AU2008242764B2 - Diabetes-related biomarkers and methods of use thereof - Google Patents
Diabetes-related biomarkers and methods of use thereof Download PDFInfo
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- AU2008242764B2 AU2008242764B2 AU2008242764A AU2008242764A AU2008242764B2 AU 2008242764 B2 AU2008242764 B2 AU 2008242764B2 AU 2008242764 A AU2008242764 A AU 2008242764A AU 2008242764 A AU2008242764 A AU 2008242764A AU 2008242764 B2 AU2008242764 B2 AU 2008242764B2
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023084199A1 (en) * | 2021-11-09 | 2023-05-19 | Randox Laboratories Ltd. | Biomarkers of hidden obesity for use in preventative healthcare |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8119358B2 (en) | 2005-10-11 | 2012-02-21 | Tethys Bioscience, Inc. | Diabetes-related biomarkers and methods of use thereof |
| US9817001B2 (en) | 2008-05-27 | 2017-11-14 | Boston Heart Diagnostics Corporation | Methods for determining LDL cholesterol treatment |
| JP2011528117A (ja) * | 2008-07-15 | 2011-11-10 | メタノミクス ヘルス ゲーエムベーハー | 胃バイパス及びそれに関連する状態を診断する手段及び方法 |
| US8762306B2 (en) | 2008-08-14 | 2014-06-24 | The University Of Toledo | Neural network for glucose therapy recommendation |
| US8470541B1 (en) | 2008-09-27 | 2013-06-25 | Boston Heart Diagnostics Corporation | Methods for separation and immuno-detection of biomolecules, and apparatus related thereto |
| WO2010146182A1 (en) * | 2009-06-19 | 2010-12-23 | Roche Diagnostics Gmbh | Method for monitoring the effect of ace inhibitor therapy on peripheral insulin resistance |
| BR112012004834A2 (pt) * | 2009-09-02 | 2018-03-13 | Univ Virginia Patent Foundation | acompanhar a probabilidade de hipoglicemia iminente em diabetes de dados de automonitiração de glicose no sangue (smbg) |
| US8163704B2 (en) | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
| JP2013509588A (ja) * | 2009-10-29 | 2013-03-14 | テシス バイオサイエンス, インコーポレイテッド | 2型糖尿病の予防に対して一貫した改善をもたらすタンパク質バイオマーカーおよび脂質代謝物バイオマーカー |
| US8775095B2 (en) | 2010-06-18 | 2014-07-08 | Roche Diagnostics Operations, Inc. | Methods and apparatus for decentralized diabetes monitoring |
| AU2012322018B2 (en) | 2011-10-13 | 2017-09-21 | Boston Heart Diagnostics | Compositions and methods for treating and preventing coronary heart disease |
| CN103376325A (zh) * | 2012-04-25 | 2013-10-30 | 中国科学院上海生命科学研究院 | 血管紧张素原蛋白前体作为肥胖型糖尿病标志物的应用 |
| WO2014055718A1 (en) * | 2012-10-04 | 2014-04-10 | Aptima, Inc. | Clinical support systems and methods |
| RU2015136673A (ru) * | 2013-01-31 | 2017-03-10 | Каприон Протеомикс Инк. | Биомаркеры сахарного диабета 2 типа и их применение |
| CN103198211B (zh) * | 2013-03-08 | 2017-02-22 | 北京理工大学 | 2型糖尿病发病危险因素对血糖影响的定量分析方法 |
| US9828624B2 (en) | 2013-07-24 | 2017-11-28 | Boston Heart Diagnostics Corporation | Driving patient compliance with therapy |
| CN104714022B (zh) * | 2013-12-12 | 2016-08-17 | 张曼 | 尿液纤维蛋白原α链在2型糖尿病合并冠心病中的应用 |
| AU2014364539B2 (en) * | 2013-12-20 | 2019-08-01 | Metabolon, Inc. | Biomarkers of de novo lipogenesis and methods using the same" (i.e. change Biomakers to Biomarkers) |
| CA2968221A1 (en) | 2014-11-17 | 2016-05-26 | Boston Heart Diagnostic Corporation | Cardiovascular disease risk assessment |
| EP3308291A4 (en) * | 2015-06-15 | 2019-03-20 | Kirontech Holding SAL | METHOD AND DEVICE FOR PROVIDING A PREDICTION |
| US11464456B2 (en) | 2015-08-07 | 2022-10-11 | Aptima, Inc. | Systems and methods to support medical therapy decisions |
| CN108289642B (zh) * | 2015-10-09 | 2021-02-23 | 迪诺威特公司 | 确定胰岛素疗法相关的参数、预测葡萄糖值和提供胰岛素给药建议的医学布置和方法 |
| CN105758984B (zh) * | 2015-12-15 | 2017-07-14 | 中国药科大学 | 衍生化hplc‑dad法测定药物中小分子卤代羧酸的方法 |
| CN106979982B (zh) * | 2016-01-19 | 2021-01-05 | 上海市第六人民医院 | 一种用于糖尿病风险预测、治疗评价的方法及试剂盒 |
| CN105567852A (zh) * | 2016-02-29 | 2016-05-11 | 北京泱深生物信息技术有限公司 | Iqce基因及其表达产物在i型糖尿病诊断中的用途 |
| CN105567851A (zh) * | 2016-02-29 | 2016-05-11 | 北京泱深生物信息技术有限公司 | 一种与糖尿病相关的分子标志物 |
| US10783801B1 (en) | 2016-12-21 | 2020-09-22 | Aptima, Inc. | Simulation based training system for measurement of team cognitive load to automatically customize simulation content |
| US20200124612A1 (en) * | 2017-04-11 | 2020-04-23 | University Of Iowa Research Foundation | Detection of predictors of preeclampsia |
| TWI682330B (zh) * | 2018-05-15 | 2020-01-11 | 美爾敦股份有限公司 | 自學式資料分類系統及方法 |
| CN108760706B (zh) * | 2018-06-08 | 2021-08-06 | 农业部环境保护科研监测所 | 一种快速筛选镉低积累水稻品种的方法 |
| CN109065174B (zh) * | 2018-07-27 | 2022-02-18 | 合肥工业大学 | 考虑相似约束的病历主题获取方法及装置 |
| EP3837286A4 (en) | 2018-08-16 | 2022-08-10 | The Johns Hopkins University | ANTIBODIES TO HUMAN ZNT8 |
| CN109559013A (zh) * | 2018-10-18 | 2019-04-02 | 深圳壹账通智能科技有限公司 | 基于小游戏的风险测试方法及装置、电子设备及可读存储介质 |
| CA3118297A1 (en) * | 2018-10-31 | 2020-05-07 | Better Therapeutics, Inc. | Systems, methods, and apparatuses for managing data for artificial intelligence software and mobile applications in digital health therapeutics |
| CN111378734A (zh) * | 2018-12-28 | 2020-07-07 | 康多富国际有限公司 | 新陈代谢疾病保健食品组合确定方法及其可读存储介质 |
| KR102839365B1 (ko) * | 2019-01-08 | 2025-07-29 | 일루리아 엘티디. | 주의력 결핍 과잉행동 장애 모니터링의 진단 및 효율성 |
| CN110231335A (zh) * | 2019-06-18 | 2019-09-13 | 济南大学 | 一种基于铁蛋白三维结构免疫传感器的制备方法及应用 |
| US12366570B2 (en) | 2019-10-01 | 2025-07-22 | The Johns Hopkins University | Cell-based ZNT8 assay |
| US20210153787A1 (en) * | 2019-11-26 | 2021-05-27 | Dexcom, Inc. | Recommendations based on continuous glucose monitoring |
| CN112881689B (zh) * | 2019-11-29 | 2023-02-10 | 张曼 | 尿液凝血因子ix蛋白及其多肽片段在正常妊娠或妊娠糖尿病中的应用 |
| CN112924682B (zh) * | 2019-12-05 | 2023-02-10 | 张曼 | 尿液纤维蛋白原α链蛋白及其多肽片段在正常妊娠中的应用 |
| CN112924675B (zh) * | 2019-12-05 | 2023-01-13 | 张曼 | 尿液胰腺甘油三酯脂肪酶蛋白及其多肽片段在正常妊娠中的应用 |
| CN111297329B (zh) * | 2020-02-24 | 2023-05-12 | 苏州大学 | 预测糖尿病患者心血管并发症动态发病风险的方法及系统 |
| CN114487431A (zh) * | 2020-11-12 | 2022-05-13 | 首都医科大学附属北京世纪坛医院 | 尿液α-2-HS-糖蛋白及其多肽片段在妊娠糖尿病中的应用 |
| TWI775253B (zh) * | 2020-12-24 | 2022-08-21 | 宏碁股份有限公司 | 高風險用藥路徑的計算方法 |
| CN114048374A (zh) * | 2021-10-28 | 2022-02-15 | 盐城金堤科技有限公司 | 待推荐对象的确定方法以及待推荐对象的确定装置 |
| WO2023102204A1 (en) * | 2021-12-03 | 2023-06-08 | The Trustees Of Indiana University | Biomarker for type 1 diabetes |
| CN115006536A (zh) * | 2022-04-19 | 2022-09-06 | 上海交通大学医学院附属瑞金医院 | Sgk1作为靶点在制备抑制肝糖异生药物中的应用 |
| CN114609395B (zh) * | 2022-04-25 | 2024-03-29 | 李玉凤 | 一种预测或诊断糖尿病或糖尿病肾病患者中的早期动脉粥样硬化的应用 |
| CN116631578B (zh) * | 2023-07-25 | 2023-10-13 | 山东硕杰医疗科技有限公司 | 一种肺癌网络综合管理信息平台 |
| WO2025117310A1 (en) * | 2023-12-01 | 2025-06-05 | Mars, Incorporated | Diabetes prognosis in a feline |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006072654A1 (en) * | 2005-01-05 | 2006-07-13 | Oy Jurilab Ltd | Novel genes and markers associated to type 2 diabetes mellitus |
Family Cites Families (132)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4302386A (en) | 1978-08-25 | 1981-11-24 | The Ohio State University | Antigenic modification of polypeptides |
| US4105776A (en) | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
| CA1178414A (en) | 1978-02-08 | 1984-11-27 | Toyo Boseki Kabushiki Kaisha (Trading Under The Name Of Toyobo Co., Ltd.) | Packaging material having excellent seal packaging property |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| US4316906A (en) | 1978-08-11 | 1982-02-23 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of substituted prolines |
| IL58849A (en) | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4508729A (en) | 1979-12-07 | 1985-04-02 | Adir | Substituted iminodiacids, their preparation and pharmaceutical compositions containing them |
| US4444784A (en) | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| DK149080C (da) | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4344949A (en) | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| ZA817261B (en) | 1980-10-23 | 1982-09-29 | Schering Corp | Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them |
| US4337201A (en) | 1980-12-04 | 1982-06-29 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl substituted prolines |
| US4410520A (en) | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| GB2128984B (en) | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
| US4659678A (en) | 1982-09-29 | 1987-04-21 | Serono Diagnostics Limited | Immunoassay of antigens |
| US4739073A (en) | 1983-11-04 | 1988-04-19 | Sandoz Pharmaceuticals Corp. | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof |
| US4727022A (en) | 1984-03-14 | 1988-02-23 | Syntex (U.S.A.) Inc. | Methods for modulating ligand-receptor interactions and their application |
| US4780401A (en) | 1984-04-09 | 1988-10-25 | Ciba-Geigy Corporation | Novel monoclonal antibodies to human renin and hybridoma cells, processes for their preparation and their applications |
| US4845079A (en) | 1985-01-23 | 1989-07-04 | Luly Jay R | Peptidylaminodiols |
| US5066643A (en) | 1985-02-19 | 1991-11-19 | Sandoz Ltd. | Fluorine and chlorine statine or statone containing peptides and method of use |
| US4894437A (en) | 1985-11-15 | 1990-01-16 | The Upjohn Company | Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties |
| US4885292A (en) | 1986-02-03 | 1989-12-05 | E. R. Squibb & Sons, Inc. | N-heterocyclic alcohol renin inhibitors |
| US4816463A (en) | 1986-04-01 | 1989-03-28 | Warner-Lambert Company | Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity |
| US4940727A (en) | 1986-06-23 | 1990-07-10 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| US5116870A (en) | 1986-06-23 | 1992-05-26 | Merck & Co., Inc. | HMG-CoA reductase inhibitors |
| CA1334092C (en) | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| US5018067A (en) | 1987-01-12 | 1991-05-21 | Iameter Incorporated | Apparatus and method for improved estimation of health resource consumption through use of diagnostic and/or procedure grouping and severity of illness indicators |
| US4772684A (en) | 1987-01-20 | 1988-09-20 | Triton Biosciences, Inc. | Peptides affecting blood pressure regulation |
| US5017716A (en) | 1987-05-22 | 1991-05-21 | E.R. Squibb & Sons, Inc. | Phosphorous-containing HMG-CoA reductase inhibitors, new intermediates and method |
| US5091378A (en) | 1987-05-22 | 1992-02-25 | E. R. Squibb & Sons, Inc. | Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method |
| US4904646A (en) | 1987-05-22 | 1990-02-27 | E. R. Squibb & Sons, Inc. | Phosphorus-containing HMG-COA reductase inhibitors |
| US4997837A (en) | 1987-09-08 | 1991-03-05 | Warner-Lambert Company | 6-(((substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
| US4906624A (en) | 1987-09-08 | 1990-03-06 | Warner-Lambert Company | 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
| US5089471A (en) | 1987-10-01 | 1992-02-18 | G. D. Searle & Co. | Peptidyl beta-aminoacyl aminodiol carbamates as anti-hypertensive agents |
| US4980283A (en) | 1987-10-01 | 1990-12-25 | Merck & Co., Inc. | Renin-inhibitory pepstatin phenyl derivatives |
| US5034512A (en) | 1987-10-22 | 1991-07-23 | Warner-Lambert Company | Branched backbone renin inhibitors |
| US5063207A (en) | 1987-10-26 | 1991-11-05 | Warner-Lambert Company | Renin inhibitors, method for using them, and compositions containing them |
| US5055466A (en) | 1987-11-23 | 1991-10-08 | E. R. Squibb & Sons, Inc. | N-morpholino derivatives and their use as anti-hypertensive agents |
| US4929620A (en) | 1987-12-10 | 1990-05-29 | Warner-Lambert Company | 5-pyrimidinyl-3,5-dihydroxy-6-heptenoic acid compounds useful as inhibitors of cholesterol biosynthesis |
| US4939143A (en) | 1987-12-21 | 1990-07-03 | Rorer Pharmaceutical Corporation | Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors |
| US5001128A (en) | 1987-12-21 | 1991-03-19 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | HMG-COA reductase inhibitors |
| US4994494A (en) | 1987-12-21 | 1991-02-19 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | HMG-COA reductase inhibitors |
| US5001144A (en) | 1987-12-21 | 1991-03-19 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors |
| US4900754A (en) | 1987-12-21 | 1990-02-13 | Rorer Pharmaceutical Corp. | HMG-COA reductase inhibitors |
| US5081127A (en) | 1988-01-07 | 1992-01-14 | E. I. Du Pont De Nemours And Company | Substituted 1,2,3-triazole angiotensin II antagonists |
| US4946864A (en) | 1988-02-01 | 1990-08-07 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| US5036054A (en) | 1988-02-11 | 1991-07-30 | Warner-Lambert Company | Renin inhibitors containing alpha-heteroatom amino acids |
| US5021453A (en) | 1988-03-02 | 1991-06-04 | Merck & Co., Inc. | 3-keto HMG-CoA reductase inhibitors |
| EP0331250B1 (en) | 1988-03-02 | 1994-04-13 | Merck & Co. Inc. | Antihypercholesterolemic agents |
| US4920109A (en) | 1988-04-18 | 1990-04-24 | Merck & Co., Inc. | Antifungal compositions and method of controlling mycotic infections |
| US5166171A (en) | 1988-05-13 | 1992-11-24 | Hoechst Aktiengesellschaft | 6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, and in treating hypercholesterolemia |
| US5036053A (en) | 1988-05-27 | 1991-07-30 | Warner-Lambert Company | Diol-containing renin inhibitors |
| US4963538A (en) | 1988-06-29 | 1990-10-16 | Merck & Co., Inc. | 5-oxygenated HMG-CoA reductase inhibitors |
| US4897402A (en) | 1988-06-29 | 1990-01-30 | Merck & Co., Inc. | 5-oxa, 5-thia, 5-aza HmG-CoA reductase inhibitors |
| IT1226726B (it) | 1988-07-29 | 1991-02-05 | Zambon Spa | Composti attivi come inibitori della biosintesi del colesterolo. |
| US5196440A (en) | 1988-07-29 | 1993-03-23 | Zambon Group S.P.A. | Compounds active as inhibitors of the cholesterol biosynthesis |
| DE3832570A1 (de) | 1988-09-24 | 1990-03-29 | Hoechst Ag | 7-substituierte derivate der 3,5-dihydroxyhept-6-insaeure, verfahren zur ihrer herstellung, ihre verwendung als arzneimittel, sowie zwischenprodukte |
| DE3841520A1 (de) | 1988-12-09 | 1990-06-13 | Hoechst Ag | Enzymhemmende harnstoffderivate von dipeptiden, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
| US4950675A (en) | 1988-12-21 | 1990-08-21 | Warner-Lambert Company | Pyridine di-mevalono-lactones as inhibitors of cholesterol biosynthesis |
| US4906657A (en) | 1988-12-21 | 1990-03-06 | Warner-Lambert Company | Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis |
| US4957940A (en) | 1988-12-21 | 1990-09-18 | Warner-Lambert Company | Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis |
| US5106835A (en) | 1988-12-27 | 1992-04-21 | American Cyanamid Company | Renin inhibitors |
| US4923861A (en) | 1989-02-07 | 1990-05-08 | Warner-Lambert Company | 6-(2-(2-(Substituted amino)-3-quinolinyl) ethenyl and ethyl) tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
| US5130306A (en) | 1989-03-13 | 1992-07-14 | Merck & Co., Inc. | 5-Oxygenated HMG-COA reductase inhibitors |
| US5132312A (en) | 1989-03-27 | 1992-07-21 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors |
| DE4004820A1 (de) | 1989-08-05 | 1991-04-25 | Bayer Ag | Renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln |
| US5064825A (en) | 1989-06-01 | 1991-11-12 | Merck & Co., Inc. | Angiotensin ii antagonists |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5102911A (en) | 1989-06-09 | 1992-04-07 | Merck & Co, Inc. | 4-Substituted HMG-CoA reductase inhibitors |
| US4970231A (en) | 1989-06-09 | 1990-11-13 | Merck & Co., Inc. | 4-substituted HMG-CoA reductase inhibitors |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5063208A (en) | 1989-07-26 | 1991-11-05 | Abbott Laboratories | Peptidyl aminodiol renin inhibitors |
| US4992429A (en) | 1989-08-24 | 1991-02-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Novel HMG-COA reductase inhibitors |
| US5098931A (en) | 1989-08-31 | 1992-03-24 | Merck & Co., Inc. | 7-substituted HMG-CoA reductase inhibitors |
| US5098924A (en) | 1989-09-15 | 1992-03-24 | E. R. Squibb & Sons, Inc. | Diol sulfonamide and sulfinyl renin inhibitors |
| US5104869A (en) | 1989-10-11 | 1992-04-14 | American Cyanamid Company | Renin inhibitors |
| US4946860A (en) | 1989-11-03 | 1990-08-07 | Rorer Pharmaceutical Corporation | Benzothiopyranyl derivatives as HMG-CoA reductase inhibitors |
| US5114937A (en) | 1989-11-28 | 1992-05-19 | Warner-Lambert Company | Renin inhibiting nonpeptides |
| US5073566A (en) | 1989-11-30 | 1991-12-17 | Eli Lilly And Company | Angiotensin ii antagonist 1,3-imidazoles and use thereas |
| IT1237793B (it) | 1989-12-21 | 1993-06-17 | Zambon Spa | Composti attivi come inibitori dell'enzima hmg-coa reduttasi |
| US5025000A (en) | 1990-03-02 | 1991-06-18 | E. R. Squibb & Sons, Inc. | Phosphorus-containing HMG-CoA reductase inhibitor compounds |
| US5064965A (en) | 1990-03-08 | 1991-11-12 | American Home Products Corporation | Renin inhibitors |
| US5075451A (en) | 1990-03-08 | 1991-12-24 | American Home Products Corporation | Pyrrolimidazolones useful as renin inhibitors |
| US5095119A (en) | 1990-03-08 | 1992-03-10 | American Home Products Corporation | Renin inhibitors |
| US5622985A (en) | 1990-06-11 | 1997-04-22 | Bristol-Myers Squibb Company | Method for preventing a second heart attack employing an HMG CoA reductase inhibitor |
| US5085992A (en) | 1990-07-19 | 1992-02-04 | Merck & Co., Inc. | Microbial transformation process for antihypertensive products |
| US5112857A (en) | 1990-09-04 | 1992-05-12 | Merck & Co., Inc. | Hmg-coa reductase inhibitor metabolites |
| US5087634A (en) | 1990-10-31 | 1992-02-11 | G. D. Searle & Co. | N-substituted imidazol-2-one compounds for treatment of circulatory disorders |
| US5071837A (en) | 1990-11-28 | 1991-12-10 | Warner-Lambert Company | Novel renin inhibiting peptides |
| US5182298A (en) | 1991-03-18 | 1993-01-26 | Merck & Co., Inc. | Cholesterol lowering agents |
| US5256689A (en) | 1991-05-10 | 1993-10-26 | Merck & Co., Inc. | Cholesterol lowering compounds |
| US5135935A (en) | 1991-05-17 | 1992-08-04 | Merck & Co., Inc. | Squalene synthetase inhibitors |
| US5250435A (en) | 1991-06-04 | 1993-10-05 | Merck & Co., Inc. | Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I) |
| US5202327A (en) | 1991-07-10 | 1993-04-13 | E. R. Squibb & Sons, Inc. | Phosphorus-containing hmg-coa reductase inhibitors |
| HU9203780D0 (en) | 1991-12-12 | 1993-03-29 | Sandoz Ag | Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them |
| US5260332A (en) | 1992-02-07 | 1993-11-09 | Merci & Co., Inc. | Cholesterol lowering compounds |
| US5262435A (en) | 1992-02-10 | 1993-11-16 | Merck & Co., Inc. | Cholesterol lowering compounds |
| US5286895A (en) | 1992-02-19 | 1994-02-15 | Merck & Co., Inc. | Cholesterol lowering compounds |
| US5302604A (en) | 1992-03-09 | 1994-04-12 | Merck & Co., Inc. | Cholesterol lowering compounds produced by directed biosynthesis |
| US5369125A (en) | 1992-07-17 | 1994-11-29 | Merck & Co., Inc. | Cholesterol-lowering agents |
| US5283256A (en) | 1992-07-22 | 1994-02-01 | Merck & Co., Inc. | Cholesterol-lowering agents |
| US5317031A (en) | 1992-10-19 | 1994-05-31 | Merck & Co., Inc. | Cholesterol lowering compounds |
| US5604260A (en) | 1992-12-11 | 1997-02-18 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
| US5543297A (en) | 1992-12-22 | 1996-08-06 | Merck Frosst Canada, Inc. | Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity |
| US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| GB9602877D0 (en) | 1996-02-13 | 1996-04-10 | Merck Frosst Canada Inc | 3,4-Diaryl-2-hydroxy-2,5- dihydrofurans as prodrugs to cox-2 inhibitors |
| WO1995018799A1 (en) | 1994-01-10 | 1995-07-13 | Merck Frosst Canada Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5521213A (en) | 1994-08-29 | 1996-05-28 | Merck Frosst Canada, Inc. | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 |
| JPH10507765A (ja) | 1994-10-27 | 1998-07-28 | メルク フロスト カナダ インコーポレーテツド | シクロオキシゲナーゼ−2阻害剤として有用なスチルベン誘導体 |
| US5552422A (en) | 1995-01-11 | 1996-09-03 | Merck Frosst Canada, Inc. | Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents |
| US5691374A (en) | 1995-05-18 | 1997-11-25 | Merck Frosst Canada Inc. | Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors |
| US5604253A (en) | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
| US5639780A (en) | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
| US5643933A (en) | 1995-06-02 | 1997-07-01 | G. D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
| US5733909A (en) | 1996-02-01 | 1998-03-31 | Merck Frosst Canada, Inc. | Diphenyl stilbenes as prodrugs to COX-2 inhibitors |
| US5789413A (en) | 1996-02-01 | 1998-08-04 | Merck Frosst Canada, Inc. | Alkylated styrenes as prodrugs to COX-2 inhibitors |
| GB9607503D0 (en) | 1996-04-11 | 1996-06-12 | Merck Frosst Canada Inc | Bisaryl cyclobutenes derivatives as cyclooxygenase inhibitors |
| US5922742A (en) | 1996-04-23 | 1999-07-13 | Merck Frosst Canada | Pyridinyl-2-cyclopenten-1-ones as selective cyclooxygenase-2 inhibitors |
| US5677318A (en) | 1996-07-11 | 1997-10-14 | Merck Frosst Canada, Inc. | Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents |
| US5861419A (en) | 1996-07-18 | 1999-01-19 | Merck Frosst Canad, Inc. | Substituted pyridines as selective cyclooxygenase-2 inhibitors |
| US20020038227A1 (en) | 2000-02-25 | 2002-03-28 | Fey Christopher T. | Method for centralized health data management |
| AU2002230848B2 (en) | 2000-12-14 | 2008-01-24 | The Brigham And Women's Hospital, Inc. | Inflammatory markers for detection and prevention of diabetes mellitus |
| US20040122296A1 (en) | 2002-12-18 | 2004-06-24 | John Hatlestad | Advanced patient management for triaging health-related data |
| US7468032B2 (en) | 2002-12-18 | 2008-12-23 | Cardiac Pacemakers, Inc. | Advanced patient management for identifying, displaying and assisting with correlating health-related data |
| US20040121305A1 (en) | 2002-12-18 | 2004-06-24 | Wiegand Roger Charles | Generation of efficacy, toxicity and disease signatures and methods of use thereof |
| WO2004088309A2 (en) | 2003-03-28 | 2004-10-14 | Cantata Laboratories, Inc. | Methods for diagnosing urinary tract and prostatic disorders |
| US20070218519A1 (en) * | 2005-10-11 | 2007-09-20 | Tethys Bioscience, Inc. | Diabetes-associated markers and methods of use thereof |
| US20070259377A1 (en) | 2005-10-11 | 2007-11-08 | Mickey Urdea | Diabetes-associated markers and methods of use thereof |
| EP2407562A1 (en) * | 2006-05-08 | 2012-01-18 | Tethys Bioscience, Inc. | Systems and methods for developing diagnostic tests based on biomarker information from legacy clinical sample sets |
-
2008
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- 2008-04-18 JP JP2010504273A patent/JP5271350B2/ja not_active Expired - Fee Related
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006072654A1 (en) * | 2005-01-05 | 2006-07-13 | Oy Jurilab Ltd | Novel genes and markers associated to type 2 diabetes mellitus |
Non-Patent Citations (1)
| Title |
|---|
| BAYES, B. et al. American Journal of Transplantation 2007, vol. 7, pages 416-422 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023084199A1 (en) * | 2021-11-09 | 2023-05-19 | Randox Laboratories Ltd. | Biomarkers of hidden obesity for use in preventative healthcare |
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| AU2008242764A1 (en) | 2008-10-30 |
| ES2434215T3 (es) | 2013-12-16 |
| EP2147315B1 (en) | 2013-06-26 |
| JP2013079981A (ja) | 2013-05-02 |
| TW200849035A (en) | 2008-12-16 |
| WO2008131224A3 (en) | 2009-01-15 |
| EP2891885A2 (en) | 2015-07-08 |
| EP2891885A3 (en) | 2015-10-14 |
| CA2684308A1 (en) | 2008-10-30 |
| JP5271350B2 (ja) | 2013-08-21 |
| EP2541254A3 (en) | 2013-03-13 |
| EP2541254A2 (en) | 2013-01-02 |
| DK2147315T3 (da) | 2013-09-23 |
| CN102317786A (zh) | 2012-01-11 |
| JP2010525332A (ja) | 2010-07-22 |
| EP2541254B1 (en) | 2014-11-12 |
| BRPI0810409A2 (pt) | 2015-02-18 |
| EP2147315A2 (en) | 2010-01-27 |
| WO2008131224A2 (en) | 2008-10-30 |
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