AU2005281703B2 - Novel 3-thia-10-aza-phenanthrene derivatives - Google Patents

Novel 3-thia-10-aza-phenanthrene derivatives Download PDF

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Publication number
AU2005281703B2
AU2005281703B2 AU2005281703A AU2005281703A AU2005281703B2 AU 2005281703 B2 AU2005281703 B2 AU 2005281703B2 AU 2005281703 A AU2005281703 A AU 2005281703A AU 2005281703 A AU2005281703 A AU 2005281703A AU 2005281703 B2 AU2005281703 B2 AU 2005281703B2
Authority
AU
Australia
Prior art keywords
solvate
salt
hydrate
formula
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005281703A
Other languages
English (en)
Other versions
AU2005281703A1 (en
Inventor
Jens Christoffers
Dieter Flockerzi
Armin Hatzelmann
Ulrich Kautz
Hans-Peter Kley
Degenhard Marx
Anna Rosiak
Andrea Wohlsen
Christof Zitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Takeda GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda GmbH filed Critical Takeda GmbH
Publication of AU2005281703A1 publication Critical patent/AU2005281703A1/en
Assigned to NYCOMED GMBH reassignment NYCOMED GMBH Request for Assignment Assignors: ALTANA PHARMA AG
Application granted granted Critical
Publication of AU2005281703B2 publication Critical patent/AU2005281703B2/en
Assigned to TAKEDA GMBH reassignment TAKEDA GMBH Request to Amend Deed and Register Assignors: NYCOMED GMBH
Assigned to TAKEDA GMBH reassignment TAKEDA GMBH Request to Amend Deed and Register Assignors: TAKEDA GMBH
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2005281703A 2004-09-08 2005-09-05 Novel 3-thia-10-aza-phenanthrene derivatives Ceased AU2005281703B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04104319 2004-09-08
EP04104319.1 2004-09-08
PCT/EP2005/054365 WO2006027345A2 (en) 2004-09-08 2005-09-05 Novel 3-thia-10-aza-phenanthrene derivatives

Publications (2)

Publication Number Publication Date
AU2005281703A1 AU2005281703A1 (en) 2006-03-16
AU2005281703B2 true AU2005281703B2 (en) 2011-11-17

Family

ID=34929550

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005281703A Ceased AU2005281703B2 (en) 2004-09-08 2005-09-05 Novel 3-thia-10-aza-phenanthrene derivatives

Country Status (6)

Country Link
US (2) US7589205B2 (enExample)
EP (1) EP1791847A2 (enExample)
JP (1) JP4960870B2 (enExample)
AU (1) AU2005281703B2 (enExample)
CA (1) CA2579000C (enExample)
WO (1) WO2006027345A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005027866D1 (de) 2004-09-08 2011-06-16 Nycomed Gmbh 3-oxa-10-aza-phenanthrene als pde4- oder pde3/4-inhibitoren
AR079451A1 (es) * 2009-12-18 2012-01-25 Nycomed Gmbh Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
EP2721036B1 (en) 2011-06-15 2015-07-22 Takeda GmbH Novel 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c]isoquinoline compounds
WO2018069210A1 (en) * 2016-10-10 2018-04-19 Takeda Gmbh Tetrahydrofuro[3,4-c]isoquinolines as inhibitors of pde4
CN107998147A (zh) * 2017-11-06 2018-05-08 广州医科大学附属第医院 一种抑制或治疗copd的雾化吸入制剂及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012501A1 (de) * 1998-08-31 2000-03-09 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridin-n-oxide mit pde3 und pde4 inhibierender aktivität
WO2002005616A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Novel 6-phenylphenanthridines

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU221380B1 (en) 1996-01-31 2002-09-28 Byk Gulden Lomberg Chem Fab Phosphodiesterase inhibitor phenanthridines derivatives and use thereof
PL189641B1 (pl) 1996-11-11 2005-09-30 Altana Pharma Ag Benzonaftyrydyny, środki farmaceutyczne je zawierające oraz zastosowanie benzonaftyrydyn
WO1998040382A1 (en) 1997-03-07 1998-09-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel tetrazoles
US6306869B1 (en) 1998-05-05 2001-10-23 Byk Gulden Lomberg Chemische Febrik Gmbh N-oxides
IT1303272B1 (it) 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
JP2002534506A (ja) 1999-01-15 2002-10-15 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング Ｐｄｅ−ｉｖ抑制作用を有する多重に置換された６−フェニルフェナントリジン
CZ300366B6 (cs) 1999-01-15 2009-05-06 Nycomed Gmbh Fenylfenanthridinová sloucenina, farmaceutický prostredek s jejím obsahem a její použití
JP2002534505A (ja) * 1999-01-15 2002-10-15 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 新規フェナントリジン−ｎ−オキシド
CO5150225A1 (es) 1999-03-19 2002-04-29 Merck Sharp & Dohme Derivados del tetrahidropirano y su uso como agentes terapeuticos
JPWO2002056160A1 (ja) 2001-01-15 2004-05-20 ソニー株式会社 記録媒体並びにデータ処理装置及び方法
ES2279215T3 (es) 2002-08-29 2007-08-16 Altana Pharma Ag 2-hidroxi-6-fenilfenantridinas como inhibidores de pde-4.
KR20060130697A (ko) 2004-03-10 2006-12-19 알타나 파마 아게 신규한 아미도-치환 히드록시-6-페닐페난트리딘 및 ｐｄｅ4억제제로서의 이의 용도
DE602005027866D1 (de) 2004-09-08 2011-06-16 Nycomed Gmbh 3-oxa-10-aza-phenanthrene als pde4- oder pde3/4-inhibitoren

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012501A1 (de) * 1998-08-31 2000-03-09 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridin-n-oxide mit pde3 und pde4 inhibierender aktivität
WO2002005616A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Novel 6-phenylphenanthridines

Also Published As

Publication number Publication date
CA2579000C (en) 2013-02-05
JP2008512367A (ja) 2008-04-24
US7589205B2 (en) 2009-09-15
WO2006027345A3 (en) 2006-08-31
US20080103168A1 (en) 2008-05-01
US8324404B2 (en) 2012-12-04
CA2579000A1 (en) 2006-03-16
EP1791847A2 (en) 2007-06-06
WO2006027345A2 (en) 2006-03-16
US20090239895A1 (en) 2009-09-24
AU2005281703A1 (en) 2006-03-16
JP4960870B2 (ja) 2012-06-27

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Owner name: NYCOMED GMBH

Free format text: FORMER NAME: ALTANA PHARMA AG

FGA Letters patent sealed or granted (standard patent)
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE PATAMENDMENTS ENTEE TO READ TAKEDA GMBH .

MK14 Patent ceased section 143(a) (annual fees not paid) or expired