AU2005277357B2 - IL-1 antagonist formulations - Google Patents
IL-1 antagonist formulations Download PDFInfo
- Publication number
- AU2005277357B2 AU2005277357B2 AU2005277357A AU2005277357A AU2005277357B2 AU 2005277357 B2 AU2005277357 B2 AU 2005277357B2 AU 2005277357 A AU2005277357 A AU 2005277357A AU 2005277357 A AU2005277357 A AU 2005277357A AU 2005277357 B2 AU2005277357 B2 AU 2005277357B2
- Authority
- AU
- Australia
- Prior art keywords
- formulation
- antagonist
- lyophilized
- sucrose
- trap
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2006—IL-1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Marine Sciences & Fisheries (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60213704P | 2004-08-17 | 2004-08-17 | |
| US60/602,137 | 2004-08-17 | ||
| PCT/US2005/029428 WO2006023665A2 (en) | 2004-08-17 | 2005-08-17 | Il-1 antagonist formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2005277357A1 AU2005277357A1 (en) | 2006-03-02 |
| AU2005277357B2 true AU2005277357B2 (en) | 2011-08-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005277357A Ceased AU2005277357B2 (en) | 2004-08-17 | 2005-08-17 | IL-1 antagonist formulations |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7365165B2 (https=) |
| EP (2) | EP2311871A3 (https=) |
| JP (2) | JP4948410B2 (https=) |
| CN (1) | CN101014617B (https=) |
| AU (1) | AU2005277357B2 (https=) |
| BR (1) | BRPI0514411B8 (https=) |
| CA (1) | CA2576519C (https=) |
| DK (1) | DK1778723T3 (https=) |
| ES (1) | ES2395035T3 (https=) |
| PL (1) | PL1778723T3 (https=) |
| PT (1) | PT1778723E (https=) |
| SI (1) | SI1778723T1 (https=) |
| WO (1) | WO2006023665A2 (https=) |
| ZA (1) | ZA200701529B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2531988C (en) | 2003-08-05 | 2016-06-28 | Novo Nordisk A/S | Novel insulin derivatives |
| ES2371361T3 (es) | 2005-12-28 | 2011-12-30 | Novo Nordisk A/S | Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones. |
| CA2654510C (en) | 2006-06-16 | 2015-03-17 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations suitable for intravitreal administration |
| US7879805B2 (en) * | 2007-06-01 | 2011-02-01 | Acologix, Inc. | High temperature stable peptide formulation |
| JP5552046B2 (ja) | 2007-06-13 | 2014-07-16 | ノボ・ノルデイスク・エー／エス | インスリン誘導体を含有する薬学的製剤 |
| PE20091174A1 (es) * | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| US9492375B2 (en) | 2008-07-23 | 2016-11-15 | Warsaw Orthopedic, Inc. | Foam carrier for bone grafting |
| JP4959005B2 (ja) | 2008-10-30 | 2012-06-20 | ノボ・ノルデイスク・エー／エス | 毎日の注射頻度より少ないインスリン注射での真性糖尿病の治療 |
| ES2952394T3 (es) | 2010-07-29 | 2023-10-31 | Buzzard Pharmaceuticals AB | Antagonistas quiméricos del receptor IL-1 de tipo I |
| DK2632478T3 (da) | 2010-10-27 | 2019-10-07 | Novo Nordisk As | Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller |
| ES2985784T3 (es) | 2011-11-18 | 2024-11-07 | Regeneron Pharma | Micropartículas de proteínas recubiertas con polímeros para formulaciones de liberación prolongada para su uso en el humor vítreo del ojo para tratar trastornos oculares vasculares |
| EP2834262B1 (en) * | 2012-04-04 | 2020-09-02 | Polaris Group | Composition comprising pegylated arginine deiminase |
| WO2014035361A1 (en) * | 2012-08-26 | 2014-03-06 | R-PHARM, CJSC (Closed Joint Stock Company) | IL-1β INHIBITOR COMPOSITION AND USE THEREOF |
| EP2968468B1 (en) | 2013-03-13 | 2021-07-14 | Buzzard Pharmaceuticals AB | Chimeric cytokine formulations for ocular delivery |
| EP2991672A1 (en) | 2013-04-30 | 2016-03-09 | Novo Nordisk A/S | Novel administration regime |
| US11166915B2 (en) | 2016-09-16 | 2021-11-09 | Leukocare Ag | Method for obtaining efficient viral vector-based compositions for vaccination or gene therapy |
| KR20190053908A (ko) | 2016-09-16 | 2019-05-20 | 로이코케어 아게 | 가공 동안 바이오 의약품의 안정화를 위한 신규한 방법 |
| TWI784982B (zh) | 2016-11-02 | 2022-12-01 | 開曼群島商北極星藥業集團股份有限公司 | 聚乙二醇化精胺酸脫亞胺酶之調配物 |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| US12343383B2 (en) | 2019-07-12 | 2025-07-01 | Novo Nordisk A/S | High concentration insulin formulation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993000807A1 (en) * | 1991-07-03 | 1993-01-21 | Cryolife, Inc. | Method for stabilization of biomaterials |
| US20030143697A1 (en) * | 1998-09-25 | 2003-07-31 | Neil Stahl | Receptor based antagonists and methods of making and using |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3822383B2 (ja) * | 1993-12-17 | 2006-09-20 | 持田製薬株式会社 | 可溶性トロンボモジュリン含有組成物 |
| JP2000510813A (ja) * | 1995-02-06 | 2000-08-22 | ジェネテイックス・インスティテュート・インコーポレイテッド | Ｉｌ−１２用処方 |
| US5763401A (en) * | 1996-07-12 | 1998-06-09 | Bayer Corporation | Stabilized albumin-free recombinant factor VIII preparation having a low sugar content |
| JP4172842B2 (ja) * | 1997-05-02 | 2008-10-29 | 生化学工業株式会社 | コンドロイチナーゼ組成物 |
| US6436897B2 (en) | 1998-06-01 | 2002-08-20 | Celtrix Pharmaceuticals, Inc. | Pharmaceutical formulations for IGF/IGFBP |
| US6472179B2 (en) * | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
| MXPA04000747A (es) * | 2001-07-25 | 2004-07-08 | Protein Desing Labs Inc | Formulacion farmaceutica liofilizada estable de anticuerpos igg. |
| DE10204792A1 (de) * | 2002-02-06 | 2003-08-14 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Immuncytokine |
| CA2512680A1 (en) * | 2003-01-08 | 2004-07-29 | Chiron Corporation | Stabilized lyophilized compositions comprising tissue factor pathway inhibitor or tissue factor pathway inhibitor variants |
-
2005
- 2005-08-17 CA CA2576519A patent/CA2576519C/en not_active Expired - Fee Related
- 2005-08-17 CN CN2005800281894A patent/CN101014617B/zh not_active Expired - Lifetime
- 2005-08-17 PL PL05789252T patent/PL1778723T3/pl unknown
- 2005-08-17 BR BRPI0514411A patent/BRPI0514411B8/pt not_active IP Right Cessation
- 2005-08-17 DK DK05789252.3T patent/DK1778723T3/da active
- 2005-08-17 PT PT57892523T patent/PT1778723E/pt unknown
- 2005-08-17 EP EP10010576A patent/EP2311871A3/en not_active Withdrawn
- 2005-08-17 SI SI200531654T patent/SI1778723T1/sl unknown
- 2005-08-17 EP EP05789252A patent/EP1778723B1/en not_active Expired - Lifetime
- 2005-08-17 WO PCT/US2005/029428 patent/WO2006023665A2/en not_active Ceased
- 2005-08-17 ES ES05789252T patent/ES2395035T3/es not_active Expired - Lifetime
- 2005-08-17 US US11/205,935 patent/US7365165B2/en not_active Expired - Lifetime
- 2005-08-17 AU AU2005277357A patent/AU2005277357B2/en not_active Ceased
- 2005-08-17 JP JP2007528019A patent/JP4948410B2/ja not_active Expired - Fee Related
-
2007
- 2007-02-21 ZA ZA2007/01529A patent/ZA200701529B/en unknown
-
2012
- 2012-01-26 JP JP2012013973A patent/JP2012121894A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993000807A1 (en) * | 1991-07-03 | 1993-01-21 | Cryolife, Inc. | Method for stabilization of biomaterials |
| US20030143697A1 (en) * | 1998-09-25 | 2003-07-31 | Neil Stahl | Receptor based antagonists and methods of making and using |
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| CARPENTER J.F et al. Pharmaceutical Research. 1997. 14(8): 969-975 * |
| CHANGE BYEONG S et al. Archives of Biochemistry and Biophysics. 1996. 331(2): 249-258 * |
| KATAYAMA DERRICK S et al. Journal of Pharmaceutical Sciences. 2004. 93(10): 2609-2623 * |
| WANG WEI. International Journal of Pharmaceutics. 1999. 185(2): 129-188 * |
| WEBB S.D et al. Journal of Pharmaceutical Sciences. 2002. 91(2): 543-558 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012121894A (ja) | 2012-06-28 |
| EP1778723A2 (en) | 2007-05-02 |
| DK1778723T3 (da) | 2012-12-03 |
| CN101014617B (zh) | 2011-03-30 |
| CN101014617A (zh) | 2007-08-08 |
| EP1778723B1 (en) | 2012-11-14 |
| CA2576519C (en) | 2013-05-21 |
| EP2311871A3 (en) | 2012-08-08 |
| SI1778723T1 (sl) | 2013-02-28 |
| AU2005277357A1 (en) | 2006-03-02 |
| BRPI0514411A (pt) | 2008-06-10 |
| EP2311871A2 (en) | 2011-04-20 |
| HK1105421A1 (zh) | 2008-02-15 |
| BRPI0514411B1 (pt) | 2020-09-15 |
| BRPI0514411B8 (pt) | 2021-05-25 |
| US7365165B2 (en) | 2008-04-29 |
| CA2576519A1 (en) | 2006-03-02 |
| ZA200701529B (en) | 2008-09-25 |
| ES2395035T3 (es) | 2013-02-07 |
| WO2006023665A3 (en) | 2006-08-03 |
| PL1778723T3 (pl) | 2013-03-29 |
| JP4948410B2 (ja) | 2012-06-06 |
| US20060040852A1 (en) | 2006-02-23 |
| WO2006023665A2 (en) | 2006-03-02 |
| PT1778723E (pt) | 2013-01-25 |
| JP2008510716A (ja) | 2008-04-10 |
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Legal Events
| Date | Code | Title | Description |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |