JP5586223B2 - モルヒノンの立体選択的還元 - Google Patents

モルヒノンの立体選択的還元 Download PDF

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Publication number
JP5586223B2
JP5586223B2 JP2009506622A JP2009506622A JP5586223B2 JP 5586223 B2 JP5586223 B2 JP 5586223B2 JP 2009506622 A JP2009506622 A JP 2009506622A JP 2009506622 A JP2009506622 A JP 2009506622A JP 5586223 B2 JP5586223 B2 JP 5586223B2
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morphinone
group
daltons
mem
water
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Japanese (ja)
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JP2009534393A (ja
JP2009534393A5 (enExample
Inventor
リン チェン，
マイケル ディー． ベントレー，
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ネクター セラピューティクス
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Catalysts (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Steroid Compounds (AREA)
JP2009506622A 2006-04-21 2007-04-19 モルヒノンの立体選択的還元 Active JP5586223B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74533606P 2006-04-21 2006-04-21
US60/745,336 2006-04-21
PCT/US2007/009761 WO2007124114A2 (en) 2006-04-21 2007-04-19 Stereoselective reduction of a morphinone

Publications (3)

Publication Number Publication Date
JP2009534393A JP2009534393A (ja) 2009-09-24
JP2009534393A5 JP2009534393A5 (enExample) 2010-06-03
JP5586223B2 true JP5586223B2 (ja) 2014-09-10

Family

ID=38625648

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009506622A Active JP5586223B2 (ja) 2006-04-21 2007-04-19 モルヒノンの立体選択的還元

Country Status (13)

Country Link
US (2) US8183376B2 (enExample)
EP (1) EP2010539B1 (enExample)
JP (1) JP5586223B2 (enExample)
KR (1) KR101421747B1 (enExample)
CN (1) CN101466381B (enExample)
AU (1) AU2007240680B2 (enExample)
CA (1) CA2646313C (enExample)
ES (1) ES2629766T3 (enExample)
IL (1) IL194735A (enExample)
MX (1) MX2008013594A (enExample)
NZ (1) NZ572252A (enExample)
WO (1) WO2007124114A2 (enExample)
ZA (1) ZA200809258B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2236161A1 (en) 2001-10-18 2010-10-06 Nektar Therapeutics Polymer conjugates of opioid antagonists
US20060182692A1 (en) * 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
HRP20140361T1 (hr) * 2003-12-16 2014-05-23 Nektar Therapeutics Monodisperzne smjese pegiliranog naloksola
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
KR20110004425A (ko) * 2008-05-07 2011-01-13 넥타르 테라퓨틱스 말초적 작용 오피오이드 길항제의 경구 투여
AU2009260303A1 (en) 2008-06-17 2009-12-23 Mallinckrodt Inc. Processes for the preparation of 6- beta-hydroxy morphinan compounds
CA2734333A1 (en) * 2008-09-16 2010-03-25 Nektar Therapeutics Pegylated opioids with low potential for abuse
CN102459275A (zh) 2009-04-24 2012-05-16 布鲁克大学 制备吗啡烷和吗啡酮化合物的方法
JP2013529595A (ja) 2010-06-11 2013-07-22 ローズ テクノロジーズ 第３級アミンのｎ−脱アルキル化方法
ES2645725T3 (es) 2010-06-11 2017-12-07 Rhodes Technologies Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
PE20140636A1 (es) 2010-09-30 2014-06-18 Astrazeneca Ab Conjugado de naloxol-peg cristalino
CN103289075B (zh) * 2012-02-22 2016-01-20 天津键凯科技有限公司 聚乙二醇与纳洛酮的结合物及其药物组合物和应用
SMT201800083T1 (it) 2012-10-30 2018-03-08 Nektar Therapeutics Forme saline solide di alfa-6-mpeg6-o-idrossicodone come oppioidi agonisti e relativi usi
HUE036084T2 (hu) 2014-04-28 2018-06-28 Orphomed Inc Buprenorfin dimer és alkalmazása gasztrointesztinális rendellenességek kezelésénél
US20160067362A1 (en) * 2014-08-16 2016-03-10 Memorial Sloan Kettering Cancer Center Helical polycarbodiimide polymers and associated imaging, diagnostic, and therapeutic methods
CN107033155B (zh) * 2016-02-04 2019-04-26 国药集团国瑞药业有限公司 一种吗啡酮类化合物的立体选择性还原方法
EP3544590A4 (en) * 2016-11-23 2020-10-28 Aurobindo Pharma Limited NALOXEGOL OXALATE AND SOLID DISPERSION OF IT
CN110305142B (zh) * 2019-07-12 2021-11-16 宜昌人福药业有限责任公司 一种6β-羟基吗啡衍生物的立体选择性合成方法
CN110330500B (zh) * 2019-07-12 2021-11-23 宜昌人福药业有限责任公司 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2654756A (en) 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
US2628962A (en) 1949-10-20 1953-02-17 Mallinckrodt Chemical Works Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone
US2715626A (en) 1950-07-05 1955-08-16 Merck & Co Inc Process of preparing dihydrocodeinone
US2649454A (en) 1951-08-20 1953-08-18 Univ California Method for preparing dihydromorphinone, dihydrocodeinone, and dihydropseudocodeinone
US2654746A (en) 1952-02-13 1953-10-06 Lilly Co Eli 1-dimethylamino-4-chloro-4-phenylbutane salt of penicillin
US2806033A (en) 1955-08-03 1957-09-10 Lewenstein Morphine derivative
US3254088A (en) 1961-03-14 1966-05-31 Lewenstein Morphine derivative
US3332950A (en) 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
DE2538075A1 (de) * 1975-08-27 1977-03-17 Boehringer Sohn Ingelheim N-tetrahydrofurfuryl-noroxymorphone, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung
US4089855A (en) * 1976-04-23 1978-05-16 Cornell Research Foundation, Inc. Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby
GB1593191A (en) * 1977-03-23 1981-07-15 Reckitt & Colmann Prod Ltd Derivatives of morphine
US4451470A (en) * 1982-07-06 1984-05-29 E. I. Du Pont De Nemours And Company Analgesic, antagonist, and/or anorectic 14-fluoromorphinans
US5208338A (en) * 1991-06-14 1993-05-04 The United States Of America As Represented By The Department Of Health & Human Services. Radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans
DE4132159A1 (de) * 1991-09-27 1993-04-01 Boehringer Ingelheim Kg 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel
US6323212B1 (en) * 1992-01-23 2001-11-27 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications
US5428159A (en) 1994-04-08 1995-06-27 Ciba-Geigy Corporation Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine
ATE176472T1 (de) * 1994-05-31 1999-02-15 Mallinckrodt Chemical Inc Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
EP2236161A1 (en) 2001-10-18 2010-10-06 Nektar Therapeutics Polymer conjugates of opioid antagonists
HRP20140361T1 (hr) 2003-12-16 2014-05-23 Nektar Therapeutics Monodisperzne smjese pegiliranog naloksola

Also Published As

Publication number Publication date
JP2009534393A (ja) 2009-09-24
US20090221766A1 (en) 2009-09-03
AU2007240680B2 (en) 2013-05-02
HK1134903A1 (en) 2010-05-20
IL194735A (en) 2015-09-24
ZA200809258B (en) 2010-08-25
EP2010539A2 (en) 2009-01-07
IL194735A0 (en) 2009-08-03
US8183376B2 (en) 2012-05-22
KR101421747B1 (ko) 2014-07-30
EP2010539A4 (en) 2010-06-02
WO2007124114A2 (en) 2007-11-01
WO2007124114A3 (en) 2008-11-27
NZ572252A (en) 2011-09-30
US8563726B2 (en) 2013-10-22
US20130018190A1 (en) 2013-01-17
MX2008013594A (es) 2009-01-16
AU2007240680A1 (en) 2007-11-01
CA2646313A1 (en) 2007-11-01
ES2629766T3 (es) 2017-08-14
CA2646313C (en) 2014-05-20
EP2010539B1 (en) 2017-06-14
KR20080110910A (ko) 2008-12-19
CN101466381A (zh) 2009-06-24
CN101466381B (zh) 2012-11-14

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