AR060622A1 - Proceso para la preparcion del ester 2-[ 4-(4- fluoro-2 - metil-1h -indol-5- iloxi)-5-metil pirrolo [2,1-f] [ 1,2,4] triazin -6-iloxi] -1- metiletilico del acido [(1r),2s ] -2- aminopropinoico - Google Patents
Proceso para la preparcion del ester 2-[ 4-(4- fluoro-2 - metil-1h -indol-5- iloxi)-5-metil pirrolo [2,1-f] [ 1,2,4] triazin -6-iloxi] -1- metiletilico del acido [(1r),2s ] -2- aminopropinoicoInfo
- Publication number
- AR060622A1 AR060622A1 ARP070101727A ARP070101727A AR060622A1 AR 060622 A1 AR060622 A1 AR 060622A1 AR P070101727 A ARP070101727 A AR P070101727A AR P070101727 A ARP070101727 A AR P070101727A AR 060622 A1 AR060622 A1 AR 060622A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- iloxi
- methyl
- give
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
El compuesto 1 se ha mostrado que va a ser util para el tratamiento de ciertos tipos de cáncer. Reivindicacion 1: Un proceso para la preparacion del compuesto de la formula (1) caracterizado porque comprende las etapas de: (a) hacer reaccionar el compuesto de la formula (2) con un agente de metilacion en un solvente adecuado para producir el compuesto de formula (3), b) el cual se hace reaccionar en una oxidacion continua seguido por una reaccion de apagado para preparar el compuesto de formula (4) y proteccion para convertir el compuesto de formula (4) al compuesto de formula (5), c) clorar el compuesto de formula (5) para dar el compuesto de formula (6), d) el cual es unido con el compuesto de formula (7) para dar el compuesto de formula (8), que es cristalizado opcionalmente para mejorar la calidad, y e) el cual es desprotegido subsiguientemente y se hace reaccionar con el oxido de (R)-(+)-propileno en un solvente adecuado, y opcionalmente recristalizado para mejorar la calidad, para dar el compuesto de formula (9), f) el cual se hace reaccionar con una Cbz-L-alanina y un agente de union para dar el compuesto de la formula (10).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74530006P | 2006-04-21 | 2006-04-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR060622A1 true AR060622A1 (es) | 2008-07-02 |
Family
ID=38357966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070101727A AR060622A1 (es) | 2006-04-21 | 2007-04-20 | Proceso para la preparcion del ester 2-[ 4-(4- fluoro-2 - metil-1h -indol-5- iloxi)-5-metil pirrolo [2,1-f] [ 1,2,4] triazin -6-iloxi] -1- metiletilico del acido [(1r),2s ] -2- aminopropinoico |
Country Status (23)
Country | Link |
---|---|
US (1) | US7671199B2 (es) |
EP (1) | EP2010538B1 (es) |
JP (1) | JP5203353B2 (es) |
KR (1) | KR101423789B1 (es) |
CN (1) | CN101472927B (es) |
AR (1) | AR060622A1 (es) |
AU (1) | AU2007240453B2 (es) |
BR (1) | BRPI0710691A2 (es) |
CA (1) | CA2650059A1 (es) |
CL (2) | CL2007001141A1 (es) |
DK (1) | DK2010538T3 (es) |
EA (1) | EA019693B1 (es) |
ES (1) | ES2399379T3 (es) |
HR (1) | HRP20130099T1 (es) |
IL (1) | IL194715A (es) |
MX (1) | MX2008013232A (es) |
NO (1) | NO20084326L (es) |
PE (1) | PE20080193A1 (es) |
PL (1) | PL2010538T3 (es) |
PT (1) | PT2010538E (es) |
SI (1) | SI2010538T1 (es) |
TW (1) | TWI378100B (es) |
WO (1) | WO2007124332A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101291934B (zh) * | 2005-09-27 | 2012-06-27 | 布里斯托尔-迈尔斯·斯奎布公司 | [(1R),2S]-2-氨基丙酸2-[4-(4-氟-2-甲基-1H-吲哚-5-基氧基)-5-甲基吡咯并[2,1-f][1,2,4]三嗪-6-基氧基]-1-甲基乙基酯的晶型 |
US20120135875A1 (en) * | 2008-02-29 | 2012-05-31 | Bristol-Myers Squibb Company | Methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators |
AR074830A1 (es) | 2008-12-19 | 2011-02-16 | Cephalon Inc | Pirrolotriazinas como inhibidores de alk y jak2 |
WO2020074863A1 (en) | 2018-10-08 | 2020-04-16 | Applied Photophysics Limited | System and method for analysing the composition of a quenched flow reaction liquid |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6982265B1 (en) | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
TWI329112B (en) * | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
US6933386B2 (en) | 2002-07-19 | 2005-08-23 | Bristol Myers Squibb Company | Process for preparing certain pyrrolotriazine compounds |
US7432373B2 (en) * | 2004-06-28 | 2008-10-07 | Bristol-Meyers Squibb Company | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors |
US7173031B2 (en) * | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
WO2006130657A2 (en) | 2005-05-31 | 2006-12-07 | Bristol-Myers Squibb Company | Stereoselective reduction process for the preparation of pyrrolotriazine compounds |
CN101291934B (zh) | 2005-09-27 | 2012-06-27 | 布里斯托尔-迈尔斯·斯奎布公司 | [(1R),2S]-2-氨基丙酸2-[4-(4-氟-2-甲基-1H-吲哚-5-基氧基)-5-甲基吡咯并[2,1-f][1,2,4]三嗪-6-基氧基]-1-甲基乙基酯的晶型 |
-
2007
- 2007-04-19 EA EA200802171A patent/EA019693B1/ru not_active IP Right Cessation
- 2007-04-19 BR BRPI0710691-2A patent/BRPI0710691A2/pt not_active IP Right Cessation
- 2007-04-19 PT PT77608727T patent/PT2010538E/pt unknown
- 2007-04-19 AU AU2007240453A patent/AU2007240453B2/en not_active Ceased
- 2007-04-19 ES ES07760872T patent/ES2399379T3/es active Active
- 2007-04-19 PL PL07760872T patent/PL2010538T3/pl unknown
- 2007-04-19 JP JP2009506761A patent/JP5203353B2/ja not_active Expired - Fee Related
- 2007-04-19 CA CA002650059A patent/CA2650059A1/en not_active Abandoned
- 2007-04-19 WO PCT/US2007/066911 patent/WO2007124332A1/en active Application Filing
- 2007-04-19 KR KR1020087025577A patent/KR101423789B1/ko active IP Right Grant
- 2007-04-19 EP EP07760872A patent/EP2010538B1/en active Active
- 2007-04-19 CN CN2007800232897A patent/CN101472927B/zh active Active
- 2007-04-19 DK DK07760872.7T patent/DK2010538T3/da active
- 2007-04-19 MX MX2008013232A patent/MX2008013232A/es active IP Right Grant
- 2007-04-19 SI SI200731167T patent/SI2010538T1/sl unknown
- 2007-04-20 TW TW096114144A patent/TWI378100B/zh not_active IP Right Cessation
- 2007-04-20 PE PE2007000492A patent/PE20080193A1/es not_active Application Discontinuation
- 2007-04-20 AR ARP070101727A patent/AR060622A1/es unknown
- 2007-04-20 US US11/737,787 patent/US7671199B2/en active Active
- 2007-04-20 CL CL2007001141A patent/CL2007001141A1/es unknown
-
2008
- 2008-10-12 IL IL194715A patent/IL194715A/en not_active IP Right Cessation
- 2008-10-16 NO NO20084326A patent/NO20084326L/no not_active Application Discontinuation
-
2010
- 2010-05-28 CL CL2010000554A patent/CL2010000554A1/es unknown
-
2013
- 2013-02-05 HR HRP20130099TT patent/HRP20130099T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
US7671199B2 (en) | 2010-03-02 |
KR101423789B1 (ko) | 2014-07-30 |
PT2010538E (pt) | 2013-02-22 |
CN101472927A (zh) | 2009-07-01 |
EA019693B1 (ru) | 2014-05-30 |
US20070249610A1 (en) | 2007-10-25 |
SI2010538T1 (sl) | 2013-06-28 |
ES2399379T3 (es) | 2013-04-01 |
JP2009534413A (ja) | 2009-09-24 |
MX2008013232A (es) | 2008-10-21 |
JP5203353B2 (ja) | 2013-06-05 |
TW200808799A (en) | 2008-02-16 |
NO20084326L (no) | 2008-11-18 |
EP2010538B1 (en) | 2012-12-05 |
CL2007001141A1 (es) | 2008-01-18 |
PE20080193A1 (es) | 2008-03-10 |
WO2007124332A1 (en) | 2007-11-01 |
CL2010000554A1 (es) | 2010-10-15 |
CN101472927B (zh) | 2012-07-04 |
CA2650059A1 (en) | 2007-11-01 |
KR20090008246A (ko) | 2009-01-21 |
IL194715A (en) | 2013-10-31 |
AU2007240453A1 (en) | 2007-11-01 |
DK2010538T3 (da) | 2013-03-18 |
EA200802171A1 (ru) | 2009-08-28 |
BRPI0710691A2 (pt) | 2011-08-23 |
AU2007240453B2 (en) | 2012-04-12 |
TWI378100B (en) | 2012-12-01 |
HRP20130099T1 (hr) | 2013-03-31 |
EP2010538A1 (en) | 2009-01-07 |
PL2010538T3 (pl) | 2013-04-30 |
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