AU2007240453B2 - Process for the preparation of [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester - Google Patents

Process for the preparation of [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester Download PDF

Info

Publication number
AU2007240453B2
AU2007240453B2 AU2007240453A AU2007240453A AU2007240453B2 AU 2007240453 B2 AU2007240453 B2 AU 2007240453B2 AU 2007240453 A AU2007240453 A AU 2007240453A AU 2007240453 A AU2007240453 A AU 2007240453A AU 2007240453 B2 AU2007240453 B2 AU 2007240453B2
Authority
AU
Australia
Prior art keywords
compound
process according
pct
solution
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007240453A
Other languages
English (en)
Other versions
AU2007240453A1 (en
Inventor
Gerard A. Crispino
Robert P. Discordia
Mourad Hamedi
Chiajen Lai
Thomas L. Laporte
David K. Leahy
Paul C. Lobben
Jale Muslehiddinoglu
Jaan A. Pesti
Lori Ann Spangler
John E. Thornton
Zhongmin Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38357966&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2007240453(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AU2007240453A1 publication Critical patent/AU2007240453A1/en
Application granted granted Critical
Publication of AU2007240453B2 publication Critical patent/AU2007240453B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2007240453A 2006-04-21 2007-04-19 Process for the preparation of [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester Ceased AU2007240453B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74530006P 2006-04-21 2006-04-21
US60/745,300 2006-04-21
PCT/US2007/066911 WO2007124332A1 (en) 2006-04-21 2007-04-19 PROCESS FOR THE PREPARATION OF [(1R), 2S]-2-AMINOPROPIONIC ACID 2-[4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO[2,1-f][1,2,4]TRIAZIN-6-YLOXY]-1-METHYLETHYL ESTER

Publications (2)

Publication Number Publication Date
AU2007240453A1 AU2007240453A1 (en) 2007-11-01
AU2007240453B2 true AU2007240453B2 (en) 2012-04-12

Family

ID=38357966

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007240453A Ceased AU2007240453B2 (en) 2006-04-21 2007-04-19 Process for the preparation of [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester

Country Status (23)

Country Link
US (1) US7671199B2 (ru)
EP (1) EP2010538B1 (ru)
JP (1) JP5203353B2 (ru)
KR (1) KR101423789B1 (ru)
CN (1) CN101472927B (ru)
AR (1) AR060622A1 (ru)
AU (1) AU2007240453B2 (ru)
BR (1) BRPI0710691A2 (ru)
CA (1) CA2650059A1 (ru)
CL (2) CL2007001141A1 (ru)
DK (1) DK2010538T3 (ru)
EA (1) EA019693B1 (ru)
ES (1) ES2399379T3 (ru)
HR (1) HRP20130099T1 (ru)
IL (1) IL194715A (ru)
MX (1) MX2008013232A (ru)
NO (1) NO20084326L (ru)
PE (1) PE20080193A1 (ru)
PL (1) PL2010538T3 (ru)
PT (1) PT2010538E (ru)
SI (1) SI2010538T1 (ru)
TW (1) TWI378100B (ru)
WO (1) WO2007124332A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1928880A1 (en) * 2005-09-27 2008-06-11 Brystol-Myers Squibb Company Crystalline forms of [(1r), 2s]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1h-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester
US20120135875A1 (en) * 2008-02-29 2012-05-31 Bristol-Myers Squibb Company Methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators
EP2376491B1 (en) 2008-12-19 2015-03-04 Cephalon, Inc. Pyrrolotriazines as alk and jak2 inhibitors
WO2020074863A1 (en) 2018-10-08 2020-04-16 Applied Photophysics Limited System and method for analysing the composition of a quenched flow reaction liquid

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009784A2 (en) * 2002-07-19 2004-01-29 Bristol-Myers Squibb Company Novel inhibitors of kinases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6982265B1 (en) 1999-05-21 2006-01-03 Bristol Myers Squibb Company Pyrrolotriazine inhibitors of kinases
US6933386B2 (en) 2002-07-19 2005-08-23 Bristol Myers Squibb Company Process for preparing certain pyrrolotriazine compounds
US7432373B2 (en) * 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US20050288290A1 (en) * 2004-06-28 2005-12-29 Borzilleri Robert M Fused heterocyclic kinase inhibitors
WO2006130657A2 (en) 2005-05-31 2006-12-07 Bristol-Myers Squibb Company Stereoselective reduction process for the preparation of pyrrolotriazine compounds
EP1928880A1 (en) 2005-09-27 2008-06-11 Brystol-Myers Squibb Company Crystalline forms of [(1r), 2s]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1h-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009784A2 (en) * 2002-07-19 2004-01-29 Bristol-Myers Squibb Company Novel inhibitors of kinases

Also Published As

Publication number Publication date
CL2010000554A1 (es) 2010-10-15
EP2010538A1 (en) 2009-01-07
US20070249610A1 (en) 2007-10-25
WO2007124332A1 (en) 2007-11-01
AR060622A1 (es) 2008-07-02
DK2010538T3 (da) 2013-03-18
IL194715A (en) 2013-10-31
SI2010538T1 (sl) 2013-06-28
PL2010538T3 (pl) 2013-04-30
CL2007001141A1 (es) 2008-01-18
TW200808799A (en) 2008-02-16
EA019693B1 (ru) 2014-05-30
KR20090008246A (ko) 2009-01-21
NO20084326L (no) 2008-11-18
PE20080193A1 (es) 2008-03-10
EA200802171A1 (ru) 2009-08-28
AU2007240453A1 (en) 2007-11-01
MX2008013232A (es) 2008-10-21
KR101423789B1 (ko) 2014-07-30
CN101472927A (zh) 2009-07-01
BRPI0710691A2 (pt) 2011-08-23
HRP20130099T1 (hr) 2013-03-31
JP2009534413A (ja) 2009-09-24
JP5203353B2 (ja) 2013-06-05
CN101472927B (zh) 2012-07-04
ES2399379T3 (es) 2013-04-01
PT2010538E (pt) 2013-02-22
TWI378100B (en) 2012-12-01
US7671199B2 (en) 2010-03-02
EP2010538B1 (en) 2012-12-05
CA2650059A1 (en) 2007-11-01

Similar Documents

Publication Publication Date Title
JP6002825B2 (ja) 増殖性疾患の治療のための大環状誘導体
EP3068784B1 (en) Substituted 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine derivatives as casein kinase 1 d/e inhibitors
CA2829939C (en) Tricyclic gyrase inhibitors
EP2272850B1 (en) Process for purifying staurosporine
EP2099794B1 (en) Thiazolyl compounds useful as kinase inhibitors
AU2007240453B2 (en) Process for the preparation of [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester
CN114380837A (zh) 一种具有Janus激酶抑制活性的化合物、包括该化合物的组合物及其应用
US7932383B2 (en) Crystalline forms of [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester
WO2008086128A2 (en) Aminopyrazole kinase inhibitors
JP2019510053A (ja) シクロフィリンの阻害のための化合物及びその使用
WO2017070135A1 (en) Prodrugs of 2-(4-(3-((4-amino-7-cyano-imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)piperaz in-1-yl)propanamide derivatives as ck2 inhibitors for the treatment of cancer
CN115403575A (zh) 杂芳环类衍生物及其制备方法和用途
WO2007082946A1 (en) Solid forms of a pyrrolopyrimidine derivative and their use as anti-tumor agents

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired