AU2005259787B2 - Method of detecting mutations in the gene encoding cytochrome P450-2D6 - Google Patents

Method of detecting mutations in the gene encoding cytochrome P450-2D6 Download PDF

Info

Publication number
AU2005259787B2
AU2005259787B2 AU2005259787A AU2005259787A AU2005259787B2 AU 2005259787 B2 AU2005259787 B2 AU 2005259787B2 AU 2005259787 A AU2005259787 A AU 2005259787A AU 2005259787 A AU2005259787 A AU 2005259787A AU 2005259787 B2 AU2005259787 B2 AU 2005259787B2
Authority
AU
Australia
Prior art keywords
seq
primers
pcr
primer
variants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005259787A
Other languages
English (en)
Other versions
AU2005259787A1 (en
Inventor
James D. Gordon
Frank Merante
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Luminex Molecular Diagnostics Inc
Original Assignee
Luminex Molecular Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luminex Molecular Diagnostics Inc filed Critical Luminex Molecular Diagnostics Inc
Publication of AU2005259787A1 publication Critical patent/AU2005259787A1/en
Assigned to LUMINEX MOLECULAR DIAGNOSTICS, INC. reassignment LUMINEX MOLECULAR DIAGNOSTICS, INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: TM BIOSCIENCE PGX, INC.
Application granted granted Critical
Publication of AU2005259787B2 publication Critical patent/AU2005259787B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Foundations (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Investigation Of Foundation Soil And Reinforcement Of Foundation Soil By Compacting Or Drainage (AREA)
AU2005259787A 2004-06-30 2005-06-30 Method of detecting mutations in the gene encoding cytochrome P450-2D6 Ceased AU2005259787B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58360504P 2004-06-30 2004-06-30
US60/583,605 2004-06-30
PCT/CA2005/001000 WO2006002526A1 (en) 2004-06-30 2005-06-30 Method of detecting mutations in the gene encoding cytochrome p450-2d6

Publications (2)

Publication Number Publication Date
AU2005259787A1 AU2005259787A1 (en) 2006-01-12
AU2005259787B2 true AU2005259787B2 (en) 2011-02-24

Family

ID=35782443

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005259787A Ceased AU2005259787B2 (en) 2004-06-30 2005-06-30 Method of detecting mutations in the gene encoding cytochrome P450-2D6

Country Status (8)

Country Link
US (1) US20090215637A1 (enExample)
EP (1) EP1781811B1 (enExample)
JP (1) JP2008504826A (enExample)
AT (1) ATE471991T1 (enExample)
AU (1) AU2005259787B2 (enExample)
CA (1) CA2571823A1 (enExample)
DE (1) DE602005021971D1 (enExample)
WO (1) WO2006002526A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8688385B2 (en) * 2003-02-20 2014-04-01 Mayo Foundation For Medical Education And Research Methods for selecting initial doses of psychotropic medications based on a CYP2D6 genotype
WO2008076856A2 (en) * 2006-12-14 2008-06-26 Siemens Healthcare Diagnostics Inc. Reagents and methods for detecting cyp2d6 polymorphisms
JP5785942B2 (ja) 2009-06-29 2015-09-30 ルミネックス コーポレーション ヘアピンコンフォメーションを有するキメラプライマーおよびその使用法
CN104195229A (zh) * 2014-07-24 2014-12-10 益善生物技术股份有限公司 表皮生长因子受体抑制剂类药物疗效相关基因表达检测液相芯片试剂盒

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991010745A1 (en) * 1990-01-18 1991-07-25 Imperial Cancer Research Technology Limited Genetic assay for cytochrome p450
WO2001029260A2 (en) * 1999-10-19 2001-04-26 Affymetrix, Inc. Allele detection using primer extension with sequence-coded identity tags
WO2001055432A2 (en) * 2000-01-31 2001-08-02 Epidauros Biotechnologie Ag Polymorphisms in the human cyp2d6 gene promoter region and their use in diagnostic and therapeutic applications
JP2002119299A (ja) * 2000-10-16 2002-04-23 Internatl Reagents Corp 遺伝子変異分析法
WO2002083839A2 (en) * 2001-03-30 2002-10-24 Amersham Biosciences Ab P450 single nucleotide polymorphism biochip analysis
WO2003050282A1 (en) * 2001-12-06 2003-06-19 Tsumura & Co. Mutated cyp2d6 genes
US20040091909A1 (en) * 2002-07-05 2004-05-13 Huang Doug Hui High throughput cytochrome P450 genotyping
US20040096874A1 (en) * 2002-04-11 2004-05-20 Third Wave Technologies, Inc. Characterization of CYP 2D6 genotypes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4851331A (en) 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
EP0463395B1 (en) * 1990-06-22 1997-05-14 F. Hoffmann-La Roche Ag Detection of poor metabolizers of drugs
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
GB9902971D0 (en) * 1999-02-11 1999-03-31 Zeneca Ltd Assay
JP4422963B2 (ja) * 2001-01-25 2010-03-03 ルミネックス モレキュラー ダイアグノスティックス， インク． 標識および標識補体として使用するための非クロス交雑しているポリヌクレオチドのファミリー、製品、ならびにその使用方法
WO2006002525A1 (en) * 2004-06-30 2006-01-12 Tm Bioscience Pgx, Inc. Method of detecting mutations in the gene encoding cytochrome p450-2c9
WO2006010266A1 (en) * 2004-07-30 2006-02-02 Tm Bioscience Pgx, Inc. Et Al Method of detecting mutations in the gene encoding cytochrome p450-2c19

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991010745A1 (en) * 1990-01-18 1991-07-25 Imperial Cancer Research Technology Limited Genetic assay for cytochrome p450
WO2001029260A2 (en) * 1999-10-19 2001-04-26 Affymetrix, Inc. Allele detection using primer extension with sequence-coded identity tags
WO2001055432A2 (en) * 2000-01-31 2001-08-02 Epidauros Biotechnologie Ag Polymorphisms in the human cyp2d6 gene promoter region and their use in diagnostic and therapeutic applications
JP2002119299A (ja) * 2000-10-16 2002-04-23 Internatl Reagents Corp 遺伝子変異分析法
WO2002083839A2 (en) * 2001-03-30 2002-10-24 Amersham Biosciences Ab P450 single nucleotide polymorphism biochip analysis
WO2003050282A1 (en) * 2001-12-06 2003-06-19 Tsumura & Co. Mutated cyp2d6 genes
US20040096874A1 (en) * 2002-04-11 2004-05-20 Third Wave Technologies, Inc. Characterization of CYP 2D6 genotypes
US20040091909A1 (en) * 2002-07-05 2004-05-13 Huang Doug Hui High throughput cytochrome P450 genotyping

Also Published As

Publication number Publication date
EP1781811A4 (en) 2008-02-13
AU2005259787A1 (en) 2006-01-12
JP2008504826A (ja) 2008-02-21
DE602005021971D1 (de) 2010-08-05
EP1781811A1 (en) 2007-05-09
CA2571823A1 (en) 2006-01-12
US20090215637A1 (en) 2009-08-27
WO2006002526A1 (en) 2006-01-12
ATE471991T1 (de) 2010-07-15
EP1781811B1 (en) 2010-06-23

Similar Documents

Publication Publication Date Title
US7879543B2 (en) Method of detecting mutations associated with thrombosis
CA2420322A1 (en) Detection of cyp2d6 polymorphisms
Voisey et al. SNP technologies for drug discovery: a current review
Daca-Roszak et al. EurEAs_Gplex—a new SNaPshot assay for continental population discrimination and gender identification
JP2005524388A (ja) パクリタキセル応答性予測の一塩基多型及びそれらの組合せ
AU2005259786B2 (en) Method of detecting mutations in the gene encoding cytochrome P450-2C9
WO2005123951A2 (en) Methods of human leukocyte antigen typing by neighboring single nucleotide polymorphism haplotypes
EP1781811B1 (en) Method of detecting mutations in the gene encoding cytochrome p450-2d6
AU2005266805B2 (en) Method of detecting mutations in the gene encoding Cytochrome P450-2C19
Freimuth et al. High-throughput genotyping methods for pharmacogenomic studies
WO2002008468A1 (en) Diagnostic polymorphisms for the tgf-beta1 promoter
KR101145178B1 (ko) 트라마돌 구토 부작용 예후 유전표지 조합
CA2294572A1 (en) Genetic compositions and methods
JP2004283049A (ja) 日本人における貧メタボライザー（ｐｏｏｒｍｅｔａｂｏｌｉｚｅｒ）の判定方法
JP2005176601A (ja) Ｃｙｐ２ｄ６変異遺伝子
JP2005027519A (ja) ヒトチトクロームｐ４５０２ａ６遺伝子多型の簡易検出方法および検出用試薬

Legal Events

Date Code Title Description
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ MERANTE, FRANK AND GORDON, JAMES D..

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ MERANTE, FRANK AND GORDON, JAMES D.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired