AU2008239683B2 - Melatonin tablet and methods of preparation and use - Google Patents

Melatonin tablet and methods of preparation and use Download PDF

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Publication number
AU2008239683B2
AU2008239683B2 AU2008239683A AU2008239683A AU2008239683B2 AU 2008239683 B2 AU2008239683 B2 AU 2008239683B2 AU 2008239683 A AU2008239683 A AU 2008239683A AU 2008239683 A AU2008239683 A AU 2008239683A AU 2008239683 B2 AU2008239683 B2 AU 2008239683B2
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AU
Australia
Prior art keywords
dosage form
melatonin
hormone
pharmaceutically acceptable
form according
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AU2008239683A
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English (en)
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AU2008239683A1 (en
Inventor
John A. Mccarty
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PHARMACEUTICALS PRODUCTIONS Inc
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PHARMACEUTICALS PRODUCTIONS Inc
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Publication of AU2008239683A1 publication Critical patent/AU2008239683A1/en
Assigned to PHARMACEUTICALS PRODUCTIONS INC reassignment PHARMACEUTICALS PRODUCTIONS INC Request for Assignment Assignors: MCCARTY, JOHN
Application granted granted Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2008239683A 2007-04-11 2008-04-10 Melatonin tablet and methods of preparation and use Active AU2008239683B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92292107P 2007-04-11 2007-04-11
US60/922,921 2007-04-11
PCT/US2008/004615 WO2008127609A1 (en) 2007-04-11 2008-04-10 Melatonin tablet and methods of preparation and use

Publications (2)

Publication Number Publication Date
AU2008239683A1 AU2008239683A1 (en) 2008-10-23
AU2008239683B2 true AU2008239683B2 (en) 2014-03-27

Family

ID=39864239

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008239683A Active AU2008239683B2 (en) 2007-04-11 2008-04-10 Melatonin tablet and methods of preparation and use

Country Status (11)

Country Link
US (3) US20100119601A1 (https=)
EP (2) EP2144610B1 (https=)
JP (2) JP5600058B2 (https=)
CN (1) CN101677994B (https=)
AU (1) AU2008239683B2 (https=)
CA (1) CA2683436C (https=)
ES (1) ES2575549T3 (https=)
IL (2) IL201383A (https=)
MX (1) MX2009010878A (https=)
RU (1) RU2485949C2 (https=)
WO (1) WO2008127609A1 (https=)

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US10172810B2 (en) * 2003-02-24 2019-01-08 Pharmaceutical Productions, Inc. Transmucosal ketamine delivery composition
ES2575549T3 (es) * 2007-04-11 2016-06-29 John A. Mccarty Comprimido de melatonina y métodos de preparación y uso
TR200907338A1 (tr) * 2009-09-28 2011-04-21 Yed�Tepe �N�Vers�Tes� Doğal bileşenler içeren bir film şeridi.
CN103429223A (zh) 2011-01-17 2013-12-04 武田药品工业株式会社 口腔分散片
WO2012103411A2 (en) 2011-01-28 2012-08-02 Zx Pharma, Llc Controlled-release melatonin composition and related methods
US9532952B2 (en) 2011-01-28 2017-01-03 Physician's Seal, LLC Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients
WO2012109216A1 (en) 2011-02-11 2012-08-16 Zx Pharma, Llc Multiparticulate l-menthol formulations and related methods
US8808736B2 (en) 2011-02-11 2014-08-19 Zx Pharma, Llc Enteric coated multiparticulate controlled release peppermint oil composition and related methods
US8911780B2 (en) 2011-02-11 2014-12-16 Zx Pharma, Llc Multiparticulate L-menthol formulations and related methods
EP2570126B1 (en) * 2011-09-16 2014-03-26 Darius Rassoulian Use of melatonin for treating acute alcohol intoxication
ITMI20112042A1 (it) * 2011-11-10 2013-05-11 Eratech S R L Polvere da ricostituire prima dell'uso comprendente melatonina e preparazione iniettabile ottenibile da tale polvere.
RU2488388C1 (ru) 2012-05-24 2013-07-27 Ооо "Валента Интеллект" Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств
UA107653U (uk) 2012-10-01 2016-06-24 Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" Композиція лікарських засобів для лікування та профілактики поведінкових, психічних та когнітивних розладів
CN113842362A (zh) 2012-11-14 2021-12-28 格雷斯公司 含有生物活性材料与无序无机氧化物的组合物
US20140303128A1 (en) * 2013-03-14 2014-10-09 Pharmaceutical Productions Inc. Transmucosal hormone delivery system
CA2909591C (en) 2013-04-23 2017-03-28 Zx Pharma, Llc Enteric coated multiparticulate composition with proteinaceous subcoat
ES2995732T3 (en) 2014-07-21 2025-02-11 Pharmaceutical Productions Inc Solid dosage form composition for buccal or sublingual administration of cannabinoids
CN105663061A (zh) * 2014-11-16 2016-06-15 刘佳迪 褪黑素滴丸的制法和用法
NL2015272B1 (en) * 2015-08-05 2017-05-02 Versailles B V Melatonin formulations and methods for preparation and use.
WO2018167273A1 (en) * 2017-03-16 2018-09-20 Repoceuticals Aps Compositions for retarding the decomposition of melatonin in solution
US10806789B2 (en) 2017-05-12 2020-10-20 The LIV Group Inc. Composition for enhanced absorption of supplements
BR112019027286B1 (pt) 2017-06-20 2022-02-22 Société Des Produits Nestlé S.A Composição de dissolução oral de melatonina com agente acidificante que torna melatonina solúvel em saliva
WO2019038586A1 (en) 2017-08-19 2019-02-28 Ftf Pharma Private Limited PHARMACEUTICAL COMPOSITION OF MELATONIN
CN109953953B (zh) * 2017-12-22 2021-09-21 深圳大学 一种褪黑素纳米缓释给药系统的制备方法
CN111757728A (zh) * 2018-03-11 2020-10-09 纳诺洛吉卡股份公司 用于压缩的药物剂型的多孔二氧化硅颗粒
WO2021205053A1 (es) * 2020-04-09 2021-10-14 Universidad De Granada Composición inyectable de melatonina para el tratamiento de enfermedades virales
KR102506059B1 (ko) * 2020-10-20 2023-03-07 코스맥스 주식회사 멜라토닌을 포함하는 항산화용 화장료 조성물
CN112426408B (zh) * 2020-12-08 2023-12-19 广州帝奇医药技术有限公司 一种褪黑素组合物及其制备工艺
CN112870193B (zh) * 2021-03-11 2022-07-08 大连医科大学附属第二医院 褪黑素在制备治疗对靶向药物耐药的her2阳性乳腺癌的药物中的应用
JP2025119064A (ja) * 2022-04-28 2025-08-14 日本たばこ産業株式会社 無機多孔質材料を含む口腔用組成物
JP2025119063A (ja) * 2022-04-28 2025-08-14 日本たばこ産業株式会社 無機多孔質材料を含む口腔用組成物
JP2025119061A (ja) * 2022-04-28 2025-08-14 日本たばこ産業株式会社 無機多孔質材料を含む口腔用組成物
JP2025119062A (ja) * 2022-04-28 2025-08-14 日本たばこ産業株式会社 無機多孔質材料を含む口腔用組成物

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US5688520A (en) * 1995-03-29 1997-11-18 Minnesota Mining And Manufacturing Company Transmucosal delivery of melatonin for prevention of migraine
US20030023559A1 (en) * 2001-07-30 2003-01-30 Jong-Uk Choi Method for securing digital information and system therefor

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US5688520A (en) * 1995-03-29 1997-11-18 Minnesota Mining And Manufacturing Company Transmucosal delivery of melatonin for prevention of migraine
US20030023559A1 (en) * 2001-07-30 2003-01-30 Jong-Uk Choi Method for securing digital information and system therefor

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Also Published As

Publication number Publication date
IL201383A (en) 2017-01-31
EP2144610B1 (en) 2016-04-06
RU2485949C2 (ru) 2013-06-27
RU2009137472A (ru) 2011-05-20
JP2010523673A (ja) 2010-07-15
JP5600058B2 (ja) 2014-10-01
IL201383A0 (en) 2010-05-31
US9381190B2 (en) 2016-07-05
EP2144610A4 (en) 2013-08-07
US20130028943A1 (en) 2013-01-31
CA2683436C (en) 2016-07-26
EP3056220A1 (en) 2016-08-17
AU2008239683A1 (en) 2008-10-23
EP2144610A1 (en) 2010-01-20
CA2683436A1 (en) 2008-10-23
US8992948B2 (en) 2015-03-31
JP2014237700A (ja) 2014-12-18
CN101677994A (zh) 2010-03-24
US20150174101A1 (en) 2015-06-25
CN101677994B (zh) 2015-07-22
ES2575549T3 (es) 2016-06-29
IL249102A0 (en) 2017-01-31
US20100119601A1 (en) 2010-05-13
MX2009010878A (es) 2010-03-26
WO2008127609A1 (en) 2008-10-23

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PC1 Assignment before grant (sect. 113)

Owner name: PHARMACEUTICALS PRODUCTIONS INC

Free format text: FORMER APPLICANT(S): MCCARTY, JOHN

FGA Letters patent sealed or granted (standard patent)