AU2004311849B2 - Enteric coated aliphatic amine polymer bile acid sequestrants - Google Patents

Enteric coated aliphatic amine polymer bile acid sequestrants Download PDF

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Publication number
AU2004311849B2
AU2004311849B2 AU2004311849A AU2004311849A AU2004311849B2 AU 2004311849 B2 AU2004311849 B2 AU 2004311849B2 AU 2004311849 A AU2004311849 A AU 2004311849A AU 2004311849 A AU2004311849 A AU 2004311849A AU 2004311849 B2 AU2004311849 B2 AU 2004311849B2
Authority
AU
Australia
Prior art keywords
tablet
aliphatic amine
enteric coating
amine polymer
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004311849A
Other languages
English (en)
Other versions
AU2004311849A1 (en
Inventor
Hitesh R. Bhagat
William Braunlin
Joanne M. Donovan
Robert Sacchiero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of AU2004311849A1 publication Critical patent/AU2004311849A1/en
Application granted granted Critical
Publication of AU2004311849B2 publication Critical patent/AU2004311849B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2004311849A 2003-12-31 2004-12-23 Enteric coated aliphatic amine polymer bile acid sequestrants Ceased AU2004311849B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53356303P 2003-12-31 2003-12-31
US60/533,563 2003-12-31
PCT/US2004/043537 WO2005065291A2 (en) 2003-12-31 2004-12-23 Enteric coated aliphatic amine polymer bile acid sequestrants

Publications (2)

Publication Number Publication Date
AU2004311849A1 AU2004311849A1 (en) 2005-07-21
AU2004311849B2 true AU2004311849B2 (en) 2009-04-02

Family

ID=34748918

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004311849A Ceased AU2004311849B2 (en) 2003-12-31 2004-12-23 Enteric coated aliphatic amine polymer bile acid sequestrants

Country Status (6)

Country Link
US (1) US20070098678A1 (https=)
EP (1) EP1699442A2 (https=)
JP (1) JP2007517047A (https=)
AU (1) AU2004311849B2 (https=)
CA (1) CA2551528A1 (https=)
WO (1) WO2005065291A2 (https=)

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US7608674B2 (en) 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7767768B2 (en) 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7449605B2 (en) 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7335795B2 (en) 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7385012B2 (en) 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US8282960B2 (en) 2004-03-30 2012-10-09 Relypsa, Inc. Ion binding compositions
US7429394B2 (en) 2004-03-30 2008-09-30 Relypsa, Inc. Ion binding compositions
BRPI0509331B8 (pt) 2004-03-30 2021-05-25 Ilypsa Inc uso de uma composição de ligação de sódio
US7854924B2 (en) 2004-03-30 2010-12-21 Relypsa, Inc. Methods and compositions for treatment of ion imbalances
US7556799B2 (en) 2004-03-30 2009-07-07 Relypsa, Inc. Ion binding polymers and uses thereof
US8192758B2 (en) 2004-03-30 2012-06-05 Relypsa, Inc. Ion binding compositions
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
US7522961B2 (en) 2004-11-17 2009-04-21 Advanced Bionics, Llc Inner hair cell stimulation model for the use by an intra-cochlear implant
WO2006072054A1 (en) * 2004-12-30 2006-07-06 Genzyme Corporation Zinc-containing treatments for hyperphosphatemia
US8986669B2 (en) * 2005-09-02 2015-03-24 Genzyme Corporation Method for removing phosphate and polymer used therefore
AU2012205214B2 (en) * 2005-09-15 2015-05-21 Genzyme Corporation Formulation for Amine Polymers
EP3000460A1 (en) 2005-09-15 2016-03-30 Genzyme Corporation Sachet formulation for amine polymers
CA2624112A1 (en) 2005-09-30 2007-04-05 Ilypsa, Inc. Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom
GB2446077B (en) 2005-09-30 2010-10-13 Ilypsa Inc Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal
EP1945196A2 (en) * 2005-11-08 2008-07-23 Genzyme Corporation Magnesium-containing polymers for hyperphosphatemia
EP2016114A2 (en) * 2006-05-05 2009-01-21 Genzyme Corporation Amine condensation polymers as phosphate sequestrants
WO2008005217A2 (en) * 2006-07-05 2008-01-10 Genzyme Corporation Iron(ii)-containing treatments for hyperphosphatemia
AU2007275711A1 (en) * 2006-07-18 2008-01-24 Genzyme Corporation Amine dendrimers
EP2066293A2 (en) 2006-09-29 2009-06-10 Genzyme Corporation Amide dendrimer compositions
US8163799B2 (en) * 2006-12-14 2012-04-24 Genzyme Corporation Amido-amine polymer compositions
JP2010519298A (ja) * 2007-02-23 2010-06-03 ゲンズイメ コーポレーション アミンポリマー組成物
EP2131820A1 (en) * 2007-03-08 2009-12-16 Genzyme Corporation Sulfone polymer compositions
EP2152277A1 (en) * 2007-04-27 2010-02-17 Genzyme Corporation Amido-amine dendrimer compositions
WO2009078958A1 (en) * 2007-12-14 2009-06-25 Genzyme Corporation Coated pharmaceutical compositions
US20110142952A1 (en) * 2008-06-20 2011-06-16 Harris David J Pharmaceutical Compositions
DE102008030046A1 (de) * 2008-06-25 2009-12-31 Ratiopharm Gmbh Kompaktiertes Polyallylamin-Polymer
US8337824B2 (en) 2008-08-22 2012-12-25 Relypsa, Inc. Linear polyol stabilized polyfluoroacrylate compositions
WO2010041268A2 (en) 2008-09-02 2010-04-15 Usv Limited Crosslinked polymers
DE112011100657T5 (de) 2010-02-24 2013-02-28 Relypsa, Inc. Amin-polymere zur verwendung als gallensäuresequestriermittel
JP6475624B2 (ja) 2012-10-08 2019-02-27 レリプサ， インコーポレイテッド 高血圧症及び高カリウム血症を治療するためのカリウム結合剤
SI3287133T1 (sl) 2013-06-05 2019-09-30 Tricida Inc. Polimeri, ki vežejo protone,za peroralno dajanje
CN106573066A (zh) 2014-06-13 2017-04-19 联合治疗学有限公司 曲前列环素制剂
LT3229816T (lt) 2014-12-10 2020-05-25 Tricida Inc. Protoną prijungiantys polimerai, skirti peroraliniam įvedimui
MA41202A (fr) 2014-12-18 2017-10-24 Genzyme Corp Copolymères polydiallymine réticulé pour le traitement du diabète de type 2
US10245284B2 (en) 2015-08-19 2019-04-02 Alpex Pharma S.A. Granular composition for oral administration
US20190105277A1 (en) * 2016-04-05 2019-04-11 Pharmathen S.A. Pharmaceutical composition comprising an atypical antipsychotic agent and method for the preparation thereof
WO2017193024A1 (en) 2016-05-06 2017-11-09 Tricida, Inc. Hcl-binding compositions for and method of treating acid-base disorders
CN106405028A (zh) * 2016-10-10 2017-02-15 方达医药技术（苏州）有限公司 溶出仪在评价碳酸司维拉姆片生物等效中的应用
IL319146A (en) 2017-11-03 2025-04-01 Tricida Inc Compositions for and method of treating acid-base disorders
US11524029B2 (en) 2018-08-13 2022-12-13 Viscera Labs, Inc. Therapeutic composition and methods
US11590161B2 (en) 2018-08-13 2023-02-28 Viscera Labs, Inc. Therapeutic composition and methods
WO2021163007A1 (en) * 2020-02-12 2021-08-19 Viscera Labs, Inc. Therapeutic composition and methods
EP4295836A1 (en) * 2022-06-22 2023-12-27 Labomed Pharmaceutical Company S.A. Sachet comprising a liquid suspension of a sevelamer salt
CN119564718B (zh) * 2023-11-30 2026-04-14 成都施桂行医药科技有限责任公司 靶向回肠递送内毒素螯合剂药物及其制备方法和应用
US20250177436A1 (en) * 2023-11-30 2025-06-05 Sq Biopharma Inc. Method for treating metabolic disorders by ileum-targeted delivery of endotoxin sequestrant

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WO1993000915A1 (en) * 1991-07-03 1993-01-21 The Upjohn Company Colestipol hydrochloride high-content tablets
WO1994028881A1 (en) * 1993-06-11 1994-12-22 Merix Corporation Delayed release and trapping formulation for a bile acid adsorbent
EP0637447A2 (en) * 1993-08-03 1995-02-08 Mitsubishi Chemical Corporation Orally administrable cholesterol lowering agent
EP0922461A1 (en) * 1996-07-19 1999-06-16 Nikken Chemicals Company, Limited Remedies for hyperphosphatemia
WO2001028527A2 (en) * 1999-10-19 2001-04-26 Geltex Pharmaceuticals, Inc. Direct compression polymer tablet core
WO2001060392A1 (en) * 2000-02-18 2001-08-23 Yeda Research And Development Co., Ltd. At The Weizmann Institute Of Science Oral, nasal and pulmonary dosage formualtions of copolymer 1

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DE4446468A1 (de) * 1994-12-23 1996-06-27 Basf Ag Verfahren zur Herstellung von umhüllten Tabletten
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US6733780B1 (en) * 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US20020054903A1 (en) * 1999-10-19 2002-05-09 Joseph Tyler Direct compression polymer tablet core
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Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
WO1993000915A1 (en) * 1991-07-03 1993-01-21 The Upjohn Company Colestipol hydrochloride high-content tablets
WO1994028881A1 (en) * 1993-06-11 1994-12-22 Merix Corporation Delayed release and trapping formulation for a bile acid adsorbent
EP0637447A2 (en) * 1993-08-03 1995-02-08 Mitsubishi Chemical Corporation Orally administrable cholesterol lowering agent
EP0922461A1 (en) * 1996-07-19 1999-06-16 Nikken Chemicals Company, Limited Remedies for hyperphosphatemia
WO2001028527A2 (en) * 1999-10-19 2001-04-26 Geltex Pharmaceuticals, Inc. Direct compression polymer tablet core
WO2001060392A1 (en) * 2000-02-18 2001-08-23 Yeda Research And Development Co., Ltd. At The Weizmann Institute Of Science Oral, nasal and pulmonary dosage formualtions of copolymer 1

Also Published As

Publication number Publication date
WO2005065291A3 (en) 2006-02-09
EP1699442A2 (en) 2006-09-13
WO2005065291A2 (en) 2005-07-21
JP2007517047A (ja) 2007-06-28
AU2004311849A1 (en) 2005-07-21
CA2551528A1 (en) 2005-07-21
US20070098678A1 (en) 2007-05-03

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired