AU2007240680B2 - Stereoselective reduction of a morphinone - Google Patents

Stereoselective reduction of a morphinone Download PDF

Info

Publication number
AU2007240680B2
AU2007240680B2 AU2007240680A AU2007240680A AU2007240680B2 AU 2007240680 B2 AU2007240680 B2 AU 2007240680B2 AU 2007240680 A AU2007240680 A AU 2007240680A AU 2007240680 A AU2007240680 A AU 2007240680A AU 2007240680 B2 AU2007240680 B2 AU 2007240680B2
Authority
AU
Australia
Prior art keywords
morphinone
group
daltons
sodium
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2007240680A
Other languages
English (en)
Other versions
AU2007240680A1 (en
Inventor
Michael D. Bentley
Lin Cheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nektar Therapeutics
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38625648&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2007240680(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of AU2007240680A1 publication Critical patent/AU2007240680A1/en
Application granted granted Critical
Publication of AU2007240680B2 publication Critical patent/AU2007240680B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Catalysts (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Steroid Compounds (AREA)
AU2007240680A 2006-04-21 2007-04-19 Stereoselective reduction of a morphinone Active AU2007240680B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74533606P 2006-04-21 2006-04-21
US60/745,336 2006-04-21
PCT/US2007/009761 WO2007124114A2 (en) 2006-04-21 2007-04-19 Stereoselective reduction of a morphinone

Publications (2)

Publication Number Publication Date
AU2007240680A1 AU2007240680A1 (en) 2007-11-01
AU2007240680B2 true AU2007240680B2 (en) 2013-05-02

Family

ID=38625648

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007240680A Active AU2007240680B2 (en) 2006-04-21 2007-04-19 Stereoselective reduction of a morphinone

Country Status (13)

Country Link
US (2) US8183376B2 (enExample)
EP (1) EP2010539B1 (enExample)
JP (1) JP5586223B2 (enExample)
KR (1) KR101421747B1 (enExample)
CN (1) CN101466381B (enExample)
AU (1) AU2007240680B2 (enExample)
CA (1) CA2646313C (enExample)
ES (1) ES2629766T3 (enExample)
IL (1) IL194735A (enExample)
MX (1) MX2008013594A (enExample)
NZ (1) NZ572252A (enExample)
WO (1) WO2007124114A2 (enExample)
ZA (1) ZA200809258B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2236161A1 (en) 2001-10-18 2010-10-06 Nektar Therapeutics Polymer conjugates of opioid antagonists
US20060182692A1 (en) * 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
HRP20140361T1 (hr) * 2003-12-16 2014-05-23 Nektar Therapeutics Monodisperzne smjese pegiliranog naloksola
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
KR20110004425A (ko) * 2008-05-07 2011-01-13 넥타르 테라퓨틱스 말초적 작용 오피오이드 길항제의 경구 투여
AU2009260303A1 (en) 2008-06-17 2009-12-23 Mallinckrodt Inc. Processes for the preparation of 6- beta-hydroxy morphinan compounds
CA2734333A1 (en) * 2008-09-16 2010-03-25 Nektar Therapeutics Pegylated opioids with low potential for abuse
CN102459275A (zh) 2009-04-24 2012-05-16 布鲁克大学 制备吗啡烷和吗啡酮化合物的方法
JP2013529595A (ja) 2010-06-11 2013-07-22 ローズ テクノロジーズ 第３級アミンのｎ−脱アルキル化方法
ES2645725T3 (es) 2010-06-11 2017-12-07 Rhodes Technologies Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
PE20140636A1 (es) 2010-09-30 2014-06-18 Astrazeneca Ab Conjugado de naloxol-peg cristalino
CN103289075B (zh) * 2012-02-22 2016-01-20 天津键凯科技有限公司 聚乙二醇与纳洛酮的结合物及其药物组合物和应用
SMT201800083T1 (it) 2012-10-30 2018-03-08 Nektar Therapeutics Forme saline solide di alfa-6-mpeg6-o-idrossicodone come oppioidi agonisti e relativi usi
HUE036084T2 (hu) 2014-04-28 2018-06-28 Orphomed Inc Buprenorfin dimer és alkalmazása gasztrointesztinális rendellenességek kezelésénél
US20160067362A1 (en) * 2014-08-16 2016-03-10 Memorial Sloan Kettering Cancer Center Helical polycarbodiimide polymers and associated imaging, diagnostic, and therapeutic methods
CN107033155B (zh) * 2016-02-04 2019-04-26 国药集团国瑞药业有限公司 一种吗啡酮类化合物的立体选择性还原方法
EP3544590A4 (en) * 2016-11-23 2020-10-28 Aurobindo Pharma Limited NALOXEGOL OXALATE AND SOLID DISPERSION OF IT
CN110305142B (zh) * 2019-07-12 2021-11-16 宜昌人福药业有限责任公司 一种6β-羟基吗啡衍生物的立体选择性合成方法
CN110330500B (zh) * 2019-07-12 2021-11-23 宜昌人福药业有限责任公司 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005058367A2 (en) * 2003-12-16 2005-06-30 Nektar Therapeutics Al, Corporation Pegylated small molecules

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2654756A (en) 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
US2628962A (en) 1949-10-20 1953-02-17 Mallinckrodt Chemical Works Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone
US2715626A (en) 1950-07-05 1955-08-16 Merck & Co Inc Process of preparing dihydrocodeinone
US2649454A (en) 1951-08-20 1953-08-18 Univ California Method for preparing dihydromorphinone, dihydrocodeinone, and dihydropseudocodeinone
US2654746A (en) 1952-02-13 1953-10-06 Lilly Co Eli 1-dimethylamino-4-chloro-4-phenylbutane salt of penicillin
US2806033A (en) 1955-08-03 1957-09-10 Lewenstein Morphine derivative
US3254088A (en) 1961-03-14 1966-05-31 Lewenstein Morphine derivative
US3332950A (en) 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
DE2538075A1 (de) * 1975-08-27 1977-03-17 Boehringer Sohn Ingelheim N-tetrahydrofurfuryl-noroxymorphone, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung
US4089855A (en) * 1976-04-23 1978-05-16 Cornell Research Foundation, Inc. Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby
GB1593191A (en) * 1977-03-23 1981-07-15 Reckitt & Colmann Prod Ltd Derivatives of morphine
US4451470A (en) * 1982-07-06 1984-05-29 E. I. Du Pont De Nemours And Company Analgesic, antagonist, and/or anorectic 14-fluoromorphinans
US5208338A (en) * 1991-06-14 1993-05-04 The United States Of America As Represented By The Department Of Health & Human Services. Radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans
DE4132159A1 (de) * 1991-09-27 1993-04-01 Boehringer Ingelheim Kg 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel
US6323212B1 (en) * 1992-01-23 2001-11-27 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications
US5428159A (en) 1994-04-08 1995-06-27 Ciba-Geigy Corporation Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine
ATE176472T1 (de) * 1994-05-31 1999-02-15 Mallinckrodt Chemical Inc Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
EP2236161A1 (en) 2001-10-18 2010-10-06 Nektar Therapeutics Polymer conjugates of opioid antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005058367A2 (en) * 2003-12-16 2005-06-30 Nektar Therapeutics Al, Corporation Pegylated small molecules

Also Published As

Publication number Publication date
JP2009534393A (ja) 2009-09-24
US20090221766A1 (en) 2009-09-03
HK1134903A1 (en) 2010-05-20
IL194735A (en) 2015-09-24
ZA200809258B (en) 2010-08-25
EP2010539A2 (en) 2009-01-07
IL194735A0 (en) 2009-08-03
US8183376B2 (en) 2012-05-22
KR101421747B1 (ko) 2014-07-30
EP2010539A4 (en) 2010-06-02
WO2007124114A2 (en) 2007-11-01
WO2007124114A3 (en) 2008-11-27
JP5586223B2 (ja) 2014-09-10
NZ572252A (en) 2011-09-30
US8563726B2 (en) 2013-10-22
US20130018190A1 (en) 2013-01-17
MX2008013594A (es) 2009-01-16
AU2007240680A1 (en) 2007-11-01
CA2646313A1 (en) 2007-11-01
ES2629766T3 (es) 2017-08-14
CA2646313C (en) 2014-05-20
EP2010539B1 (en) 2017-06-14
KR20080110910A (ko) 2008-12-19
CN101466381A (zh) 2009-06-24
CN101466381B (zh) 2012-11-14

Similar Documents

Publication Publication Date Title
CA2646313C (en) Stereoselective reduction of a morphinone
KR101009309B1 (ko) 아편양 길항제의 중합체 공액
AU2007317788B2 (en) Dosage forms and co-administration of an opioid agonist and an opioid antagonist
AU2008226822B2 (en) Oligomer-opioid agonist conjugates
AU2002360284A1 (en) Polymer conjugates of opioid antagonists
JP2013500256A (ja) オリゴマー−オピオイドアゴニスト抱合体
US8633277B2 (en) Methods for forming polymer-drug conjugates
US9126926B2 (en) Oligomer-anticholinergic agent conjugates
HK1134903B (en) Stereoselective reduction of a morphinone
HK1147436A (en) Polymer conjugates of opioid antagonists

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: NEKTAR THERAPEUTICS

Free format text: FORMER APPLICANT(S): NEKTAR THERAPEUTICS AL, CORPORATION

FGA Letters patent sealed or granted (standard patent)