AU2006320374B2 - Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents - Google Patents

Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents Download PDF

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Publication number
AU2006320374B2
AU2006320374B2 AU2006320374A AU2006320374A AU2006320374B2 AU 2006320374 B2 AU2006320374 B2 AU 2006320374B2 AU 2006320374 A AU2006320374 A AU 2006320374A AU 2006320374 A AU2006320374 A AU 2006320374A AU 2006320374 B2 AU2006320374 B2 AU 2006320374B2
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AU
Australia
Prior art keywords
substituted
compound
alkyl
alkynyl
alkenyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2006320374A
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English (en)
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AU2006320374A1 (en
Inventor
Susanta Sekhar Adhikari
Richard H. Griffey
Stephen Hanessian
Michael T. Migawa
Kandasamy Pachamuthu
Eric E. Swayze
Janek Szychowski
Xiaojing Wang
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Ionis Pharmaceuticals Inc
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Isis Pharmaceuticals Inc
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Publication of AU2006320374B2 publication Critical patent/AU2006320374B2/en
Ceased legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/232—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with at least three saccharide radicals in the molecule, e.g. lividomycin, neomycin, paromomycin

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AU2006320374A 2005-12-02 2006-12-01 Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents Ceased AU2006320374B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74205105P 2005-12-02 2005-12-02
US60/742,051 2005-12-02
PCT/US2006/046122 WO2007064954A2 (en) 2005-12-02 2006-12-01 Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents

Publications (2)

Publication Number Publication Date
AU2006320374A1 AU2006320374A1 (en) 2007-06-07
AU2006320374B2 true AU2006320374B2 (en) 2012-08-30

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ID=37890104

Family Applications (1)

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AU2006320374A Ceased AU2006320374B2 (en) 2005-12-02 2006-12-01 Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents

Country Status (7)

Country Link
US (3) US7893039B2 (enExample)
EP (1) EP1957507B1 (enExample)
JP (1) JP5256043B2 (enExample)
AU (1) AU2006320374B2 (enExample)
CA (1) CA2632968A1 (enExample)
ES (1) ES2707787T3 (enExample)
WO (1) WO2007064954A2 (enExample)

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EP1957507B1 (en) 2005-12-02 2018-10-24 Ionis Pharmaceuticals, Inc. Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
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WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
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WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
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EP2556079A4 (en) * 2010-04-06 2013-10-09 Univ Manitoba POLYOLED MODIFIED AMINOGLYCOSIDE LIPID CONJUGATES
DK2620428T3 (da) 2010-09-24 2019-07-01 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
EP2640735A1 (en) 2010-11-17 2013-09-25 Achaogen, Inc. Antibacterial amiinoglycoside analogs
BR112014001244A2 (pt) 2011-07-19 2017-02-21 Wave Life Sciences Pte Ltd métodos para a síntese de ácidos nucléicos funcionalizados
SG10201912895PA (en) 2012-07-13 2020-02-27 Wave Life Sciences Ltd Chiral control
MX356830B (es) 2012-07-13 2018-06-15 Shin Nippon Biomedical Laboratories Ltd Adyuvante de acido nucleico quiral.
CN104684893B (zh) 2012-07-13 2016-10-26 日本波涛生命科学公司 不对称辅助基团
EP3095460A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
US10149905B2 (en) 2014-01-15 2018-12-11 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
RU2016133035A (ru) 2014-01-16 2018-02-21 Уэйв Лайф Сайенсес Лтд. Хиральный дизайн
US20180193270A1 (en) 2016-11-29 2018-07-12 PureTech Health LLC Exosomes for delivery of therapeutic agents

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Also Published As

Publication number Publication date
JP5256043B2 (ja) 2013-08-07
WO2007064954A3 (en) 2007-08-16
US20080293649A1 (en) 2008-11-27
EP1957507B1 (en) 2018-10-24
US8569264B2 (en) 2013-10-29
JP2009519243A (ja) 2009-05-14
CA2632968A1 (en) 2007-06-07
ES2707787T3 (es) 2019-04-05
US20110166334A1 (en) 2011-07-07
US7893039B2 (en) 2011-02-22
AU2006320374A1 (en) 2007-06-07
US8114856B2 (en) 2012-02-14
EP1957507A2 (en) 2008-08-20
US20130005674A1 (en) 2013-01-03
WO2007064954A2 (en) 2007-06-07

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