AU2006279643B2 - Neurorestoration with R(+) pramipexole - Google Patents
Neurorestoration with R(+) pramipexole Download PDFInfo
- Publication number
- AU2006279643B2 AU2006279643B2 AU2006279643A AU2006279643A AU2006279643B2 AU 2006279643 B2 AU2006279643 B2 AU 2006279643B2 AU 2006279643 A AU2006279643 A AU 2006279643A AU 2006279643 A AU2006279643 A AU 2006279643A AU 2006279643 B2 AU2006279643 B2 AU 2006279643B2
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- Australia
- Prior art keywords
- daily
- formulation
- disease
- pramipexole
- tetrahydrobenzathiazole
- Prior art date
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- Ceased
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Neurosurgery (AREA)
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- Biochemistry (AREA)
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- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US70821305P | 2005-08-15 | 2005-08-15 | |
| US60/708,213 | 2005-08-15 | ||
| PCT/US2006/031831 WO2007022182A1 (en) | 2005-08-15 | 2006-08-15 | Neurorestoration with r(+) pramipexole |
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| AU2006279643A1 AU2006279643A1 (en) | 2007-02-22 |
| AU2006279643B2 true AU2006279643B2 (en) | 2010-06-17 |
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| AU2006279643A Ceased AU2006279643B2 (en) | 2005-08-15 | 2006-08-15 | Neurorestoration with R(+) pramipexole |
Country Status (10)
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| US (3) | US20080234338A1 (OSRAM) |
| EP (1) | EP1917014B1 (OSRAM) |
| JP (2) | JP2009504748A (OSRAM) |
| AT (1) | ATE444750T1 (OSRAM) |
| AU (1) | AU2006279643B2 (OSRAM) |
| CA (1) | CA2619217A1 (OSRAM) |
| DE (1) | DE602006009670D1 (OSRAM) |
| ES (1) | ES2334061T3 (OSRAM) |
| IL (1) | IL189512A (OSRAM) |
| WO (1) | WO2007022182A1 (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8017598B2 (en) | 2006-05-16 | 2011-09-13 | Knopp Neurosciences, Inc. | Compositions of R(+) and S(−) pramipexole and methods of using the same |
| US8518926B2 (en) | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| US8524695B2 (en) | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| US9512096B2 (en) | 2011-12-22 | 2016-12-06 | Knopp Biosciences, LLP | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| US9642840B2 (en) | 2013-08-13 | 2017-05-09 | Knopp Biosciences, Llc | Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| US9763918B2 (en) | 2013-08-13 | 2017-09-19 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
| US9849116B2 (en) | 2008-08-19 | 2017-12-26 | Knopp Biosciences Llc | Compositions and methods of using (R)-pramipexole |
| US10179774B2 (en) | 2007-03-14 | 2019-01-15 | Knopp Biosciences Llc | Synthesis of chirally purified substituted benzothiazole diamines |
| US10828284B2 (en) | 2013-07-12 | 2020-11-10 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
| ATE480235T1 (de) * | 2001-12-11 | 2010-09-15 | Univ Virginia | Verwendung von pramipexol zur behandlung von amyotrophischer lateralsklerose |
| US20050226926A1 (en) | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
| DE602005024570D1 (de) | 2004-08-13 | 2010-12-16 | Boehringer Ingelheim Pharma | Tablettenformulierung mit verlängerter freisetzung mit pramipexol oder einem pharmazeutisch zulässigen salz davon, herstellungsverfahren und verwendung dafür |
| SG164375A1 (en) | 2004-08-13 | 2010-09-29 | Boehringer Ingelheim Int | Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof |
| EP1917014B1 (en) * | 2005-08-15 | 2009-10-07 | University Of Virginia Patent Foundation | Neurorestoration with r(+) pramipexole |
| WO2007090882A2 (en) * | 2006-02-10 | 2007-08-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical extended release compositions comprising pramipexole |
| EP2497473A1 (en) * | 2006-05-16 | 2012-09-12 | Knopp Neurosciences, Inc. | Therapeutically effective amounts of R(+) and S(-) pramipexole for use in the treatment of Parkinson's disease and pharmaceutical compositions thereof |
| PT2101766T (pt) * | 2006-12-14 | 2016-12-28 | Knopp Biosciences Llc | Composições e métodos de utilização de (r)-pramipexole |
| CA2680800A1 (en) * | 2007-03-14 | 2008-09-18 | Knopp Neurosciences, Inc. | Modified release formulations of (6r)-4,5,6,7-tetrahydro-n6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| EP2156833B1 (en) * | 2007-05-11 | 2011-11-30 | Santen Pharmaceutical Co., Ltd | Prophylactic or therapeutic agent for posterior ocular disease comprising non-ergot selective d2 receptor agonist as active ingredient |
| GB0721333D0 (en) * | 2007-10-31 | 2007-12-12 | Motac Neuroscience Ltd | Medicaments |
| CA2749253A1 (en) * | 2009-04-09 | 2010-10-14 | Purdue Pharma | Once-daily oral ir/cr pramipexole formulation |
| CA2765876A1 (en) * | 2009-06-19 | 2010-12-23 | Knopp Neurosciences, Inc. | Compositions and methods for treating amyotrophic lateral sclerosis |
| KR101799429B1 (ko) | 2010-05-03 | 2017-11-21 | 에스케이바이오팜 주식회사 | 신경 세포 사멸 또는 신경 퇴화를 억제하기 위한 약학적 조성물 |
| WO2016194015A2 (en) * | 2015-06-04 | 2016-12-08 | Chiarugi Alberto | Use of r(+)-pramipexole (dexpramipexole) for the treatment of cerebral ischemia of the focal type |
| WO2018183192A1 (en) * | 2017-03-27 | 2018-10-04 | Chase Therapeutics Corporation | Compositions and methods for treating synucleinopathies |
| IL312486B2 (en) | 2017-04-10 | 2025-05-01 | Chase Therapeutics Corp | NK1 antagonist combination and method for treating synucleinopathies |
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| WO2003049705A2 (en) * | 2001-12-11 | 2003-06-19 | University Of Virginia Patent Foundation | Use of pramipexole to treat amyotrophic lateral sclerosis |
| WO2005011687A1 (de) * | 2003-07-23 | 2005-02-10 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches system mit dem wirkstoff pramipexol |
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| DE3572485D1 (en) * | 1984-12-22 | 1989-09-28 | Thomae Gmbh Dr K | Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs |
| DE3937271A1 (de) * | 1989-11-09 | 1991-05-16 | Boehringer Ingelheim Kg | Transdermale applikation von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazol |
| US6156777A (en) * | 1994-12-15 | 2000-12-05 | Pharmacia & Upjohn Company | Use of pramipexole as a neuroprotective agent |
| ES2159362T3 (es) * | 1995-10-26 | 2001-10-01 | Sanofi Synthelabo | Utilizacion de la 1-(2-naft-2-iletil)-4-(3-trifluorometilfenil)-1,2,3,6-tetrahidropiridina para la preparacion de medicamentos destinados para el tratamiento de la esclerosis lateral amiotrofica. |
| GB9705428D0 (en) * | 1997-03-15 | 1997-04-30 | Knoll Ag | Therapeutic agents |
| US6197339B1 (en) * | 1997-09-30 | 2001-03-06 | Pharmacia & Upjohn Company | Sustained release tablet formulation to treat Parkinson's disease |
| PE20000728A1 (es) * | 1998-06-26 | 2000-08-21 | Cocensys Inc | Heterociclos 4-bencil piperidina alquilsulfoxido y su uso como antagonistas receptores subtipo-selectivo nmda |
| DE19830201A1 (de) * | 1998-07-07 | 2000-01-13 | Boehringer Ingelheim Pharma | Mittel mit antidepressiver Wirkung |
| WO2000006162A1 (de) * | 1998-07-27 | 2000-02-10 | Boehringer Ingelheim Pharma Kg | Mittel mit antidepressiver wirkung, mit pramipexol und einem weiteren antidepressivum |
| CA2348871C (en) * | 1998-11-02 | 2009-04-14 | John G. Devane | Multiparticulate modified release composition |
| US20040067991A1 (en) * | 2000-07-06 | 2004-04-08 | Greig Nigel H | Tetrahydrobenzothiazole analogues as neuroprotective agents |
| DE10037619A1 (de) * | 2000-08-02 | 2002-02-14 | Daimler Chrysler Ag | Anordnung von Bedienelementen |
| ES2187249B1 (es) * | 2000-09-18 | 2004-09-16 | Synthon Bv | Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles. |
| AU2001296703A1 (en) * | 2000-10-06 | 2002-04-15 | Xenoport, Inc. | Bile acid prodrugs of l-dopa and their use in the sustained treatment of parkinsonism |
| DE10137082A1 (de) * | 2001-07-28 | 2003-02-13 | Hexal Ag | Matrixkontrolliertes transdermales therapeutisches System zur Anwendung von Pramiprexol und Ropinirol |
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| EP1485082A4 (en) * | 2002-02-19 | 2009-12-30 | Xenoport Inc | PROCESS FOR THE SYNTHESIS OF PROMEDICAMENTS FROM 1-ACYL-ALKYL DERIVATIVES AND CORRESPONDING COMPOSITIONS |
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-
2006
- 2006-08-15 EP EP06801521A patent/EP1917014B1/en not_active Not-in-force
- 2006-08-15 AU AU2006279643A patent/AU2006279643B2/en not_active Ceased
- 2006-08-15 US US12/063,943 patent/US20080234338A1/en not_active Abandoned
- 2006-08-15 AT AT06801521T patent/ATE444750T1/de not_active IP Right Cessation
- 2006-08-15 JP JP2008527061A patent/JP2009504748A/ja not_active Withdrawn
- 2006-08-15 WO PCT/US2006/031831 patent/WO2007022182A1/en not_active Ceased
- 2006-08-15 DE DE602006009670T patent/DE602006009670D1/de active Active
- 2006-08-15 ES ES06801521T patent/ES2334061T3/es active Active
- 2006-08-15 CA CA002619217A patent/CA2619217A1/en not_active Abandoned
-
2008
- 2008-02-13 IL IL189512A patent/IL189512A/en not_active IP Right Cessation
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2011
- 2011-05-06 US US13/102,757 patent/US20110218222A1/en not_active Abandoned
-
2012
- 2012-10-23 JP JP2012233610A patent/JP2013014629A/ja active Pending
- 2012-12-27 US US13/728,504 patent/US20130116292A1/en not_active Abandoned
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| WO1996018395A1 (en) * | 1994-12-15 | 1996-06-20 | Pharmacia & Upjohn Company | Use of pramipexole as a neuroprotective agent |
| WO2003049705A2 (en) * | 2001-12-11 | 2003-06-19 | University Of Virginia Patent Foundation | Use of pramipexole to treat amyotrophic lateral sclerosis |
| WO2005011687A1 (de) * | 2003-07-23 | 2005-02-10 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches system mit dem wirkstoff pramipexol |
Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8518926B2 (en) | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
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Also Published As
| Publication number | Publication date |
|---|---|
| ES2334061T3 (es) | 2010-03-04 |
| WO2007022182A1 (en) | 2007-02-22 |
| EP1917014A1 (en) | 2008-05-07 |
| JP2013014629A (ja) | 2013-01-24 |
| US20130116292A1 (en) | 2013-05-09 |
| EP1917014B1 (en) | 2009-10-07 |
| IL189512A (en) | 2013-03-24 |
| ATE444750T1 (de) | 2009-10-15 |
| JP2009504748A (ja) | 2009-02-05 |
| US20080234338A1 (en) | 2008-09-25 |
| AU2006279643A1 (en) | 2007-02-22 |
| CA2619217A1 (en) | 2007-02-22 |
| US20110218222A1 (en) | 2011-09-08 |
| DE602006009670D1 (de) | 2009-11-19 |
| IL189512A0 (en) | 2011-08-01 |
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