AU2008355461B2 - Cyanobacteria saxitoxin gene cluster and detection of cyanotoxic organisms - Google Patents

Cyanobacteria saxitoxin gene cluster and detection of cyanotoxic organisms Download PDF

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AU2008355461B2
AU2008355461B2 AU2008355461A AU2008355461A AU2008355461B2 AU 2008355461 B2 AU2008355461 B2 AU 2008355461B2 AU 2008355461 A AU2008355461 A AU 2008355461A AU 2008355461 A AU2008355461 A AU 2008355461A AU 2008355461 B2 AU2008355461 B2 AU 2008355461B2
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seq
sequence
gene
polypeptide
sxt
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AU2008355461A1 (en
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Young Jae Jeon
Ralf Kellmann
Troco Kaan Mihali
Brett A. Neilan
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NewSouth Innovations Pty Ltd
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AU2008355461A 2008-04-24 2008-12-05 Cyanobacteria saxitoxin gene cluster and detection of cyanotoxic organisms Active AU2008355461B2 (en)

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Application Number Priority Date Filing Date Title
AU2008355461A AU2008355461B2 (en) 2008-04-24 2008-12-05 Cyanobacteria saxitoxin gene cluster and detection of cyanotoxic organisms

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Application Number Priority Date Filing Date Title
AU2008902056 2008-04-24
AU2008902056A AU2008902056A0 (en) 2008-04-24 Detection of cyanotoxic organisms
AU2008355461A AU2008355461B2 (en) 2008-04-24 2008-12-05 Cyanobacteria saxitoxin gene cluster and detection of cyanotoxic organisms
PCT/AU2008/001805 WO2009129558A1 (en) 2008-04-24 2008-12-05 Cyanobacteria saxitoxin gene cluster and detection of cyanotoxic organisms

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AU2008355461A1 AU2008355461A1 (en) 2009-10-29
AU2008355461B2 true AU2008355461B2 (en) 2015-07-30

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EP (1) EP2279265B1 (enExample)
JP (1) JP5722765B2 (enExample)
AU (1) AU2008355461B2 (enExample)
DK (1) DK2279265T3 (enExample)
ES (1) ES2525045T3 (enExample)
PT (1) PT2279265E (enExample)
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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5722765B2 (ja) 2008-04-24 2015-05-27 ニューサウス イノベイションズ ピーティーワイ リミテッド 藍藻類サキシトキシン遺伝子クラスタおよびシアノトキシンを有する生物の検出
CN103748235B (zh) * 2011-05-16 2016-04-27 新南创新有限公司 产石房蛤毒素的鞭毛藻的检测
WO2014016706A2 (en) * 2012-05-16 2014-01-30 University Of Oslo Detection of dinoflagellates
US9353165B2 (en) * 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
GB201602576D0 (en) 2016-02-12 2016-03-30 Bergen Teknologioverforing As Process
US10395889B2 (en) * 2016-09-07 2019-08-27 Axcelis Technologies, Inc. In situ beam current monitoring and control in scanned ion implantation systems
US12391996B2 (en) 2018-09-26 2025-08-19 The U.S. Epa Early warning genetic testing of toxic cyanobacteria in water supply
CN112342279B (zh) * 2020-11-06 2022-10-14 中国科学院城市环境研究所 一种同时检测水华蓝藻拉氏尖头藻和产拟柱胞藻毒素特异基因的试剂盒及其方法
KR102707891B1 (ko) * 2021-12-03 2024-09-23 대한민국 항-남조류 활성 물질을 생산하는 신규 스트렙토마이세스 속 nibr000498259 균주
CN120129742A (zh) * 2022-11-03 2025-06-10 赢创运营有限公司 通过靶向引入或增加属于氨基酸-多胺-有机阳离子超家族的跨膜转运蛋白的活性来产生胍基乙酸(gaa)的改进的生物技术工艺
EP4612280A1 (en) 2022-11-03 2025-09-10 Evonik Operations GmbH Improved biotechnological process to produce guanidinoacetic acid (gaa) by targeted introduction or by increasing the activity of a transmembrane exporter protein
KR102674005B1 (ko) * 2023-03-14 2024-06-19 대한민국 실린드로스페르몹신 합성 유전자 검출용 프라이머 세트
KR102674001B1 (ko) * 2023-03-14 2024-06-19 대한민국 실린드로스페르몹신 합성 유전자 검출용 프라이머 세트
KR102674008B1 (ko) * 2023-03-14 2024-06-19 대한민국 삭시톡신 합성 유전자 검출용 프라이머 세트
CN116926218B (zh) * 2023-08-14 2024-03-15 中国科学院水生生物研究所 一种检测拟柱孢藻菌型的探针组合、基因芯片、试剂盒及方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4356270A (en) 1977-11-08 1982-10-26 Genentech, Inc. Recombinant DNA cloning vehicle
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5296348A (en) 1989-05-16 1994-03-22 The Wistar Institute Of Anatomy And Biology Methods for screening monoclonal antibodies for therapeutic use
JP3091492B2 (ja) 1991-11-14 2000-09-25 ダイジーン ダイアグノスティクス,インコーポレイテッド 非放射性ハイブリダイゼーションアッセイおよびキット
ATE526405T1 (de) 1998-03-20 2011-10-15 Commw Scient Ind Res Org Synthetische gene und genetische zusammensetzungen diesen enthaltend
AU2001240375A1 (en) 2000-03-17 2001-10-03 Benitec Australia Limited Genetic silencing
US7601497B2 (en) 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
EP1379549A2 (fr) * 2001-02-07 2004-01-14 Institut Pasteur Sequence du genome de photorhabdus luminescens souche tto1 et utilisations
US7314974B2 (en) * 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
JP4274948B2 (ja) 2002-03-13 2009-06-10 シンジェンタ・パティシペーションズ・アクチェンゲゼルシャフト 核酸検出方法
US6995243B2 (en) 2002-08-13 2006-02-07 New York University Antibodies that recognize and bind phosphorylated human glucocorticoid receptor and methods of using same
US7109297B2 (en) * 2004-09-13 2006-09-19 The Hong Kong Polytechnic University Biomarkers for toxic algae
US7348147B2 (en) 2004-11-15 2008-03-25 Carestream Health, Inc. Method and system for nucleic acid detection
EP1974049A2 (en) * 2004-12-17 2008-10-01 Metanomics GmbH Process for the control of production of fine chemicals
EP2194140A2 (en) * 2005-03-02 2010-06-09 Metanomics GmbH Process for the production of fine chemicals
JP5722765B2 (ja) 2008-04-24 2015-05-27 ニューサウス イノベイションズ ピーティーワイ リミテッド 藍藻類サキシトキシン遺伝子クラスタおよびシアノトキシンを有する生物の検出

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
POMATI, F. et al., Nucleic Acids Research, 2004, Vol. 32, No. 1, e7 *

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Publication number Publication date
PT2279265E (pt) 2014-12-09
AU2008355461A1 (en) 2009-10-29
EP2279265B1 (en) 2014-08-27
ZA201007749B (en) 2011-08-31
US20160153030A1 (en) 2016-06-02
JP5722765B2 (ja) 2015-05-27
EP2279265A1 (en) 2011-02-02
US20110129842A1 (en) 2011-06-02
ES2525045T3 (es) 2014-12-16
US10415097B2 (en) 2019-09-17
WO2009129558A1 (en) 2009-10-29
EP2279265A4 (en) 2011-06-29
JP2011519275A (ja) 2011-07-07
DK2279265T3 (da) 2014-12-08

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