AU2005246073B2 - Method of improving T cell receptors - Google Patents

Method of improving T cell receptors Download PDF

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Publication number
AU2005246073B2
AU2005246073B2 AU2005246073A AU2005246073A AU2005246073B2 AU 2005246073 B2 AU2005246073 B2 AU 2005246073B2 AU 2005246073 A AU2005246073 A AU 2005246073A AU 2005246073 A AU2005246073 A AU 2005246073A AU 2005246073 B2 AU2005246073 B2 AU 2005246073B2
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AU
Australia
Prior art keywords
tcr
tcrs
sequence
chain
affinity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
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AU2005246073A
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English (en)
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AU2005246073A1 (en
Inventor
Jonathan Michael Boulter
Steven Mark Dunn
Yi Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunocore Ltd
Adaptimmune Ltd
Original Assignee
Immunocore Ltd
Adaptimmune Ltd
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Filing date
Publication date
Priority claimed from GB0411125A external-priority patent/GB0411125D0/en
Priority claimed from GB0419646A external-priority patent/GB0419646D0/en
Application filed by Immunocore Ltd, Adaptimmune Ltd filed Critical Immunocore Ltd
Publication of AU2005246073A1 publication Critical patent/AU2005246073A1/en
Assigned to IMMUNOCORE LIMITED reassignment IMMUNOCORE LIMITED Request for Assignment Assignors: AVIDEX LTD
Application granted granted Critical
Publication of AU2005246073B2 publication Critical patent/AU2005246073B2/en
Assigned to IMMUNOCORE LIMITED, ADAPTIMMUNE LIMITED reassignment IMMUNOCORE LIMITED Request for Assignment Assignors: IMMUNOCORE LIMITED
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2005246073A 2004-05-19 2005-05-10 Method of improving T cell receptors Expired AU2005246073B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0411125.8 2004-05-19
GB0411125A GB0411125D0 (en) 2004-05-19 2004-05-19 Method of improving T-cell receptors
GB0419646A GB0419646D0 (en) 2004-09-03 2004-09-03 Method of improving t cell receptors
GB0419646.5 2004-09-03
PCT/GB2005/001781 WO2005114215A2 (en) 2004-05-19 2005-05-10 Method of improving t cell receptors

Publications (2)

Publication Number Publication Date
AU2005246073A1 AU2005246073A1 (en) 2005-12-01
AU2005246073B2 true AU2005246073B2 (en) 2010-10-28

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AU2005246073A Expired AU2005246073B2 (en) 2004-05-19 2005-05-10 Method of improving T cell receptors

Country Status (10)

Country Link
US (1) US7608410B2 (https=)
EP (1) EP1756278B1 (https=)
JP (1) JP4972549B2 (https=)
AT (1) ATE408684T1 (https=)
AU (1) AU2005246073B2 (https=)
CA (1) CA2567349C (https=)
DE (1) DE602005009825D1 (https=)
NZ (1) NZ550815A (https=)
WO (1) WO2005114215A2 (https=)
ZA (1) ZA200609462B (https=)

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Publication number Publication date
EP1756278B1 (en) 2008-09-17
CA2567349C (en) 2012-11-27
JP2007537743A (ja) 2007-12-27
DE602005009825D1 (de) 2008-10-30
US7608410B2 (en) 2009-10-27
EP1756278A2 (en) 2007-02-28
HK1105995A1 (en) 2008-02-29
ATE408684T1 (de) 2008-10-15
WO2005114215A2 (en) 2005-12-01
ZA200609462B (en) 2008-04-30
AU2005246073A1 (en) 2005-12-01
CA2567349A1 (en) 2005-12-01
NZ550815A (en) 2009-04-30
JP4972549B2 (ja) 2012-07-11
WO2005114215A3 (en) 2006-03-16
US20090054257A1 (en) 2009-02-26
WO2005114215A9 (en) 2006-07-20

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