AU2006320556A1 - Isotopically-labeled benzothiazole compounds as imaging agents for amyloidogenic proteins - Google Patents
Isotopically-labeled benzothiazole compounds as imaging agents for amyloidogenic proteins Download PDFInfo
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74106705P | 2005-12-01 | 2005-12-01 | |
| US60/741,067 | 2005-12-01 | ||
| PCT/US2006/045807 WO2007064773A2 (en) | 2005-12-01 | 2006-11-30 | Isotopically-labeled benzothiazole compounds as imaging agents for amyloidogenic proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2006320556A1 true AU2006320556A1 (en) | 2007-06-07 |
| AU2006320556A8 AU2006320556A8 (en) | 2008-07-31 |
Family
ID=37981903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2006320556A Abandoned AU2006320556A1 (en) | 2005-12-01 | 2006-11-30 | Isotopically-labeled benzothiazole compounds as imaging agents for amyloidogenic proteins |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090142269A1 (ja) |
| EP (1) | EP1971584A2 (ja) |
| JP (1) | JP2009519239A (ja) |
| CN (1) | CN101351458A (ja) |
| AU (1) | AU2006320556A1 (ja) |
| BR (1) | BRPI0619251A2 (ja) |
| CA (1) | CA2631905A1 (ja) |
| NO (1) | NO20082837L (ja) |
| RU (1) | RU2008126463A (ja) |
| WO (1) | WO2007064773A2 (ja) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009508863A (ja) * | 2005-09-16 | 2009-03-05 | ユニバーシティー オブ ピッツバーグ | 少なくとも１種のアミロイド形成タンパク質を含むアミロイド沈着物を検出するためのｉｎｖｉｖｏまたはｉｎｖｉｔｒｏ方法 |
| FR2916762B1 (fr) * | 2007-05-31 | 2013-11-15 | Biomerieux Sa | Nouveaux substrats enzymatiques de nitroreductase |
| CN103450077B (zh) | 2007-06-08 | 2016-07-06 | 满康德股份有限公司 | IRE-1α抑制剂 |
| CA2694084C (en) * | 2007-08-30 | 2015-07-07 | Ge Healthcare Limited | Radiopharmaceutical composition |
| EP2350032B1 (en) * | 2008-09-26 | 2016-05-25 | Eisai R&D Management Co., Ltd. | Benzoxazole compounds and methods of use |
| BRPI0919816A2 (pt) * | 2008-09-26 | 2019-09-24 | Eisai R&D Man Co Ltd | uso compostos benzoxazólicos no tratamento de malária |
| GB0821994D0 (en) * | 2008-12-02 | 2009-01-07 | Ge Healthcare Ltd | In viva imaging method |
| KR101123178B1 (ko) * | 2009-04-09 | 2012-06-13 | (주)에스메디 | 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물 |
| US20130203083A1 (en) * | 2010-02-10 | 2013-08-08 | Trustees Of Boston University | Serum clusterin levels in systemic amyloidosis featuring cardiomyopathy |
| CN102558091B (zh) * | 2011-12-22 | 2014-10-08 | 合肥工业大学 | 一种苯并噻唑类衍生物及其用途 |
| KR102053484B1 (ko) | 2012-12-21 | 2019-12-06 | 국립연구개발법인 양자과학기술연구개발기구 | 뇌 안에 축적된 타우 단백질을 이미징하기 위한 신규한 화합물 |
| CN102977051B (zh) * | 2012-12-24 | 2015-06-10 | 湖南大学 | 一种合成2-取代苯并噻唑衍生物的方法 |
| JP2016079108A (ja) * | 2014-10-10 | 2016-05-16 | 国立大学法人京都大学 | 放射性ヨウ素標識スチリル置換芳香族ヘテロ環化合物 |
| GB201617339D0 (en) | 2016-10-12 | 2016-11-23 | Lytix Biopharma As | Therapeutic compounds |
| JP2023502605A (ja) | 2019-11-13 | 2023-01-25 | アプリノイア セラピューティクス リミテッド | タウタンパク質凝集物を分解する化合物及びその使用 |
| CN111925343B (zh) * | 2020-08-12 | 2021-11-23 | 石家庄四药有限公司 | 一种利奈唑胺降解杂质的合成方法 |
| EP4281442A1 (en) * | 2021-01-19 | 2023-11-29 | Cold Spring Harbor Laboratory | Inhibitors of dyrk and pim |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666829A (en) * | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
| US5231000A (en) * | 1987-10-08 | 1993-07-27 | The Mclean Hospital | Antibodies to A4 amyloid peptide |
| US6168776B1 (en) * | 1994-07-19 | 2001-01-02 | University Of Pittsburgh | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| WO1997026919A2 (en) * | 1996-01-24 | 1997-07-31 | Warner-Lambert Company | Method of imaging amyloid deposits |
| DK1334091T3 (da) * | 2000-08-24 | 2012-10-15 | Univ Pittsburgh | Thioflavinderivater og deres anvendelse til diagnose og terapi af Alzheimer's sygdom |
| AU2003212490A1 (en) * | 2002-02-13 | 2003-09-04 | Amersham Plc | Benzothiazole derivatives for in vivo imaging of amyloid plaques |
| CA2438032C (en) * | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
-
2006
- 2006-11-30 AU AU2006320556A patent/AU2006320556A1/en not_active Abandoned
- 2006-11-30 CA CA002631905A patent/CA2631905A1/en not_active Abandoned
- 2006-11-30 EP EP06844660A patent/EP1971584A2/en not_active Withdrawn
- 2006-11-30 WO PCT/US2006/045807 patent/WO2007064773A2/en active Application Filing
- 2006-11-30 JP JP2008543445A patent/JP2009519239A/ja active Pending
- 2006-11-30 US US12/095,760 patent/US20090142269A1/en not_active Abandoned
- 2006-11-30 CN CNA2006800502158A patent/CN101351458A/zh active Pending
- 2006-11-30 RU RU2008126463/04A patent/RU2008126463A/ru not_active Application Discontinuation
- 2006-11-30 BR BRPI0619251A patent/BRPI0619251A2/pt not_active IP Right Cessation
-
2008
- 2008-06-26 NO NO20082837A patent/NO20082837L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20090142269A1 (en) | 2009-06-04 |
| JP2009519239A (ja) | 2009-05-14 |
| RU2008126463A (ru) | 2010-01-10 |
| CN101351458A (zh) | 2009-01-21 |
| EP1971584A2 (en) | 2008-09-24 |
| AU2006320556A8 (en) | 2008-07-31 |
| BRPI0619251A2 (pt) | 2016-09-06 |
| NO20082837L (no) | 2008-08-28 |
| WO2007064773A3 (en) | 2007-11-15 |
| CA2631905A1 (en) | 2007-06-07 |
| WO2007064773A2 (en) | 2007-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |