AU2005209921B2 - Methods and compositions for modulating angiogenesis - Google Patents

Methods and compositions for modulating angiogenesis Download PDF

Info

Publication number
AU2005209921B2
AU2005209921B2 AU2005209921A AU2005209921A AU2005209921B2 AU 2005209921 B2 AU2005209921 B2 AU 2005209921B2 AU 2005209921 A AU2005209921 A AU 2005209921A AU 2005209921 A AU2005209921 A AU 2005209921A AU 2005209921 B2 AU2005209921 B2 AU 2005209921B2
Authority
AU
Australia
Prior art keywords
cancer
ccx
ckr2
cells
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005209921A
Other languages
English (en)
Other versions
AU2005209921A1 (en
Inventor
Jennifer Burns
Maureen Howard
Zhenhua Miao
Thomas Schall
Bretton Summers
Yu Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemocentryx Inc
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Publication of AU2005209921A1 publication Critical patent/AU2005209921A1/en
Application granted granted Critical
Publication of AU2005209921B2 publication Critical patent/AU2005209921B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/195—Chemokines, e.g. RANTES
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2005209921A 2004-02-03 2005-02-02 Methods and compositions for modulating angiogenesis Ceased AU2005209921B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US54184904P 2004-02-03 2004-02-03
US60/541,849 2004-02-03
US59895804P 2004-08-04 2004-08-04
US60/598,958 2004-08-04
US62619504P 2004-11-08 2004-11-08
US60/626,195 2004-11-08
PCT/US2005/003521 WO2005074645A2 (en) 2004-02-03 2005-02-02 Methods and compositions for modulating angiogenesis

Publications (2)

Publication Number Publication Date
AU2005209921A1 AU2005209921A1 (en) 2005-08-18
AU2005209921B2 true AU2005209921B2 (en) 2011-04-07

Family

ID=34841735

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005209921A Ceased AU2005209921B2 (en) 2004-02-03 2005-02-02 Methods and compositions for modulating angiogenesis

Country Status (7)

Country Link
US (1) US20050214287A1 (cg-RX-API-DMAC7.html)
EP (1) EP1715892A4 (cg-RX-API-DMAC7.html)
JP (1) JP4916889B2 (cg-RX-API-DMAC7.html)
AU (1) AU2005209921B2 (cg-RX-API-DMAC7.html)
CA (1) CA2554880A1 (cg-RX-API-DMAC7.html)
IL (1) IL177104A (cg-RX-API-DMAC7.html)
WO (1) WO2005074645A2 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006038989A1 (en) * 2004-09-29 2006-04-13 Chemocentryx, Inc. Substituted arylamides
AU2006263657A1 (en) * 2005-06-29 2007-01-04 Chemocentryx, Inc. Substituted N-cinnamyl benzamides
US8088895B2 (en) * 2006-10-18 2012-01-03 Chemocentryx, Inc. Antibodies that bind CXCR7 epitopes
JP2009091339A (ja) * 2007-10-12 2009-04-30 Seikagaku Kogyo Co Ltd 関節リウマチの処置剤
US8853202B2 (en) * 2008-11-04 2014-10-07 Chemocentryx, Inc. Modulators of CXCR7
US20110014121A1 (en) * 2008-11-04 2011-01-20 Chemocentryx, Inc. Modulators of cxcr7
CA2742515C (en) * 2008-11-04 2017-07-11 Chemocentryx, Inc. 1,4-diazepane modulators of cxcr7
US20120045393A1 (en) 2009-03-17 2012-02-23 Linder Karen E Lhrh-ii peptide analogs
MX359651B (es) 2012-11-29 2018-10-05 Chemocentryx Inc Antagonistas de cxcr7.
MX2021006915A (es) 2018-12-12 2021-08-24 Chemocentryx Inc Inhibidores de cxcr7 para el tratamiento de cancer.
CN111593022B (zh) * 2018-12-27 2023-10-24 广州溯原生物科技股份有限公司 vMIP-Ⅱ诱导CD8+ T细胞去磷酸化为Tcm及其在药物中的应用
EP4326257A4 (en) 2021-04-19 2025-03-12 ChemoCentryx, Inc. AZETIDINYLACETAMIDES AS CXCR7 INHIBITORS

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040019917A1 (en) * 1998-02-10 2004-01-29 Millennium Pharmaceuticals, Inc. NEOKINE protein and nucleic acid molecules and uses therefor
WO2004058705A2 (en) * 2002-12-20 2004-07-15 Chemocentryx Inhibitors of the binding of chemokines i-tac or sdf-1 to the ccxckr2 receptor
WO2004062591A2 (en) * 2003-01-06 2004-07-29 Oregon Health And Science University Methods of treatment and diagnosis of kaposi's sarcoma (ks) and ks related diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002506830A (ja) * 1998-03-13 2002-03-05 ザ ユニバーシティ オブ ブリティッシュ コロンビア 治療的ケモカイン受容体アンタゴニスト
US20020107195A1 (en) * 1998-07-21 2002-08-08 Smithkline Beecham Corporation Method for inducing chemotaxis in endothelial cells by administering stromal cell derived factor-1alpha
DE60137435D1 (de) * 2000-09-15 2009-03-05 Anormed Inc Chemokin rezeptor bindenden heterozyklische verbindungen
US20040157818A1 (en) * 2001-05-24 2004-08-12 Mikiro Yanaka Cxcr4-antagonistic drugs composed of nitrogen-containing compound
US7253007B2 (en) * 2001-11-30 2007-08-07 Chemocentryx, Inc. Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040019917A1 (en) * 1998-02-10 2004-01-29 Millennium Pharmaceuticals, Inc. NEOKINE protein and nucleic acid molecules and uses therefor
WO2004058705A2 (en) * 2002-12-20 2004-07-15 Chemocentryx Inhibitors of the binding of chemokines i-tac or sdf-1 to the ccxckr2 receptor
WO2004062591A2 (en) * 2003-01-06 2004-07-29 Oregon Health And Science University Methods of treatment and diagnosis of kaposi's sarcoma (ks) and ks related diseases

Also Published As

Publication number Publication date
IL177104A (en) 2010-12-30
WO2005074645A3 (en) 2005-12-22
JP2007520564A (ja) 2007-07-26
EP1715892A2 (en) 2006-11-02
US20050214287A1 (en) 2005-09-29
JP4916889B2 (ja) 2012-04-18
EP1715892A4 (en) 2008-07-09
WO2005074645A2 (en) 2005-08-18
AU2005209921A1 (en) 2005-08-18
CA2554880A1 (en) 2005-08-18
IL177104A0 (en) 2006-12-10

Similar Documents

Publication Publication Date Title
US7871619B2 (en) Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
AU2005209921B2 (en) Methods and compositions for modulating angiogenesis
US7777009B2 (en) Compositions for detecting and treating diseases and conditions related to chemokine receptors
KR20060136373A (ko) 케모카인 수용체와 관련된 질병 및 증상의 검출 및 치료용조성물 및 방법
US20100247540A1 (en) Methods and Compositions For Modulating Angiogenesis
KR101149115B1 (ko) 혈관신생을 조절하기 위한 방법 및 조성물
MXPA06008680A (es) Metodos y composiciones para modular la angiogenesis
HK1094203B (en) Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
MXPA06004843A (es) Composiciones y metodos para detectar y tratar enfermedades y condiciones relacionadas con receptores de quemocina
Timmer et al. Gene expression profiling provides a link between high inflammatory synovitis and myofibroblast-like synoviocytes
Mewar et al. Antibodies to ferritin in rheumatoid arthritis are associated with disease severity
Djouad et al. Phenotypic, genotypic and functional characterization of mesenchymal stem cells from synovial membrane compared with bone marrow
Fearon et al. Oncostatin M in rheumatoid arthritis: a key cytokine acts synergistically with other proinflammatory cytokines to promote human cartilage loss
Dell'Accio et al. Molecular response to cartilage injury
Remans et al. Free radicals regulate glucocorticoid-induced apoptosis in T lymphocytes
Stummvoll et al. Autoreactive T cells to histone H1 and core histones in patients with systemic lupus erythematosus
Svenungsson et al. Endothelial function and activation in women with systemic lupus erythematosus
Clavel et al. Kinetic and influence of angiogenesis in the course of collagen-induced arthritis
Bessis et al. NKT cell status and IL-10-dependent therapeutic effect of NKT cell stimulation on collagen-arthritis in DBA/1 mice
Palmer et al. Intracellular IL-1 receptor antagonist (icIL-1Ra1) does not antagonize growth inhibitory effects of pre-IL-1α in SaOS-2 cells
Ali et al. Complement and Fc receptor cross-talk in the Arthus reaction: the inflammatory cascade confirmed and refined
Smith et al. Rheumatoid synovial fibroblasts activate endothelial cells and promote neutrophil recruitment in a flow based multicellular model of the rheumatoid pannus
Joosten et al. Local IL-18 gene transfer prevents severe joint destruction in murine collagen-induced arthritis by induction of IL-4 and osteoprotegerin
Rynne et al. Hearing improvement in a variant Muckle–Wells syndrome case in response to IL-1 receptor antagonism
Gerlag et al. Real-time quantitative PCR used as a biomarker for synovial gene expression after oral prednisolone therapy in patients with rheumatoid arthritis

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired