AU2005299473B2 - Therapeutic and delivery methods of prostaglandin EP4 agonists - Google Patents
Therapeutic and delivery methods of prostaglandin EP4 agonists Download PDFInfo
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- AU2005299473B2 AU2005299473B2 AU2005299473A AU2005299473A AU2005299473B2 AU 2005299473 B2 AU2005299473 B2 AU 2005299473B2 AU 2005299473 A AU2005299473 A AU 2005299473A AU 2005299473 A AU2005299473 A AU 2005299473A AU 2005299473 B2 AU2005299473 B2 AU 2005299473B2
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- Prior art keywords
- colitis
- prodrug
- prostaglandin
- mammal
- ester
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- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
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| AU2012227306A AU2012227306A1 (en) | 2004-10-26 | 2012-09-25 | Therapeutic and delivery methods of prostaglandin EP4 agonists |
Applications Claiming Priority (3)
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| US62242204P | 2004-10-26 | 2004-10-26 | |
| US60/622,422 | 2004-10-26 | ||
| PCT/US2005/038303 WO2006047476A2 (en) | 2004-10-26 | 2005-10-24 | Therapeutic and delivery methods of prostaglandin ep4 agonists |
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| AU2012227306A Division AU2012227306A1 (en) | 2004-10-26 | 2012-09-25 | Therapeutic and delivery methods of prostaglandin EP4 agonists |
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| EP (1) | EP1805139A2 (enExample) |
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| BR (1) | BRPI0518242A2 (enExample) |
| CA (1) | CA2585367A1 (enExample) |
| WO (1) | WO2006047476A2 (enExample) |
Families Citing this family (17)
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|---|---|---|---|---|
| EP1841733A2 (en) * | 2004-11-08 | 2007-10-10 | Allergan, Inc. | Substituted pyrrolidone compounds as prostaglandin ep4 agonists |
| US20060281818A1 (en) * | 2005-03-21 | 2006-12-14 | Sucampo Ag, North Carolina State University | Method for treating mucosal disorders |
| US20070232660A1 (en) * | 2006-04-04 | 2007-10-04 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin ep4 agonists |
| EP2465506A1 (en) * | 2006-12-18 | 2012-06-20 | Allergan, Inc. | Methods and compositions for treating gastrointestinal disorders |
| JP5836262B2 (ja) | 2009-03-19 | 2015-12-24 | フェイト セラピューティクス， インコーポレイテッド | サイクリックａｍｐエンハンサーおよび／またはｅｐリガンドを含む組成物、ならびにこれを調製および使用する方法 |
| JP2013508282A (ja) | 2009-10-14 | 2013-03-07 | ジェンムス ファーマ インコーポレイティド | ウイルス感染のための併用療法処置 |
| WO2012021845A2 (en) | 2010-08-12 | 2012-02-16 | Fate Therapeutics, Inc. | Improved hematopoietic stem and progenitor cell therapy |
| EP2694120A1 (en) * | 2011-04-07 | 2014-02-12 | Allergan, Inc. | Devices, compositions and methods utilizing ep4 and ep2 receptor agonists for preventing, reducing or treating capsular contracture |
| ES2913633T3 (es) | 2011-09-30 | 2022-06-03 | Bluebird Bio Inc | Compuestos para transducción viral mejorada |
| AU2012321088B8 (en) | 2011-12-02 | 2016-12-15 | Fate Therapeutics, Inc. | Enhanced stem cell composition |
| EP2785350B1 (en) | 2011-12-02 | 2018-05-02 | Fate Therapeutics, Inc. | Improved methods of treating ischemia |
| US9943545B2 (en) | 2013-03-15 | 2018-04-17 | Fate Therapeutics, Inc. | Stem cell culture media and methods of enhancing cell survival |
| US10851412B2 (en) | 2013-03-15 | 2020-12-01 | Fate Therapeutics, Inc. | Cell potency assay for therapeutic potential |
| AU2014305843B2 (en) | 2013-08-09 | 2019-08-29 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| AU2017217813B2 (en) | 2016-02-12 | 2023-08-03 | Bluebird Bio, Inc. | VCN enhancer compositions and methods of using the same |
| WO2017139561A1 (en) | 2016-02-12 | 2017-08-17 | Bluebird Bio, Inc. | Vcn enhancer compositions and methods of using the same |
| US20200368223A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Methods for inhibiting phosphate transport |
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|---|---|---|---|---|
| JPS5052047A (enExample) * | 1973-07-12 | 1975-05-09 | ||
| EP0287036A2 (en) * | 1987-04-13 | 1988-10-19 | Ono Pharmaceutical Co., Ltd. | New pharmaceutical compositions comprising esters or amides as active ingredients |
| EP0985663A1 (en) * | 1998-04-16 | 2000-03-15 | Ono Pharmaceutical Co., Ltd. | A 3.7-dithiaprostanoic acid derivative |
| EP1097922A1 (en) * | 1998-07-15 | 2001-05-09 | Ono Pharmaceutical Co., Ltd. | 5-thia-omega-substituted phenyl-prostaglandin e derivatives, process for producing the same and drugs containing the same as the active ingredient |
| US20020002140A1 (en) * | 2000-01-14 | 2002-01-03 | Holick Michael F. | Novel bisphosphonates and uses thereof |
| US6586468B1 (en) * | 1998-09-14 | 2003-07-01 | Ono Pharmaceutical Co., Ltd. | ω-substituted phenyl-prostaglandin E derivatives and drugs containing the same as the active ingredient |
| EP1417975A1 (en) * | 2001-07-23 | 2004-05-12 | Ono Pharmaceutical Co., Ltd. | REMEDIES FOR DISEASES WITH BONE MASS LOSS HAVING EP sb 4 /sb AGONIST AS THE ACTIVE INGREDIENT |
| US20040102499A1 (en) * | 2001-06-14 | 2004-05-27 | Allergan, Inc. | EP4 agonists as agents for lowering intraocular pressure |
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Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1339678B1 (en) * | 2000-11-27 | 2007-09-26 | Pfizer Products Inc. | Ep4 receptor selective agonists in the treatment of osteoporosis |
| KR20040015364A (ko) * | 2001-07-16 | 2004-02-18 | 에프. 호프만-라 로슈 아게 | Ｅｐ4 수용체 작용물질로서의 프로스타글란딘 유사체 |
| EP1487437B1 (en) * | 2002-03-18 | 2006-08-16 | Pfizer Products Inc. | Use of selective ep4 receptor agonists for the treatment of diseases |
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2005
- 2005-10-24 US US11/574,528 patent/US20080132543A1/en not_active Abandoned
- 2005-10-24 AU AU2005299473A patent/AU2005299473B2/en not_active Ceased
- 2005-10-24 CA CA002585367A patent/CA2585367A1/en not_active Abandoned
- 2005-10-24 JP JP2007539030A patent/JP2008518013A/ja active Pending
- 2005-10-24 BR BRPI0518242-5A patent/BRPI0518242A2/pt not_active Application Discontinuation
- 2005-10-24 EP EP05817142A patent/EP1805139A2/en not_active Withdrawn
- 2005-10-24 WO PCT/US2005/038303 patent/WO2006047476A2/en not_active Ceased
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| EP1097922A1 (en) * | 1998-07-15 | 2001-05-09 | Ono Pharmaceutical Co., Ltd. | 5-thia-omega-substituted phenyl-prostaglandin e derivatives, process for producing the same and drugs containing the same as the active ingredient |
| US6586468B1 (en) * | 1998-09-14 | 2003-07-01 | Ono Pharmaceutical Co., Ltd. | ω-substituted phenyl-prostaglandin E derivatives and drugs containing the same as the active ingredient |
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| US20040102499A1 (en) * | 2001-06-14 | 2004-05-27 | Allergan, Inc. | EP4 agonists as agents for lowering intraocular pressure |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP1805139A2 (en) | 2007-07-11 |
| JP2008518013A (ja) | 2008-05-29 |
| WO2006047476A2 (en) | 2006-05-04 |
| AU2005299473A1 (en) | 2006-05-04 |
| CA2585367A1 (en) | 2006-05-04 |
| US20080132543A1 (en) | 2008-06-05 |
| BRPI0518242A2 (pt) | 2008-11-11 |
| WO2006047476A3 (en) | 2006-09-28 |
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