AU2009204084A1 - Intrathecal treatment of neuropathic pain with A2AR agonists - Google Patents
Intrathecal treatment of neuropathic pain with A2AR agonists Download PDFInfo
- Publication number
- AU2009204084A1 AU2009204084A1 AU2009204084A AU2009204084A AU2009204084A1 AU 2009204084 A1 AU2009204084 A1 AU 2009204084A1 AU 2009204084 A AU2009204084 A AU 2009204084A AU 2009204084 A AU2009204084 A AU 2009204084A AU 2009204084 A1 AU2009204084 A1 AU 2009204084A1
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- alkylene
- aryl
- heteroaryl
- pct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 239000000556 agonist Substances 0.000 title claims description 42
- 208000004296 neuralgia Diseases 0.000 title claims description 20
- 208000021722 neuropathic pain Diseases 0.000 title claims description 20
- 238000007913 intrathecal administration Methods 0.000 title claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 113
- 150000001875 compounds Chemical class 0.000 claims description 105
- 125000003118 aryl group Chemical group 0.000 claims description 89
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- 125000002947 alkylene group Chemical group 0.000 claims description 71
- 229910052739 hydrogen Inorganic materials 0.000 claims description 66
- 239000001257 hydrogen Substances 0.000 claims description 59
- 125000001072 heteroaryl group Chemical group 0.000 claims description 57
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 45
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 40
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- 150000002431 hydrogen Chemical class 0.000 claims description 23
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1991208P | 2008-01-09 | 2008-01-09 | |
| US61/019,912 | 2008-01-09 | ||
| PCT/US2009/030565 WO2009089425A1 (en) | 2008-01-09 | 2009-01-09 | Intrathecal treatment of neuropathic pain with a2ar agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
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| US5801188A (en) * | 1997-01-08 | 1998-09-01 | Medtronic Inc. | Clonidine therapy enhancement |
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| NZ556354A (en) * | 2001-10-01 | 2008-10-31 | Univ Virginia | 2-Propynyl adenosine analogs having A2A agonist activity and compositions thereof |
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| US8188063B2 (en) * | 2006-06-19 | 2012-05-29 | University Of Virginia Patent Foundation | Use of adenosine A2A modulators to treat spinal cord injury |
-
2009
- 2009-01-09 CN CN2009801042314A patent/CN101938904A/zh active Pending
- 2009-01-09 EA EA201001135A patent/EA201001135A1/ru unknown
- 2009-01-09 CA CA2711495A patent/CA2711495A1/en not_active Abandoned
- 2009-01-09 AU AU2009204084A patent/AU2009204084A1/en not_active Abandoned
- 2009-01-09 WO PCT/US2009/030565 patent/WO2009089425A1/en not_active Ceased
- 2009-01-09 JP JP2010542368A patent/JP2011509305A/ja active Pending
- 2009-01-09 BR BRPI0907248-9A patent/BRPI0907248A2/pt not_active IP Right Cessation
- 2009-01-09 EP EP09700821A patent/EP2240020A4/en not_active Withdrawn
- 2009-01-09 US US12/351,209 patent/US20090181920A1/en not_active Abandoned
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2010
- 2010-07-04 IL IL206801A patent/IL206801A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009089425A1 (en) | 2009-07-16 |
| US20090181920A1 (en) | 2009-07-16 |
| BRPI0907248A2 (pt) | 2019-02-26 |
| JP2011509305A (ja) | 2011-03-24 |
| CA2711495A1 (en) | 2009-07-16 |
| CN101938904A (zh) | 2011-01-05 |
| EP2240020A1 (en) | 2010-10-20 |
| EA201001135A1 (ru) | 2011-02-28 |
| IL206801A0 (en) | 2010-12-30 |
| EP2240020A4 (en) | 2011-05-11 |
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