AU2008211172A1 - 1-H-pyrazolo(3,4B)pyrimidine derivatives and their use as modulators of mitotic kinases - Google Patents
1-H-pyrazolo(3,4B)pyrimidine derivatives and their use as modulators of mitotic kinases Download PDFInfo
- Publication number
- AU2008211172A1 AU2008211172A1 AU2008211172A AU2008211172A AU2008211172A1 AU 2008211172 A1 AU2008211172 A1 AU 2008211172A1 AU 2008211172 A AU2008211172 A AU 2008211172A AU 2008211172 A AU2008211172 A AU 2008211172A AU 2008211172 A1 AU2008211172 A1 AU 2008211172A1
- Authority
- AU
- Australia
- Prior art keywords
- pyrazolo
- pyrimidin
- phenyl
- dihydro
- ylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108091000080 Phosphotransferase Proteins 0.000 title description 16
- 102000020233 phosphotransferase Human genes 0.000 title description 16
- 230000000394 mitotic effect Effects 0.000 title description 12
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 268
- -1 amino, hydroxy Chemical group 0.000 claims description 261
- 125000001072 heteroaryl group Chemical group 0.000 claims description 155
- 125000003118 aryl group Chemical group 0.000 claims description 153
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 147
- 125000000217 alkyl group Chemical group 0.000 claims description 137
- 238000000034 method Methods 0.000 claims description 110
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 90
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 89
- 125000001424 substituent group Chemical group 0.000 claims description 75
- 229910052739 hydrogen Inorganic materials 0.000 claims description 73
- 239000001257 hydrogen Substances 0.000 claims description 73
- 150000002431 hydrogen Chemical class 0.000 claims description 53
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 48
- 206010028980 Neoplasm Diseases 0.000 claims description 40
- 125000004475 heteroaralkyl group Chemical group 0.000 claims description 39
- 125000003342 alkenyl group Chemical group 0.000 claims description 37
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 37
- 125000000304 alkynyl group Chemical group 0.000 claims description 34
- 125000005843 halogen group Chemical group 0.000 claims description 28
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 28
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims description 27
- 125000003545 alkoxy group Chemical group 0.000 claims description 24
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims description 21
- SMXRCJBCWRHDJE-UHFFFAOYSA-N 7-deaza-8-aza-2-aminopurine Chemical compound NC1=NC=C2C=NNC2=N1 SMXRCJBCWRHDJE-UHFFFAOYSA-N 0.000 claims description 20
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 20
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 20
- 239000005711 Benzoic acid Substances 0.000 claims description 18
- 229960004365 benzoic acid Drugs 0.000 claims description 18
- 125000006413 ring segment Chemical group 0.000 claims description 18
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims description 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 17
- 235000010233 benzoic acid Nutrition 0.000 claims description 16
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims description 15
- 201000011510 cancer Diseases 0.000 claims description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 15
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 15
- 125000004429 atom Chemical group 0.000 claims description 14
- 125000004639 dihydroindenyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims description 14
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 13
- 230000002401 inhibitory effect Effects 0.000 claims description 13
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims description 13
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 12
- 101000582926 Dictyostelium discoideum Probable serine/threonine-protein kinase PLK Proteins 0.000 claims description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 230000011278 mitosis Effects 0.000 claims description 12
- 125000001624 naphthyl group Chemical group 0.000 claims description 12
- 102000003989 Aurora kinases Human genes 0.000 claims description 11
- 108090000433 Aurora kinases Proteins 0.000 claims description 11
- 201000010099 disease Diseases 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 11
- CBCKQZAAMUWICA-UHFFFAOYSA-N 1,4-phenylenediamine Chemical compound NC1=CC=C(N)C=C1 CBCKQZAAMUWICA-UHFFFAOYSA-N 0.000 claims description 10
- 150000001412 amines Chemical class 0.000 claims description 10
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 10
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 10
- 125000003831 tetrazolyl group Chemical group 0.000 claims description 9
- 125000004001 thioalkyl group Chemical group 0.000 claims description 9
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims description 8
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 8
- 125000004193 piperazinyl group Chemical group 0.000 claims description 8
- 102000001253 Protein Kinase Human genes 0.000 claims description 7
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims description 7
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 7
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 7
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 7
- 229940002612 prodrug Drugs 0.000 claims description 7
- 239000000651 prodrug Substances 0.000 claims description 7
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 7
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 6
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 claims description 6
- BSCCSDNZEIHXOK-UHFFFAOYSA-N phenyl carbamate Chemical compound NC(=O)OC1=CC=CC=C1 BSCCSDNZEIHXOK-UHFFFAOYSA-N 0.000 claims description 6
- 108060006633 protein kinase Proteins 0.000 claims description 6
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 6
- 206010006187 Breast cancer Diseases 0.000 claims description 5
- 208000026310 Breast neoplasm Diseases 0.000 claims description 5
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 5
- 229940050390 benzoate Drugs 0.000 claims description 5
- UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 claims description 5
- 125000001041 indolyl group Chemical group 0.000 claims description 5
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims description 4
- 208000032839 leukemia Diseases 0.000 claims description 4
- REVKUCDZNKPRTC-UHFFFAOYSA-N n-methyl-n-[4-[(1-naphthalen-1-ylpyrazolo[3,4-d]pyrimidin-6-yl)amino]phenyl]methanesulfonamide Chemical compound C1=CC(N(C)S(C)(=O)=O)=CC=C1NC1=NC=C(C=NN2C=3C4=CC=CC=C4C=CC=3)C2=N1 REVKUCDZNKPRTC-UHFFFAOYSA-N 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 125000001792 phenanthrenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C=CC12)* 0.000 claims description 4
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 claims description 3
- YWWDYBTVVGBFFA-UHFFFAOYSA-N 4-[[1-(2,3-dihydro-1h-inden-1-yl)pyrazolo[3,4-d]pyrimidin-6-yl]amino]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1NC1=NC=C(C=NN2C3C4=CC=CC=C4CC3)C2=N1 YWWDYBTVVGBFFA-UHFFFAOYSA-N 0.000 claims description 3
- 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims description 3
- SKGSQBQCAXCKMQ-UHFFFAOYSA-N 4-n-(1-naphthalen-1-ylpyrazolo[3,4-d]pyrimidin-6-yl)benzene-1,4-diamine Chemical compound C1=CC(N)=CC=C1NC1=NC=C(C=NN2C=3C4=CC=CC=C4C=CC=3)C2=N1 SKGSQBQCAXCKMQ-UHFFFAOYSA-N 0.000 claims description 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 3
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 claims description 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 3
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 3
- 150000001204 N-oxides Chemical class 0.000 claims description 3
- WARCRYXKINZHGQ-UHFFFAOYSA-N benzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1 WARCRYXKINZHGQ-UHFFFAOYSA-N 0.000 claims description 3
- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 claims description 3
- 201000005202 lung cancer Diseases 0.000 claims description 3
- 208000020816 lung neoplasm Diseases 0.000 claims description 3
- 208000029559 malignant endocrine neoplasm Diseases 0.000 claims description 3
- 230000001404 mediated effect Effects 0.000 claims description 3
- SMIKNYWLKWJEOC-UHFFFAOYSA-N n-[4-[(1-phenanthren-4-ylpyrazolo[3,4-d]pyrimidin-6-yl)amino]phenyl]methanesulfonamide Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1NC1=NC=C(C=NN2C=3C4=C5C=CC=CC5=CC=C4C=CC=3)C2=N1 SMIKNYWLKWJEOC-UHFFFAOYSA-N 0.000 claims description 3
- GOSVAUXUVQRGFY-UHFFFAOYSA-N 1-(1,2-dihydroacenaphthylen-1-yl)-n-[4-(4-methylpiperazin-1-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-amine Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C(C=NN2C3C=4C=CC=C5C=CC=C(C=45)C3)C2=N1 GOSVAUXUVQRGFY-UHFFFAOYSA-N 0.000 claims description 2
- JDETXPDWBDCORH-UHFFFAOYSA-N 1-(2,3-dihydro-1h-inden-1-yl)-n-[4-(4-propylsulfonylpiperazin-1-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-amine Chemical compound C1CN(S(=O)(=O)CCC)CCN1C(C=C1)=CC=C1NC1=NC=C(C=NN2C3C4=CC=CC=C4CC3)C2=N1 JDETXPDWBDCORH-UHFFFAOYSA-N 0.000 claims description 2
- CMZPOHZDPDVHJR-UHFFFAOYSA-N 1-(2,3-dihydro-1h-inden-1-yl)-n-[4-[4-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]piperazin-1-yl]phenyl]pyrazolo[3,4-d]pyrimidin-6-amine Chemical compound COC1=C(C)C=NC(CN2CCN(CC2)C=2C=CC(NC=3N=C4N(C5C6=CC=CC=C6CC5)N=CC4=CN=3)=CC=2)=C1C CMZPOHZDPDVHJR-UHFFFAOYSA-N 0.000 claims description 2
- YVDUPENJMTVWOZ-HXUWFJFHSA-N 1-[(1r)-1,2-dihydroacenaphthylen-1-yl]-n-[4-(2h-tetrazol-5-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-amine Chemical compound N1=C2N([C@@H]3CC=4C=CC=C5C=CC=C3C=45)N=CC2=CN=C1NC(C=C1)=CC=C1C1=NN=NN1 YVDUPENJMTVWOZ-HXUWFJFHSA-N 0.000 claims description 2
- YVDUPENJMTVWOZ-FQEVSTJZSA-N 1-[(1s)-1,2-dihydroacenaphthylen-1-yl]-n-[4-(2h-tetrazol-5-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-amine Chemical compound N1=C2N([C@H]3CC=4C=CC=C5C=CC=C3C=45)N=CC2=CN=C1NC(C=C1)=CC=C1C1=NN=NN1 YVDUPENJMTVWOZ-FQEVSTJZSA-N 0.000 claims description 2
- CSHMUOIYRRXBTL-URLMMPGGSA-N 1-[(1s)-2,3-dihydro-1h-inden-1-yl]-n-[3-[1-[(1r)-2,3-dihydro-1h-inden-1-yl]pyrazolo[3,4-d]pyrimidin-6-yl]oxy-4-methoxyphenyl]pyrazolo[3,4-d]pyrimidin-6-amine Chemical compound C1CC2=CC=CC=C2[C@@H]1N(C1=N2)N=CC1=CN=C2OC1=CC(NC=2N=C3N([C@@H]4C5=CC=CC=C5CC4)N=CC3=CN=2)=CC=C1OC CSHMUOIYRRXBTL-URLMMPGGSA-N 0.000 claims description 2
- DVEWUYYKNPUDCY-QHCPKHFHSA-N 1-[(1s)-2,3-dihydro-1h-inden-1-yl]-n-[4-(4-methylpiperazin-1-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-amine Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C(C=NN2[C@@H]3C4=CC=CC=C4CC3)C2=N1 DVEWUYYKNPUDCY-QHCPKHFHSA-N 0.000 claims description 2
- GNLYDYBTNQWAIR-QHCPKHFHSA-N 1-[(1s)-2,3-dihydro-1h-inden-1-yl]-n-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-amine Chemical compound C1CN(S(=O)(=O)C)CCN1C(C=C1)=CC=C1NC1=NC=C(C=NN2[C@@H]3C4=CC=CC=C4CC3)C2=N1 GNLYDYBTNQWAIR-QHCPKHFHSA-N 0.000 claims description 2
- JDETXPDWBDCORH-VWLOTQADSA-N 1-[(1s)-2,3-dihydro-1h-inden-1-yl]-n-[4-(4-propylsulfonylpiperazin-1-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-amine Chemical compound C1CN(S(=O)(=O)CCC)CCN1C(C=C1)=CC=C1NC1=NC=C(C=NN2[C@@H]3C4=CC=CC=C4CC3)C2=N1 JDETXPDWBDCORH-VWLOTQADSA-N 0.000 claims description 2
- ZUFKTYQSDJJFFZ-UHFFFAOYSA-N 1-[(6-fluoro-4h-1,3-benzodioxin-8-yl)methyl]-n-(4-morpholin-4-ylphenyl)pyrazolo[3,4-d]pyrimidin-6-amine Chemical compound C=12OCOCC2=CC(F)=CC=1CN(C1=N2)N=CC1=CN=C2NC(C=C1)=CC=C1N1CCOCC1 ZUFKTYQSDJJFFZ-UHFFFAOYSA-N 0.000 claims description 2
- DUYVDLCXTYYWPT-UHFFFAOYSA-N 1-[6-[4-(4-methylpiperazin-1-yl)anilino]pyrazolo[3,4-d]pyrimidin-1-yl]-2,3-dihydro-1h-inden-4-ol Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C(C=NN2C3C4=C(C(=CC=C4)O)CC3)C2=N1 DUYVDLCXTYYWPT-UHFFFAOYSA-N 0.000 claims description 2
- HTJZFHBHAKJNOX-UHFFFAOYSA-N 1-butyl-n-(4-piperidin-1-ylphenyl)pyrazolo[3,4-d]pyrimidin-6-amine Chemical compound N1=C2N(CCCC)N=CC2=CN=C1NC(C=C1)=CC=C1N1CCCCC1 HTJZFHBHAKJNOX-UHFFFAOYSA-N 0.000 claims description 2
- ZKWBELIXZBEOLR-UHFFFAOYSA-N 1-methyl-n-(4-piperidin-1-ylphenyl)pyrazolo[3,4-d]pyrimidin-6-amine Chemical compound N1=C2N(C)N=CC2=CN=C1NC(C=C1)=CC=C1N1CCCCC1 ZKWBELIXZBEOLR-UHFFFAOYSA-N 0.000 claims description 2
- VJASYXGEGDPVHV-UHFFFAOYSA-N 1-methylsulfonyl-n-[4-[(1-naphthalen-1-ylpyrazolo[3,4-d]pyrimidin-6-yl)amino]phenyl]methanesulfonamide Chemical compound C1=CC(NS(=O)(=O)CS(=O)(=O)C)=CC=C1NC1=NC=C(C=NN2C=3C4=CC=CC=C4C=CC=3)C2=N1 VJASYXGEGDPVHV-UHFFFAOYSA-N 0.000 claims description 2
- LVMUIDNHXZXROD-UHFFFAOYSA-N 1-naphthalen-1-yl-n-(4-piperazin-1-ylphenyl)pyrazolo[3,4-d]pyrimidin-6-amine Chemical compound C1CNCCN1C(C=C1)=CC=C1NC1=NC=C(C=NN2C=3C4=CC=CC=C4C=CC=3)C2=N1 LVMUIDNHXZXROD-UHFFFAOYSA-N 0.000 claims description 2
- ATCDJGOFGGIRGG-UHFFFAOYSA-N 1-naphthalen-1-yl-n-[4-(2h-tetrazol-5-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-amine Chemical compound N=1C=C2C=NN(C=3C4=CC=CC=C4C=CC=3)C2=NC=1NC(C=C1)=CC=C1C1=NN=NN1 ATCDJGOFGGIRGG-UHFFFAOYSA-N 0.000 claims description 2
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89838207P | 2007-01-30 | 2007-01-30 | |
| US89830007P | 2007-01-30 | 2007-01-30 | |
| US60/898,382 | 2007-01-30 | ||
| US60/898,300 | 2007-01-30 | ||
| PCT/US2008/001195 WO2008094575A2 (en) | 2007-01-30 | 2008-01-30 | 1-h-pyrazolo(3,4b)pyrimidine derivatives and their use as modulators of mitotic kinases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2008211172A1 true AU2008211172A1 (en) | 2008-08-07 |
| AU2008211172A2 AU2008211172A2 (en) | 2009-12-17 |
Family
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| WO (2) | WO2008094575A2 (enExample) |
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| JP5650193B2 (ja) * | 2009-03-20 | 2015-01-07 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | 胸腺腫の治療のためのキナーゼ阻害剤の使用 |
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| US11780848B2 (en) | 2015-10-16 | 2023-10-10 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof |
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| US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
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| EP3380466A1 (en) | 2015-11-25 | 2018-10-03 | Genentech, Inc. | Substituted benzamides useful as sodium channel blockers |
| US10766858B2 (en) | 2016-03-30 | 2020-09-08 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| JP2019519582A (ja) | 2016-06-29 | 2019-07-11 | オリオン コーポレーション | ベンゾジオキサン誘導体およびその医薬用途 |
| JP2019532077A (ja) | 2016-10-17 | 2019-11-07 | ジェネンテック, インコーポレイテッド | 治療用化合物及びその使用方法 |
| CN110546148A (zh) | 2017-03-24 | 2019-12-06 | 基因泰克公司 | 作为钠通道抑制剂的4-哌啶-n-(嘧啶-4-基)色满-7-磺酰胺衍生物 |
| WO2019090272A1 (en) | 2017-11-06 | 2019-05-09 | Flx Bio, Inc. | Chemokine receptor modulators for treatment of epstein barr virus positive cancer |
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| EP3774801A1 (en) | 2018-03-30 | 2021-02-17 | F. Hoffmann-La Roche AG | Fused ring hydro-pyrido compounds as sodium channel inhibitors |
| TW202003490A (zh) | 2018-05-22 | 2020-01-16 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及其使用方法 |
| WO2019236631A1 (en) * | 2018-06-05 | 2019-12-12 | Rapt Therapeutics, Inc. | Pyrazolo-pyrimidin-amino-cycloalkyl compounds and their therapeutic uses |
| CN114269734A (zh) | 2019-05-08 | 2022-04-01 | 维玛兰生物科学公司 | Jak抑制剂 |
| WO2020257145A1 (en) * | 2019-06-18 | 2020-12-24 | Genentech, Inc. | Pyrazolopyrimidine sulfone inhibitors of jak kinases and uses thereof |
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| CN115403582A (zh) * | 2021-05-28 | 2022-11-29 | 江苏天士力帝益药业有限公司 | Wee1抑制剂及其用途 |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
| CN118126043B (zh) * | 2022-12-02 | 2025-01-28 | 沈阳药科大学 | 一种高选择性的plk4抑制剂及制备方法和应用 |
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| EA010160B1 (ru) * | 2003-09-18 | 2008-06-30 | Конформа Терапьютикс Корпорейшн | Новые гетероциклические соединения - ингибиторы hsp90 и способы их получения |
| JP2008513463A (ja) * | 2004-09-15 | 2008-05-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | チアゾロピリジンキナーゼ阻害剤 |
| ES2345997T3 (es) * | 2005-01-14 | 2010-10-07 | Janssen Pharmaceutica Nv | Pirazolopiramidinas como inhibidores de las quinasas del ciclo celular. |
| AU2006205851A1 (en) * | 2005-01-14 | 2006-07-20 | Janssen Pharmaceutica N.V. | 5-membered annelated heterocyclic pyrimidines as kinase inhibitors |
| WO2006091737A1 (en) * | 2005-02-24 | 2006-08-31 | Kemia, Inc. | Modulators of gsk-3 activity |
| WO2008094575A2 (en) * | 2007-01-30 | 2008-08-07 | Biogen Idec Ma Inc. | 1-h-pyrazolo(3,4b)pyrimidine derivatives and their use as modulators of mitotic kinases |
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2008
- 2008-01-30 WO PCT/US2008/001195 patent/WO2008094575A2/en not_active Ceased
- 2008-01-30 JP JP2009548293A patent/JP2010532312A/ja not_active Withdrawn
- 2008-01-30 US US12/525,174 patent/US20110281821A9/en not_active Abandoned
- 2008-01-30 JP JP2009548286A patent/JP2010516812A/ja not_active Withdrawn
- 2008-01-30 WO PCT/US2008/001230 patent/WO2008094602A2/en not_active Ceased
- 2008-01-30 AU AU2008211172A patent/AU2008211172A1/en not_active Abandoned
- 2008-01-30 EP EP08724974A patent/EP2108020A2/en not_active Withdrawn
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- 2008-01-30 CA CA002676665A patent/CA2676665A1/en not_active Abandoned
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Also Published As
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| EP2108020A2 (en) | 2009-10-14 |
| US20110281821A9 (en) | 2011-11-17 |
| AU2008211108A2 (en) | 2010-02-18 |
| AU2008211172A2 (en) | 2009-12-17 |
| US20100190787A1 (en) | 2010-07-29 |
| JP2010516812A (ja) | 2010-05-20 |
| JP2010532312A (ja) | 2010-10-07 |
| CA2676658A1 (en) | 2008-08-07 |
| WO2008094602A2 (en) | 2008-08-07 |
| US20100249067A1 (en) | 2010-09-30 |
| CA2676665A1 (en) | 2008-08-07 |
| EP2108019A2 (en) | 2009-10-14 |
| WO2008094575A2 (en) | 2008-08-07 |
| WO2008094575A3 (en) | 2008-12-18 |
| AU2008211108A1 (en) | 2008-08-07 |
| WO2008094602A3 (en) | 2008-11-13 |
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