AU2007231012B2 - Phenolic hydrazone macrophage migration inhibitory factor inhibitors - Google Patents

Phenolic hydrazone macrophage migration inhibitory factor inhibitors Download PDF

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Publication number
AU2007231012B2
AU2007231012B2 AU2007231012A AU2007231012A AU2007231012B2 AU 2007231012 B2 AU2007231012 B2 AU 2007231012B2 AU 2007231012 A AU2007231012 A AU 2007231012A AU 2007231012 A AU2007231012 A AU 2007231012A AU 2007231012 B2 AU2007231012 B2 AU 2007231012B2
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disease
compound
mammal
autoimmune
syndrome
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AU2007231012A
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AU2007231012A1 (en
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Yousef Al-Abed
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Feinstein Institutes for Medical Research
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Feinstein Institutes for Medical Research
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P31/12—Antivirals
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    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02—Compounds containing any of the groups, e.g. carbazates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
AU2007231012A 2006-03-24 2007-03-23 Phenolic hydrazone macrophage migration inhibitory factor inhibitors Ceased AU2007231012B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78583406P 2006-03-24 2006-03-24
US60/785,834 2006-03-24
PCT/US2007/007277 WO2007112015A2 (en) 2006-03-24 2007-03-23 Phenolic hydrazone macrophage migration inhibitory factor inhibitors

Publications (2)

Publication Number Publication Date
AU2007231012A1 AU2007231012A1 (en) 2007-10-04
AU2007231012B2 true AU2007231012B2 (en) 2013-07-04

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ID=38541686

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Application Number Title Priority Date Filing Date
AU2007231012A Ceased AU2007231012B2 (en) 2006-03-24 2007-03-23 Phenolic hydrazone macrophage migration inhibitory factor inhibitors

Country Status (6)

Country Link
US (2) US8193247B2 (https=)
EP (1) EP2004649B1 (https=)
JP (1) JP2009530401A (https=)
AU (1) AU2007231012B2 (https=)
CA (1) CA2647045A1 (https=)
WO (1) WO2007112015A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2004192B1 (en) * 2006-03-24 2014-03-12 The Feinstein Institute for Medical Research Modified macrophage migration inhibitory factor inhibitors
EP2287149A1 (en) 2009-08-20 2011-02-23 Max-Delbrück-Centrum Für Molekulare Medizin Enhancers of protein degradation
WO2011070444A2 (en) * 2009-12-07 2011-06-16 Roberto Testi Compositions and methods for treating friedreich's ataxia
US9567306B2 (en) 2014-06-17 2017-02-14 The Feinstein Institute For Medical Research Inhibition of macrophage migration inhibitory factor in melanoma and colon cancer
CN104402771B (zh) * 2014-11-26 2016-09-28 玉林师范学院 对羟基苯甲醛缩氨基脲的合成及在防治植物病害中的应用
WO2016196297A1 (en) 2015-05-29 2016-12-08 Emory University 2-amino-n'-benzylideneacetohydrazides and derivatives for the management of cftr protein mediated diseases
WO2016196303A1 (en) 2015-05-29 2016-12-08 Emory University 3-(phenyl)-n-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide compounds for the management of cftr protein mediated diseases
EP3374027B1 (en) * 2015-11-12 2021-06-23 The Trustees of Columbia University in the City of New York Rational drug design targeting resistant gram-negative bacterial infections to polymyxin-class antibiotics
US20210353683A1 (en) * 2018-09-28 2021-11-18 Nissan Chemical Corporation Additive for medium for promoting production of paracrine factor
CN111909082B (zh) * 2019-05-07 2022-09-13 湖南大学 吡啶腙衍生物及其制备方法与应用
CN110229081B (zh) * 2019-07-01 2022-02-08 长沙理工大学 2,4-二硝基苯腙衍生物及其制备方法与应用
WO2022087719A1 (en) * 2020-10-28 2022-05-05 University Health Network Methods of treating spondyloarthritis or symptoms thereof

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US6503914B1 (en) * 2000-10-23 2003-01-07 Board Of Regents, The University Of Texas System Thienopyrimidine-based inhibitors of the Src family
DE10346913A1 (de) * 2003-10-09 2005-05-04 Merck Patent Gmbh Acylhydrazonderivate
US20050239740A1 (en) * 2004-03-30 2005-10-27 Alan Verkman Hydrazide-containing CFTR inhibitor compounds and uses thereof
US20060004002A1 (en) * 2004-07-02 2006-01-05 Thomas Thrash Small molecule thienopyrimidine-based protein tyrosine kinase inhibitors

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JP2006514918A (ja) * 2002-07-23 2006-05-18 スミスクライン ビーチャム コーポレーション キナーゼインヒビターとしてのピラゾロピリミジン
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DE10348022A1 (de) * 2003-10-15 2005-05-25 Imtm Gmbh Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
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Publication number Priority date Publication date Assignee Title
US6503914B1 (en) * 2000-10-23 2003-01-07 Board Of Regents, The University Of Texas System Thienopyrimidine-based inhibitors of the Src family
DE10346913A1 (de) * 2003-10-09 2005-05-04 Merck Patent Gmbh Acylhydrazonderivate
US20050239740A1 (en) * 2004-03-30 2005-10-27 Alan Verkman Hydrazide-containing CFTR inhibitor compounds and uses thereof
US20060004002A1 (en) * 2004-07-02 2006-01-05 Thomas Thrash Small molecule thienopyrimidine-based protein tyrosine kinase inhibitors

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Publication number Publication date
US8193247B2 (en) 2012-06-05
US20090170951A1 (en) 2009-07-02
WO2007112015A3 (en) 2008-07-24
JP2009530401A (ja) 2009-08-27
EP2004649A4 (en) 2009-07-15
EP2004649B1 (en) 2012-07-04
WO2007112015A2 (en) 2007-10-04
EP2004649A2 (en) 2008-12-24
AU2007231012A1 (en) 2007-10-04
US20120178805A1 (en) 2012-07-12
US8742173B2 (en) 2014-06-03
CA2647045A1 (en) 2007-10-04

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