AU2005299473B2 - Therapeutic and delivery methods of prostaglandin EP4 agonists - Google Patents

Therapeutic and delivery methods of prostaglandin EP4 agonists Download PDF

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Publication number
AU2005299473B2
AU2005299473B2 AU2005299473A AU2005299473A AU2005299473B2 AU 2005299473 B2 AU2005299473 B2 AU 2005299473B2 AU 2005299473 A AU2005299473 A AU 2005299473A AU 2005299473 A AU2005299473 A AU 2005299473A AU 2005299473 B2 AU2005299473 B2 AU 2005299473B2
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AU
Australia
Prior art keywords
colitis
prodrug
prostaglandin
mammal
ester
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005299473A
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English (en)
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AU2005299473A1 (en
Inventor
Robert M. Burk
Yariv Donde
John E. Donello
Todd S. Gac
Daniel W. Gil
Mark Holoboski
Wha Bin Im
Karen M. Kedzie
David W. Old
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Allergan Inc
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Allergan Inc
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Application filed by Allergan Inc filed Critical Allergan Inc
Publication of AU2005299473A1 publication Critical patent/AU2005299473A1/en
Application granted granted Critical
Publication of AU2005299473B2 publication Critical patent/AU2005299473B2/en
Priority to AU2012227306A priority Critical patent/AU2012227306A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2005299473A 2004-10-26 2005-10-24 Therapeutic and delivery methods of prostaglandin EP4 agonists Ceased AU2005299473B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012227306A AU2012227306A1 (en) 2004-10-26 2012-09-25 Therapeutic and delivery methods of prostaglandin EP4 agonists

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62242204P 2004-10-26 2004-10-26
US60/622,422 2004-10-26
PCT/US2005/038303 WO2006047476A2 (en) 2004-10-26 2005-10-24 Therapeutic and delivery methods of prostaglandin ep4 agonists

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012227306A Division AU2012227306A1 (en) 2004-10-26 2012-09-25 Therapeutic and delivery methods of prostaglandin EP4 agonists

Publications (2)

Publication Number Publication Date
AU2005299473A1 AU2005299473A1 (en) 2006-05-04
AU2005299473B2 true AU2005299473B2 (en) 2012-06-28

Family

ID=35840538

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005299473A Ceased AU2005299473B2 (en) 2004-10-26 2005-10-24 Therapeutic and delivery methods of prostaglandin EP4 agonists

Country Status (7)

Country Link
US (1) US20080132543A1 (enExample)
EP (1) EP1805139A2 (enExample)
JP (1) JP2008518013A (enExample)
AU (1) AU2005299473B2 (enExample)
BR (1) BRPI0518242A2 (enExample)
CA (1) CA2585367A1 (enExample)
WO (1) WO2006047476A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006052893A2 (en) * 2004-11-08 2006-05-18 Allergan, Inc. Substituted pyrrolidone compounds as ep4 agonists
US20060281818A1 (en) * 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
US20070232660A1 (en) * 2006-04-04 2007-10-04 Allergan, Inc. Therapeutic and delivery methods of prostaglandin ep4 agonists
JP2010513551A (ja) * 2006-12-18 2010-04-30 アラーガン インコーポレイテッド 胃腸疾患の治療方法および組成物
EP3533445A1 (en) 2009-03-19 2019-09-04 Fate Therapeutics, Inc. Compositions comprising cyclic amp enhancers and/or ep ligands, and methods of preparing and using the same
US20120190637A1 (en) 2009-10-14 2012-07-26 Gemmus Pharma, Inc. Combination therapy treatment for viral infections
CN103167876B (zh) 2010-08-12 2016-08-31 菲特治疗公司 改进的造血干细胞和祖细胞疗法
US20120259413A1 (en) * 2011-04-07 2012-10-11 Allergan, Inc. Devices, compositions and methods utilizing ep4 and ep2 receptor agonists for preventing, reducing or treating capsular contracture
CA2850484C (en) 2011-09-30 2021-01-26 Bluebird Bio, Inc. Compounds for improved viral transduction
EP2785350B1 (en) 2011-12-02 2018-05-02 Fate Therapeutics, Inc. Improved methods of treating ischemia
CN104066837B (zh) 2011-12-02 2020-12-08 菲特治疗公司 增强的干细胞组合物
US10851412B2 (en) 2013-03-15 2020-12-01 Fate Therapeutics, Inc. Cell potency assay for therapeutic potential
US9943545B2 (en) 2013-03-15 2018-04-17 Fate Therapeutics, Inc. Stem cell culture media and methods of enhancing cell survival
CA2920856C (en) 2013-08-09 2026-03-03 Ardelyx, Inc. Ph modulating compounds for inhibiting gastrointestinal phosphate uptake
KR20250134722A (ko) 2016-02-12 2025-09-11 블루버드 바이오, 인코포레이티드. Vcn 인핸서 조성물 및 이의 사용 방법
CN108883136A (zh) 2016-02-12 2018-11-23 蓝鸟生物公司 Vcn增强子组合物及其使用方法
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ
GB202211232D0 (en) 2022-08-02 2022-09-14 Heptares Therapeutics Ltd Prostaglandin EP4 receptor agonist compounds

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5052047A (enExample) * 1973-07-12 1975-05-09
EP0287036A2 (en) * 1987-04-13 1988-10-19 Ono Pharmaceutical Co., Ltd. New pharmaceutical compositions comprising esters or amides as active ingredients
EP0985663A1 (en) * 1998-04-16 2000-03-15 Ono Pharmaceutical Co., Ltd. A 3.7-dithiaprostanoic acid derivative
EP1097922A1 (en) * 1998-07-15 2001-05-09 Ono Pharmaceutical Co., Ltd. 5-thia-omega-substituted phenyl-prostaglandin e derivatives, process for producing the same and drugs containing the same as the active ingredient
US20020002140A1 (en) * 2000-01-14 2002-01-03 Holick Michael F. Novel bisphosphonates and uses thereof
US6586468B1 (en) * 1998-09-14 2003-07-01 Ono Pharmaceutical Co., Ltd. ω-substituted phenyl-prostaglandin E derivatives and drugs containing the same as the active ingredient
EP1417975A1 (en) * 2001-07-23 2004-05-12 Ono Pharmaceutical Co., Ltd. REMEDIES FOR DISEASES WITH BONE MASS LOSS HAVING EP sb 4 /sb AGONIST AS THE ACTIVE INGREDIENT
US20040102499A1 (en) * 2001-06-14 2004-05-27 Allergan, Inc. EP4 agonists as agents for lowering intraocular pressure
US20040157901A1 (en) * 2003-02-11 2004-08-12 Allergan, Inc. 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure
US20050222094A1 (en) * 2001-06-14 2005-10-06 Burk Robert M Treatment of inflammatory bowel disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200300379A1 (ru) * 2000-11-27 2003-08-28 Пфайзер Продактс Инк. Селективные агонисты рецептора ep4 в лечении остеопороза
JP2004521954A (ja) * 2001-07-16 2004-07-22 エフ．ホフマン−ラ　ロシュ　アーゲー Ｅｐ４受容体作用薬としてのプロスタグランジン類似体
ATE336247T1 (de) * 2002-03-18 2006-09-15 Pfizer Prod Inc Verwendung von selektiven ep4 rezeptor agonisten zur behandlung von krankheiten
US7053085B2 (en) * 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
CA2511255C (en) * 2003-01-10 2009-04-07 F. Hoffmann-La Roche Ag 2-piperidone derivatives as prostaglandin agonists
JP5319065B2 (ja) * 2003-02-11 2013-10-16 アラーガン インコーポレイテッド 眼圧降下剤としての１０，１０−ジアルキルプロスタン酸誘導体

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5052047A (enExample) * 1973-07-12 1975-05-09
EP0287036A2 (en) * 1987-04-13 1988-10-19 Ono Pharmaceutical Co., Ltd. New pharmaceutical compositions comprising esters or amides as active ingredients
EP0985663A1 (en) * 1998-04-16 2000-03-15 Ono Pharmaceutical Co., Ltd. A 3.7-dithiaprostanoic acid derivative
EP1097922A1 (en) * 1998-07-15 2001-05-09 Ono Pharmaceutical Co., Ltd. 5-thia-omega-substituted phenyl-prostaglandin e derivatives, process for producing the same and drugs containing the same as the active ingredient
US6586468B1 (en) * 1998-09-14 2003-07-01 Ono Pharmaceutical Co., Ltd. ω-substituted phenyl-prostaglandin E derivatives and drugs containing the same as the active ingredient
US20020002140A1 (en) * 2000-01-14 2002-01-03 Holick Michael F. Novel bisphosphonates and uses thereof
US20040102499A1 (en) * 2001-06-14 2004-05-27 Allergan, Inc. EP4 agonists as agents for lowering intraocular pressure
US20050222094A1 (en) * 2001-06-14 2005-10-06 Burk Robert M Treatment of inflammatory bowel disease
EP1417975A1 (en) * 2001-07-23 2004-05-12 Ono Pharmaceutical Co., Ltd. REMEDIES FOR DISEASES WITH BONE MASS LOSS HAVING EP sb 4 /sb AGONIST AS THE ACTIVE INGREDIENT
US20040157901A1 (en) * 2003-02-11 2004-08-12 Allergan, Inc. 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
AKAMATSU K et al. Int. J of Pharmaceutics, vol. 155 (1), 1997, pp. 65-74. *
ANDERSON, BRADLEY D. et al. J. Pharmaceutical Sci. vol. 69 (4), pp. 424-430. *
CHOURASIA M. K. et al. J. of Delivery & Targeting of Therapeutic Agents, vol. 11 (2), 2004, pp. 129-148. *
FRIEND D. R. et al. J. of Controlled Release, vol. 15 (1), 1991, pp. 47-54. *
KABASHIMA K et al. J. of Clinical Investigation, vol. 109 (7), 2002, pp. 883-893. *
KAJINO HIROKI et al. Pediatric Research, vol. 56 (4), pp. 586-590. *
MARUYAMA T et al. Bioorganic & Medicinal Chemistry, vol. 10, 2002, pp. 2103-2110. *
YOSHIDA K et al. Proceedings of the National Academy of Sciences of the United States of America, vol. 99 (7), pp. 4580-4585. *

Also Published As

Publication number Publication date
AU2005299473A1 (en) 2006-05-04
WO2006047476A3 (en) 2006-09-28
JP2008518013A (ja) 2008-05-29
US20080132543A1 (en) 2008-06-05
BRPI0518242A2 (pt) 2008-11-11
EP1805139A2 (en) 2007-07-11
CA2585367A1 (en) 2006-05-04
WO2006047476A2 (en) 2006-05-04

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Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired