AU2006256530B2 - Scaffold - Google Patents

Scaffold Download PDF

Info

Publication number
AU2006256530B2
AU2006256530B2 AU2006256530A AU2006256530A AU2006256530B2 AU 2006256530 B2 AU2006256530 B2 AU 2006256530B2 AU 2006256530 A AU2006256530 A AU 2006256530A AU 2006256530 A AU2006256530 A AU 2006256530A AU 2006256530 B2 AU2006256530 B2 AU 2006256530B2
Authority
AU
Australia
Prior art keywords
peptide
scaffold
protein
stm
stefin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006256530A
Other languages
English (en)
Other versions
AU2006256530A1 (en
Inventor
Paul Ko Ferrigno
Sophie Laurenson
Robbie Woodman
Johannes Tsung-Han Yeh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United Kingdom Research and Innovation
Original Assignee
United Kingdom Research and Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0511873A external-priority patent/GB0511873D0/en
Priority claimed from GB0608836A external-priority patent/GB0608836D0/en
Application filed by United Kingdom Research and Innovation filed Critical United Kingdom Research and Innovation
Publication of AU2006256530A1 publication Critical patent/AU2006256530A1/en
Application granted granted Critical
Publication of AU2006256530B2 publication Critical patent/AU2006256530B2/en
Assigned to UNITED KINGDOM RESEARCH AND INNOVATION reassignment UNITED KINGDOM RESEARCH AND INNOVATION Request for Assignment Assignors: MEDICAL RESEARCH COUNCIL
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2006256530A 2005-06-10 2006-06-08 Scaffold Ceased AU2006256530B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0511873A GB0511873D0 (en) 2005-06-10 2005-06-10 Scaffold
GB0511873.2 2005-06-10
GB0608836A GB0608836D0 (en) 2006-05-04 2006-05-04 Scaffold
GB0608836.3 2006-05-04
PCT/GB2006/002115 WO2006131749A2 (en) 2005-06-10 2006-06-08 Scaffold

Publications (2)

Publication Number Publication Date
AU2006256530A1 AU2006256530A1 (en) 2006-12-14
AU2006256530B2 true AU2006256530B2 (en) 2012-12-20

Family

ID=37314237

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006256530A Ceased AU2006256530B2 (en) 2005-06-10 2006-06-08 Scaffold

Country Status (9)

Country Link
US (2) US8063019B2 (https=)
EP (1) EP1904529B1 (https=)
JP (1) JP4989638B2 (https=)
AT (1) ATE477272T1 (https=)
AU (1) AU2006256530B2 (https=)
CA (1) CA2610976C (https=)
DE (1) DE602006016133D1 (https=)
DK (1) DK1904529T3 (https=)
WO (1) WO2006131749A2 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4989638B2 (ja) * 2005-06-10 2012-08-01 メディカル リサーチ カウンシル 足場
GB0807065D0 (en) 2008-04-18 2008-05-21 Univ Leeds Novel scaffolds
GB201302597D0 (en) * 2013-02-14 2013-04-03 Univ Leeds Novel Synthetic Proteins
JP6655074B2 (ja) * 2014-06-20 2020-02-26 ジェネンテック， インコーポレイテッド シャガシンに基づく足場組成物、方法及び使用
EP3405579A1 (en) 2016-01-22 2018-11-28 Modernatx, Inc. Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof
ES3026859T3 (en) 2017-01-04 2025-06-12 Mgi Tech Co Ltd Stepwise sequencing by non-labeled reversible terminators or natural nucleotides
KR102582297B1 (ko) 2017-05-19 2023-09-25 필립모리스 프로덕츠 에스.에이. 대상체의 흡연 상태를 구별하기 위한 진단 테스트
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
CN114761431B (zh) * 2019-10-16 2025-04-25 株式会社Lg化学 新生儿Fc受体结合AFFIMER
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
US20230366023A1 (en) 2020-10-09 2023-11-16 Bgi Shenzhen Co., Ltd. Methods and compositions for bioluminescence-based sequencing
CN119213021A (zh) * 2022-02-10 2024-12-27 艾菲赛尔治疗株式会社 与CD40L特异性结合的Stefin A蛋白变体及其用途
US20250346630A1 (en) * 2022-03-24 2025-11-13 Agency For Science, Technology And Research Engineering Peptides Using Peptide Epitope Linker Evolution
WO2024141788A1 (en) * 2022-12-29 2024-07-04 Affyxell Therapeutics Co., Ltd. Genetically modified stem cells expressing exogenous binding agents and uses thereof
GB202403780D0 (en) 2024-03-15 2024-05-01 Avacta Life Sciences Ltd Polypeptides and methods for detecting and quantifying small molecules

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005406A1 (en) * 1998-07-20 2000-02-03 M & E Biotech A/S Novel methods for the identification of ligand and target biomolecules

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2205356A1 (en) * 1994-11-21 1996-05-30 Peter Edward Urwin Modified proteinase inhibitors
ATE482972T1 (de) * 2003-11-06 2010-10-15 Danisco Us Inc Tgf-beta1-bindende und geträgerte peptide
JP4989638B2 (ja) * 2005-06-10 2012-08-01 メディカル リサーチ カウンシル 足場

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005406A1 (en) * 1998-07-20 2000-02-03 M & E Biotech A/S Novel methods for the identification of ligand and target biomolecules

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Database EMBL Accession No. X05978, "Human Radiated Keratinocyte mRNA for Cysteine Protease Inhibitor". 1988, [Online]. *

Also Published As

Publication number Publication date
JP4989638B2 (ja) 2012-08-01
US8063019B2 (en) 2011-11-22
US20120190819A1 (en) 2012-07-26
JP2008541776A (ja) 2008-11-27
ATE477272T1 (de) 2010-08-15
DK1904529T3 (da) 2010-11-15
US8481491B2 (en) 2013-07-09
DE602006016133D1 (de) 2010-09-23
EP1904529B1 (en) 2010-08-11
AU2006256530A1 (en) 2006-12-14
WO2006131749A3 (en) 2007-05-18
CA2610976C (en) 2020-11-24
EP1904529A2 (en) 2008-04-02
US20080207509A1 (en) 2008-08-28
CA2610976A1 (en) 2006-12-14
WO2006131749A2 (en) 2006-12-14

Similar Documents

Publication Publication Date Title
US8481491B2 (en) Scaffold polypeptides for heterologous peptide display
Owens et al. MOrPH-PhD: an integrated phage display platform for the discovery of functional genetically encoded peptide macrocycles
US8853131B2 (en) Modified Stefin A scaffold proteins
Woodman et al. Design and validation of a neutral protein scaffold for the presentation of peptide aptamers
US20090130676A1 (en) Interaction trap systems for detecting protein interactions
EP2917388B1 (en) Nucleic acids encoding chimeric polypeptides for library screening
CN105120885B (zh) 从植物半胱氨酸蛋白酶抑制剂衍生的支架蛋白
US6399296B1 (en) Interaction trap systems for detecting protein interactions
EP1248840A2 (en) Circularly permutated, interaction-activated proteins
Nejedla et al. A fluorophore fusion construct of human profilin I with non-compromised poly (L-proline) binding capacity suitable for Imaging
ES2350455T3 (es) Uso de estefina a como proteína de armazón.
Caponigro et al. Functional analysis of expressed peptides that bind yeast STE proteins
Justice In vivo analysis of the Pho2 homeodomain protein: A study of homeodomain-DNA interactions
Whitman et al. The Dissertation Committee for Gabrielle Nina Thibodeaux Certifies that this is the
Spiliotopoulos et al. Discovery of peptide ligands targeting a specific ubiquitin-like domain-binding site in the deubiquitinase USP11 Anastasios Spiliotopoulos1, 2, Lia Blokpoel Ferreras1, Ruth M. Densham3, Simon G. Caulton1, Ben C. Maddison4, Joanna R. Morris3, James E. Dixon1, Kevin C. Gough2* and Ingrid Dreveny1
Rajagopal Directed evolution of a beta-sheet scaffold for targeting proteins involved in human disease–Thrombin and the vascular endothelial growth factor (VEGF)

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: UNITED KINGDOM RESEARCH AND INNOVATION

Free format text: FORMER OWNER(S): MEDICAL RESEARCH COUNCIL

MK14 Patent ceased section 143(a) (annual fees not paid) or expired