino acid
antibody
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AU2009316076A1 (en
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Vladimir Berezin
Elisabeth Bock
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Københavns Universitet
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P37/08—Antiallergic agents
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Pharmacology & Pharmacy (AREA)
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  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
AU2009316076A 2008-11-17 2009-11-17 IL-4-derived peptides for modulation of the chronic inflammatory response and treatment of autoimmune diseases Ceased AU2009316076B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200801601 2008-11-17
DKPA200801601 2008-11-17
PCT/DK2009/050304 WO2010054667A1 (en) 2008-11-17 2009-11-17 Il-4-derived peptides for modulation of the chronic inflammatory response and treatment of autoimmune diseases

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AU2009316076A1 AU2009316076A1 (en) 2010-05-20
AU2009316076B2 true AU2009316076B2 (en) 2015-11-19

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AU2009316076A Ceased AU2009316076B2 (en) 2008-11-17 2009-11-17 IL-4-derived peptides for modulation of the chronic inflammatory response and treatment of autoimmune diseases

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US (1) US8546321B2 (OSRAM)
EP (1) EP2365983B1 (OSRAM)
JP (1) JP5750373B2 (OSRAM)
CN (1) CN102216323B (OSRAM)
AU (1) AU2009316076B2 (OSRAM)
BR (1) BRPI0921717A2 (OSRAM)
CA (1) CA2743394C (OSRAM)
ES (1) ES2620437T3 (OSRAM)
IL (1) IL212962A0 (OSRAM)
NZ (1) NZ592943A (OSRAM)
RU (1) RU2542375C2 (OSRAM)
WO (1) WO2010054667A1 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2778053T3 (es) 2011-01-18 2020-08-07 Bioniz Llc Composiciones para modular la actividad de la citocina gamma-c
WO2015089217A2 (en) 2013-12-10 2015-06-18 Bionz, Llc Methods of developing selective peptide antagonists
CN113861294B (zh) 2015-04-02 2024-03-08 英特维特国际股份有限公司 针对犬白介素-4受体α的抗体
KR102654684B1 (ko) 2015-10-09 2024-04-04 바이오니즈 테라퓨틱스, 아이엔씨. 감마-ｃ-사이토카인 활성의 조정
AU2018250210B2 (en) * 2017-04-07 2022-04-28 Bioniz Therapeutics, Inc. Stable modulators of gamma-c-cytokine activity
KR102095284B1 (ko) 2017-05-11 2020-04-01 (주)케어젠 메토트렉세이트와 펩타이드의 결합체
EP3530320B1 (en) 2018-02-27 2023-11-15 Universitätsmedizin der Johannes Gutenberg-Universität Mainz Novel il-4-/il-13-derived peptide compounds for the treatment or prevention of neurodegenerative or neuroinflammatory diseases
CN111514292B (zh) * 2018-12-25 2023-06-20 江苏荃信生物医药股份有限公司 抗人白介素4受体α单克隆抗体的制药用途
US12030936B2 (en) 2019-05-03 2024-07-09 Bioniz Therapeutics, Inc. Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders
CA3242457A1 (en) * 2022-01-05 2023-07-13 Serodus Aps Il-4 derived peptides for use in the treatment of obesity
AU2023262616B2 (en) * 2022-04-29 2024-07-11 Serodus Aps Il-4 derived peptide fragments for use in the treatment of diabetic nephropathy

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009059A1 (en) * 1989-12-20 1991-06-27 Schering Corporation Antibody antagonists of human interleukin-4
WO2004096849A2 (en) * 2003-04-25 2004-11-11 University Of Manitoba Peptide-based cytokine/chemokine vaccines against allergy
US20060241286A1 (en) * 2002-04-10 2006-10-26 Jean-Francois Zagury Novel peptides and the application thereof in therapy
US20070207947A1 (en) * 2003-10-16 2007-09-06 Aplagen Gmbh Stabilized Peptides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05503088A (ja) * 1989-11-21 1993-05-27 ザ ユニバーシティー オブ メルボルン 抗炎症用の組成物及び方法
US6337072B1 (en) * 1998-04-03 2002-01-08 Hyseq, Inc. Interleukin-1 receptor antagonist and recombinant production thereof
US7115261B1 (en) * 1999-02-12 2006-10-03 The Scripps Research Institute Methods for treatment of tumors and metastases using a combination of anti-angiogenic and immuno therapies
GB9912350D0 (en) * 1999-05-26 1999-07-28 European Molecular Biology Lab Embl Modified cytokine
US20030056244A1 (en) * 2000-05-02 2003-03-20 Ning Huang Feed additive compositions and methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009059A1 (en) * 1989-12-20 1991-06-27 Schering Corporation Antibody antagonists of human interleukin-4
US20060241286A1 (en) * 2002-04-10 2006-10-26 Jean-Francois Zagury Novel peptides and the application thereof in therapy
WO2004096849A2 (en) * 2003-04-25 2004-11-11 University Of Manitoba Peptide-based cytokine/chemokine vaccines against allergy
US20070207947A1 (en) * 2003-10-16 2007-09-06 Aplagen Gmbh Stabilized Peptides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MUELLER, T. D. et al., Biochimica et Biophysica Acta, 2002, Vol. 1592, pages 237-250 *

Also Published As

Publication number Publication date
US20110300148A1 (en) 2011-12-08
RU2542375C2 (ru) 2015-02-20
CN102216323A (zh) 2011-10-12
BRPI0921717A2 (pt) 2018-10-09
CN102216323B (zh) 2016-08-03
JP5750373B2 (ja) 2015-07-22
ES2620437T3 (es) 2017-06-28
EP2365983B1 (en) 2016-12-28
US8546321B2 (en) 2013-10-01
AU2009316076A1 (en) 2010-05-20
JP2012508698A (ja) 2012-04-12
EP2365983A1 (en) 2011-09-21
CA2743394A1 (en) 2010-05-20
WO2010054667A1 (en) 2010-05-20
RU2011121971A (ru) 2012-12-27
NZ592943A (en) 2012-09-28
IL212962A0 (en) 2011-07-31
CA2743394C (en) 2018-01-02

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