AU2008206486C1 - Tetrahydrobiopterin prodrugs - Google Patents
Tetrahydrobiopterin prodrugs Download PDFInfo
- Publication number
- AU2008206486C1 AU2008206486C1 AU2008206486A AU2008206486A AU2008206486C1 AU 2008206486 C1 AU2008206486 C1 AU 2008206486C1 AU 2008206486 A AU2008206486 A AU 2008206486A AU 2008206486 A AU2008206486 A AU 2008206486A AU 2008206486 C1 AU2008206486 C1 AU 2008206486C1
- Authority
- AU
- Australia
- Prior art keywords
- cycloalkyl
- heterocycloalkyl
- alkenyl
- alkenylenec
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- FNKQXYHWGSIFBK-RPDRRWSUSA-N sapropterin Chemical compound N1=C(N)NC(=O)C2=C1NC[C@H]([C@@H](O)[C@@H](O)C)N2 FNKQXYHWGSIFBK-RPDRRWSUSA-N 0.000 title abstract description 314
- 229960004617 sapropterin Drugs 0.000 title abstract description 58
- 229940002612 prodrug Drugs 0.000 title description 19
- 239000000651 prodrug Substances 0.000 title description 19
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- 238000000034 method Methods 0.000 claims abstract description 76
- 150000001875 compounds Chemical class 0.000 claims description 169
- 229910052739 hydrogen Inorganic materials 0.000 claims description 143
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 136
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 101
- 239000001257 hydrogen Substances 0.000 claims description 100
- 125000000217 alkyl group Chemical group 0.000 claims description 92
- 125000003118 aryl group Chemical group 0.000 claims description 91
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 83
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 78
- 125000005275 alkylenearyl group Chemical group 0.000 claims description 69
- 125000005218 alkyleneheteroaryl group Chemical group 0.000 claims description 67
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims description 65
- 150000002431 hydrogen Chemical class 0.000 claims description 61
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 51
- -1 aminoglucosyl Chemical group 0.000 claims description 41
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 39
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- 208000014249 Classic phenylketonuria Diseases 0.000 claims description 3
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- LHQIJBMDNUYRAM-AWFVSMACSA-N D-erythro-biopterin Chemical compound N1=C(N)NC(=O)C2=NC([C@H](O)[C@H](O)C)=CN=C21 LHQIJBMDNUYRAM-AWFVSMACSA-N 0.000 description 50
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Classifications
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- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
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Landscapes
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| PE (1) | PE20081612A1 (enExample) |
| TW (1) | TW200843778A (enExample) |
| WO (1) | WO2008089008A2 (enExample) |
Cited By (1)
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| US11834697B2 (en) | 2017-09-15 | 2023-12-05 | Oxford University Innovation Limited | Electrochemical recognition and quantification of cytochrome c oxidase expression in bacteria |
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| JPS574990A (en) * | 1980-05-09 | 1982-01-11 | Bisukonchiini Matsukusu | Polyacylated tetrahydropterin derivative and manufacture |
| GB8318833D0 (en) * | 1983-07-12 | 1983-08-10 | Wellcome Found | Chemical compounds |
| ZA836957B (en) * | 1982-09-20 | 1985-04-24 | Wellcome Found | Neurologically active chemical compounds |
| JPS59112987A (ja) * | 1982-12-20 | 1984-06-29 | Kanegafuchi Chem Ind Co Ltd | １′，２′―ジアシル―（６ｒ，ｓ）―５，６，７，８―テトラヒドロ―ｌ―ビオプテリンおよびその製法 |
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| JPS60178887A (ja) * | 1984-02-23 | 1985-09-12 | Kanegafuchi Chem Ind Co Ltd | ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法 |
| JPS60199889A (ja) * | 1984-03-24 | 1985-10-09 | Kanegafuchi Chem Ind Co Ltd | ５，６，７，８−テトラヒドロ−ｌ−エリスロ−ビオプテリンの硫酸塩およびその製法 |
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2008
- 2008-01-09 CA CA002675134A patent/CA2675134A1/en not_active Abandoned
- 2008-01-09 AU AU2008206486A patent/AU2008206486C1/en not_active Ceased
- 2008-01-09 JP JP2009545660A patent/JP2010515747A/ja active Pending
- 2008-01-09 EP EP08705803A patent/EP2114944A2/en not_active Withdrawn
- 2008-01-09 WO PCT/US2008/050637 patent/WO2008089008A2/en not_active Ceased
- 2008-01-11 CL CL200800094A patent/CL2008000094A1/es unknown
- 2008-01-11 AR ARP080100139A patent/AR064874A1/es unknown
- 2008-01-11 PE PE2008000117A patent/PE20081612A1/es not_active Application Discontinuation
- 2008-01-11 TW TW097101226A patent/TW200843778A/zh unknown
-
2009
- 2009-07-09 US US12/500,537 patent/US20100016328A1/en not_active Abandoned
-
2011
- 2011-09-16 US US13/235,115 patent/US20120022072A1/en not_active Abandoned
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11834697B2 (en) | 2017-09-15 | 2023-12-05 | Oxford University Innovation Limited | Electrochemical recognition and quantification of cytochrome c oxidase expression in bacteria |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010515747A (ja) | 2010-05-13 |
| US20100016328A1 (en) | 2010-01-21 |
| PE20081612A1 (es) | 2008-11-12 |
| AR064874A1 (es) | 2009-04-29 |
| AU2008206486A1 (en) | 2008-07-24 |
| CA2675134A1 (en) | 2008-07-24 |
| US20120022072A1 (en) | 2012-01-26 |
| AU2008206486B2 (en) | 2013-04-18 |
| TW200843778A (en) | 2008-11-16 |
| WO2008089008A2 (en) | 2008-07-24 |
| CL2008000094A1 (es) | 2008-05-23 |
| WO2008089008A3 (en) | 2008-10-09 |
| EP2114944A2 (en) | 2009-11-11 |
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