AU2009308706C1 - Pyrido (4,3-b) indoles containing rigid moieties - Google Patents

Info

Publication number

AU2009308706C1

AU2009308706C1 AU2009308706A AU2009308706A AU2009308706C1 AU 2009308706 C1 AU2009308706 C1 AU 2009308706C1 AU 2009308706 A AU2009308706 A AU 2009308706A AU 2009308706 A AU2009308706 A AU 2009308706A AU 2009308706 C1 AU2009308706 C1 AU 2009308706C1

Authority

AU

Australia

Prior art keywords

substituted

unsubstituted

formula

compound

alkyl

Prior art date

2008-10-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

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• RDMFHRSPDKWERA-UHFFFAOYSA-N 5H-Pyrido[4,3-b]indole Chemical class C1=NC=C2C3=CC=CC=C3NC2=C1 RDMFHRSPDKWERA-UHFFFAOYSA-N 0.000 title abstract description 7
• 150000001875 compounds Chemical class 0.000 claims abstract description 630
• 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 177
• 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 143
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 103
• 208000010877 cognitive disease Diseases 0.000 claims abstract description 49
• 238000000034 method Methods 0.000 claims abstract description 47
• 238000011282 treatment Methods 0.000 claims abstract description 43
• 125000000392 cycloalkenyl group Chemical group 0.000 claims abstract description 42
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• 239000002858 neurotransmitter agent Substances 0.000 claims abstract description 26
• 230000001404 mediated effect Effects 0.000 claims abstract description 22
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 9
• 125000000217 alkyl group Chemical group 0.000 claims description 378
• -1 Ci-Cs perhaloalkyl Chemical group 0.000 claims description 353
• 125000001072 heteroaryl group Chemical group 0.000 claims description 204
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 201
• 125000003118 aryl group Chemical group 0.000 claims description 191
• 125000003545 alkoxy group Chemical group 0.000 claims description 162
• 150000003839 salts Chemical class 0.000 claims description 151
• PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 112
• 125000004442 acylamino group Chemical group 0.000 claims description 107
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 105
• 125000005102 carbonylalkoxy group Chemical group 0.000 claims description 100
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 98
• 239000012453 solvate Substances 0.000 claims description 95
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 94
• 229910052799 carbon Inorganic materials 0.000 claims description 88
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 86
• 125000003342 alkenyl group Chemical group 0.000 claims description 85
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 85
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 82
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 79
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 69
• 125000000266 alpha-aminoacyl group Chemical group 0.000 claims description 67
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• 125000004423 acyloxy group Chemical group 0.000 claims description 62
• 125000004076 pyridyl group Chemical group 0.000 claims description 59
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• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
• WNJHDSAISXIKTF-DTQAZKPQSA-N 5-[(e)-2-(4-fluorophenyl)prop-1-enyl]-2,8-dimethyl-3,4-dihydro-1h-pyrido[4,3-b]indole Chemical compound C1N(C)CCC2=C1C1=CC(C)=CC=C1N2\C=C(/C)C1=CC=C(F)C=C1 WNJHDSAISXIKTF-DTQAZKPQSA-N 0.000 claims 1
• WNJHDSAISXIKTF-SSZFMOIBSA-N 5-[(z)-2-(4-fluorophenyl)prop-1-enyl]-2,8-dimethyl-3,4-dihydro-1h-pyrido[4,3-b]indole Chemical compound C1N(C)CCC2=C1C1=CC(C)=CC=C1N2\C=C(\C)C1=CC=C(F)C=C1 WNJHDSAISXIKTF-SSZFMOIBSA-N 0.000 claims 1
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