AU2005200615B8 - New process for the synthesis of (7-methoxy-1-naphthyl)acetonitrile and its application in the synthesis of agomelatine - Google Patents

New process for the synthesis of (7-methoxy-1-naphthyl)acetonitrile and its application in the synthesis of agomelatine Download PDF

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Publication number
AU2005200615B8
AU2005200615B8 AU2005200615A AU2005200615A AU2005200615B8 AU 2005200615 B8 AU2005200615 B8 AU 2005200615B8 AU 2005200615 A AU2005200615 A AU 2005200615A AU 2005200615 A AU2005200615 A AU 2005200615A AU 2005200615 B8 AU2005200615 B8 AU 2005200615B8
Authority
AU
Australia
Prior art keywords
compound
synthesis
formula
methoxy
acetonitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU2005200615A
Other languages
English (en)
Other versions
AU2005200615A1 (en
AU2005200615B2 (en
Inventor
Isaac Gonzalez Blanco
Jean-Claude Souvie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Publication of AU2005200615A1 publication Critical patent/AU2005200615A1/en
Publication of AU2005200615B2 publication Critical patent/AU2005200615B2/en
Application granted granted Critical
Publication of AU2005200615B8 publication Critical patent/AU2005200615B8/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/24—Surgical instruments, devices or methods for use in the oral cavity, larynx, bronchial passages or nose; Tongue scrapers
    • A61B17/244—Surgical instruments, devices or methods for use in the oral cavity, larynx, bronchial passages or nose; Tongue scrapers for cleaning of the tongue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C17/00—Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Dentistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2005200615A 2004-02-13 2005-02-11 New process for the synthesis of (7-methoxy-1-naphthyl)acetonitrile and its application in the synthesis of agomelatine Expired AU2005200615B8 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR04.01437 2004-02-13
FR0401437A FR2866337B1 (fr) 2004-02-13 2004-02-13 Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'aglomelatine

Publications (3)

Publication Number Publication Date
AU2005200615A1 AU2005200615A1 (en) 2005-09-01
AU2005200615B2 AU2005200615B2 (en) 2011-05-12
AU2005200615B8 true AU2005200615B8 (en) 2011-05-26

Family

ID=34685017

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005200615A Expired AU2005200615B8 (en) 2004-02-13 2005-02-11 New process for the synthesis of (7-methoxy-1-naphthyl)acetonitrile and its application in the synthesis of agomelatine

Country Status (32)

Country Link
US (2) US7470806B2 (en:Method)
EP (1) EP1564205B1 (en:Method)
JP (1) JP4157529B2 (en:Method)
KR (1) KR100682698B1 (en:Method)
CN (1) CN1300100C (en:Method)
AR (1) AR047740A1 (en:Method)
AT (1) ATE395326T1 (en:Method)
AU (1) AU2005200615B8 (en:Method)
BR (1) BRPI0502037B8 (en:Method)
CA (1) CA2495975A1 (en:Method)
CY (1) CY1111081T1 (en:Method)
DE (1) DE602005006634D1 (en:Method)
DK (1) DK1564205T3 (en:Method)
EA (1) EA007787B1 (en:Method)
ES (1) ES2308409T3 (en:Method)
FR (1) FR2866337B1 (en:Method)
GE (1) GEP20063929B (en:Method)
HR (1) HRP20080315T3 (en:Method)
MA (1) MA27516A1 (en:Method)
ME (1) ME01403B (en:Method)
MX (1) MXPA05001636A (en:Method)
MY (1) MY140089A (en:Method)
NO (1) NO333493B1 (en:Method)
NZ (1) NZ538193A (en:Method)
PL (1) PL1564205T3 (en:Method)
PT (1) PT1564205E (en:Method)
RS (1) RS50594B (en:Method)
SG (1) SG114705A1 (en:Method)
SI (1) SI1564205T1 (en:Method)
UA (1) UA79623C2 (en:Method)
WO (1) WO2005077889A1 (en:Method)
ZA (1) ZA200501255B (en:Method)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011154140A2 (en) 2010-06-10 2011-12-15 Gador S.A. New process for the preparation of n-[2-(7-methoxy-1-naphthyl)-ethyl]acetamide and new crystalline form
WO2013054273A2 (en) 2011-10-11 2013-04-18 Ranbaxy Laboratories Limited Process for the preparation of agomelatine
US20140336380A1 (en) 2011-12-01 2014-11-13 Ranbaxy Laboratories Limited Process for the preparation of agomelatine
ITMI20121444A1 (it) 2012-08-27 2014-02-28 Procos Spa Processo per la produzione di agomelatine
FR3014434B1 (fr) * 2013-12-05 2015-12-25 Servier Lab Nouveau procede de synthese du 7-methoxy-naphtalene-1-carbaldehyde et application a la synthese de l'agomelatine
CN112574066B (zh) * 2019-09-27 2024-10-25 江苏豪森药业集团有限公司 一种阿戈美拉汀中间体的制备方法
CN111377829A (zh) * 2020-04-10 2020-07-07 苏州敬业医药化工有限公司 一种7-甲氧基-1-萘乙腈的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169108A (en) * 1973-08-16 1979-09-25 Sterling Drug Inc. 5(OR 6)-[(Substituted-amino)alkyl]-2,3-naphthalenediols
US4327022A (en) * 1973-08-16 1982-04-27 Sterling Drug Inc. Heterocyclic alkyl naphthols
US3931188A (en) * 1974-05-06 1976-01-06 Bristol-Myers Company 3-Hydroxy-5,6-benzomorphinan derivatives
US3992403A (en) * 1975-05-30 1976-11-16 Schering Corporation 2-Imidazolines and their use as hypoglycemic agents
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
RS50594B (sr) 2010-05-07
US20050182270A1 (en) 2005-08-18
AU2005200615A1 (en) 2005-09-01
PL1564205T3 (pl) 2008-09-30
AU2005200615B2 (en) 2011-05-12
MY140089A (en) 2009-11-30
BRPI0502037B8 (pt) 2021-05-25
DE602005006634D1 (de) 2008-06-26
DK1564205T3 (da) 2008-09-29
NZ538193A (en) 2005-12-23
NO20050739L (no) 2005-08-15
MXPA05001636A (es) 2005-08-19
UA79623C2 (en) 2007-07-10
CY1111081T1 (el) 2015-06-11
US7470806B2 (en) 2008-12-30
ATE395326T1 (de) 2008-05-15
SG114705A1 (en) 2005-09-28
KR100682698B1 (ko) 2007-02-15
JP4157529B2 (ja) 2008-10-01
WO2005077889A1 (fr) 2005-08-25
CN1300100C (zh) 2007-02-14
AR047740A1 (es) 2006-02-15
ZA200501255B (en) 2005-11-30
JP2005239717A (ja) 2005-09-08
HK1078564A1 (en) 2006-03-17
KR20060041903A (ko) 2006-05-12
FR2866337B1 (fr) 2006-05-26
BRPI0502037A (pt) 2005-11-16
FR2866337A1 (fr) 2005-08-19
ME01403B (me) 2010-05-07
GEP20063929B (en) 2006-09-25
MA27516A1 (fr) 2005-09-01
NO20050739D0 (no) 2005-02-11
SI1564205T1 (sl) 2008-08-31
PT1564205E (pt) 2008-06-19
US20090118544A1 (en) 2009-05-07
EP1564205A1 (fr) 2005-08-17
HRP20080315T3 (en) 2008-07-31
EP1564205B1 (fr) 2008-05-14
BRPI0502037B1 (pt) 2018-07-10
US7994359B2 (en) 2011-08-09
EA200500204A1 (ru) 2005-08-25
NO333493B1 (no) 2013-06-24
CN1680297A (zh) 2005-10-12
ES2308409T3 (es) 2008-12-01
CA2495975A1 (fr) 2005-08-13
EA007787B1 (ru) 2007-02-27

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US7999129B2 (en) Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine
AU2005200616B8 (en) New process for the synthesis and new crystalline form of agomelatine and pharmaceutical compositions containing it
AU2009203052B2 (en) New process for the synthesis of agomelatine
US7994359B2 (en) Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine
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Legal Events

Date Code Title Description
TH Corrigenda

Free format text: IN VOL 25, NO 18, PAGE(S) 2284 UNDER THE HEADING APPLICATIONS AC- CEPTED - NAME INDEX UNDER THE NAME LES LABORATOIRES SERVIER, APPLICATION NO. 2005200615, UNDER INID (72) CORRECT THE CO-INVENTOR TO GONZALEZ BLANCO, ISAAC

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired