AU2009315736B2 - Crystalline forms of fingolimod HCL - Google Patents

Crystalline forms of fingolimod HCL Download PDF

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Publication number
AU2009315736B2
AU2009315736B2 AU2009315736A AU2009315736A AU2009315736B2 AU 2009315736 B2 AU2009315736 B2 AU 2009315736B2 AU 2009315736 A AU2009315736 A AU 2009315736A AU 2009315736 A AU2009315736 A AU 2009315736A AU 2009315736 B2 AU2009315736 B2 AU 2009315736B2
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AU
Australia
Prior art keywords
weak
fty720
crystalline
salt
composition according
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Ceased
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AU2009315736A
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English (en)
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AU2009315736A1 (en
Inventor
Guido Jordine
Michael Mutz
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Novartis AG
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Novartis AG
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Publication of AU2009315736A1 publication Critical patent/AU2009315736A1/en
Priority to AU2013100533A priority Critical patent/AU2013100533B4/en
Priority to AU2013100532A priority patent/AU2013100532B4/en
Priority to AU2013100531A priority patent/AU2013100531B4/en
Priority to AU2013100530A priority patent/AU2013100530B4/en
Application granted granted Critical
Publication of AU2009315736B2 publication Critical patent/AU2009315736B2/en
Priority to AU2013263791A priority patent/AU2013263791B2/en
Priority to AU2016225785A priority patent/AU2016225785A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2009315736A 2008-11-11 2009-11-10 Crystalline forms of fingolimod HCL Ceased AU2009315736B2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2013100533A AU2013100533B4 (en) 2008-11-11 2013-04-12 Crystalline forms of fingolimod HCL
AU2013100532A AU2013100532B4 (en) 2008-11-11 2013-04-12 Crystalline forms of fingolimod HCL
AU2013100531A AU2013100531B4 (en) 2008-11-11 2013-04-12 Crystalline forms of fingolimod HCL
AU2013100530A AU2013100530B4 (en) 2008-11-11 2013-04-12 Crystalline forms of fingolimod HCL
AU2013263791A AU2013263791B2 (en) 2008-11-11 2013-11-28 Crystalline forms of fingolimod HCL
AU2016225785A AU2016225785A1 (en) 2008-11-11 2016-09-05 Crystalline forms of fingolimod HCL

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08168865.7 2008-11-11
EP08168865 2008-11-11
PCT/EP2009/064891 WO2010055028A2 (en) 2008-11-11 2009-11-10 Organic compounds

Related Child Applications (5)

Application Number Title Priority Date Filing Date
AU2013100530A Division AU2013100530B4 (en) 2008-11-11 2013-04-12 Crystalline forms of fingolimod HCL
AU2013100533A Division AU2013100533B4 (en) 2008-11-11 2013-04-12 Crystalline forms of fingolimod HCL
AU2013100531A Division AU2013100531B4 (en) 2008-11-11 2013-04-12 Crystalline forms of fingolimod HCL
AU2013100532A Division AU2013100532B4 (en) 2008-11-11 2013-04-12 Crystalline forms of fingolimod HCL
AU2013263791A Division AU2013263791B2 (en) 2008-11-11 2013-11-28 Crystalline forms of fingolimod HCL

Publications (2)

Publication Number Publication Date
AU2009315736A1 AU2009315736A1 (en) 2010-05-20
AU2009315736B2 true AU2009315736B2 (en) 2013-08-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009315736A Ceased AU2009315736B2 (en) 2008-11-11 2009-11-10 Crystalline forms of fingolimod HCL

Country Status (14)

Country Link
US (2) US8530522B2 (enExample)
EP (1) EP2356090B1 (enExample)
JP (4) JP2012508216A (enExample)
KR (2) KR101393994B1 (enExample)
CN (3) CN104788325A (enExample)
AU (1) AU2009315736B2 (enExample)
BR (1) BRPI0921826A2 (enExample)
CA (1) CA2743232C (enExample)
ES (1) ES2643161T3 (enExample)
MX (1) MX2011004962A (enExample)
PL (1) PL2356090T3 (enExample)
PT (1) PT2356090T (enExample)
RU (2) RU2015111229A (enExample)
WO (1) WO2010055028A2 (enExample)

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PT2621889T (pt) * 2010-10-01 2019-10-30 Synthon Bv Processo para produzir cristais de cloridrato de fingolimod
US8735627B2 (en) 2010-10-28 2014-05-27 Mapi Pharma Ltd. Intermediate compounds and process for the preparation of fingolimod
WO2012071524A1 (en) 2010-11-24 2012-05-31 Ratiopharm Gmbh Arylsulfonate salts of fingolimod and processes for preparation thereof
WO2012070059A1 (en) 2010-11-25 2012-05-31 Shilpa Medicare Limited Fingolimod polymorphs and their processes
WO2012089238A1 (en) 2010-12-28 2012-07-05 Synthon Bv Process for making fingolimod hydrochloride crystals
WO2012097330A2 (en) * 2011-01-14 2012-07-19 University Of Washington Compositions and methods for treating degenerative muscle conditions
EP2702034A4 (en) 2011-04-29 2015-03-25 Reddys Lab Ltd Dr PREPARATION OF FINGOLIMOD AND ITS SALTS
WO2012160188A1 (en) 2011-05-26 2012-11-29 Jado Technologies Gmbh Hydroxy-substituted amino and ammonium derivatives and their medical use
DK3610868T3 (da) 2011-05-26 2025-03-31 Gri Bio Inc Amino- eller ammoniumholdige sulfonsyrederivater og medicinsk anvendelse deraf
WO2012160186A1 (en) 2011-05-26 2012-11-29 Jado Technologies Gmbh Oxygenated amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives and their medical use
WO2013019872A1 (en) 2011-08-01 2013-02-07 Teva Pharmaceutical Industries Ltd. Process for preparing pharmaceutical compositions comprising fingolimod
WO2013091704A1 (en) * 2011-12-22 2013-06-27 Synthon Bv Pharmaceutical composition comprising fingolimod
CN102887829B (zh) * 2012-09-05 2014-07-02 中国科学院上海药物研究所 芬戈莫德粘酸盐及其晶体的制备方法和用途
NZ630290A (en) * 2013-01-17 2016-09-30 Shilpa Medicare Ltd Process for preparation of fingolimod and its salts
AU2014224237B2 (en) * 2013-03-05 2017-07-20 Biocon Limited A process for the preparation of 2-amino-1,3-propane diol compounds and salts thereof
EP3027174B1 (en) 2013-07-29 2019-07-24 Aizant Drug Research Solutions Private Limited Pharmaceutical compositions of fingolimod
WO2016042493A1 (en) 2014-09-19 2016-03-24 Aizant Drug Research Pvt. Ltd Pharmaceutical compositions of fingolimod
WO2016118515A1 (en) 2015-01-20 2016-07-28 Handa Pharmaceuticals, Llc Stable solid fingolimod dosage forms
RU2627691C1 (ru) * 2016-07-06 2017-08-10 Олег Ростиславович Михайлов Кристаллическая η-модификация 2-амино-2-(2-(4-октилфенил)этил)пропан-1,3-диол гидрохлорида, способ её получения и фармацевтическая композиция на её основе
CN106667981B (zh) * 2017-01-16 2019-05-14 南京医科大学第二附属医院 盐酸芬戈莫德在制备治疗药物性肝损伤药物中的应用
CN106860440A (zh) * 2017-01-16 2017-06-20 南京医科大学第二附属医院 盐酸芬戈莫德在制备治疗系统性红斑狼疮脑病药物中的应用
GR1009654B (el) 2018-08-31 2019-11-18 Φαρματεν Α.Β.Ε.Ε. Φαρμακευτικο σκευασμα που περιλαμβανει εναν ανοσοτροποποιητικο παραγοντα και μεθοδος για την παρασκευη αυτου
WO2020245775A1 (en) * 2019-06-05 2020-12-10 Biocon Limited Crystalline forms of 2-amino-2-(2-(4-octylphenyl) ethyl) propane-1,3-diol
CA3156298A1 (en) 2019-10-31 2021-05-06 Laetitia POUZOL Combination of a cxcr7 antagonist with an s1p1 receptor modulator
JP2024521882A (ja) 2021-05-31 2024-06-04 上海雲晟研新生物科技有限公司 フィンゴリモド薬用塩、製造方法、それを含む医薬組成物及び使用
EP4212156A1 (en) 2022-01-13 2023-07-19 Abivax Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator

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Also Published As

Publication number Publication date
US8530522B2 (en) 2013-09-10
RU2011123371A (ru) 2012-12-20
WO2010055028A3 (en) 2010-07-08
EP2356090B1 (en) 2017-07-05
JP2012508216A (ja) 2012-04-05
CN102209705A (zh) 2011-10-05
BRPI0921826A2 (pt) 2016-01-12
CN104788325A (zh) 2015-07-22
PT2356090T (pt) 2017-10-16
CA2743232A1 (en) 2010-05-20
JP2014139179A (ja) 2014-07-31
KR101393994B1 (ko) 2014-05-14
WO2010055028A2 (en) 2010-05-20
KR20130109254A (ko) 2013-10-07
MX2011004962A (es) 2011-05-30
US20110229501A1 (en) 2011-09-22
RU2015111229A3 (enExample) 2018-11-08
KR20110069156A (ko) 2011-06-22
CA2743232C (en) 2015-12-29
ES2643161T3 (es) 2017-11-21
CN107233336A (zh) 2017-10-10
US20140051766A1 (en) 2014-02-20
PL2356090T3 (pl) 2017-12-29
EP2356090A2 (en) 2011-08-17
JP2018035160A (ja) 2018-03-08
AU2009315736A1 (en) 2010-05-20
RU2549899C2 (ru) 2015-05-10
JP2016028056A (ja) 2016-02-25
RU2015111229A (ru) 2015-11-20

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
GD Licence registered

Name of requester: NOVARTIS PHARMACEUTICALS AUSTRALIA PTY LIMITED

MK14 Patent ceased section 143(a) (annual fees not paid) or expired