AU2008243817B2 - Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis - Google Patents
Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis Download PDFInfo
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- AU2008243817B2 AU2008243817B2 AU2008243817A AU2008243817A AU2008243817B2 AU 2008243817 B2 AU2008243817 B2 AU 2008243817B2 AU 2008243817 A AU2008243817 A AU 2008243817A AU 2008243817 A AU2008243817 A AU 2008243817A AU 2008243817 B2 AU2008243817 B2 AU 2008243817B2
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| PCT/IL2008/000543 WO2008132729A2 (en) | 2007-04-30 | 2008-04-27 | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
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| US6838452B2 (en) | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
| MXPA04003514A (es) * | 2001-10-19 | 2004-07-23 | Vascular Biogenics Ltd | Construcciones de polinucleotidos, composiciones farmaceuticas y metodos para reducir la regulacion dirigida de angionesis y terapia anticancer. |
| EP2310507A4 (en) * | 2008-07-08 | 2013-03-20 | David Gladstone Inst | METHOD AND COMPOSITIONS FOR ANGIOGENIC MODULATION |
| JP6151515B2 (ja) * | 2010-01-05 | 2017-06-21 | バスキュラー バイオジェニックス リミテッド | 神経膠芽腫ｇｂｍを治療するための組成物および方法 |
| EP2521776B1 (en) * | 2010-01-05 | 2016-11-02 | Vascular Biogenics Ltd. | Methods for use of a specific anti-angiogenic adenoviral agent |
| SG10201500015TA (en) * | 2010-01-12 | 2015-02-27 | Vascular Biogenics Ltd | Methods of producing adenovirus vectors and viral preparations generated thereby |
| WO2012052878A1 (en) | 2010-10-19 | 2012-04-26 | Vascular Biogenics Ltd. | Isolated polynucleotides and nucleic acid constructs for directing expression of a gene-of-interest in cells |
| KR20140027063A (ko) * | 2010-10-28 | 2014-03-06 | 버지니아 커먼웰스 유니버시티 | 치료와 병용하는 암 영상화: 치료진단 |
| WO2012112586A1 (en) | 2011-02-14 | 2012-08-23 | Revivicor, Inc. | Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof |
| HUE042262T2 (hu) | 2012-10-17 | 2019-06-28 | Vascular Biogenics Ltd | FAS-kimérát kifejezõ adenovírus és alkalmazása rákkezelési módszerekben |
| WO2014118643A2 (en) | 2013-02-04 | 2014-08-07 | Vascular Biogenics Ltd. | Methods of inducing responsiveness to anti-angiogenic agent |
| CN107630004B (zh) | 2017-09-01 | 2021-01-15 | 康希诺生物股份公司 | 降低可复制性腺病毒产生的细胞株及构建方法和应用 |
| WO2019077593A1 (en) | 2017-10-20 | 2019-04-25 | Vascular Biogenics Ltd. | DIAGNOSTIC METHODS FOR ANTI-ANGIOGENIC AGENT TREATMENT |
| JP2022524321A (ja) | 2019-03-13 | 2022-05-02 | バスキュラー バイオジェニックス リミテッド | 抗腫瘍療法の方法 |
| MX2021012398A (es) | 2019-04-12 | 2021-11-12 | Vascular Biogenics Ltd | Metodos de terapia antitumoral. |
| CN110714028B (zh) * | 2019-11-04 | 2021-08-31 | 中国人民解放军第四军医大学 | 可控性上调Ang-(1-7)靶向性防治低氧性肺动脉高压的表达载体 |
| EP3995569A1 (en) | 2020-11-10 | 2022-05-11 | Vessl Therapeutics Ltd | Methods of preconditioning vascular cells for transduction, methods of transduction and methods of preserving transduced cells |
| CN118434281A (zh) * | 2021-09-20 | 2024-08-02 | 雷维维科公司 | 用于异种移植的包含十个基因修饰的多转基因猪 |
| FR3158516A1 (fr) * | 2024-01-23 | 2025-07-25 | Asfalia Biologics | Production de vecteurs toxiques |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060204478A1 (en) * | 2000-11-17 | 2006-09-14 | Dror Harats | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US207985A (en) * | 1878-09-10 | Improvement in grain-separators | ||
| US4866042A (en) * | 1987-11-18 | 1989-09-12 | Neuwelt Edward A | Method for the delivery of genetic material across the blood brain barrier |
| US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| US6337209B1 (en) * | 1992-02-26 | 2002-01-08 | Glaxo Wellcome Inc. | Molecular constructs containing a carcinoembryonic antigen regulatory sequence |
| AU663702B2 (en) * | 1991-03-06 | 1995-10-19 | Board Of Regents, The University Of Texas System | Methods and compositions for the selective inhibition of gene expression |
| US5635385A (en) * | 1993-09-15 | 1997-06-03 | Temple University-Of The Commonwealth System Of Higher Education | Multi-unit ribozyme inhibition of oncogene gene expression |
| US6037329A (en) * | 1994-03-15 | 2000-03-14 | Selective Genetics, Inc. | Compositions containing nucleic acids and ligands for therapeutic treatment |
| US6579697B1 (en) * | 1995-05-11 | 2003-06-17 | Yeda Research And Development Co. Ltd. | Modulator of TNF/NGF superfamily receptors and soluble oligomeric TNF/NGF superfamily receptors |
| US8715645B2 (en) * | 1994-05-27 | 2014-05-06 | The Regents Of The University Of Colorado | Viral vectors encoding apoptosis-inducing proteins and methods for making and using the same |
| US5747340A (en) * | 1994-06-03 | 1998-05-05 | Syntex (U.S.A.) Inc. | Targeted gene expression using preproendothelin-1 promoters |
| US5906827A (en) * | 1994-06-03 | 1999-05-25 | Creative Biomolecules, Inc. | Matrix for the manufacture of autogenous replacement body parts |
| GB9506466D0 (en) * | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
| US5734039A (en) * | 1994-09-15 | 1998-03-31 | Thomas Jefferson University | Antisense oligonucleotides targeting cooperating oncogenes |
| US5712149A (en) * | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
| US5792453A (en) * | 1995-02-28 | 1998-08-11 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
| EP0760682A4 (en) * | 1995-02-28 | 1998-09-09 | Univ California | ANGIOGENIC THERAPY BY GENE TRANSFER |
| US5916763A (en) * | 1995-11-09 | 1999-06-29 | The Regents Of The University Of California | Promoter for VEGF receptor |
| EP0937104B1 (en) * | 1996-11-08 | 2005-03-23 | Oklahoma Medical Research Foundation | Endothelium specific expression regulated by epcr control elements |
| CA2628857C (en) * | 1996-12-30 | 2011-09-13 | Batelle Memorial Institute | Formulation and method for treating neoplasms by inhalation |
| US6206917B1 (en) * | 1997-05-02 | 2001-03-27 | St. Jude Medical, Inc. | Differential treatment of prosthetic devices |
| CA2297489A1 (en) * | 1997-07-30 | 1999-02-11 | Emory University | Novel bone mineralization proteins, dna, vectors, expression systems |
| EP0909532A1 (en) * | 1997-10-16 | 1999-04-21 | Development Center For Biotechnology | Environmentally compatible porous material comprising beneficial nematodes and its preparation |
| EP1030676B1 (en) * | 1997-10-30 | 2005-09-14 | The General Hospital Corporation | Bonding of cartilaginous matrices using isolated chondrocytes |
| US5882893A (en) * | 1997-12-04 | 1999-03-16 | Millennium Pharmaceuticals, Inc. | Nucleic acids encoding muscarinic receptors and uses therefor |
| US6417168B1 (en) * | 1998-03-04 | 2002-07-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
| JP2002513914A (ja) * | 1998-05-07 | 2002-05-14 | ユニバーシティ・オブ・メリーランド， ボルティモア | 慢性骨盤痛症候群の診断および治療方法 |
| US6239151B1 (en) * | 1998-06-26 | 2001-05-29 | Hoffmann-La Roche Inc. | Compounds as inhibitor of tumor necrosis factor alpha release |
| US6545048B1 (en) * | 1999-06-29 | 2003-04-08 | California Institute Of Technology | Compositions and methods of treating cancer using compositions comprising an inhibitor or endothelin receptor activity |
| US6576265B1 (en) * | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
| US6376244B1 (en) * | 1999-12-29 | 2002-04-23 | Children's Medical Center Corporation | Methods and compositions for organ decellularization |
| US6479064B1 (en) * | 1999-12-29 | 2002-11-12 | Children's Medical Center Corporation | Culturing different cell populations on a decellularized natural biostructure for organ reconstruction |
| US6265216B1 (en) * | 2000-01-20 | 2001-07-24 | Isis Pharmaceuticals, Inc. | Antisense modulation of cot oncogene expression |
| US6866864B2 (en) * | 2000-03-20 | 2005-03-15 | Ahmed Mousa | Compositions and methods of use in the treatment of angiogenesis and vascular-related disorders |
| US6652583B2 (en) * | 2000-04-07 | 2003-11-25 | Rhode Island Hospital | Cardiac valve replacement |
| US8071740B2 (en) * | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
| US20100282634A1 (en) * | 2000-11-17 | 2010-11-11 | Dror Harats | Promoters Exhibiting Endothelial Cell Specificity and Methods of Using Same for Regulation of Angiogenesis |
| MXPA03004325A (es) * | 2000-11-17 | 2004-01-26 | Vascular Biogenics Ltd | Promotores que muestran especificidad celular endotelial y metodos para su uso. |
| AU2003222427B8 (en) * | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
| US7067649B2 (en) * | 2000-11-17 | 2006-06-27 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
| EP1207205A1 (en) * | 2000-11-20 | 2002-05-22 | Crucell Holland B.V. | Adenoviral replicons |
| US6438802B1 (en) * | 2001-06-07 | 2002-08-27 | Randolph Scott Beeman | Locking mechanism and method for securely fastening resilient cords and tubing |
| CN1195056C (zh) * | 2001-07-12 | 2005-03-30 | 钱其军 | 一种在肿瘤细胞中特异性增殖及高效表达抗癌基因的重组病毒及其构建方法 |
| MXPA04003514A (es) * | 2001-10-19 | 2004-07-23 | Vascular Biogenics Ltd | Construcciones de polinucleotidos, composiciones farmaceuticas y metodos para reducir la regulacion dirigida de angionesis y terapia anticancer. |
| US9738907B2 (en) * | 2002-02-01 | 2017-08-22 | Oxford Biomedica (Uk) Limited | Viral vector |
| AU2003244347A1 (en) * | 2002-02-04 | 2003-09-02 | Takeda Chemical Industries, Ltd. | Angiogenesis inhibitors |
| CN1424401A (zh) * | 2003-01-06 | 2003-06-18 | 李川源 | 有条件复制型腺病毒及其构建方法和用途 |
-
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060204478A1 (en) * | 2000-11-17 | 2006-09-14 | Dror Harats | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
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| CN101808669A (zh) | 2010-08-18 |
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