AU2009310310A1 - 7-Hydroxy-benzoimidazole-4-yl-methanone Derivatives and PBK inhibitors containing the same - Google Patents

7-Hydroxy-benzoimidazole-4-yl-methanone Derivatives and PBK inhibitors containing the same Download PDF

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Publication number
AU2009310310A1
AU2009310310A1 AU2009310310A AU2009310310A AU2009310310A1 AU 2009310310 A1 AU2009310310 A1 AU 2009310310A1 AU 2009310310 A AU2009310310 A AU 2009310310A AU 2009310310 A AU2009310310 A AU 2009310310A AU 2009310310 A1 AU2009310310 A1 AU 2009310310A1
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AU
Australia
Prior art keywords
benzo
hydroxy
imidazole
carboxamide
piperidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
AU2009310310A
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English (en)
Other versions
AU2009310310A2 (en
Inventor
Feryan Ahmed
Shoji Hisada
Yingfu Li
Yo Matsuo
Ryuji Ohsawa
Joel R. Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncotherapy Science Inc
Original Assignee
Oncotherapy Science Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncotherapy Science Inc filed Critical Oncotherapy Science Inc
Publication of AU2009310310A1 publication Critical patent/AU2009310310A1/en
Publication of AU2009310310A2 publication Critical patent/AU2009310310A2/en
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2009310310A 2008-10-30 2009-07-30 7-Hydroxy-benzoimidazole-4-yl-methanone Derivatives and PBK inhibitors containing the same Withdrawn AU2009310310A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10980108P 2008-10-30 2008-10-30
US61/109,801 2008-10-30
PCT/US2009/052228 WO2010051085A1 (en) 2008-10-30 2009-07-30 7-hydroxy-benzoimidazole-4-yl-methanone derivatives and pbk inhibitors containing the same

Publications (2)

Publication Number Publication Date
AU2009310310A1 true AU2009310310A1 (en) 2010-05-06
AU2009310310A2 AU2009310310A2 (en) 2011-10-06

Family

ID=42129188

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009310310A Withdrawn AU2009310310A1 (en) 2008-10-30 2009-07-30 7-Hydroxy-benzoimidazole-4-yl-methanone Derivatives and PBK inhibitors containing the same

Country Status (14)

Country Link
US (1) US20110263566A1 (enExample)
EP (1) EP2364087A4 (enExample)
JP (1) JP2012507525A (enExample)
KR (1) KR20110079847A (enExample)
CN (1) CN102271514A (enExample)
AU (1) AU2009310310A1 (enExample)
BR (1) BRPI0919977A2 (enExample)
CA (1) CA2741988A1 (enExample)
CO (1) CO6361855A2 (enExample)
IL (1) IL212544A0 (enExample)
MX (1) MX2011004414A (enExample)
RU (1) RU2011121665A (enExample)
WO (1) WO2010051085A1 (enExample)
ZA (1) ZA201103964B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0716498A2 (pt) 2006-08-10 2015-01-27 Oncotherapy Science Inc Genes e polipeptídeos relacionados a cânceres de mama
JP2011529903A (ja) * 2008-07-30 2011-12-15 オンコセラピー・サイエンス株式会社 ベンゾイミダゾール誘導体およびこれを含むグリコーゲンシンターゼキナーゼ３β阻害剤
EP2358365A4 (en) * 2008-11-20 2012-05-30 Oncotherapy Science Inc GLYCOGEN SYNTHASE KINASE 3 BETA HEMMER WITH 7-HYDROXY BENZOIMIDAZOLE-4-YL METHANONE DERIVATIVES
CN101619058A (zh) * 2009-01-08 2010-01-06 上海交通大学 一种苯并咪唑-4-酰胺型衍生物
CN104854087B (zh) * 2012-12-18 2017-03-22 埃科特莱茵药品有限公司 作为p2x7受体拮抗剂的吲哚羧酰胺衍生物
CN105017221B (zh) * 2014-04-30 2019-05-28 中国医学科学院药物研究所 苯并咪唑衍生物及其制法和药物组合物与用途
JP6009135B1 (ja) * 2015-07-30 2016-10-19 第一三共株式会社 成人ｔ細胞白血病リンパ腫の治療及び／又は予防剤
CA2993605C (en) * 2015-07-30 2020-01-07 Daiichi Sankyo Company, Limited 1,3-benzodioxole derivatives for the treatment or prevention of adult t cell leukemia/lymphoma
WO2019124608A1 (ko) * 2017-12-22 2019-06-27 경상대학교병원 4'-(p-톨루엔설포닐아미도)-4-하이드록시칼콘을 유효성분으로 함유하는 류마티스 관절염 예방 또는 치료용 약학 조성물
CN109320461B (zh) * 2018-12-12 2020-02-07 迪嘉药业集团有限公司 一种替米沙坦中间体的制备方法
US11198699B2 (en) 2019-04-02 2021-12-14 Aligos Therapeutics, Inc. Compounds targeting PRMT5

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6288100B1 (en) * 1995-06-06 2001-09-11 American Home Products Corporation Benzimidazole derivatives
US20040002524A1 (en) * 2002-06-24 2004-01-01 Richard Chesworth Benzimidazole compounds and their use as estrogen agonists/antagonists
KR100791252B1 (ko) * 2003-01-23 2008-01-03 크리스탈지노믹스(주) 글리코겐 합성효소 키나아제 3β 활성 억제제, 이의제조방법 및 이를 유효성분으로 함유하는 약학 조성물

Also Published As

Publication number Publication date
CO6361855A2 (es) 2012-01-20
AU2009310310A2 (en) 2011-10-06
IL212544A0 (en) 2011-06-30
EP2364087A4 (en) 2012-05-30
US20110263566A1 (en) 2011-10-27
CN102271514A (zh) 2011-12-07
BRPI0919977A2 (pt) 2015-08-25
ZA201103964B (en) 2012-02-29
WO2010051085A1 (en) 2010-05-06
RU2011121665A (ru) 2012-12-10
MX2011004414A (es) 2011-06-21
JP2012507525A (ja) 2012-03-29
EP2364087A1 (en) 2011-09-14
CA2741988A1 (en) 2010-05-06
KR20110079847A (ko) 2011-07-08

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 15 SEP 2011

MK12 Application lapsed section 141(1)/reg 8.3(2) - applicant filed a written notice of withdrawal