AU2006226084B2 - 2,3-substituted fused pyrimidin-4(3H)-ones as VR1 antagonists - Google Patents
2,3-substituted fused pyrimidin-4(3H)-ones as VR1 antagonists Download PDFInfo
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- AU2006226084B2 AU2006226084B2 AU2006226084A AU2006226084A AU2006226084B2 AU 2006226084 B2 AU2006226084 B2 AU 2006226084B2 AU 2006226084 A AU2006226084 A AU 2006226084A AU 2006226084 A AU2006226084 A AU 2006226084A AU 2006226084 B2 AU2006226084 B2 AU 2006226084B2
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- Prior art keywords
- pain
- alkyl
- membered heteroaromatic
- alkoxy
- heteroaromatic ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000005557 antagonist Substances 0.000 title abstract description 16
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- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 247
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- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 38
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 37
- 150000002367 halogens Chemical class 0.000 claims abstract description 37
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 36
- 150000003839 salts Chemical class 0.000 claims abstract description 36
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 34
- 238000000034 method Methods 0.000 claims abstract description 33
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 32
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Classifications
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Landscapes
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- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0506147.8 | 2005-03-24 | ||
| GBGB0506147.8A GB0506147D0 (en) | 2005-03-24 | 2005-03-24 | Therapeutic agents |
| PCT/GB2006/050060 WO2006100520A1 (en) | 2005-03-24 | 2006-03-21 | 2,3-substituted fused pyrimidin-4(3h)-ones as vr1 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2006226084A1 AU2006226084A1 (en) | 2006-09-28 |
| AU2006226084B2 true AU2006226084B2 (en) | 2011-09-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2006226084A Ceased AU2006226084B2 (en) | 2005-03-24 | 2006-03-21 | 2,3-substituted fused pyrimidin-4(3H)-ones as VR1 antagonists |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110152242A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1866310B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5097696B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2006226084B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2602395A1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB0506147D0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006100520A1 (cg-RX-API-DMAC7.html) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2007002752A1 (es) | 2006-09-26 | 2008-07-11 | Celgene Corp Soc Organizada Ba | Compuestos derivados de 3-(4-oxo-4h-quinazolin-3-il)-piperidina-2,6-diona; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar o prevenir enfermedades tales como cancer, dolor, degeneracion macular, trastorno pulmonar, tr |
| CN101558069A (zh) * | 2006-11-06 | 2009-10-14 | 神经能质公司 | 顺式环己基取代的嘧啶酮衍生物 |
| NZ576997A (en) * | 2006-11-13 | 2012-02-24 | Icos Corp | Thienopyrimidinones for treatment of inflammatory disorders and cancers |
| US7803940B2 (en) | 2006-11-24 | 2010-09-28 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases |
| JP5643112B2 (ja) | 2008-01-28 | 2014-12-17 | アモーレパシフィック コーポレイションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ | バニロイド受容体としての新規化合物、その異性体または薬剤学的に許容し得る塩、及びこれを含有する医薬組成物 |
| KR101621444B1 (ko) | 2008-07-02 | 2016-05-19 | (주)아모레퍼시픽 | 바닐로이드 수용체 길항제로 작용하는 신규 화합물, 이의 이성질체 또는 이의 약제학적으로 허용 가능한 염, 및 이를 포함하는 약학 조성물 |
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| WO2002076946A2 (en) * | 2001-03-26 | 2002-10-03 | Novartis Ag | Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain. |
| WO2003014064A1 (en) * | 2001-07-31 | 2003-02-20 | Bayer Healthcare Ag | Naphthylurea and naphthylacetamide derivatives as vanilloid receptor 1 (vr1) antagonists |
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- 2006-03-21 CA CA002602395A patent/CA2602395A1/en not_active Abandoned
- 2006-03-21 AU AU2006226084A patent/AU2006226084B2/en not_active Ceased
- 2006-03-21 EP EP06710177A patent/EP1866310B1/en not_active Not-in-force
- 2006-03-21 JP JP2008502490A patent/JP5097696B2/ja not_active Expired - Fee Related
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| US3674786A (en) * | 1968-10-17 | 1972-07-04 | Ciba Geigy Corp | New-6-amino-4-oxo-4,5-dihydro-isothiazolo(5,4-d)pyrimidines |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP1866310A1 (en) | 2007-12-19 |
| EP1866310B1 (en) | 2012-07-11 |
| JP5097696B2 (ja) | 2012-12-12 |
| US20110152242A1 (en) | 2011-06-23 |
| GB0506147D0 (en) | 2005-05-04 |
| CA2602395A1 (en) | 2006-09-28 |
| AU2006226084A1 (en) | 2006-09-28 |
| WO2006100520A1 (en) | 2006-09-28 |
| JP2008534486A (ja) | 2008-08-28 |
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