AU2006321172B2 - Methods of improving stem cell homing and engraftment - Google Patents

Methods of improving stem cell homing and engraftment Download PDF

Info

Publication number
AU2006321172B2
AU2006321172B2 AU2006321172A AU2006321172A AU2006321172B2 AU 2006321172 B2 AU2006321172 B2 AU 2006321172B2 AU 2006321172 A AU2006321172 A AU 2006321172A AU 2006321172 A AU2006321172 A AU 2006321172A AU 2006321172 B2 AU2006321172 B2 AU 2006321172B2
Authority
AU
Australia
Prior art keywords
cells
population
stem
nicotinamide
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2006321172A
Other languages
English (en)
Other versions
AU2006321172A1 (en
Inventor
Tony Peled
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gamida Cell Ltd
Original Assignee
Gamida Cell Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gamida Cell Ltd filed Critical Gamida Cell Ltd
Publication of AU2006321172A1 publication Critical patent/AU2006321172A1/en
Application granted granted Critical
Publication of AU2006321172B2 publication Critical patent/AU2006321172B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2006321172A 2005-11-29 2006-11-29 Methods of improving stem cell homing and engraftment Active AU2006321172B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28900405A 2005-11-29 2005-11-29
US11/289,004 2005-11-29
PCT/IL2006/001381 WO2007063545A2 (en) 2005-11-29 2006-11-29 Methods of improving stem cell homing and engraftment

Publications (2)

Publication Number Publication Date
AU2006321172A1 AU2006321172A1 (en) 2007-06-07
AU2006321172B2 true AU2006321172B2 (en) 2012-02-23

Family

ID=37895790

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006321172A Active AU2006321172B2 (en) 2005-11-29 2006-11-29 Methods of improving stem cell homing and engraftment

Country Status (9)

Country Link
EP (2) EP1974012B1 (enExample)
JP (1) JP5102773B2 (enExample)
KR (1) KR20080072748A (enExample)
AU (1) AU2006321172B2 (enExample)
BR (1) BRPI0620523A2 (enExample)
CA (1) CA2632288A1 (enExample)
ES (1) ES2409128T3 (enExample)
WO (1) WO2007063545A2 (enExample)
ZA (1) ZA200805210B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2344653A1 (en) 1998-09-29 2000-04-06 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
JP5763894B2 (ja) * 2009-07-01 2015-08-12 タカラバイオ株式会社 細胞の分離方法
ES2851601T3 (es) 2009-12-29 2021-09-08 Gamida Cell Ltd Métodos para mejorar la proliferación y actividad de los linfocitos citolíticos naturales
WO2012121451A1 (ko) * 2011-03-08 2012-09-13 연세대학교 산학협력단 줄기세포의 인 비보 이동 유도방법
JP6348848B2 (ja) 2012-02-13 2018-06-27 ガミダ セル リミテッド 間葉系幹細胞の増殖
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
JP7295810B2 (ja) 2017-05-16 2023-06-21 ガミダ セル リミテッド 移植に適した臍帯細胞画分の選択と使用
US11746325B2 (en) 2017-05-16 2023-09-05 Gamida Cell Ltd. Selection and use of umbilical cord cell fractions suitable for transplantation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050008624A1 (en) * 2002-01-24 2005-01-13 Tony Peled Expansion of renewable stem cell populations
WO2005007073A2 (en) * 2003-07-17 2005-01-27 Gamida-Cell Ltd. Ex vivo progenitor and stem cell expansion for use in the treatment of disease of endodermally-derived organs

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
ES2285713T3 (es) 1995-06-07 2007-11-16 Bioveris Corporation Enzimoinmunoanalisis electroquimioluminiscente.
US6866842B1 (en) 1998-05-01 2005-03-15 University Of Pittsburgh Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction
US6713245B2 (en) 1998-07-06 2004-03-30 Diacrin, Inc. Methods for storing neural cells such that they are suitable for transplantation
US6326201B1 (en) 1999-02-10 2001-12-04 Curis, Inc. Pancreatic progenitor cells, methods and uses related thereto
US7045349B2 (en) 2001-01-23 2006-05-16 Benedict Daniel J Method of islet isolation using process control
CA2479679A1 (en) * 2002-03-18 2003-09-25 Gamida-Cell Ltd. Methods of inducing differentiation in ex vivo expanded stem cells
EP1534820A4 (en) * 2002-08-19 2006-04-26 Gamida Cell Ltd EX-VIVO EXPANSION OF HUMATOPOETIC STEM CELL POPULATIONS IN MONONUCLEOUS CELL CULTURES
EP1601759A4 (en) * 2003-03-07 2007-02-14 Gamida Cell Ltd EXPANSION OF RENEWABLE STEM CELL POPULATIONS USING PI-3 KINASE MODULATORS
US20040247574A1 (en) 2003-05-27 2004-12-09 Christopherson Kent W. Methods for enhancing stem cell engraftment during transplantation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050008624A1 (en) * 2002-01-24 2005-01-13 Tony Peled Expansion of renewable stem cell populations
WO2005007073A2 (en) * 2003-07-17 2005-01-27 Gamida-Cell Ltd. Ex vivo progenitor and stem cell expansion for use in the treatment of disease of endodermally-derived organs

Also Published As

Publication number Publication date
EP2390312A1 (en) 2011-11-30
JP2009517078A (ja) 2009-04-30
ES2409128T3 (es) 2013-06-25
ZA200805210B (en) 2009-09-30
WO2007063545A3 (en) 2007-07-19
AU2006321172A1 (en) 2007-06-07
CA2632288A1 (en) 2007-06-07
EP1974012B1 (en) 2013-02-27
BRPI0620523A2 (pt) 2011-11-16
JP5102773B2 (ja) 2012-12-19
EP1974012A2 (en) 2008-10-01
KR20080072748A (ko) 2008-08-06
WO2007063545A2 (en) 2007-06-07

Similar Documents

Publication Publication Date Title
Dexter et al. Stromal cells in haemopoiesis
Davis et al. Porcine brain microvascular endothelial cells support the in vitro expansion of human primitive hematopoietic bone marrow progenitor cells with a high replating potential: requirement for cell-to-cell interactions and colony-stimulating factors
US20040235160A1 (en) Process for preparing hematopoietic stem cells
US6642049B1 (en) Human brain endothelial cells and growth medium and method for expansion of primitive CD34+CD38-bone marrow stem cells
JP2007536936A (ja) 幹細胞集団および使用方法
JP2002516085A (ja) 哺乳動物における造血幹細胞集団に影響を及ぼす組成物および使用法
EP1682653B1 (en) Haematopoietic stem cells suitable for transplantation, their preparation and pharmaceutical compositions comprising them
TW202003837A (zh) 表現趨化因子受體及細胞接著分子之cd3陰性細胞之集團、及其用途及其製造方法
JP2014523741A (ja) 血小板産生のための巨核球前駆細胞
US8846393B2 (en) Methods of improving stem cell homing and engraftment
AU2006321172B2 (en) Methods of improving stem cell homing and engraftment
Shih et al. Ex vivo expansion of transplantable human hematopoietic stem cells: where do we stand in the year 2000?
WO2021131261A1 (ja) 細胞群及びその取得方法
US8802434B2 (en) Biological cell culture, cell culture media and therapeutic use of biological cells
HK1164367A (en) Methods of improving stem cell homing and engraftment
Tushinski et al. Expansion and Clinical use of Hematopoietic Progenitor Cells in Human Marrow and Peripheral Blood
EP1881063A1 (en) Stem cell populations and methods of use
Case The cytokine-mediated expansion of human umbilical cord blood stem and progenitor cells
JP2004503215A (ja) 造血細胞集団において静止細胞を濃縮するための方法
Summers Identification, isolation and ex vivo expansion of haemopoietic progenitor and stem cells
TUSHINSKI et al. been published by Long. 82

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)