AU2009220931B2 - N-substitutedbenzenepropanamide or benzenepropenamide derivatives for use in the treatment of pain and inflammation - Google Patents

N-substitutedbenzenepropanamide or benzenepropenamide derivatives for use in the treatment of pain and inflammation Download PDF

Info

Publication number
AU2009220931B2
AU2009220931B2 AU2009220931A AU2009220931A AU2009220931B2 AU 2009220931 B2 AU2009220931 B2 AU 2009220931B2 AU 2009220931 A AU2009220931 A AU 2009220931A AU 2009220931 A AU2009220931 A AU 2009220931A AU 2009220931 B2 AU2009220931 B2 AU 2009220931B2
Authority
AU
Australia
Prior art keywords
compound
compounds
pain
pharmaceutical composition
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2009220931A
Other languages
English (en)
Other versions
AU2009220931A1 (en
Inventor
Eliahu Kaplan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novaremed Ltd
Original Assignee
Novaremed Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novaremed Ltd filed Critical Novaremed Ltd
Publication of AU2009220931A1 publication Critical patent/AU2009220931A1/en
Application granted granted Critical
Publication of AU2009220931B2 publication Critical patent/AU2009220931B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/90—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated
    • C07C233/91—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated with carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic Table without C-Metal linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2009220931A 2008-03-06 2009-03-06 N-substitutedbenzenepropanamide or benzenepropenamide derivatives for use in the treatment of pain and inflammation Ceased AU2009220931B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0804213.7A GB0804213D0 (en) 2008-03-06 2008-03-06 A method of printing or preventing pain
GB0804213.7 2008-03-06
PCT/IB2009/000448 WO2009109850A2 (en) 2008-03-06 2009-03-06 A method of treating or preventing pain

Publications (2)

Publication Number Publication Date
AU2009220931A1 AU2009220931A1 (en) 2009-09-11
AU2009220931B2 true AU2009220931B2 (en) 2014-11-13

Family

ID=39327664

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009220931A Ceased AU2009220931B2 (en) 2008-03-06 2009-03-06 N-substitutedbenzenepropanamide or benzenepropenamide derivatives for use in the treatment of pain and inflammation

Country Status (12)

Country Link
US (2) US8883853B2 (enExample)
EP (1) EP2323644B1 (enExample)
JP (1) JP5657394B2 (enExample)
AU (1) AU2009220931B2 (enExample)
CA (1) CA2717692C (enExample)
DK (1) DK2323644T3 (enExample)
ES (1) ES2505325T3 (enExample)
GB (1) GB0804213D0 (enExample)
IL (1) IL207965A (enExample)
PL (1) PL2323644T3 (enExample)
PT (1) PT2323644E (enExample)
WO (1) WO2009109850A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7674829B2 (en) 2004-03-26 2010-03-09 Novaremed Limited Compounds for the treatment of AIDS and other viral diseases
GB0804213D0 (en) 2008-03-06 2008-04-16 New Era Biotech Ltd A method of printing or preventing pain
WO2011030205A1 (en) * 2009-09-09 2011-03-17 Novaremed Ltd. N-substituted benzenepropanamide or benzenepropenamide for use in the treatment of pain and inflammation
US8802734B2 (en) 2009-09-09 2014-08-12 Novaremed Limited Method of treating or preventing pain
GB201116335D0 (en) * 2011-09-21 2011-11-02 Novaremed Ltd A method of treating or preventing affective disorders
CN103998420B (zh) * 2011-12-08 2018-04-17 诺瓦麦有限公司 (s)2‑n(3‑o‑(丙‑2‑醇)‑1‑丙基‑4‑羟基苯)‑3‑苯基丙酰胺的分离的立体异构形式
RS63270B1 (sr) 2019-01-23 2022-06-30 Novaremed Ltd Jedinjenja za upotrebu u tretmanu ili profilaksi bola, inflamacije i/ili autoimuniteta
EP3939578A1 (en) 2020-07-13 2022-01-19 Novaremed Ltd. Compounds for treatment or prevention of an infection resulting from a coronavirus and/or a coronavirus-induced disease
WO2026037478A1 (en) 2023-08-11 2026-02-19 Novaremed AG (s,s)-(3-o-(propan-2-ol)-2-amino-prop-1-yl-4-hydroxybenzene and its analogues for the treatment of chronic pain

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023202A1 (en) * 1995-12-22 1997-07-03 STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITYA ND THE UNIVERSITY OF OREGON, EUGENE OREGON Subtype-selective nmda receptor ligands and the use thereof
EP0877340A1 (en) * 1997-05-06 1998-11-11 Konami Co., Ltd. Apparatus and method for processing an image display and a readable storage medium storing a computer program
WO2004031129A2 (en) * 2002-10-03 2004-04-15 New Era Biotech, Ltd. Compounds for use in the treatment of autoimmune diseases, immuno-allergical diseases and organ or tissue transplantation rejection
EP1876169A1 (en) * 2005-03-25 2008-01-09 Obschestvo S Ogranichennoi Otvetstennostiyu "Pharmenterprises" Phenyl-containing n-acyl amine and aminoacid derivatives, methods for the production thereof, a pharmaceutical composition and the use thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2908691A (en) 1958-07-14 1959-10-13 Searle & Co Hydroxyphenalkylaminoalkylindoles and ethers corresponding thereto
GB1037655A (en) * 1964-05-20 1966-08-03 Koninklijke Pharma Fab Nv Di(aralkyl)amines
ZA732136B (en) 1972-04-12 1974-03-27 Lilly Co Eli Dopamine derivatives
JPS5236606A (en) 1975-09-12 1977-03-22 Tanabe Seiyaku Co Ltd Process for preparation of amino compounds
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4908322A (en) 1985-09-06 1990-03-13 The United States Of America As Represented By The Department Of Health And Human Services Derivatization of amines for electrochemical detection
US5696270A (en) 1989-05-23 1997-12-09 Abbott Laboratories Intermediate for making retroviral protease inhibiting compounds
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
JP2848232B2 (ja) 1993-02-19 1999-01-20 武田薬品工業株式会社 アルデヒド誘導体
US6017919A (en) * 1996-02-06 2000-01-25 Japan Tobacco Inc. Compounds and pharmaceutical use thereof
WO2002046176A1 (en) 2000-12-05 2002-06-13 Nippon Chemiphar Co., Ltd. Ppar (peroxisome proliferator activated receptor) activators
AU2003294441A1 (en) * 2002-11-22 2004-06-18 Bristol-Myers Squibb Company 1-aryl-2-hydroxyethyl amides as potassium channel openers
US7674829B2 (en) 2004-03-26 2010-03-09 Novaremed Limited Compounds for the treatment of AIDS and other viral diseases
DE102004039373A1 (de) * 2004-08-12 2006-02-23 Grünenthal GmbH Para-Alkyl-substituierte N-(4-Hydroxy-3-methoxy-benzyl)-zimtsäureamide und deren Verwendung zur Herstellung von Arzneimitteln
PL2026775T3 (pl) 2006-05-09 2015-12-31 Novaremed Ltd Zastosowanie inhibitorów kinazy tyrozynowej Syk w leczeniu komórkowych zaburzeń proliferacyjnych
KR20100087099A (ko) 2007-09-17 2010-08-03 아카데미아 시니카 플렉트란투스 암보이니쿠스 추출물에 의해 염증 및 염증-관련 질병을 치료하기 위한 조성물 및 방법
GB0804213D0 (en) 2008-03-06 2008-04-16 New Era Biotech Ltd A method of printing or preventing pain
CN101503370B (zh) 2009-03-02 2012-08-22 上海应用技术学院 一种n-环丙基-反-2-顺-6-壬二烯酸酰胺的合成方法
CN101503373B (zh) 2009-03-13 2013-07-24 山东大学 2-氨基-1-(4-硝基苯基)-1-乙醇类金属蛋白酶抑制剂及其制备方法和用途
US8802734B2 (en) 2009-09-09 2014-08-12 Novaremed Limited Method of treating or preventing pain

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023202A1 (en) * 1995-12-22 1997-07-03 STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITYA ND THE UNIVERSITY OF OREGON, EUGENE OREGON Subtype-selective nmda receptor ligands and the use thereof
EP0877340A1 (en) * 1997-05-06 1998-11-11 Konami Co., Ltd. Apparatus and method for processing an image display and a readable storage medium storing a computer program
WO2004031129A2 (en) * 2002-10-03 2004-04-15 New Era Biotech, Ltd. Compounds for use in the treatment of autoimmune diseases, immuno-allergical diseases and organ or tissue transplantation rejection
EP1876169A1 (en) * 2005-03-25 2008-01-09 Obschestvo S Ogranichennoi Otvetstennostiyu "Pharmenterprises" Phenyl-containing n-acyl amine and aminoacid derivatives, methods for the production thereof, a pharmaceutical composition and the use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Lee, Y-T. et al, Clinica Chimica Acta, 2005, v. 352, pp. 135-141 *
Marquez, L. et al, Acta Farm. Bonaerense, 2005, vol. 24, pp. 325-330 *
Park, J.B., J. Agric. Food Chem., 2007, vol. 55, pp. 2171-2175 *

Also Published As

Publication number Publication date
CA2717692C (en) 2016-06-07
US9199917B2 (en) 2015-12-01
WO2009109850A2 (en) 2009-09-11
AU2009220931A1 (en) 2009-09-11
EP2323644B1 (en) 2014-04-23
PL2323644T3 (pl) 2014-10-31
JP5657394B2 (ja) 2015-01-21
GB0804213D0 (en) 2008-04-16
IL207965A0 (en) 2010-12-30
US20110039936A1 (en) 2011-02-17
IL207965A (en) 2015-10-29
PT2323644E (pt) 2014-07-25
US8883853B2 (en) 2014-11-11
CA2717692A1 (en) 2009-09-11
DK2323644T3 (da) 2014-07-21
JP2011513377A (ja) 2011-04-28
WO2009109850A3 (en) 2009-12-10
US20150080473A1 (en) 2015-03-19
ES2505325T3 (es) 2014-10-09
EP2323644A2 (en) 2011-05-25

Similar Documents

Publication Publication Date Title
US9199917B2 (en) N-substituted benzenepropanamide or benzenepropenamide derivatives for use in the treatment of pain and inflammation
EP1244447B1 (en) Novel methods and compositions involving opioids and antagonists thereof
JP5921539B2 (ja) 下肢静止不能症候群を治療する方法
EP0132114B1 (en) Novel compounds and compositions useful for producing analgesia
JP2010521501A (ja) 睡眠および認知に関するうつ病における残存症状の治療のための組み合わされたセロトニン再取り込み、５−ｈｔ３および５−ｈｔ１ａ活性を有する化合物としての１−［２−（２，４−ジメチルフェニルスルファニル）フェニル］ピペラジン
US20160317479A1 (en) Method of treating or preventing pain
CN102985085A (zh) 治疗双相型障碍的方法
JP6016179B2 (ja) 疼痛の治療又は予防用医薬組成物
RU2005101876A (ru) Производные аминоспиртов
KR101471585B1 (ko) 트라마돌 및 콕시브의 공결정
JP2005015434A (ja) 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
ES2983998T3 (es) Compuesto de indol para tratar la cistitis intersticial
EP3860582B1 (en) Compounds for use in the treatment or prophylaxis of pain, inflammation and/or autoimmunity
CN1107333A (zh) 那布扶林镇痛剂的长效前体药物及其制备方法
HK1179523B (en) N-substituted benzenepropanamide or benzenepropenamide for use in the treatment of pain and inflammation
CN115697316B (zh) 加巴喷丁和酮洛芬的协同掺加物、药物组合物及其医疗用途
CN1411459A (zh) 治疗疼痛的化合物及方法
WO2005016331A1 (ja) Ｎ−（ベンゾイル）アミノ酸誘導体を有効成分とするニューロパシー性疼痛治療剤
HK40061961B (en) Compounds for use in the treatment or prophylaxis of pain, inflammation and/or autoimmunity
HK40061961A (en) Compounds for use in the treatment or prophylaxis of pain, inflammation and/or autoimmunity
HK1140683A (en) 1-[2-(2-4-dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of pain or residual symptoms in depression relating to sleep and cognition

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired