AU2008251748B2 - Novel antimicrobial peptides - Google Patents
Novel antimicrobial peptides Download PDFInfo
- Publication number
- AU2008251748B2 AU2008251748B2 AU2008251748A AU2008251748A AU2008251748B2 AU 2008251748 B2 AU2008251748 B2 AU 2008251748B2 AU 2008251748 A AU2008251748 A AU 2008251748A AU 2008251748 A AU2008251748 A AU 2008251748A AU 2008251748 B2 AU2008251748 B2 AU 2008251748B2
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- Australia
- Prior art keywords
- seq
- peptide
- peptides
- antimicrobial
- amps
- Prior art date
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- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88078307P | 2007-01-16 | 2007-01-16 | |
| US60/880,783 | 2007-01-16 | ||
| PCT/US2008/051101 WO2008140834A2 (en) | 2007-01-16 | 2008-01-15 | Novel antimicrobial peptides |
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| AU2008251748A1 AU2008251748A1 (en) | 2008-11-20 |
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| EP (1) | EP2118122B1 (enExample) |
| JP (1) | JP2010516688A (enExample) |
| CN (1) | CN101622271B (enExample) |
| AU (1) | AU2008251748B2 (enExample) |
| ES (1) | ES2548767T3 (enExample) |
| IL (1) | IL199835A (enExample) |
| WO (1) | WO2008140834A2 (enExample) |
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| WO2008030988A2 (en) | 2006-09-06 | 2008-03-13 | The Regents Of The University Of California | Selectively targeted antimicrobial peptides and the use thereof |
| WO2008140834A2 (en) * | 2007-01-16 | 2008-11-20 | The Regents Of The University Of California | Novel antimicrobial peptides |
| EP2168976A1 (en) * | 2008-09-24 | 2010-03-31 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Antimicrobial peptides |
| US20100184684A1 (en) * | 2009-01-06 | 2010-07-22 | C3 Jian, Inc. | Antibacterial and antifungal peptides |
| US20100202983A1 (en) * | 2009-02-09 | 2010-08-12 | Jernberg Gary R | Selectively targeted antimicrobials for the treatment of periodontal disease |
| US12257272B2 (en) | 2015-12-24 | 2025-03-25 | Seed Health, Inc. | Method and system for reducing the likelihood of developing depression in an individual |
| US10085938B2 (en) * | 2011-02-04 | 2018-10-02 | Joseph E. Kovarik | Method and system for preventing sore throat in humans |
| US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
| US10687975B2 (en) | 2011-02-04 | 2020-06-23 | Joseph E. Kovarik | Method and system to facilitate the growth of desired bacteria in a human's mouth |
| US11523934B2 (en) | 2011-02-04 | 2022-12-13 | Seed Health, Inc. | Method and system to facilitate the growth of desired bacteria in a human's mouth |
| US11357722B2 (en) | 2011-02-04 | 2022-06-14 | Seed Health, Inc. | Method and system for preventing sore throat in humans |
| US9987224B2 (en) * | 2011-02-04 | 2018-06-05 | Joseph E. Kovarik | Method and system for preventing migraine headaches, cluster headaches and dizziness |
| US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| US11998479B2 (en) | 2011-02-04 | 2024-06-04 | Seed Health, Inc. | Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure |
| US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
| US12279989B2 (en) | 2011-02-04 | 2025-04-22 | Seed Health, Inc. | Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity |
| WO2012154959A1 (en) * | 2011-05-11 | 2012-11-15 | Elixir Institute Of Regenerative Medicine | Peptide tyrosinase inhibitors and uses thereof |
| US12083158B2 (en) * | 2011-10-07 | 2024-09-10 | Morehouse School Of Medicine | Antibacterial compositions, methods of making and use thereof |
| US9028807B2 (en) | 2012-04-05 | 2015-05-12 | Ues, Inc. | Synthesis models for antimicrobial agents via the halogenation of organic/inorganic composites |
| CN103172701B (zh) * | 2013-03-18 | 2015-09-30 | 中国科学院过程工程研究所 | 一种新型穿膜肽及其应用 |
| JP2014218496A (ja) * | 2013-04-08 | 2014-11-20 | 和興フィルタテクノロジー株式会社 | 高保存性抗体溶液 |
| US11833177B2 (en) | 2013-12-20 | 2023-12-05 | Seed Health, Inc. | Probiotic to enhance an individual's skin microbiome |
| US12329783B2 (en) | 2013-12-20 | 2025-06-17 | Seed Health, Inc. | Method and system to improve the health of a person's skin microbiome |
| US11826388B2 (en) | 2013-12-20 | 2023-11-28 | Seed Health, Inc. | Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation |
| US11969445B2 (en) | 2013-12-20 | 2024-04-30 | Seed Health, Inc. | Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH |
| US11839632B2 (en) | 2013-12-20 | 2023-12-12 | Seed Health, Inc. | Topical application of CRISPR-modified bacteria to treat acne vulgaris |
| US11998574B2 (en) | 2013-12-20 | 2024-06-04 | Seed Health, Inc. | Method and system for modulating an individual's skin microbiome |
| US12246043B2 (en) | 2013-12-20 | 2025-03-11 | Seed Health, Inc. | Topical application to treat acne vulgaris |
| US12005085B2 (en) | 2013-12-20 | 2024-06-11 | Seed Health, Inc. | Probiotic method and composition for maintaining a healthy vaginal microbiome |
| US11980643B2 (en) | 2013-12-20 | 2024-05-14 | Seed Health, Inc. | Method and system to modify an individual's gut-brain axis to provide neurocognitive protection |
| CN103830145B (zh) * | 2014-03-18 | 2015-10-28 | 林彤 | 一种含有生物肽与中药的牙膏 |
| RU2726124C2 (ru) | 2014-05-09 | 2020-07-09 | Юниверситейт Утрехт Холдинг Б.В. | Новые производные сатн2 |
| US10131698B2 (en) * | 2014-08-14 | 2018-11-20 | Council Of Scientific & Industrial Research | Synthetic antimicrobial peptides |
| CN106674329B (zh) * | 2015-11-05 | 2021-07-23 | 程家维 | 具备抗微生物、抗癌/促进伤口愈合活性的肽及其用途 |
| WO2017134661A1 (en) * | 2016-02-04 | 2017-08-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods for disrupting biofilms |
| CN107337713B (zh) * | 2016-05-03 | 2022-05-13 | 上海医药工业研究院 | 一组抑菌肽及其制备方法 |
| CN106390206B (zh) * | 2016-08-17 | 2019-06-28 | 广州宏柯源生物科技有限公司 | 一种多肽水凝胶、其制备方法及应用 |
| KR101899552B1 (ko) * | 2016-11-18 | 2018-09-17 | 군산대학교 산학협력단 | 전복에서 유래한 항균 펩타이드 유사체 및 이를 포함하는 항균용 약학 조성물 |
| US10111929B1 (en) * | 2017-04-07 | 2018-10-30 | Ez Ip, Llc | Growth hormone releasing factor analogs and uses |
| CN109232719B (zh) * | 2018-09-21 | 2021-06-29 | 中国科学院理化技术研究所 | 一种pH响应的抗菌肽及其制备方法和应用 |
| US20200102356A1 (en) * | 2018-10-01 | 2020-04-02 | NMC Inc. | Compositions and Methods for the Treatment of Huanglongbing (HLB) aka Citrus Greening in Citrus Plants |
| US20220053773A1 (en) * | 2018-10-01 | 2022-02-24 | Innate Immunity LLC | Compositions and methods for the treatment of pathogenic infections in plants |
| KR102170236B1 (ko) * | 2019-03-19 | 2020-10-29 | (주)노바셀테크놀로지 | 신규 다중 기능성 펩타이드 및 그의 용도 |
| CN115244067A (zh) * | 2019-08-29 | 2022-10-25 | Ajk生物制药有限责任公司 | 合成抗微生物肽 |
| EP4085064A4 (en) * | 2019-12-30 | 2024-05-29 | Ohio State Innovation Foundation | LOOP PROTEINS INCLUDING CELL-PENETRATING PEPTIDES |
| EP4126906A1 (en) * | 2020-03-31 | 2023-02-08 | Innate Immunity LLC | Recombinant peptide to treat fire blight |
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| DE102020211387A1 (de) | 2020-09-10 | 2022-03-10 | Beiersdorf Aktiengesellschaft | Wirkstoffhaltige Wundverschlusszubereitung |
| CN113248572B (zh) * | 2021-04-30 | 2023-04-11 | 重庆理工大学 | 一种抗多重耐药菌环肽及其应用 |
| CN116134045A (zh) * | 2021-09-03 | 2023-05-16 | 深圳千越生物科技有限公司 | 抗菌肽或肽衍生物、替换体以及其组合物、制备方法和应用 |
| US20230134577A1 (en) * | 2021-09-20 | 2023-05-04 | The Procter & Gamble Company | Jammed Emulsion Toothpaste Compositions Comprising Fluoride |
| CN120289633B (zh) * | 2025-02-27 | 2025-11-28 | 黄冈师范学院 | 抗变形链球菌的多肽、核酸分子及在制备抗变形链球菌的药物应用 |
| CN120617172A (zh) * | 2025-06-25 | 2025-09-12 | 中国科学院南海海洋研究所 | 一种安全无防腐剂的海龙抗菌肽喷雾剂及其制备方法和应用 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999003488A2 (en) * | 1997-07-15 | 1999-01-28 | Magainin Pharmaceuticals Inc. | Biologically active peptides with reduced toxicity in animals and a method for preparing same |
| WO2002014345A2 (en) * | 2000-08-15 | 2002-02-21 | North Carolina State University | Antimicrobial peptides isolated from mast cells |
| US20030083243A1 (en) * | 2001-03-28 | 2003-05-01 | Owen Donald R. | Short bioactive peptides |
| WO2006107921A2 (en) * | 2005-04-05 | 2006-10-12 | Allergan, Inc. | Lipophilic dye-based fret assays for clostridial toxin activity |
| WO2007005635A2 (en) * | 2005-07-01 | 2007-01-11 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mitotic spindle protein aspm as a diagnostic marker for neoplasia and uses therefor |
| WO2007038683A2 (en) * | 2005-09-28 | 2007-04-05 | The Regents Of The University Of California | Calcium binding peptides |
| WO2008022444A1 (en) * | 2006-08-21 | 2008-02-28 | The University Of British Columbia | Small cationic antimicrobial peptides |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2118939A1 (en) * | 1991-09-13 | 1993-04-01 | W. Lee Maloy | Biologically active amphiphilic peptide compositions and uses thereof |
| AUPN861496A0 (en) * | 1996-03-13 | 1996-04-04 | Commonwealth Scientific And Industrial Research Organisation | Lytic peptides |
| CA2320429C (en) * | 1998-02-18 | 2011-04-19 | Harbor-Ucla Research And Education Institute | Antimicrobial peptides and derived metapeptides |
| US20040052814A1 (en) * | 1998-09-28 | 2004-03-18 | Wenyuan Shi | Fusion proteins for targeted delivery of antimicrobial peptides |
| US6610836B1 (en) * | 1999-01-29 | 2003-08-26 | Genome Therapeutics Corporation | Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics |
| US20030143234A1 (en) * | 1999-08-20 | 2003-07-31 | Wenyuan Shi | Anti-microbial targeting chimeric pharmaceutical |
| US20020068066A1 (en) | 1999-08-20 | 2002-06-06 | Wenyuan Shi | Method for the treatment and prevention of dental caries |
| US7569542B2 (en) * | 1999-08-20 | 2009-08-04 | The Regents Of The University Of California | Anti-microbial targeting chimeric pharmaceutical |
| US6449760B1 (en) * | 2000-11-30 | 2002-09-10 | Lsi Logic Corporation | Pin placement method for integrated circuits |
| US7427408B2 (en) * | 2002-06-06 | 2008-09-23 | The Regents Of The University Of California | Quorum sensing and biofilm formation |
| US7087228B2 (en) * | 2002-07-03 | 2006-08-08 | University Of Southern California | Preventing tooth decay and infective endocarditis using natural oligopeptides |
| WO2004110341A2 (en) * | 2003-06-19 | 2004-12-23 | Yeda Research & Development Co. Ltd. | Antimicrobial and anticancer lipopeptides |
| US7875598B2 (en) * | 2004-03-04 | 2011-01-25 | The Regents Of The University Of California | Compositions useful for the treatment of microbial infections |
| US7452856B2 (en) * | 2004-07-06 | 2008-11-18 | Seikagaku Corporation | Antibacterial peptide |
| CA2581883A1 (en) * | 2004-09-27 | 2006-04-06 | Technion Research & Development Foundation Ltd. | Novel antimicrobial agents |
| CA2597191C (en) * | 2005-02-09 | 2014-04-01 | Helix Biomedix Inc. | Antimicrobial hexapeptides |
| CA2620935A1 (en) | 2005-09-01 | 2007-03-08 | The Regents Of The University Of California | Method of using pore-forming peptides for genetic transformation, protein extraction, and transmembrane transport |
| WO2008030988A2 (en) * | 2006-09-06 | 2008-03-13 | The Regents Of The University Of California | Selectively targeted antimicrobial peptides and the use thereof |
| WO2008140834A2 (en) | 2007-01-16 | 2008-11-20 | The Regents Of The University Of California | Novel antimicrobial peptides |
-
2008
- 2008-01-15 WO PCT/US2008/051101 patent/WO2008140834A2/en not_active Ceased
- 2008-01-15 CN CN200880002256.9A patent/CN101622271B/zh not_active Expired - Fee Related
- 2008-01-15 AU AU2008251748A patent/AU2008251748B2/en not_active Ceased
- 2008-01-15 EP EP08795782.5A patent/EP2118122B1/en active Active
- 2008-01-15 US US12/014,634 patent/US7713927B2/en active Active
- 2008-01-15 ES ES08795782.5T patent/ES2548767T3/es active Active
- 2008-01-15 JP JP2009546483A patent/JP2010516688A/ja active Pending
-
2009
- 2009-07-13 IL IL199835A patent/IL199835A/en active IP Right Grant
-
2010
- 2010-03-24 US US12/730,939 patent/US8609608B2/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999003488A2 (en) * | 1997-07-15 | 1999-01-28 | Magainin Pharmaceuticals Inc. | Biologically active peptides with reduced toxicity in animals and a method for preparing same |
| WO2002014345A2 (en) * | 2000-08-15 | 2002-02-21 | North Carolina State University | Antimicrobial peptides isolated from mast cells |
| US20030083243A1 (en) * | 2001-03-28 | 2003-05-01 | Owen Donald R. | Short bioactive peptides |
| WO2006107921A2 (en) * | 2005-04-05 | 2006-10-12 | Allergan, Inc. | Lipophilic dye-based fret assays for clostridial toxin activity |
| WO2007005635A2 (en) * | 2005-07-01 | 2007-01-11 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mitotic spindle protein aspm as a diagnostic marker for neoplasia and uses therefor |
| WO2007038683A2 (en) * | 2005-09-28 | 2007-04-05 | The Regents Of The University Of California | Calcium binding peptides |
| WO2008022444A1 (en) * | 2006-08-21 | 2008-02-28 | The University Of British Columbia | Small cationic antimicrobial peptides |
Non-Patent Citations (1)
| Title |
|---|
| Ouhara K. et al. Journal of Antimicrobial Chemotherapy (2005) 55: 888-896 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008140834A2 (en) | 2008-11-20 |
| IL199835A0 (en) | 2010-04-15 |
| US20080286210A1 (en) | 2008-11-20 |
| US7713927B2 (en) | 2010-05-11 |
| AU2008251748A1 (en) | 2008-11-20 |
| JP2010516688A (ja) | 2010-05-20 |
| EP2118122A2 (en) | 2009-11-18 |
| IL199835A (en) | 2017-09-28 |
| CN101622271B (zh) | 2014-08-27 |
| US8609608B2 (en) | 2013-12-17 |
| WO2008140834A3 (en) | 2009-08-13 |
| EP2118122A4 (en) | 2012-12-12 |
| CN101622271A (zh) | 2010-01-06 |
| ES2548767T3 (es) | 2015-10-20 |
| EP2118122B1 (en) | 2015-09-23 |
| US20110085989A1 (en) | 2011-04-14 |
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