AU2007304461A1 - Micropump-operated drug dosing system - Google Patents
Micropump-operated drug dosing system Download PDFInfo
- Publication number
- AU2007304461A1 AU2007304461A1 AU2007304461A AU2007304461A AU2007304461A1 AU 2007304461 A1 AU2007304461 A1 AU 2007304461A1 AU 2007304461 A AU2007304461 A AU 2007304461A AU 2007304461 A AU2007304461 A AU 2007304461A AU 2007304461 A1 AU2007304461 A1 AU 2007304461A1
- Authority
- AU
- Australia
- Prior art keywords
- component
- insulin
- injection
- medical apparatus
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000009516 primary packaging Methods 0.000 description 1
- 238000011324 primary prophylaxis Methods 0.000 description 1
- 229940048914 protamine Drugs 0.000 description 1
- 239000003488 releasing hormone Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 238000007395 thrombosis prophylaxis Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 239000013585 weight reducing agent Substances 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14212—Pumping with an aspiration and an expulsion action
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Materials For Medical Uses (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2014201299A AU2014201299A1 (en) | 2006-10-07 | 2014-03-07 | Micropump-operated drug dosing system |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006047538.0 | 2006-10-07 | ||
DE102006047538A DE102006047538A1 (de) | 2006-10-07 | 2006-10-07 | Medikamentendosiersystem mittels Mikropumpe |
PCT/EP2007/008362 WO2008040478A1 (de) | 2006-10-07 | 2007-09-26 | Medikamentendosiersystem mittels mikropumpe |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2014201299A Division AU2014201299A1 (en) | 2006-10-07 | 2014-03-07 | Micropump-operated drug dosing system |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2007304461A1 true AU2007304461A1 (en) | 2008-04-10 |
Family
ID=38924819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2007304461A Abandoned AU2007304461A1 (en) | 2006-10-07 | 2007-09-26 | Micropump-operated drug dosing system |
Country Status (15)
Country | Link |
---|---|
US (1) | US20090292245A1 (de) |
EP (1) | EP2076298A1 (de) |
JP (1) | JP2010505474A (de) |
KR (1) | KR20090059146A (de) |
CN (1) | CN101522236A (de) |
AR (1) | AR063135A1 (de) |
AU (1) | AU2007304461A1 (de) |
BR (1) | BRPI0718233A2 (de) |
CA (1) | CA2665274C (de) |
DE (1) | DE102006047538A1 (de) |
IL (2) | IL197974A (de) |
MX (1) | MX2009003494A (de) |
NO (1) | NO20091767L (de) |
TW (1) | TW200833386A (de) |
WO (1) | WO2008040478A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080172026A1 (en) | 2006-10-17 | 2008-07-17 | Blomquist Michael L | Insulin pump having a suspension bolus |
DE102006047613A1 (de) | 2006-10-07 | 2008-04-10 | Sanofi-Aventis Deutschland Gmbh | Peristaltische Mikropumpe mit wechselbarem Pumpenkopf |
US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
WO2010033878A2 (en) | 2008-09-19 | 2010-03-25 | David Brown | Solute concentration measurement device and related methods |
US8608699B2 (en) | 2009-03-31 | 2013-12-17 | Tandem Diabetes Care, Inc. | Systems and methods to address air, leaks and occlusions in an insulin pump system |
US8758323B2 (en) | 2009-07-30 | 2014-06-24 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
KR101086869B1 (ko) * | 2009-10-20 | 2011-11-24 | 주식회사 이담테크 | 자동 분유혼합장치 |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
US9603995B2 (en) | 2013-03-15 | 2017-03-28 | Tandem Diabetes Care. Inc. | Device and method for setting therapeutic parameters for an infusion device |
EP3003426B1 (de) | 2013-05-30 | 2021-03-10 | SHL Medical AG | Vorrichtung zur abgabe eines fluids an einen patienten |
JO3749B1 (ar) * | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
TWI746569B (zh) | 2016-06-08 | 2021-11-21 | 瑞士商瑞健醫療股份有限公司 | 計量器具、注射裝置、及其應用 |
US11286917B2 (en) | 2016-10-21 | 2022-03-29 | Franklin Electric Co., Inc. | Motor drive system and method |
JP7053614B2 (ja) | 2016-11-28 | 2022-04-12 | エスエイチエル・メディカル・アーゲー | 物質を投与する装置 |
KR102049001B1 (ko) * | 2017-11-27 | 2019-11-26 | 재단법인 대구경북첨단의료산업진흥재단 | 약물 주입 장치 |
US11174852B2 (en) | 2018-07-20 | 2021-11-16 | Becton, Dickinson And Company | Reciprocating pump |
KR102365840B1 (ko) | 2019-11-27 | 2022-02-22 | 고려대학교 산학협력단 | 초흡수성 폴리머를 이용한 하이브리드 동력 기반의 시린지리스 펌프 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6241704B1 (en) * | 1901-11-22 | 2001-06-05 | Sims Deltec, Inc. | Drug pump systems and methods |
DE1035858B (de) * | 1955-01-20 | 1958-08-07 | Dr Fritz Linder | Injektionsspritze |
US4447234A (en) * | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
US5755683A (en) * | 1995-06-07 | 1998-05-26 | Deka Products Limited Partnership | Stopcock valve |
US5713865A (en) * | 1991-11-15 | 1998-02-03 | Deka Products Limited Partnership | Intravenous-line air-elimination system |
DE4213172C1 (de) * | 1992-04-22 | 1993-05-19 | B. Braun Melsungen Ag, 3508 Melsungen, De | |
JP2530150Y2 (ja) * | 1993-01-06 | 1997-03-26 | 城田電気炉材株式会社 | 歯科用の麻酔剤等の注射装置 |
US6099502A (en) * | 1995-04-20 | 2000-08-08 | Acist Medical Systems, Inc. | Dual port syringe |
US5651775A (en) * | 1995-07-12 | 1997-07-29 | Walker; Richard Bradley | Medication delivery and monitoring system and methods |
US6248093B1 (en) * | 1998-10-29 | 2001-06-19 | Minimed Inc. | Compact pump drive system |
DE19916876A1 (de) | 1999-04-14 | 2000-11-02 | Clemens Micheler | Medizinische Dosierpumpe |
EP1381408A4 (de) * | 2001-02-22 | 2007-06-13 | Insulet Corp | Modulare infusionsvorrichtung und verfahren |
DE10235468A1 (de) * | 2001-08-08 | 2003-04-30 | Ntn Toyo Bearing Co Ltd | Spritzenpumpe |
EP1432464B1 (de) * | 2001-09-26 | 2009-01-14 | Novo Nordisk A/S | Modulare vorrichtung zur verabreichung von medikamenten |
US7033338B2 (en) * | 2002-02-28 | 2006-04-25 | Smiths Medical Md, Inc. | Cartridge and rod for axially loading medication pump |
US7722595B2 (en) * | 2002-05-06 | 2010-05-25 | Becton, Dickinson And Company | Method and device for controlling drug pharmacokinetics |
US7320676B2 (en) * | 2003-10-02 | 2008-01-22 | Medtronic, Inc. | Pressure sensing in implantable medical devices |
EP1535637A1 (de) * | 2003-11-28 | 2005-06-01 | Woo Young Medical Co., Ltd. | Automatische Infusionsvorrichtung |
KR20070027686A (ko) | 2004-07-05 | 2007-03-09 | 노보 노르디스크 에이/에스 | 신용 카드 크기의 주사 장치 |
US7569050B2 (en) * | 2005-05-06 | 2009-08-04 | Medtronic Minimed, Inc. | Infusion device and method with drive device in infusion device and method with drive device in separable durable housing portion |
-
2006
- 2006-10-07 DE DE102006047538A patent/DE102006047538A1/de not_active Withdrawn
-
2007
- 2007-09-26 BR BRPI0718233-3A patent/BRPI0718233A2/pt not_active IP Right Cessation
- 2007-09-26 JP JP2009530777A patent/JP2010505474A/ja active Pending
- 2007-09-26 WO PCT/EP2007/008362 patent/WO2008040478A1/de active Application Filing
- 2007-09-26 CN CNA2007800374258A patent/CN101522236A/zh active Pending
- 2007-09-26 CA CA2665274A patent/CA2665274C/en not_active Expired - Fee Related
- 2007-09-26 MX MX2009003494A patent/MX2009003494A/es unknown
- 2007-09-26 KR KR1020097006997A patent/KR20090059146A/ko not_active Application Discontinuation
- 2007-09-26 AU AU2007304461A patent/AU2007304461A1/en not_active Abandoned
- 2007-09-26 EP EP07818446A patent/EP2076298A1/de not_active Withdrawn
- 2007-10-04 AR ARP070104406A patent/AR063135A1/es not_active Application Discontinuation
- 2007-10-04 TW TW096137187A patent/TW200833386A/zh unknown
-
2009
- 2009-03-31 US US12/415,222 patent/US20090292245A1/en not_active Abandoned
- 2009-04-05 IL IL197974A patent/IL197974A/en not_active IP Right Cessation
- 2009-05-05 NO NO20091767A patent/NO20091767L/no not_active Application Discontinuation
-
2015
- 2015-10-12 IL IL242028A patent/IL242028A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL197974A (en) | 2015-10-29 |
DE102006047538A1 (de) | 2008-04-10 |
TW200833386A (en) | 2008-08-16 |
CN101522236A (zh) | 2009-09-02 |
BRPI0718233A2 (pt) | 2013-11-12 |
JP2010505474A (ja) | 2010-02-25 |
IL197974A0 (en) | 2009-12-24 |
CA2665274A1 (en) | 2008-04-10 |
KR20090059146A (ko) | 2009-06-10 |
WO2008040478A1 (de) | 2008-04-10 |
IL242028A0 (en) | 2015-11-30 |
NO20091767L (no) | 2009-07-01 |
CA2665274C (en) | 2015-11-10 |
AR063135A1 (es) | 2008-12-30 |
MX2009003494A (es) | 2009-04-14 |
US20090292245A1 (en) | 2009-11-26 |
EP2076298A1 (de) | 2009-07-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |