AU2006315102A1 - Multitargeting interfering RNAs having two active strands and methods for their design and use - Google Patents

Multitargeting interfering RNAs having two active strands and methods for their design and use Download PDF

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Publication number
AU2006315102A1
AU2006315102A1 AU2006315102A AU2006315102A AU2006315102A1 AU 2006315102 A1 AU2006315102 A1 AU 2006315102A1 AU 2006315102 A AU2006315102 A AU 2006315102A AU 2006315102 A AU2006315102 A AU 2006315102A AU 2006315102 A1 AU2006315102 A1 AU 2006315102A1
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Prior art keywords
sequence
rna molecule
interfering rna
target
sequences
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AU2006315102A
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Gregory Martin Arndt
Donald John Birkett
Toby Passioura
Michael Poidinger
Laurent Pierre Rivory
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Johnson and Johnson Research Pty Ltd
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Johnson and Johnson Research Pty Ltd
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity

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AU2006315102A 2005-11-21 2006-11-21 Multitargeting interfering RNAs having two active strands and methods for their design and use Abandoned AU2006315102A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US73864005P 2005-11-21 2005-11-21
US73844105P 2005-11-21 2005-11-21
US60/738,441 2005-11-21
US60/738,640 2005-11-21
PCT/AU2006/001750 WO2007056829A1 (en) 2005-11-21 2006-11-21 Multitargeting interfering rnas having two active strands and methods for their design and use

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AU2006315102A1 true AU2006315102A1 (en) 2007-05-24

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AU2006315099A Ceased AU2006315099C1 (en) 2005-11-21 2006-11-21 Multitargeting interfering RNAs and methods of their use and design

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US (3) US20070269815A1 (enExample)
EP (2) EP1951263A4 (enExample)
JP (2) JP5078904B2 (enExample)
AU (2) AU2006315102A1 (enExample)
CA (2) CA2630952A1 (enExample)
WO (2) WO2007056829A1 (enExample)

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